Skip to main content
Erschienen in: Current Urology Reports 4/2024

06.02.2024

Adult Hypospadias Outcomes for the Pediatric Urologist

verfasst von: Tyler Gaines, Jay Simhan

Erschienen in: Current Urology Reports | Ausgabe 4/2024

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

This review article will examine the current literature on hypospadias-related complications in adult patients.

Recent Findings

In this article, we will review the most recent studies evaluating hypospadias-related stricture disease, erectile function, fertility, and psychosexual outcomes in adult men with history of hypospadias repair in childhood.

Summary

Managing hypospadias-related complications in adult patients is challenging to reconstructive urologists due to the compounded complexity of innate tissue deficiency and history of prior surgical repairs. In this review, we explore overall functional outcomes of adults with history of hypospadias repair as well as repair strategies of hypospadias-related urethral stricture disease. We will review erectile function, fertility and psychosexual outcomes as well as potential complications, which often do not surface until late adolescence and adulthood. Although it is challenging to characterize and quantify hypospadias-related complications, further longitudinal study is needed to better care for this complex patient population.
Literatur
1.
Zurück zum Zitat Mai CT, Isenburg J, Langlois PH, et al. Population-based birth defects data in the United States, 2008 to 2012: presentation of state-specific data and descriptive brief on variability of prevalence. Birth Defects Res A Clin Mol Teratol. 2015;103:972–93.CrossRefPubMedPubMedCentral Mai CT, Isenburg J, Langlois PH, et al. Population-based birth defects data in the United States, 2008 to 2012: presentation of state-specific data and descriptive brief on variability of prevalence. Birth Defects Res A Clin Mol Teratol. 2015;103:972–93.CrossRefPubMedPubMedCentral
2.
Zurück zum Zitat Duckett JW. Hypospadias in Campbell's urology. In: Walsh PC, Retik AB, Vaughan ED, Wein AJ, editors. Campbell's urology. 7th ed. WA Saunders Company; 1998. p. 2093. Duckett JW. Hypospadias in Campbell's urology. In: Walsh PC, Retik AB, Vaughan ED, Wein AJ, editors. Campbell's urology. 7th ed. WA Saunders Company; 1998. p. 2093.
3.
Zurück zum Zitat Khuri FJ, Hardy BE, Churchill BM. Urologic anomalies associated with hypospadias. Urol Clin N Am. 1981;8:565–71.CrossRef Khuri FJ, Hardy BE, Churchill BM. Urologic anomalies associated with hypospadias. Urol Clin N Am. 1981;8:565–71.CrossRef
4.
Zurück zum Zitat Kass E, Kogan SJ, Mainley C. Timing of the elective surgery on the genitalia of male children with particular reference to risks benefits, psychological effects of surgery and anaesthesia. Pediatrics. 1996;97:590–4.CrossRef Kass E, Kogan SJ, Mainley C. Timing of the elective surgery on the genitalia of male children with particular reference to risks benefits, psychological effects of surgery and anaesthesia. Pediatrics. 1996;97:590–4.CrossRef
5.
Zurück zum Zitat Rushton HG, Belman AB. The split prepuce in situ onlay hypospadias repair. J Urol. 1998;160:1134.CrossRefPubMed Rushton HG, Belman AB. The split prepuce in situ onlay hypospadias repair. J Urol. 1998;160:1134.CrossRefPubMed
6.
Zurück zum Zitat Pfistermuller KL, McArdle AJ, Cuckow PM. Meta-analysis of complication rates of the tubularized incised plate (TIP) repair. J Pediatr Urol. 2015;11:54.CrossRefPubMed Pfistermuller KL, McArdle AJ, Cuckow PM. Meta-analysis of complication rates of the tubularized incised plate (TIP) repair. J Pediatr Urol. 2015;11:54.CrossRefPubMed
7.
Zurück zum Zitat Perlmutter AE, Morabito R, Tarry WF. Impact of patient age on distal hypospadias repair: a surgical perspective. Urology. 2006;68:648.CrossRefPubMed Perlmutter AE, Morabito R, Tarry WF. Impact of patient age on distal hypospadias repair: a surgical perspective. Urology. 2006;68:648.CrossRefPubMed
8.
Zurück zum Zitat Snodgrass WT, Bush N, Cost N. Algorithm for comprehensive approach to hypospadias reoperation using 3 techniques. J Urol. 2009;182:2885–91.CrossRefPubMed Snodgrass WT, Bush N, Cost N. Algorithm for comprehensive approach to hypospadias reoperation using 3 techniques. J Urol. 2009;182:2885–91.CrossRefPubMed
9.
Zurück zum Zitat Long CJ, Chu DI, Tenney RW, Morris AR, Weiss DA, Shukla AR, Srinivasan AK, Zderic SA, Kolon TF, Canning DA. Intermediate-term followup of proximal hypospadias repair reveals high complication rate. J Urol. 2017;197(3 Pt 2):852–8.CrossRefPubMed Long CJ, Chu DI, Tenney RW, Morris AR, Weiss DA, Shukla AR, Srinivasan AK, Zderic SA, Kolon TF, Canning DA. Intermediate-term followup of proximal hypospadias repair reveals high complication rate. J Urol. 2017;197(3 Pt 2):852–8.CrossRefPubMed
10.
Zurück zum Zitat Stanasel I, Le HK, Bilgutay A, Roth DR, Gonzales ET Jr, Janzen N, Koh CJ, Gargollo P, Seth A. Complications following Staged Hypospadias Repair Using Transposed Preputial Skin Flaps. J Urol. 2015;194(2):512–6.CrossRefPubMedPubMedCentral Stanasel I, Le HK, Bilgutay A, Roth DR, Gonzales ET Jr, Janzen N, Koh CJ, Gargollo P, Seth A. Complications following Staged Hypospadias Repair Using Transposed Preputial Skin Flaps. J Urol. 2015;194(2):512–6.CrossRefPubMedPubMedCentral
11.
Zurück zum Zitat McNamara ER, Schaeffer AJ, Logvinenko T, et al. Management of proximal hypospadias with 2-stage repair: 20-year experience. J Urol. 2015;194:1080.CrossRefPubMedPubMedCentral McNamara ER, Schaeffer AJ, Logvinenko T, et al. Management of proximal hypospadias with 2-stage repair: 20-year experience. J Urol. 2015;194:1080.CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat Spinoit A-F, Poelaert F, Groen L-A, Van Laecke E, Hoebeke P. Hypospadias repair at a tertiary care center: long-term followup is mandatory to determine the real complication rate. J Urol. 2013;189(6):2276–81.CrossRefPubMed Spinoit A-F, Poelaert F, Groen L-A, Van Laecke E, Hoebeke P. Hypospadias repair at a tertiary care center: long-term followup is mandatory to determine the real complication rate. J Urol. 2013;189(6):2276–81.CrossRefPubMed
13.
Zurück zum Zitat Lumen N, Hoebeke P, Willemsen P, De Troyer B, Pieters R, Oosterlinck W. Etiology of urethral stricture disease in the 21st century. J Urol. 2009;182(3):983–7.CrossRefPubMed Lumen N, Hoebeke P, Willemsen P, De Troyer B, Pieters R, Oosterlinck W. Etiology of urethral stricture disease in the 21st century. J Urol. 2009;182(3):983–7.CrossRefPubMed
14.
Zurück zum Zitat Palminteri E, Berdondini E, Verze P, et al. Contemporary urethral stricture characteristics in the developed world. Urology. 2013;81:191–6.CrossRefPubMed Palminteri E, Berdondini E, Verze P, et al. Contemporary urethral stricture characteristics in the developed world. Urology. 2013;81:191–6.CrossRefPubMed
15.
Zurück zum Zitat • Barbagli G, Perovic S, Djinovic R, Sansalone S, Lazzeri M. Retrospective descriptive analysis of 1,176 patients with failed hypospadias repair. J Urol. 2010;183(1):207–11. Retrospective chart analysis of adults with complications related to hypospadias repair. • Barbagli G, Perovic S, Djinovic R, Sansalone S, Lazzeri M. Retrospective descriptive analysis of 1,176 patients with failed hypospadias repair. J Urol. 2010;183(1):207–11. Retrospective chart analysis of adults with complications related to hypospadias repair.
16.
Zurück zum Zitat • Myers JB, McAninch JW, Erickson BA, Breyer BN. Treatment of adults with complications from previous hypospadias surgery. J Urol. 2012;188(2):459–63. Retrospective study evaluating surgical treatment outcomes of adults with history of hypospadias repair in childhood. • Myers JB, McAninch JW, Erickson BA, Breyer BN. Treatment of adults with complications from previous hypospadias surgery. J Urol. 2012;188(2):459–63. Retrospective study evaluating surgical treatment outcomes of adults with history of hypospadias repair in childhood.
17.
Zurück zum Zitat Grosfeld J, O'Neill J, Coran A et al. Pediatric Surgery (Sixth Edition),Mosby,2006,Pages i-lxviii. ISBN 9780323028424. Grosfeld J, O'Neill J, Coran A et al. Pediatric Surgery (Sixth Edition),Mosby,2006,Pages i-lxviii. ISBN 9780323028424.
18.
Zurück zum Zitat Kulkarni S, Barbagli G, Sansalone S, Lazzeri M. One-sided anterior urethroplasty: a new dorsal onlay graft technique. BJU Int. 2009;104(8):1150–5.CrossRefPubMed Kulkarni S, Barbagli G, Sansalone S, Lazzeri M. One-sided anterior urethroplasty: a new dorsal onlay graft technique. BJU Int. 2009;104(8):1150–5.CrossRefPubMed
19.
Zurück zum Zitat Hayes MC, Malone PS. The use of a dorsal buccal mucosal graft with urethral plate incision (Snodgrass) for hypospadias salvage. BJU Int. 1999;83(4):508–9.CrossRefPubMed Hayes MC, Malone PS. The use of a dorsal buccal mucosal graft with urethral plate incision (Snodgrass) for hypospadias salvage. BJU Int. 1999;83(4):508–9.CrossRefPubMed
20.
Zurück zum Zitat Asopa HS, Garg M, Singhal GG, Singh L, Asopa J, Nischal A. Dorsal free graft urethroplasty for urethral stricture by ventral sagittal urethrotomy approach. Urology. 2001;58(5):657–9.CrossRefPubMed Asopa HS, Garg M, Singhal GG, Singh L, Asopa J, Nischal A. Dorsal free graft urethroplasty for urethral stricture by ventral sagittal urethrotomy approach. Urology. 2001;58(5):657–9.CrossRefPubMed
22.
Zurück zum Zitat Kozinn SI, Harty NJ, Zinman L, Buckley JC. Management of complex anterior urethral strictures with multistage buccal mucosa graft reconstruction. Urology. 2013;82(3):718–22.CrossRefPubMed Kozinn SI, Harty NJ, Zinman L, Buckley JC. Management of complex anterior urethral strictures with multistage buccal mucosa graft reconstruction. Urology. 2013;82(3):718–22.CrossRefPubMed
24.
Zurück zum Zitat Andrich DE, Mundy AR. Climate – a potential cause of primary graft failure in buccal mucosal graft urethroplasty. J Urol. 2009;181(Suppl 4):15.CrossRef Andrich DE, Mundy AR. Climate – a potential cause of primary graft failure in buccal mucosal graft urethroplasty. J Urol. 2009;181(Suppl 4):15.CrossRef
25.
Zurück zum Zitat Joshi PM, Barbagli G, Batra V, et al. A novel composite two-stage urethroplasty for complex penile strictures: a multicenter experience. Indian J Urol. 2017;33(2):155–8.CrossRefPubMedPubMedCentral Joshi PM, Barbagli G, Batra V, et al. A novel composite two-stage urethroplasty for complex penile strictures: a multicenter experience. Indian J Urol. 2017;33(2):155–8.CrossRefPubMedPubMedCentral
26.
Zurück zum Zitat Gholami SS, Lue TF. Correction of penile curvature using the 16-dot plication technique: a review of 132 patients. J Urol. 2002;167(5):2066–9. PMID: 11956440. Gholami SS, Lue TF. Correction of penile curvature using the 16-dot plication technique: a review of 132 patients. J Urol. 2002;167(5):2066–9. PMID: 11956440.
27.
Zurück zum Zitat Castellan M, Gosalbez R, Devendra J, Bar-Yosef Y, Labbie A. Ventral corporal body grafting for correcting severe penile curvature associated with single or two-stage hypospadias repair. Castellan M, Gosalbez R, Devendra J, Bar-Yosef Y, Labbie A. Ventral corporal body grafting for correcting severe penile curvature associated with single or two-stage hypospadias repair.
28.
Zurück zum Zitat Barbagli G, De Angelis M, Romano G, Lazzeri M. Clinical outcome and quality of life assessment in patients treated with perineal urethrostomy for anterior urethral stricture disease. J Urol. 2009;182(2):548–57.CrossRefPubMed Barbagli G, De Angelis M, Romano G, Lazzeri M. Clinical outcome and quality of life assessment in patients treated with perineal urethrostomy for anterior urethral stricture disease. J Urol. 2009;182(2):548–57.CrossRefPubMed
29.
Zurück zum Zitat Elliott SP, Eisenberg ML, McAninch JW. First-stage urethroplasty: utility in the modern era. Urology. 2008;71:889–92.CrossRefPubMed Elliott SP, Eisenberg ML, McAninch JW. First-stage urethroplasty: utility in the modern era. Urology. 2008;71:889–92.CrossRefPubMed
30.
Zurück zum Zitat Rynja SP, Wouters GA, Van Schaijk M, Kok ET, De Jong TP, De Kort LM. Long-term followup of hypospadias: functional and cosmetic results. J Urol. 2009;182(4):1736–43.CrossRefPubMed Rynja SP, Wouters GA, Van Schaijk M, Kok ET, De Jong TP, De Kort LM. Long-term followup of hypospadias: functional and cosmetic results. J Urol. 2009;182(4):1736–43.CrossRefPubMed
31.
Zurück zum Zitat Vandendriessche S, Baeyens D, Van Hoecke E, Indekeu A, Hoebeke P. Body image and sexuality in adolescents after hypospadias surgery. J Pediatr Urol. 2010;6(1):54–9.CrossRefPubMed Vandendriessche S, Baeyens D, Van Hoecke E, Indekeu A, Hoebeke P. Body image and sexuality in adolescents after hypospadias surgery. J Pediatr Urol. 2010;6(1):54–9.CrossRefPubMed
32.
Zurück zum Zitat Chertin B, Natsheh A, Ben-Zion I, Prat D, Kocherov S, Farkas A, Shenfeld OZ. Objective and subjective sexual outcomes in adult patients after hypospadias repair performed in childhood. J Urol. 2013;190(4):1556–60.CrossRefPubMed Chertin B, Natsheh A, Ben-Zion I, Prat D, Kocherov S, Farkas A, Shenfeld OZ. Objective and subjective sexual outcomes in adult patients after hypospadias repair performed in childhood. J Urol. 2013;190(4):1556–60.CrossRefPubMed
33.
Zurück zum Zitat • Husmann DA. Erectile dysfunction in patients undergoing multiple attempts at hypospadias repair: Etiologies and concerns. J Pediatr Urol. 2021;17(2):166.e1-166.e7. Retrospective study evaluating erectile dysfunction in men with history of ≥ three prior hypospadias repair attempts. • Husmann DA. Erectile dysfunction in patients undergoing multiple attempts at hypospadias repair: Etiologies and concerns. J Pediatr Urol. 2021;17(2):166.e1-166.e7. Retrospective study evaluating erectile dysfunction in men with history of ≥ three prior hypospadias repair attempts.
34.
Zurück zum Zitat Skakkebaek NE, Rajpert-De Meyts E, Buck Louis GM, et al. Male reproductive disorders and fertility trends: influences of environment and genetic susceptibility. Physiol Rev. 2016;96(1):55–97.CrossRefPubMed Skakkebaek NE, Rajpert-De Meyts E, Buck Louis GM, et al. Male reproductive disorders and fertility trends: influences of environment and genetic susceptibility. Physiol Rev. 2016;96(1):55–97.CrossRefPubMed
36.
Zurück zum Zitat Asklund C, Jensen TK, Main KM, Sobotka T, Skakkebaek NE, Jørgensen N. Semen quality, reproductive hormones and fertility of men operated for hypospadias. Int J Androl. 2010;33(1):80–7.CrossRefPubMed Asklund C, Jensen TK, Main KM, Sobotka T, Skakkebaek NE, Jørgensen N. Semen quality, reproductive hormones and fertility of men operated for hypospadias. Int J Androl. 2010;33(1):80–7.CrossRefPubMed
38.
Zurück zum Zitat Olofsson K, Oldbring J, Becker M, Åberg M, Svensson H. Self-perception after hypospadias repair in young men’s perspective. Eur J Plast Surg. 2003;26:294–7.CrossRef Olofsson K, Oldbring J, Becker M, Åberg M, Svensson H. Self-perception after hypospadias repair in young men’s perspective. Eur J Plast Surg. 2003;26:294–7.CrossRef
39.
Zurück zum Zitat Liu G, Yuan J, Feng J, Geng J, Zhang W, Zhou X, et al. Factors affecting the long-term results of hypospadias repairs. J Pediatr Surg. 2006;41:554–9.CrossRefPubMed Liu G, Yuan J, Feng J, Geng J, Zhang W, Zhou X, et al. Factors affecting the long-term results of hypospadias repairs. J Pediatr Surg. 2006;41:554–9.CrossRefPubMed
40.
Zurück zum Zitat • Skarin Nordenvall A, Chen Q, Norrby C, Lundholm C, Frisén L, Nordenström A, Almqvist C, Nordenskjöld A. Fertility in adult men born with hypospadias: a nationwide register-based cohort study on birthrates, the use of assisted reproductive technologies and infertility. Andrology. 2020;8(2):372–80. Population-based cohort study evaluating fertility and confounding familial factors in men born with hypospadias. • Skarin Nordenvall A, Chen Q, Norrby C, Lundholm C, Frisén L, Nordenström A, Almqvist C, Nordenskjöld A. Fertility in adult men born with hypospadias: a nationwide register-based cohort study on birthrates, the use of assisted reproductive technologies and infertility. Andrology. 2020;8(2):372–80. Population-based cohort study evaluating fertility and confounding familial factors in men born with hypospadias.
41.
Zurück zum Zitat Kanematsu A, Tanaka S, Hashimoto T, Nojima M, Yamamoto S. Analysis of the association between paternity and reoperation for urethral obstruction in adult hypospadias patients who underwent two-stage repair in childhood. BMC Urol. 2019;19(1):88.CrossRefPubMedPubMedCentral Kanematsu A, Tanaka S, Hashimoto T, Nojima M, Yamamoto S. Analysis of the association between paternity and reoperation for urethral obstruction in adult hypospadias patients who underwent two-stage repair in childhood. BMC Urol. 2019;19(1):88.CrossRefPubMedPubMedCentral
42.
Zurück zum Zitat • Tack LJW, Springer A, Riedl S, Tonnhofer U, Weninger J, Hiess M, Van Hoecke E. Psychosexual outcome, sexual function, and long-term satisfaction of adolescent and young adult men after childhood hypospadias repair. J Sex Med. 2020;17(9):1665–1675. Cross-sectional assessment of psychosexual functioning in adolescent and young adult men after childhood hypospadias repair. • Tack LJW, Springer A, Riedl S, Tonnhofer U, Weninger J, Hiess M, Van Hoecke E. Psychosexual outcome, sexual function, and long-term satisfaction of adolescent and young adult men after childhood hypospadias repair. J Sex Med. 2020;17(9):1665–1675. Cross-sectional assessment of psychosexual functioning in adolescent and young adult men after childhood hypospadias repair.
43.
Zurück zum Zitat Andersson M, Sjöström S, Wängqvist M, Örtqvist L, Nordenskjöld A, Holmdahl G. Psychosocial and sexual outcomes in adolescents following surgery for proximal hypospadias in childhood. J Urol. 2018;200(6):1362–70.CrossRefPubMed Andersson M, Sjöström S, Wängqvist M, Örtqvist L, Nordenskjöld A, Holmdahl G. Psychosocial and sexual outcomes in adolescents following surgery for proximal hypospadias in childhood. J Urol. 2018;200(6):1362–70.CrossRefPubMed
Metadaten
Titel
Adult Hypospadias Outcomes for the Pediatric Urologist
verfasst von
Tyler Gaines
Jay Simhan
Publikationsdatum
06.02.2024
Verlag
Springer US
Erschienen in
Current Urology Reports / Ausgabe 4/2024
Print ISSN: 1527-2737
Elektronische ISSN: 1534-6285
DOI
https://doi.org/10.1007/s11934-024-01196-7

Update Urologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.