01.03.2016 | Cancer (MF Leitzmann, Section Editor) | Ausgabe 1/2016

Adult Height in Relation to the Incidence of Cancer at Different Anatomic Sites: the Epidemiology of a Challenging Association

Zeitschrift:: Current Nutrition Reports > Ausgabe 1/2016

Autoren:: Geoffrey C. Kabat, H. Dean Hosgood III, Thomas E. Rohan

Wichtige Hinweise

This article is part of the Topical Collection on Cancer

Abstract

Recent analyses of large cohort studies indicate that adult height is associated with cancer at specific sites. In this overview, we review (1) the epidemiology of the association of height with specific cancer sites/types, focusing on the consistency and magnitude of the association and the possibility of confounding; (2) genome-wide association studies (GWASs) of variants associated with height; (3) studies using Mendelian randomization to investigate the association with several types of cancer; (4) studies of dietary and hormonal exposures associated with linear growth, particularly milk intake and circulating concentrations of insulin-like growth factor-1 (IGF-1), that might mediate an association of height with cancer; and (5) the possibility that greater organ size associated with greater height may explain part of the association. We conclude that epidemiologic studies strongly suggest that height is associated with certain cancer sites/types and not with others, and propose a number of avenues for beginning to elucidate the pathways underlying this association.

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Titel: Adult Height in Relation to the Incidence of Cancer at Different Anatomic Sites: the Epidemiology of a Challenging Association
Autoren:: Geoffrey C. Kabat
H. Dean Hosgood III
Thomas E. Rohan
Publikationsdatum: 01.03.2016
DOI: https://doi.org/10.1007/s13668-016-0152-z
Verlag: Springer US
Zeitschrift: Current Nutrition Reports
Ausgabe 1/2016
Elektronische ISSN: 2161-3311

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Adult Height in Relation to the Incidence of Cancer at Different Anatomic Sites: the Epidemiology of a Challenging Association

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