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Erschienen in:
01.12.2014 | Original Research
Adoption of Radiation Therapy Oncology Group consensus guidelines for post-prostatectomy radiation therapy in an academic tertiary care center
Erschienen in: Journal of Radiation Oncology | Ausgabe 4/2014
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Objective
This study aimed to define the impact of Radiation Therapy Oncology Group (RTOG) guidelines for clinical target volume (CTV) delineation for post-prostatectomy external beam radiation therapy (EBRT) on radiation dosimetry and toxicity.
Methods
We reviewed the records of 125 patients treated with post-prostatectomy EBRT at our institution. We recorded CTV size, dosimetric parameters for the rectum and bladder, and acute and late gastrointestinal (GI) and genitourinary (GU) toxicity. To estimate the impact of the RTOG guidelines, patients treated prior to 2010 were compared to patients treated from 2010 to 2013 for each of these endpoints.
Results
CTVs were larger and less variable for patients treated from 2010 to 2013 (mean 143.6 cm3, standard deviation (SD) 43.9) compared to patients treated prior to 2010 (mean 88.9 cm3, SD 65.6) (p < 0.001). Although patients treated from 2010 to 2013 had higher bladder volume receiving 65 Gy (V65) (47.7 vs. 32.9 %, p = 0.03), V50 (58.3 vs. 45.4 %, p = 0.04), V30 (81.9 vs. 61.9 %, p = 0.03), V20 (94.3 vs. 80.8 %, p = 0.01), and V10 (97.9 vs. 90.0 %, p = 0.05), there were no differences in acute (p = 0.17) or late (p = 0.59) GU toxicity between groups. There were no differences in acute (p = 0.22) or late (p = 0.40) GI toxicity between groups.
Conclusion
Adoption of RTOG guidelines for post-prostatectomy EBRT was associated with larger and less variable CTVs at our institution. There have been no changes in treatment-related toxicity compared to patients treated prior to publication of the guidelines.