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Journal of Bone and Mineral Metabolism

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04.12.2019 | Original Article

Adult lactose intolerance, calcium intake, bone metabolism and bone density in German-Turkish immigrants

verfasst von: Philipp Klemm, Gabriel Dischereit, Uwe Lange

Erschienen in: Journal of Bone and Mineral Metabolism | Ausgabe 3/2020

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Abstract

Introduction

Adult lactose intolerance (ALI) significantly alters calcium intake and absorption, and thus may promote osteoporosis. ALI is a recessive condition with a geographical north–south gradient characterised by decreased levels of intestinal lactase. PCR-based genotyping of lactase (LCT) gene polymorphisms is a safe and easy way to diagnose ALI and may complement diagnostic procedures to identify individuals at risk for reduced calcium intake and subsequently osteoporosis due to lactose malabsorption. Therefore, we investigated the frequency of ALI and its influence on calcium intake, markers of bone metabolism and bone mineral density (BMD) in a cohort of Turkish immigrants living in Germany.

Materials and methods

We investigated single nucleotide polymorphisms of the LCT gene, calcium intake, markers of bone metabolism and BMD in 183 Turkish immigrants.

Results

ALI was diagnosed in 154 out of 183 (81%) probands. ALI was significantly associated with self-reported lactose intolerance (p < 0.001) and dislike for dairy products (p < 0.01). Osteopenia was diagnosed in 59 out of 183 (32%) and osteoporosis in 15 out of 183 (8%) probands. Probands with reduced BMD had ALI in 86%. All probands had a decreased calcium intake [mg/week]. There was no significant association between ALI, calcium intake, markers of bone metabolism or BMD.

Conclusion

Turkish immigrants mostly have ALI and overall show a reduced calcium intake per week. However, ALI did not significantly influence calcium intake, markers of bone metabolism or BMD in this cohort. Therefore, ALI in Turkish immigrants does not seem to be a risk factor for osteoporosis.

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Titel: Adult lactose intolerance, calcium intake, bone metabolism and bone density in German-Turkish immigrants
verfasst von: Philipp Klemm
Gabriel Dischereit
Uwe Lange
Publikationsdatum: 04.12.2019
Verlag: Springer Singapore
Erschienen in: Journal of Bone and Mineral Metabolism / Ausgabe 3/2020
Print ISSN: 0914-8779
Elektronische ISSN: 1435-5604
DOI: https://doi.org/10.1007/s00774-019-01070-4

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Adult lactose intolerance, calcium intake, bone metabolism and bone density in German-Turkish immigrants

Abstract

Introduction

Materials and methods

Results

Conclusion

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