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22.12.2023 | Review Article

Advancements in investigating the role of cerebral small vein loss in Alzheimer’s disease–related pathological changes

verfasst von: Zhenzhu Hu, Zhaoying Li, Yu Shi, Shanyu Liu, Yuling Shen, Fangfang Hu, Qingqing Li, Xu Liu, Xinyu Gou, Zhenwei Chen, Dongdong Yang

Erschienen in: Neurological Sciences | Ausgabe 5/2024

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Abstract

Alzheimer’s disease (AD) is the prevailing type of dementia in the elderly, yet a comprehensive comprehension of its precise underlying mechanisms remains elusive. The investigation of the involvement of cerebral small veins in the advancement of AD has yet to be sufficiently explored in previous studies, primarily due to constraints associated with pathological staining techniques. However, recent research has provided valuable insights into multiple pathophysiological occurrences concerning cerebral small veins in AD, which may manifest sequentially, concurrently, or in a self-perpetuating manner. These events are presumed to be among the initial processes in the disease’s progression. The impact of cerebral small vein loss on amyloid beta (Aβ) clearance through the glial lymphatic system is noteworthy. There exists a potential interdependence between collagen deposition and Aβ deposition in cerebral small veins. The compromised functionality of cerebral small veins can result in decreased cerebral perfusion pressure, potentially leading to cerebral tissue ischemia and edema. Additionally, the reduction of cerebral small veins may facilitate the infiltration of inflammatory factors into the brain parenchyma, thereby eliciting neuroinflammatory responses. Susceptibility-weighted imaging (SWI) is a valuable modality for the efficient assessment of cerebral small veins, precisely the deep medullary vein (DMV), and holds promise for the identification of precise and reliable imaging biomarkers for AD. This review presents a comprehensive overview of the current advancements and obstacles to the impairment of cerebral small veins in AD. Additionally, we emphasize future research avenues and the importance of conducting further investigations in this domain.

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Titel: Advancements in investigating the role of cerebral small vein loss in Alzheimer’s disease–related pathological changes
verfasst von: Zhenzhu Hu
Zhaoying Li
Yu Shi
Shanyu Liu
Yuling Shen
Fangfang Hu
Qingqing Li
Xu Liu
Xinyu Gou
Zhenwei Chen
Dongdong Yang
Publikationsdatum: 22.12.2023
Verlag: Springer International Publishing
Erschienen in: Neurological Sciences / Ausgabe 5/2024
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-023-07208-7

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Eine Analyse von Daten des statistischen Bundesamtes spricht dafür, dass Frauen in der Schlaganfallbehandlung nicht benachteiligt sind. Im Detail bleiben aber Fragen offen.

Update Neurologie

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Springer Medizin

Advancements in investigating the role of cerebral small vein loss in Alzheimer’s disease–related pathological changes

Abstract

Weitere Artikel der Ausgabe 5/2024

The use of the eye-fixation-related potential to investigate visual perception in professional domains with high attentional demand: a literature review

Causal associations between 25-hydroxyvitamin D levels and NMOSD: a two-Sample Mendelian randomization analysis

Future treatment options for facial nerve palsy: a review on electrical stimulation devices for the orbicularis oculi muscle

Association between motor symptoms of Parkinson’s disease and swallowing disorders

Only anti-GM4 antibody positivity in a Chinese girl with overlapping MFS/GBS: a case report

Impaired interhemispheric synchrony and effective connectivity in right temporal lobe epilepsy

Kompaktes Leitlinien-Wissen Neurologie (Link öffnet in neuem Fenster)

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Einjährige Valaciclovir-Therapie schützt nicht vor Zoster-Rezidiv

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Frauen akkumulieren Tau-Protein schneller als Männer

Frauen mit Apoplex in Deutschland nicht benachteiligt – oder doch?

Update Neurologie

Springer Medizin

Abstract

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