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Erschienen in: International Journal of Clinical Pharmacy 6/2015

01.12.2015 | Research Article

Adverse drug reactions experience in a teaching hospital in Jordan

verfasst von: Mohammed Alsbou, Sameh Alzubiedi, Hamed Alzobi, Nawal Abu Samhadanah, Yousef Alsaraireh, Omar Alrawashdeh, Amin Aqel, Khalil Al-Salem

Erschienen in: International Journal of Clinical Pharmacy | Ausgabe 6/2015

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Abstract

Background Adverse drug reactions (ADRs) represent a major health care problem. Objective To identify the most common ADRs, drugs implicated in ADRs, and to assess their causality, severity, preventability and risk factors predisposing to reported ADRs in Jordan. Setting Al-Karak teaching hospital, southern of Jordan. Method A cross sectional observational study was carried out for 11 months from January to November 2013. Suspected ADRs were recorded in ADRs report forms and analyzed for causality, severity, and preventability. Main outcome measure: Most common ADRs, drugs involved in these ADRs, causality, severity, and preventability of suspected ADRs. Results A total of 64 reports were received. Some patients suffered more than one ADR. The total number of ADRs identified was 108. Forty one drugs were involved in causing these ADRs. About 2/3 of adverse reactions (73.4 %) did not cause admission to the hospital, whereas 26.6 % of the ADRs resulted in admission. Majority of the ADRs were type A (62.5 %). Most of ADRs (92.2 %) were assessed as probable. Nearly, 65.6 % of ADRs were categorized as mild. Majority of ADRs were assessed as “not preventable” (75 %). The most common classes of drugs involved in ADRs were antibiotics, analgesics, vaccines and antiepileptics. The most commonly identified ADRs were abdominal pain, skin rash, shortness of breath, fever, upper gastrointestinal bleeding and vomiting. Risk factors contributed to ADRs were age and polypharmacy. Conclusion Jordanian healthcare providers should be aware of the importance of detecting and reporting ADRs, in order to prevent and reduce the incidence of ADRs. Awareness of risk factors predisposing to ADRs may help in identifying patients with higher risk and therefore reducing the risk of these ADRs and improving patient outcome.
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Metadaten
Titel
Adverse drug reactions experience in a teaching hospital in Jordan
verfasst von
Mohammed Alsbou
Sameh Alzubiedi
Hamed Alzobi
Nawal Abu Samhadanah
Yousef Alsaraireh
Omar Alrawashdeh
Amin Aqel
Khalil Al-Salem
Publikationsdatum
01.12.2015
Verlag
Springer Netherlands
Erschienen in
International Journal of Clinical Pharmacy / Ausgabe 6/2015
Print ISSN: 2210-7703
Elektronische ISSN: 2210-7711
DOI
https://doi.org/10.1007/s11096-015-0185-1

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