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Journal of Nuclear Cardiology
Erschienen in: Journal of Nuclear Cardiology 2/2019

01.04.2019 | Review Article

Advances in imaging instrumentation for nuclear cardiology

verfasst von: Jae Sung Lee, PhD, Gil Kovalski, PhD, Tali Sharir, MD, Dong Soo Lee, MD, PhD

Erschienen in: Journal of Nuclear Cardiology | Ausgabe 2/2019

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Abstract

Advances in imaging instrumentation and technology have greatly contributed to nuclear cardiology. Dedicated cardiac SPECT cameras incorporating novel, highly efficient detector, collimator, and system designs have emerged with the expansion of nuclear cardiology. Solid-state radiation detectors incorporating cadmium zinc telluride, which directly convert radiation to electrical signals and yield improved energy resolution and spatial resolution and enhanced count sensitivity geometries, are increasingly gaining favor as the detector of choice for application in dedicated cardiac SPECT systems. Additionally, hybrid imaging systems in which SPECT and PET are combined with X-ray CT are currently widely used, with PET/MRI hybrid systems having also been recently introduced. The improved quantitative SPECT/CT has the potential to measure the absolute quantification of myocardial blood flow and flow reserve. Rapid development of silicon photomultipliers leads to enhancement in PET image quality and count rates. In addition, the reduction of emission–transmission mismatch artifacts via application of accurate time-of-flight information, and cardiac motion de-blurring aided by anatomical images, are emerging techniques for further improvement of cardiac PET. This article reviews recent advances such as these in nuclear cardiology imaging instrumentation and technology, and the corresponding diagnostic benefits.
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Literatur
1.
Sharir T, Ben-Haim S, Merzon K, Prochorov V, Dickman D, Berman DS. High-speed myocardial perfusion imaging initial clinical comparison with conventional dual detector anger camera imaging. JACC Cardiovasc Imaging. 2008;1:156–63.CrossRefPubMed
2.
Esteves FP, Raggi P, Folks RD, Keidar Z, Askew JW, Rispler S, et al. Novel solid-state-detector dedicated cardiac camera for fast myocardial perfusion imaging: multicenter comparison with standard dual detector cameras. J Nucl Cardiol. 2009;16:927–34.CrossRefPubMedPubMedCentral
3.
Sharir T, Slomka PJ, Hayes SW, DiCarli MF, Ziffer JA, Martin WH, et al. Multicenter trial of high-speed versus conventional single-photon emission computed tomography imaging: quantitative results of myocardial perfusion and left ventricular function. J Am Coll Cardiol. 2010;55:1965–74.CrossRefPubMed
4.
Chang SM, Nabi F, Xu J, Pratt CM, Mahmarian AC, Frias ME, et al. Value of CACS compared with ETT and myocardial perfusion imaging for predicting long-term cardiac outcome in asymptomatic and symptomatic patients at low risk for coronary disease: clinical implications in a multimodality imaging world. JACC Cardiovasc Imaging. 2015;8:134–44.CrossRefPubMed
5.
Rischpler C, Nekolla SG, Dregely I, Schwaiger M. Hybrid PET/MR imaging of the heart: potential, initial experiences, and future prospects. J Nucl Med. 2013;54:402–15.CrossRefPubMed
6.
Ratib O, Nkoulou R. Potential applications of PET/MR imaging in cardiology. J Nucl Med. 2014;55:40–5.CrossRef
7.
Nemallapudi MV, Gundacker S, Lecoq P, Auffray E, Ferri A, Gola A, et al. Sub-100 ps coincidence time resolution for positron emission tomography with LSO: Ce codoped with Ca. Phys Med Biol. 2015;60:4635–49.CrossRefPubMed
8.
Schug D, Wehner J, Dueppenbecker PM, Weissler B, Gebhardt P, Goldschmidt B, et al. PET performance and MRI compatibility evaluation of a digital, ToF-capable PET/MRI insert equipped with clinical scintillators. Phys Med Biol. 2015;60:7045–67.CrossRefPubMed
9.
Knoll P, Kotalova D, Köchle G, Kuzelka I, Minear G, Mirzaei S, et al. Comparison of advanced iterative reconstruction methods for SPECT/CT. Med Phys. 2012;22:58–69.CrossRef
10.
Borges-Neto S, Pagnanelli RA, Shaw LK, Honeycutt E, Shwartz SC, Adams GL, et al. Clinical results of a novel wide beam reconstruction method for shortening scan time of Tc-99m cardiac SPECT perfusion studies. J Nucl Cardiol. 2007;14:555–65.CrossRefPubMed
11.
Ali I, Ruddy TD, Almgrahi A, Anstett FG, Wells RG. Half-time SPECT myocardial perfusion imaging with attenuation correction. J Nucl Med. 2009;50:554–62.CrossRefPubMed
12.
Slomka PJ, Pan T, Berman DS, Germano G. Advances in SPECT and PET hardware. Prog Cardiovasc Dis. 2015;57:566–78.CrossRefPubMed
13.
Bocher M, Blevis IM, Tsukerman L, Shrem Y, Kovalski G, Volokh L. A fast cardiac gamma camera with dynamic SPECT capabilities: design, system validation and future potential. Eur J Nucl Med Mol Imaging. 2010;37:1887–902.CrossRefPubMedPubMedCentral
14.
Imbert L, Poussier S, Franken PR, Songy B, Verger A, Morel O, et al. Compared performance of high-sensitivity cameras dedicated to myocardial perfusion SPECT: a comprehensive analysis of phantom and human images. J Nucl Med. 2012;53:1897–903.CrossRefPubMed
15.
Zoccarato O, Lizio D, Savi A, Indovina L, Scabbio C, Leva L, et al. Comparative analysis of cadmium-zincum-telluride cameras dedicated to myocardial perfusion SPECT: A phantom study. J Nucl Cardiol. 2016;23(4):885–93.CrossRefPubMed
16.
Duvall WL, Slomka PJ, Gerlach JR, Sweeny JM, Baber U, Croft LB, et al. High-efficiency SPECT MPI: comparison of automated quantification, visual interpretation, and coronary angiography. J Nucl Cardiol. 2013;20:763–73.CrossRefPubMed
17.
Einstein AJ, Blankstein R, Andrews H, Fish M, Padgett R, Hayes SW, et al. Comparison of image quality, myocardial perfusion, and left ventricular function between standard imaging and single-injection ultra-low-dose imaging using a high-efficiency SPECT camera: the MILLISIEVERT study. J Nucl Med. 2014;55:1430–7.CrossRefPubMed
18.
Sharir T, Pinskiy M, Pardes A, Rochman A, Prokhorov V, Kovalski G, et al. Comparison of the diagnostic accuracies of very low stress-dose with standard-dose myocardial perfusion imaging: Automated quantification of one-day, stress-first SPECT using a CZT camera. J Nucl Cardiol. 2016;23:11–20.CrossRefPubMed
19.
Ben-Haim S, Murthy VL, Breault C, Allie R, Sitek A, Roth N, et al. Quantification of myocardial perfusion reserve using dynamic SPECT imaging in humans: a feasibility study. J Nucl Med. 2013;54:873–9.CrossRefPubMed
20.
Ben Bouallègue F, Roubille F, Lattuca B, Cung TT, Macia JC, Gervasoni R, et al. SPECT myocardial perfusion reserve in patients with multivessel coronary disease: correlation with angiographic findings and invasive fractional flow reserve measurements. J Nucl Med. 2015;56:1712–7.CrossRefPubMed
21.
Shiraishi S, Sakamoto F, Tsuda N, Yoshida M, Tomiguchi S, Utsunomiya D, et al. Prediction of left main or 3-vessel disease using myocardial perfusion reserve on dynamic thallium-201 single-photon emission computed tomography with a semiconductor gamma camera. Circ J. 2015;79:623–31.CrossRefPubMed
22.
Mouden M, Ottervanger JP, Timmer JR, Reiffers S, Oostdijk AH, Knollema S, et al. The influence of coronary calcium score on the interpretation of myocardial perfusion imaging. J Nucl Cardiol. 2014;21:368–74.CrossRefPubMed
23.
Chang SM, Nabi F, Xu J, Peterson LE, Achari A, Pratt CM, et al. The coronary artery calcium score and stress myocardial perfusion imaging provide independent and complementary prediction of cardiac risk. J Am Coll Cardiol. 2009;54:1872–82.CrossRefPubMed
24.
Bailey DL, Willowson KP. An evidence-based review of quantitative SPECT imaging and potential clinical applications. J Nucl Med. 2013;54:83–9.CrossRefPubMed
25.
Slomka PJ, Berman DS, Germano G. Absolute myocardial blood flow quantification with SPECT/CT: is it possible? J Nucl Cardiol. 2014;21:1092–5.CrossRefPubMed
26.
Garcia EV. Are SPECT measurements of myocardial blood flow and flow reserve ready for clinical use? Eur J Nucl Med Mol Imaging. 2014;41:2291–3.CrossRefPubMedPubMedCentral
27.
Wells RG, Timmins R, Klein R, Lockwood J, Marvin B, deKemp RA, et al. Dynamic SPECT measurement of absolute myocardial blood flow in a porcine model. J Nucl Med. 2014;55:1685–91.CrossRefPubMed
28.
Alhassen F, Nguyen N, Bains S, Gould RG, Seo Y, Bacharach SL, et al. Myocardial blood flow measurement with a conventional dual-head SPECT/CT with spatiotemporal iterative reconstructions - a clinical feasibility study. Am J Nucl Med Mol Imaging. 2013;4:53–9.PubMedPubMedCentral
29.
Klein R, Hung GU, Wu TC, Huang WS, Li D, deKemp RA, et al. Feasibility and operator variability of myocardial blood flow and reserve measurements with 99mTc-sestamibi quantitative dynamic SPECT/CT imaging. J Nucl Cardiol. 2014;21:1075–88.CrossRefPubMed
30.
Hsu B, Chen FC, Wu TC, Huang WS, Hou PN, Chen CC, et al. Quantitation of myocardial blood flow and myocardial flow reserve with 99mTc-sestamibi dynamic SPECT/CT to enhance detection of coronary artery disease. Eur J Nucl Med Mol Imaging. 2014;41:2294–306.CrossRefPubMed
31.
Bettinardi V, Presotto L, Rapisarda E, Picchio M, Gianolli L, Gilardi MC. Physical performance of the new hybrid PET/CT Discovery-690. Med Phys. 2011;38:5394–411.CrossRefPubMed
32.
Grant AM, Deller TW, Khalighi MM, Maramraju SH, Delso G, Levin CS. NEMA NU 2-2012 performance studies for the SiPM-based ToF-PET component of the GE SIGNA PET/MR system. Med Phys. 2016;43:2334.CrossRefPubMed
33.
Jakoby BW, Bercier Y, Conti M, Casey ME, Bendriem B, Townsend DW. Physical and clinical performance of the mCT time-of-flight PET/CT scanner. Phys Med Biol. 2011;56:2375–89.CrossRefPubMed
34.
Delso G, Fürst S, Jakoby B, Ladebeck R, Ganter C, Nekolla SG, et al. Performance measurements of the Siemens mMR integrated whole-body PET/MR scanner. J Nucl Med. 2011;52:1914–22.CrossRefPubMed
35.
Miller M, Zhang J, Binzel K, Griesmer J, Laurence T, Narayanan M, et al. Characterization of the Vereos digital photon counting PET system. J Nucl Med. 2015;56(suppl 4):434.
36.
Zaidi H, Ojha N, Morich M, Griesmer J, Hu Z, Maniawski P, et al. Design and performance evaluation of a whole-body Ingenuity TF PET-MRI system. Phys Med Biol. 2011;56:3091–106.CrossRefPubMedPubMedCentral
37.
Burr KC, Wang GCJ, Du H, Mann G, Balakrishnan K, Wang J, et al. A new modular and scalable detector for a time-of-flight PET scanner. Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC). 2012; doi:10.​1109/​NSSMIC.​2012.​6551645.
38.
39.
Moody JB, Lee BC, Corbett JR, Ficaro EP, Murthy VL. Precision and accuracy of clinical quantification of myocardial blood flow by dynamic PET: a technical perspective. J Nucl Cardiol. 2015;22:935–51.CrossRefPubMed
40.
Lee JS, Kim JH. Recent advances in hybrid molecular imaging systems. Semin Musculoskelet Radiol. 2014;18:103–22.CrossRefPubMed
41.
Ullah MN, Pratiwi E, Cheon J, Choi H, Yeom JY. Instrumentation for time-of-flight positron emission tomography. Nucl Med Mol Imaging. 2016;50:112–22.CrossRefPubMedPubMedCentral
42.
43.
44.
Conti M. Why is TOF PET reconstruction a more robust method in the presence of inconsistent data? Phys Med Biol. 2011;56:155–68.CrossRefPubMed
45.
Mehranian A, Zaidi H. Impact of time-of-flight PET on quantification errors in MR imaging-based attenuation correction. J Nucl Med. 2015;56:635–41.CrossRefPubMed
46.
Presotto L, Busnardo E, Perani D, Gianolli L, Gilardi MC, Bettinardi V. Simultaneous reconstruction of attenuation and activity in cardiac PET can remove CT misalignment artifacts. J Nucl Cardiol. 2016;23:1086–97.CrossRefPubMed
47.
Kwon SI, Lee JS, Yoon HS, Ito M, Ko GB, Choi JY, et al. Development of small-animal PET prototype using silicon photomultiplier (SiPM): initial results of phantom and animal imaging studies. J Nucl Med. 2011;52:572–9.CrossRefPubMed
48.
Yoon HS, Ko GB, Kwon SI, Lee CM, Ito M, Song IC, et al. Initial results of simultaneous PET/MRI experiments with an MRI-compatible silicon photomultiplier PET scanner. J Nucl Med. 2012;53:608–64.CrossRefPubMed
49.
Yamamoto S, Watabe T, Watabe H, Aoki M, Sugiyama E, Imaizumi M, et al. Simultaneous imaging using Si-PM-based PET and MRI for development of an integrated PET/MRI system. Phys Med Biol. 2012;57:N1–13.CrossRefPubMed
50.
Hong KJ, Choi Y, Jung JH, Kang J, Hu W, Lim HK, et al. A prototype MR insertable brain PET using tileable GAPD arrays. Med Phys. 2013;40:042503.CrossRefPubMed
51.
Olcott P, Kim E, Hong K, Lee BJ, Grant AM, Chang CM, et al. Prototype positron emission tomography insert with electro-optical signal transmission for simultaneous operation with MRI. Phys Med Biol. 2015;60:3459–78.CrossRefPubMed
52.
Wehner J, Weissler B, Dueppenbecker PM, Gebhardt P, Goldschmidt B, Schug D, et al. MR-compatibility assessment of the first preclinical PET-MRI insert equipped with digital silicon photomultipliers. Phys Med Biol. 2015;60:2231–55.CrossRefPubMed
53.
Ko GB, Yoon HS, Kim KY, Lee MS, Yang BY, Jeong JM, et al. Simultaneous multiparametric PET/MRI with silicon photomultiplier PET and ultra-high-field MRI for small-animal imaging. J Nucl Med. 2016;57:1309–15.CrossRefPubMed
54.
55.
Levin CS, Maramraju SH, Khalighi MM, Deller TW, Delso G, Jansen F. Design features and mutual compatibility studies of the time-of-flight PET capable GE SIGNA PET/MR system. IEEE Trans Med Imaging. 2016;35:1907–14.CrossRefPubMed
56.
Miller MA, Jordan D, Laurence T, Laurence T, Muzic R, Narayanan M, et al. Initial characterization of a prototype digital photon counting PET system. J Nucl Med. 2014;55(suppl 1):658.
57.
Nguyen NC, Vercher-Conejero JL, Sattar A, Miller MA, Maniawski PJ, Jordan DW, et al. Image quality and diagnostic performance of a digital pet prototype in patients with oncologic diseases: initial experience and comparison with analog PET. J Nucl Med. 2015;56:1378–85.CrossRefPubMed
58.
Boellaard R, Quick HH. Current image acquisition options in PET/MR. Semin Nucl Med. 2015;45:192–200.CrossRefPubMed
59.
Berman DS, Maddahi J, Tamarappoo BK, Czernin J, Taillefer R, Udelson JE, et al. Phase II safety and clinical comparison with single-photon emission computed tomography myocardial perfusion imaging for detection of coronary artery disease: flurpiridaz F 18 positron emission tomography. J Am Coll Cardiol. 2013;61:469–77.CrossRefPubMed
60.
Danad I, Raijmakers PG, Harms HJ, Heymans MW, van Royen N, Lubberink M, et al. Impact of anatomical and functional severity of coronary atherosclerotic plaques on the transmural perfusion gradient: a [15O]H2O PET study. Eur Heart J. 2014;35:2094–105.CrossRefPubMed
61.
Lee WW, Marinelli B, van der Laan AM, Sena BF, Gorbatov R, Leuschner F, et al. PET/MRI of inflammation in myocardial infarction. J Am Coll Cardiol. 2012;59:153–63.CrossRefPubMedPubMedCentral
62.
Laitinen I, Saraste A, Weidl E, Poethko T, Weber AW, Nekolla SG, et al. Evaluation of alphavbeta3 integrin-targeted positron emission tomography tracer 18F-galacto-RGD for imaging of vascular inflammation in atherosclerotic mice. Circ Cardiovasc Imaging. 2009;2:331–8.CrossRefPubMed
63.
Golestani R, Mirfeizi L, Zeebregts CJ, Westra J, de Haas HJ, Glaudemans AW, et al. Feasibility of [18F]-RGD for ex vivo imaging of atherosclerosis in detection of αvβ3 integrin expression. J Nucl Cardiol. 2015;22:1179–86.CrossRefPubMed
64.
Dweck MR, Chow MW, Joshi NV, Williams MC, Jones C, Fletcher AM, et al. Coronary arterial 18F-sodium fluoride uptake: a novel marker of plaque biology. J Am Coll Cardiol. 2012;59:1539–48.CrossRefPubMed
65.
66.
Kovalski G, Keidar Z, Frenkel A, Sachs J, Attia S, Azhari H. Dual, “motion-frozen heart” combining respiration and contraction compensation in clinical myocardial perfusion SPECT imaging. J Nucl Cardiol. 2009;16:396–404.CrossRefPubMed
67.
Lamare F, Le Maitre A, Dawood M, Schäfers KP, Fernandez P, Rimoldi OE, et al. Evaluation of respiratory and cardiac motion correction schemes in dual gated PET/CT cardiac imaging. Med Phys. 2014;41:072504.CrossRefPubMed
68.
Slomka PJ, Rubeaux M, Le Meunier L, Dey D, Lazewatsky JL, Pan T, et al. Dual-gated motion-frozen cardiac PET with flurpiridaz F 18. J Nucl Med. 2015;56:1876–81.CrossRefPubMed
69.
Rubeaux M, Joshi NV, Dweck MR, Fletcher A, Motwani M, Thomson LE, et al. Motion correction of 18F-NaF PET for imaging coronary atherosclerotic plaques. J Nucl Med. 2016;57:54–9.CrossRefPubMed
70.
Huang C, Petibon Y, Ouyang J, Reese TG, Ahlman MA, Bluemke DA, et al. Accelerated acquisition of tagged MRI for cardiac motion correction in simultaneous PET-MR: phantom and patient studies. Med Phys. 2015;42:1087–97.CrossRefPubMedPubMedCentral
71.
Chun SY, Reese TG, Ouyang J, Guerin B, Catana C, Zhu X, et al. MRI-based nonrigid motion correction in simultaneous PET/MRI. J Nucl Med. 2012;53:1284–91.CrossRefPubMed
72.
Petibon Y, El Fakhri G, Nezafat R, Johnson N, Brady T, Ouyang J. Towards coronary plaque imaging using simultaneous PET-MR: a simulation study. Phys Med Biol. 2014;59:1203–22.CrossRefPubMedPubMedCentral
73.
Metadaten
Titel
Advances in imaging instrumentation for nuclear cardiology
verfasst von
Jae Sung Lee, PhD
Gil Kovalski, PhD
Tali Sharir, MD
Dong Soo Lee, MD, PhD
Publikationsdatum
01.04.2019
Verlag
Springer International Publishing
Erschienen in
Journal of Nuclear Cardiology / Ausgabe 2/2019
Print ISSN: 1071-3581
Elektronische ISSN: 1532-6551
DOI
https://doi.org/10.1007/s12350-017-0979-8

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