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Acta Neurochirurgica
Erschienen in:

08.08.2017 | Original Article - Vascular

Adolescents with moyamoya disease: clinical features, surgical treatment and long-term outcomes

verfasst von: Meng Zhao, Dong Zhang, Shuo Wang, Yan Zhang, Rong Wang, Xiaofeng Deng, Faliang Gao, Jizong Zhao

Erschienen in: Acta Neurochirurgica | Ausgabe 11/2017

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Abstract

Background

This study aimed to elucidate the clinical features, surgical treatment and long-term outcomes of adolescent patients with moyamoya disease.

Methods

We reviewed consecutive patients with moyamoya vasculopathy who were admitted to our hospital from 2009 to 2015 to identify adolescent patients with moyamoya disease. Clinical features, surgical treatment and long-term outcomes were analyzed. Follow-up was performed by face-to-face or structured telephone interviews. Outcome measures were future stroke events. We performed univariate and multivariate time-to-event analyses to identify risk factors associated with future stroke events.

Results

A total of 95 adolescent patients with moyamoya disease (age at onset, 13.1 ± 2.3 years) were included in this study. During follow-up, 12 patients (12.6%) had stroke events. We found that the patients who underwent direct/combined bypass had a significantly lower risk of future strokes [hazard ratio (HR), 0.16; 95% confidence interval (CI), 0.03–0.74; P = 0.019] compared to patients who underwent indirect bypass.

Conclusions

Our results demonstrate that direct/combined bypass can be more effective in preventing future strokes than indirect bypass in adolescent patients with moyamoya disease.
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Metadaten
Titel
Adolescents with moyamoya disease: clinical features, surgical treatment and long-term outcomes
verfasst von
Meng Zhao
Dong Zhang
Shuo Wang
Yan Zhang
Rong Wang
Xiaofeng Deng
Faliang Gao
Jizong Zhao
Publikationsdatum
08.08.2017
Verlag
Springer Vienna
Erschienen in
Acta Neurochirurgica / Ausgabe 11/2017
Print ISSN: 0001-6268
Elektronische ISSN: 0942-0940
DOI
https://doi.org/10.1007/s00701-017-3286-x

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