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Erschienen in: Journal of General Internal Medicine 2/2018

04.12.2017 | Perspective

Advancing the Science and Practice of Medication Adherence

verfasst von: Michael J. Stirratt, PhD, Jeffrey R. Curtis, MD, MS, MPH, Maria I. Danila, MD, MSc, MSPH, Richard Hansen, PhD, RPh, FAPhA, Michael J. Miller, RPh, DrPH, FAPhA, C. Ann Gakumo, PhD, RN

Erschienen in: Journal of General Internal Medicine | Ausgabe 2/2018

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Abstract

Medication adherence remains a significant unmet challenge for optimizing patient outcomes. Recent advances in the conceptualization, measurement, and support of medication adherence offer fresh opportunities to make a meaningful impact on adherence-related behavior and outcomes. These advances emphasize the multifaceted and dynamic nature of medication adherence, provide novel methods for monitoring medication adherence in clinical care, and articulate a set of multilevel strategies to more effectively improve and sustain medication adherence. Here, we offer recommendations for how clinicians can better engage with, and benefit from, these innovations to improve patient medication adherence and associated treatment outcomes.
Literatur
1.
Zurück zum Zitat Briesacher BA, Andrade SE, Fouayzi H, Chan KA. Comparison of drug adherence rates among patients with seven different medical conditions. Pharmacotherapy. 2008;28(4):437-43.CrossRefPubMedPubMedCentral Briesacher BA, Andrade SE, Fouayzi H, Chan KA. Comparison of drug adherence rates among patients with seven different medical conditions. Pharmacotherapy. 2008;28(4):437-43.CrossRefPubMedPubMedCentral
2.
Zurück zum Zitat Vink NM, Klungel OH, Stolk RP, Denig P. Comparison of various measures for assessing medication refill adherence using prescription data. Pharmacoepidemiol Drug Saf. 2009;18(2):159-65.CrossRefPubMed Vink NM, Klungel OH, Stolk RP, Denig P. Comparison of various measures for assessing medication refill adherence using prescription data. Pharmacoepidemiol Drug Saf. 2009;18(2):159-65.CrossRefPubMed
3.
Zurück zum Zitat Yeaw J, Benner JS, Walt JG, Sian S, Smith DB. Comparing adherence and persistence across 6 chronic medication classes. J Manag Care Pharm. 2009;15(9):728-40.PubMed Yeaw J, Benner JS, Walt JG, Sian S, Smith DB. Comparing adherence and persistence across 6 chronic medication classes. J Manag Care Pharm. 2009;15(9):728-40.PubMed
4.
Zurück zum Zitat Nieuwlaat R, Wilczynski N, Navarro T, et al. Interventions for enhancing medication adherence. Cochrane Database Syst Rev. 2014(11):CD000011. Nieuwlaat R, Wilczynski N, Navarro T, et al. Interventions for enhancing medication adherence. Cochrane Database Syst Rev. 2014(11):CD000011.
6.
Zurück zum Zitat Steiner JF. Self-reported adherence measures: what do they assess and how should we use them? Med Care. 2012;50(12):1011-2.CrossRefPubMed Steiner JF. Self-reported adherence measures: what do they assess and how should we use them? Med Care. 2012;50(12):1011-2.CrossRefPubMed
7.
Zurück zum Zitat Voils CI, Hoyle RH, Thorpe CT, Maciejewski ML, Yancy WS, Jr. Improving the measurement of self-reported medication nonadherence. J Clin Epidemiol. 2011;64(3):250-4.CrossRefPubMed Voils CI, Hoyle RH, Thorpe CT, Maciejewski ML, Yancy WS, Jr. Improving the measurement of self-reported medication nonadherence. J Clin Epidemiol. 2011;64(3):250-4.CrossRefPubMed
8.
Zurück zum Zitat Vrijens B, De Geest S, Hughes DA, et al. A new taxonomy for describing and defining adherence to medications. Br J Clin Pharmacol. 2012;73(5):691-705. Vrijens B, De Geest S, Hughes DA, et al. A new taxonomy for describing and defining adherence to medications. Br J Clin Pharmacol. 2012;73(5):691-705.
9.
Zurück zum Zitat Fischer MA, Stedman MR, Lii J, et al. Primary medication non-adherence: analysis of 195,930 electronic prescriptions. J Gen Intern Med. 2010;25(4):284-90. Fischer MA, Stedman MR, Lii J, et al. Primary medication non-adherence: analysis of 195,930 electronic prescriptions. J Gen Intern Med. 2010;25(4):284-90.
10.
Zurück zum Zitat Hutchins DS, Zeber JE, Roberts CS, et al. Initial medication adherence-review and recommendations for good practices in outcomes research: an ISPOR medication adherence and persistence special interest group report. Value Health. 2015;18(5):690-9. Hutchins DS, Zeber JE, Roberts CS, et al. Initial medication adherence-review and recommendations for good practices in outcomes research: an ISPOR medication adherence and persistence special interest group report. Value Health. 2015;18(5):690-9.
11.
Zurück zum Zitat DiMatteo MR. Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. Med Care. 2004;42(3):200-9.CrossRefPubMed DiMatteo MR. Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. Med Care. 2004;42(3):200-9.CrossRefPubMed
12.
Zurück zum Zitat Curtis JR, Xi J, Westfall AO, et al. Improving the prediction of medication compliance: the example of bisphosphonates for osteoporosis. Med Care. 2009;47(3):334-41. Curtis JR, Xi J, Westfall AO, et al. Improving the prediction of medication compliance: the example of bisphosphonates for osteoporosis. Med Care. 2009;47(3):334-41.
13.
Zurück zum Zitat Hess LM, Raebel MA, Conner DA, Malone DC. Measurement of adherence in pharmacy administrative databases: a proposal for standard definitions and preferred measures. Ann Pharmacother. 2006;40(7–8):1280-88.CrossRefPubMed Hess LM, Raebel MA, Conner DA, Malone DC. Measurement of adherence in pharmacy administrative databases: a proposal for standard definitions and preferred measures. Ann Pharmacother. 2006;40(7–8):1280-88.CrossRefPubMed
14.
Zurück zum Zitat Steiner JF, Prochazka AV. The assessment of refill compliance using pharmacy records: methods, validity, and applications. J Clin Epidemiol. 1997;50(1):105-16.CrossRefPubMed Steiner JF, Prochazka AV. The assessment of refill compliance using pharmacy records: methods, validity, and applications. J Clin Epidemiol. 1997;50(1):105-16.CrossRefPubMed
15.
Zurück zum Zitat Blaschke TF, Osterberg L, Vrijens B, Urquhart J. Adherence to medications: insights arising from studies on the unreliable link between prescribed and actual drug dosing histories. Annu Rev Pharmacol Toxicol. 2012;52:275-301.CrossRefPubMed Blaschke TF, Osterberg L, Vrijens B, Urquhart J. Adherence to medications: insights arising from studies on the unreliable link between prescribed and actual drug dosing histories. Annu Rev Pharmacol Toxicol. 2012;52:275-301.CrossRefPubMed
16.
Zurück zum Zitat Mathews R, Wang TY, Honeycutt E, et al. Persistence with secondary prevention medications after acute myocardial infarction: Insights from the TRANSLATE-ACS study. Am Heart J. 2015;170(1):62-9. Mathews R, Wang TY, Honeycutt E, et al. Persistence with secondary prevention medications after acute myocardial infarction: Insights from the TRANSLATE-ACS study. Am Heart J. 2015;170(1):62-9.
18.
Zurück zum Zitat Benner JS, Glynn RJ, Mogun H, Neumann PJ, Weinstein MC, Avorn J. Long-term persistence in use of statin therapy in elderly patients. JAMA. 2002;288(4):455-61.CrossRefPubMed Benner JS, Glynn RJ, Mogun H, Neumann PJ, Weinstein MC, Avorn J. Long-term persistence in use of statin therapy in elderly patients. JAMA. 2002;288(4):455-61.CrossRefPubMed
19.
Zurück zum Zitat Wilson IB, Bangsberg DR, Shen J, et al. Heterogeneity among studies in rates of decline of antiretroviral therapy adherence over time: results from the multisite adherence collaboration on HIV 14 study. J Acquir Immune Defic Syndr. 2013;64(5):448-54. Wilson IB, Bangsberg DR, Shen J, et al. Heterogeneity among studies in rates of decline of antiretroviral therapy adherence over time: results from the multisite adherence collaboration on HIV 14 study. J Acquir Immune Defic Syndr. 2013;64(5):448-54.
20.
Zurück zum Zitat Hommel KA, McGrady ME, Peugh J, et al. Longitudinal patterns of medication nonadherence and associated health care costs. Inflamm Bowel Dis. 2017;23(9):1577-83. Hommel KA, McGrady ME, Peugh J, et al. Longitudinal patterns of medication nonadherence and associated health care costs. Inflamm Bowel Dis. 2017;23(9):1577-83.
21.
Zurück zum Zitat Knafl GJ, Bova CA, Fennie KP, O'Malley JP, Dieckhaus KD, Williams AB. An analysis of electronically monitored adherence to antiretroviral medications. AIDS Behav. 2010;14(4):755-68.CrossRefPubMed Knafl GJ, Bova CA, Fennie KP, O'Malley JP, Dieckhaus KD, Williams AB. An analysis of electronically monitored adherence to antiretroviral medications. AIDS Behav. 2010;14(4):755-68.CrossRefPubMed
22.
Zurück zum Zitat Franklin JM, Shrank WH, Pakes J, et al. Group-based trajectory models: a new approach to classifying and predicting long-term medication adherence. Med Care. 2013;51(9):789-96. Franklin JM, Shrank WH, Pakes J, et al. Group-based trajectory models: a new approach to classifying and predicting long-term medication adherence. Med Care. 2013;51(9):789-96.
23.
Zurück zum Zitat Cambiano V, Lampe FC, Rodger AJ, et al. Long-term trends in adherence to antiretroviral therapy from start of HAART. AIDS (London, England). 2010;24(8):1153-62. Cambiano V, Lampe FC, Rodger AJ, et al. Long-term trends in adherence to antiretroviral therapy from start of HAART. AIDS (London, England). 2010;24(8):1153-62.
24.
Zurück zum Zitat French T, Tesoriero J, Agins B. Changes in stress, substance use and medication beliefs are associated with changes in adherence to HIV antiretroviral therapy. AIDS Behav. 2011;15(7):1416-28.CrossRefPubMed French T, Tesoriero J, Agins B. Changes in stress, substance use and medication beliefs are associated with changes in adherence to HIV antiretroviral therapy. AIDS Behav. 2011;15(7):1416-28.CrossRefPubMed
26.
Zurück zum Zitat Hansen RA, Dusetzina SB, Dominik RC, Gaynes BN. Prescription refill records as a screening tool to identify antidepressant non-adherence. Pharmacoepidemiol Drug Saf. 2010;19(1):33-7.CrossRefPubMedPubMedCentral Hansen RA, Dusetzina SB, Dominik RC, Gaynes BN. Prescription refill records as a screening tool to identify antidepressant non-adherence. Pharmacoepidemiol Drug Saf. 2010;19(1):33-7.CrossRefPubMedPubMedCentral
27.
Zurück zum Zitat Vrijens B, Antoniou S, Burnier M, de la Sierra A, Volpe M. Current situation of medication adherence in hypertension. Front Pharmacol. 2017;8:100.CrossRefPubMedPubMedCentral Vrijens B, Antoniou S, Burnier M, de la Sierra A, Volpe M. Current situation of medication adherence in hypertension. Front Pharmacol. 2017;8:100.CrossRefPubMedPubMedCentral
28.
Zurück zum Zitat Berg KM, Arnsten JH. Practical and conceptual challenges in measuring antiretroviral adherence. J Acquir Immune Defic Syndr. 2006;43 Suppl 1:S79-87.CrossRefPubMedPubMedCentral Berg KM, Arnsten JH. Practical and conceptual challenges in measuring antiretroviral adherence. J Acquir Immune Defic Syndr. 2006;43 Suppl 1:S79-87.CrossRefPubMedPubMedCentral
29.
Zurück zum Zitat Gonzalez JS, Schneider HE. Methodological issues in the assessment of diabetes treatment adherence. Curr Diab Rep. 2011;11(6):472-9.CrossRefPubMed Gonzalez JS, Schneider HE. Methodological issues in the assessment of diabetes treatment adherence. Curr Diab Rep. 2011;11(6):472-9.CrossRefPubMed
30.
Zurück zum Zitat Whalley Buono E, Vrijens B, Bosworth HB, Liu LZ, Zullig LL, Granger BB. Coming full circle in the measurement of medication adherence: opportunities and implications for health care. Patient Prefer Adherence. 2017;11:1009-17.CrossRefPubMedPubMedCentral Whalley Buono E, Vrijens B, Bosworth HB, Liu LZ, Zullig LL, Granger BB. Coming full circle in the measurement of medication adherence: opportunities and implications for health care. Patient Prefer Adherence. 2017;11:1009-17.CrossRefPubMedPubMedCentral
31.
Zurück zum Zitat Chesney MA. The elusive gold standard. Future perspectives for HIV adherence assessment and intervention. J Acquir Immune Defic Syndr. 2006;43 Suppl 1:S149-55.CrossRefPubMed Chesney MA. The elusive gold standard. Future perspectives for HIV adherence assessment and intervention. J Acquir Immune Defic Syndr. 2006;43 Suppl 1:S149-55.CrossRefPubMed
32.
Zurück zum Zitat Zullig LL, Mendys P, Bosworth HB. Medication adherence: A practical measurement selection guide using case studies. Patient Educ Couns. 2017;100(7):1410-4.CrossRefPubMed Zullig LL, Mendys P, Bosworth HB. Medication adherence: A practical measurement selection guide using case studies. Patient Educ Couns. 2017;100(7):1410-4.CrossRefPubMed
33.
Zurück zum Zitat Campbell JI, Haberer JE. Cell Phone-Based and Adherence Device Technologies for HIV Care and Treatment in Resource-Limited Settings: Recent Advances. Curr HIV/AIDS Rep. 2015;12(4):523-31.CrossRefPubMed Campbell JI, Haberer JE. Cell Phone-Based and Adherence Device Technologies for HIV Care and Treatment in Resource-Limited Settings: Recent Advances. Curr HIV/AIDS Rep. 2015;12(4):523-31.CrossRefPubMed
34.
Zurück zum Zitat Hafezi H, Robertson TL, Moon GD, Au-Yeung KY, Zdeblick MJ, Savage GM. An ingestible sensor for measuring medication adherence. IEEE Trans Biomed Eng. 2015;62(1):99-109CrossRefPubMed Hafezi H, Robertson TL, Moon GD, Au-Yeung KY, Zdeblick MJ, Savage GM. An ingestible sensor for measuring medication adherence. IEEE Trans Biomed Eng. 2015;62(1):99-109CrossRefPubMed
35.
Zurück zum Zitat Kane JM, Perlis RH, DiCarlo LA, Au-Yeung K, Duong J, Petrides G. First experience with a wireless system incorporating physiologic assessments and direct confirmation of digital tablet ingestions in ambulatory patients with schizophrenia or bipolar disorder. J Clin Psychiatry. 2013;74(6):e533-40.CrossRefPubMed Kane JM, Perlis RH, DiCarlo LA, Au-Yeung K, Duong J, Petrides G. First experience with a wireless system incorporating physiologic assessments and direct confirmation of digital tablet ingestions in ambulatory patients with schizophrenia or bipolar disorder. J Clin Psychiatry. 2013;74(6):e533-40.CrossRefPubMed
36.
Zurück zum Zitat Peters-Strickland T, Pestreich L, Hatch A, et al. Usability of a novel digital medicine system in adults with schizophrenia treated with sensor-embedded tablets of aripiprazole. Neuropsychiatr Dis Treat. 2016;12:2587-94. Peters-Strickland T, Pestreich L, Hatch A, et al. Usability of a novel digital medicine system in adults with schizophrenia treated with sensor-embedded tablets of aripiprazole. Neuropsychiatr Dis Treat. 2016;12:2587-94.
37.
Zurück zum Zitat Thompson D, Mackay T, Matthews M, Edwards J, Peters N, Connolly SB. Direct adherence measurement using an ingestible sensor compared with self-reporting in high-risk cardiovascular disease patients who knew they were being measured: a prospective intervention. JMIR Mhealth Uhealth. 2017;5(6):e76.CrossRefPubMedPubMedCentral Thompson D, Mackay T, Matthews M, Edwards J, Peters N, Connolly SB. Direct adherence measurement using an ingestible sensor compared with self-reporting in high-risk cardiovascular disease patients who knew they were being measured: a prospective intervention. JMIR Mhealth Uhealth. 2017;5(6):e76.CrossRefPubMedPubMedCentral
38.
Zurück zum Zitat Gupta P, Patel P, Strauch B, et al. Risk Factors for Nonadherence to Antihypertensive Treatment. Hypertension. 2017;69(6):1113-20. Gupta P, Patel P, Strauch B, et al. Risk Factors for Nonadherence to Antihypertensive Treatment. Hypertension. 2017;69(6):1113-20.
39.
Zurück zum Zitat McNaughton CD, Brown NJ, Rothman RL, et al. Systolic Blood Pressure and Biochemical Assessment of Adherence: A cross-sectional analysis in the emergency department. Hypertension. 2017;70(2):307-14. McNaughton CD, Brown NJ, Rothman RL, et al. Systolic Blood Pressure and Biochemical Assessment of Adherence: A cross-sectional analysis in the emergency department. Hypertension. 2017;70(2):307-14.
40.
Zurück zum Zitat Zheng JH, Rower C, McAllister K, Castillo-Mancilla J, et al. Application of an intracellular assay for determination of tenofovir-diphosphate and emtricitabine-triphosphate from erythrocytes using dried blood spots. J Pharm Biomed Anal. 2016;122:16-20. Zheng JH, Rower C, McAllister K, Castillo-Mancilla J, et al. Application of an intracellular assay for determination of tenofovir-diphosphate and emtricitabine-triphosphate from erythrocytes using dried blood spots. J Pharm Biomed Anal. 2016;122:16-20.
41.
Zurück zum Zitat Stirratt MJ, Dunbar-Jacob J, Crane HM, et al. Self-report measures of medication adherence behavior: recommendations on optimal use. Transl Behav Med. 2015;5(4):470-82. Stirratt MJ, Dunbar-Jacob J, Crane HM, et al. Self-report measures of medication adherence behavior: recommendations on optimal use. Transl Behav Med. 2015;5(4):470-82.
42.
Zurück zum Zitat Feldman BJ, Fredericksen RJ, Crane PK, et al. Evaluation of the single-item self-rating adherence scale for use in routine clinical care of people living with HIV. AIDS Behav. 2013;17(1):307-18. Feldman BJ, Fredericksen RJ, Crane PK, et al. Evaluation of the single-item self-rating adherence scale for use in routine clinical care of people living with HIV. AIDS Behav. 2013;17(1):307-18.
44.
Zurück zum Zitat Callon W, Saha S, Korthuis PT, et al. Which clinician questions elicit accurate disclosure of antiretroviral non-adherence when talking to patients? AIDS Behav. 2016;20(5):1108-15. Callon W, Saha S, Korthuis PT, et al. Which clinician questions elicit accurate disclosure of antiretroviral non-adherence when talking to patients? AIDS Behav. 2016;20(5):1108-15.
47.
Zurück zum Zitat Lester RT, Ritvo P, Mills EJ, et al. Effects of a mobile phone short message service on antiretroviral treatment adherence in Kenya (WelTel Kenya1): a randomised trial. Lancet. 2010;376(9755):1838-45. Lester RT, Ritvo P, Mills EJ, et al. Effects of a mobile phone short message service on antiretroviral treatment adherence in Kenya (WelTel Kenya1): a randomised trial. Lancet. 2010;376(9755):1838-45.
48.
Zurück zum Zitat Choudhry NK, Bykov K, Shrank WH, Toscano M, Rawlins WS, Reisman L, et al. Eliminating medication copayments reduces disparities in cardiovascular care. Health Aff (Millwood). 2014;33(5):863-70.CrossRefPubMed Choudhry NK, Bykov K, Shrank WH, Toscano M, Rawlins WS, Reisman L, et al. Eliminating medication copayments reduces disparities in cardiovascular care. Health Aff (Millwood). 2014;33(5):863-70.CrossRefPubMed
49.
Zurück zum Zitat Coca A, Agabiti-Rosei E, Cifkova R, Manolis AJ, Redon J, Mancia G. The polypill in cardiovascular prevention: evidence, limitations and perspective - position paper of the European Society of Hypertension. J Hypertens. 2017;35(8):1546-53.CrossRefPubMed Coca A, Agabiti-Rosei E, Cifkova R, Manolis AJ, Redon J, Mancia G. The polypill in cardiovascular prevention: evidence, limitations and perspective - position paper of the European Society of Hypertension. J Hypertens. 2017;35(8):1546-53.CrossRefPubMed
50.
Zurück zum Zitat Siegel SJ. Extended release drug delivery strategies in psychiatry: theory to practice. Psychiatry. 2005;2(6):22-31. Siegel SJ. Extended release drug delivery strategies in psychiatry: theory to practice. Psychiatry. 2005;2(6):22-31.
51.
Zurück zum Zitat Krumme AA, Isaman DL, Stolpe SF, Dougherty S, Choudhry NK. Prevalence, effectiveness, and characteristics of pharmacy-based medication synchronization programs. Am J Manag Care. 2016;22(3):179-86.PubMed Krumme AA, Isaman DL, Stolpe SF, Dougherty S, Choudhry NK. Prevalence, effectiveness, and characteristics of pharmacy-based medication synchronization programs. Am J Manag Care. 2016;22(3):179-86.PubMed
52.
Zurück zum Zitat Girdish C, Shrank W, Freytag S, et al. The impact of a retail prescription synchronization program on medication adherence. J Am Pharm Assoc (2003). 2017. Girdish C, Shrank W, Freytag S, et al. The impact of a retail prescription synchronization program on medication adherence. J Am Pharm Assoc (2003). 2017.
53.
Zurück zum Zitat Choudhry NK, Krumme AA, Ercole PM, et al. Effect of reminder devices on medication adherence: the REMIND randomized clinical trial. JAMA Intern Med. 2017;177(5):624-31. Choudhry NK, Krumme AA, Ercole PM, et al. Effect of reminder devices on medication adherence: the REMIND randomized clinical trial. JAMA Intern Med. 2017;177(5):624-31.
54.
Zurück zum Zitat Viswanathan M, Golin CE, Jones CD, et al. Interventions to improve adherence to self-administered medications for chronic diseases in the United States: a systematic review. Annals of internal medicine. 2012;157(11):785-95. Viswanathan M, Golin CE, Jones CD, et al. Interventions to improve adherence to self-administered medications for chronic diseases in the United States: a systematic review. Annals of internal medicine. 2012;157(11):785-95.
55.
Zurück zum Zitat Kronish IM, Moise N. In search of a "magic pill" for medication nonadherence. JAMA Intern Med. 2017;177(5):631-2. Kronish IM, Moise N. In search of a "magic pill" for medication nonadherence. JAMA Intern Med. 2017;177(5):631-2.
56.
Zurück zum Zitat DeKoekkoek T, Given B, Given CW, Ridenour K, Schueller M, Spoelstra SL. mHealth SMS text messaging interventions and to promote medication adherence: An integrative review. Journal of Clinical Nursing. 2015;24(19–20):2722-35.CrossRefPubMed DeKoekkoek T, Given B, Given CW, Ridenour K, Schueller M, Spoelstra SL. mHealth SMS text messaging interventions and to promote medication adherence: An integrative review. Journal of Clinical Nursing. 2015;24(19–20):2722-35.CrossRefPubMed
57.
Zurück zum Zitat Davidson TM, McGillicuddy J, Mueller M, et al. Evaluation of an mHealth medication regimen self-management program for African American and Hispanic uncontrolled hypertensives. J Pers Med. 2015;5(4):389-405. Davidson TM, McGillicuddy J, Mueller M, et al. Evaluation of an mHealth medication regimen self-management program for African American and Hispanic uncontrolled hypertensives. J Pers Med. 2015;5(4):389-405.
58.
Zurück zum Zitat Kronish IM, Moise N, McGinn T, et al. An electronic adherence measurement intervention to reduce clinical inertia in the treatment of uncontrolled hypertension: the MATCH cluster randomized clinical trial. J Gen Intern Med. 2016;31(11):1294-300. Kronish IM, Moise N, McGinn T, et al. An electronic adherence measurement intervention to reduce clinical inertia in the treatment of uncontrolled hypertension: the MATCH cluster randomized clinical trial. J Gen Intern Med. 2016;31(11):1294-300.
59.
Zurück zum Zitat Wilson IB, Laws MB, Safren SA, et al. Provider-focused intervention increases adherence-related dialogue but does not improve antiretroviral therapy adherence in persons with HIV. J Acquir Immune Defic Syndr. 2010a;53(3):338-47. Wilson IB, Laws MB, Safren SA, et al. Provider-focused intervention increases adherence-related dialogue but does not improve antiretroviral therapy adherence in persons with HIV. J Acquir Immune Defic Syndr. 2010a;53(3):338-47.
60.
Zurück zum Zitat Jones DL, Sued O, Cecchini D, et al. Improving adherence to care among "hard to reach" HIV-infected patients in Argentina. AIDS Behav. 2016;20(5):987-97. Jones DL, Sued O, Cecchini D, et al. Improving adherence to care among "hard to reach" HIV-infected patients in Argentina. AIDS Behav. 2016;20(5):987-97.
61.
Zurück zum Zitat Wilson SR, Strub P, Buist AS, et al. Shared treatment decision making improves adherence and outcomes in poorly controlled asthma. Am J Respir Crit Care Med. 2010b;181(6):566-77. Wilson SR, Strub P, Buist AS, et al. Shared treatment decision making improves adherence and outcomes in poorly controlled asthma. Am J Respir Crit Care Med. 2010b;181(6):566-77.
62.
Zurück zum Zitat Adams AS, Uratsu C, Dyer W, et al. Health system factors and antihypertensive adherence in a racially and ethnically diverse cohort of new users. JAMA Intern Med. 2013;173(1):54-61. Adams AS, Uratsu C, Dyer W, et al. Health system factors and antihypertensive adherence in a racially and ethnically diverse cohort of new users. JAMA Intern Med. 2013;173(1):54-61.
63.
Zurück zum Zitat Horberg MA, Hurley LB, Towner WJ, et al. Determination of optimized multidisciplinary care team for maximal antiretroviral therapy adherence. J Acquir Immune Defic Syndr. 2012;60(2):183-90. Horberg MA, Hurley LB, Towner WJ, et al. Determination of optimized multidisciplinary care team for maximal antiretroviral therapy adherence. J Acquir Immune Defic Syndr. 2012;60(2):183-90.
Metadaten
Titel
Advancing the Science and Practice of Medication Adherence
verfasst von
Michael J. Stirratt, PhD
Jeffrey R. Curtis, MD, MS, MPH
Maria I. Danila, MD, MSc, MSPH
Richard Hansen, PhD, RPh, FAPhA
Michael J. Miller, RPh, DrPH, FAPhA
C. Ann Gakumo, PhD, RN
Publikationsdatum
04.12.2017
Verlag
Springer US
Erschienen in
Journal of General Internal Medicine / Ausgabe 2/2018
Print ISSN: 0884-8734
Elektronische ISSN: 1525-1497
DOI
https://doi.org/10.1007/s11606-017-4198-4

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