Background
Circular RNAs
Biogenesis and regulation of circRNAs
Functions of circular RNAs
CircRNAs serve as ceRNAs or miRNA sponges
CircRNAs bind and sequester proteins
Regulating gene transcription
Translation
CircRNA and Breast Cancer
Expression of circRNA in breast cancer
Name | Dysregulation | Sponge target | Funcion | Ref |
---|---|---|---|---|
hsa_circ_0001982 | upregulated | miR-143 | Oncogene | [53] |
circGFRA1 | upregulated | miR-34a | Oncogene/biomarker | [59] |
circ-ABCB10 | upregulated | miR-1271 | Oncogene | [57] |
hsa_circ_103110 | upregulated | – | Biomarker | [52] |
hsa_circ_104821 | upregulated | – | Biomarker | [52] |
hsa_circ_104689 | upregulated | – | Biomarker | [52] |
hsa_circ_006054 | downregulated | – | Biomarker | [52] |
hsa_circ_100219 | downregulated | – | Biomarker | [52] |
hsa_circ_406697 | downregulated | – | Biomarker | [52] |
circ-Foxo3 | downregulated | MiR-22/miR-136/miR-138 | Tumor suppressor | [71] |
CircRNA_1093 | upregulated | MiR-342-3p | Oncogene | [54] |
circVRK1 | downregulated | – | Tumor suppressor | [81] |
hsa_circ_0001785 | upregulated | – | Biomarker | [50] |
hsa_circ_0108942 | upregulated | – | Biomarker | [50] |
hsa_circ_0068033 | downregulated | Biomarker | [50] |
CircRNA and the proliferation and progression of breast cancer
circRNA regulates the proliferation and progression of breast cancer via serving as microRNA sponges
CircRNA regulates the proliferation and progression of breast cancer via cancer-associated signaling pathways
CircRNA as potential diagnostic and prognostic biomarkers in breast cancer
Therapeutic potential of circRNAs in breast cancer
CircRNAs exhibit potential anti-cancer effects
Relationship between circRNA and chemoresistant breast cancer
Breast cancer therapy targeting circRNAs
Research strategies for circRNAs
Online databases
Name | Description | Website | Ref |
---|---|---|---|
circBase | A comprehensive database for public circRNA datasets | [72] | |
circ2Traits | A knowledgebase of human circRNAs associated with diseases or traits | [95] | |
Circnet | A database of circular RNAs derived from transcriptome sequencing data | [96] | |
CircInteractome | Exploring circRNAs and their interaction with proteins or miRNAs, as well as primer design and siRNA design | [97] | |
CIRCpedia | Annotating alternative back-splicing and alternative splicing in circRNAs | [30] | |
circRNADb | A comprehensive database for human circular RNAs with protein-coding annotations a database for cancer-specific | [98] | |
CSCD | circular RNAs A database of tissue-specific | [99] | |
TSCD | circular RNAs in the human and mouse genomes | [100] |