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Calcified Tissue International

Erschienen in:

16.02.2018 | Review

Advances in Probiotic Regulation of Bone and Mineral Metabolism

verfasst von: Laura R. McCabe, Narayanan Parameswaran

Erschienen in: Calcified Tissue International | Ausgabe 4/2018

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Abstract

Probiotics have been consumed by humans for thousands of years because they are beneficial for long-term storage of foods and promote the health of their host. Ingested probiotics reside in the gastrointestinal tract where they have many effects including modifying the microbiota composition, intestinal barrier function, and the immune system which result in systemic benefits to the host, including bone health. Probiotics benefit bone growth, density, and structure under conditions of dysbiosis, intestinal permeability, and inflammation (recognized mediators of bone loss and osteoporosis). It is likely that multiple mechanisms are involved in mediating probiotic signals from the gut to the bone. Studies indicate a role for the microbiota (composition and activity), intestinal barrier function, and immune cells in the signaling process. These mechanisms are not mutually exclusive, but rather, may synergize to provide benefits to the skeletal system of the host and serve as a starting point for investigation. Given that probiotics hold great promise for supporting bone health and are generally regarded as safe, future studies identifying mechanisms are warranted.

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Titel: Advances in Probiotic Regulation of Bone and Mineral Metabolism
verfasst von: Laura R. McCabe
Narayanan Parameswaran
Publikationsdatum: 16.02.2018
Verlag: Springer US
Erschienen in: Calcified Tissue International / Ausgabe 4/2018
Print ISSN: 0171-967X
Elektronische ISSN: 1432-0827
DOI: https://doi.org/10.1007/s00223-018-0403-7

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