Skip to main content
Erschienen in: DNP - Der Neurologe & Psychiater 1/2015

19.01.2015 | Fortbildung

Psychophytopharmaka

Ähnlich stark wirksam wie synthetische Stoffe und besser verträglich?

verfasst von: Prof. Dr. med. Hans-Peter Volz, Prof. Dr. med. Dr. h.c. mult. Siegfried Kasper

Erschienen in: DNP – Die Neurologie & Psychiatrie | Ausgabe 1/2015

Einloggen, um Zugang zu erhalten

Zusammenfassung

Eine Reihe von Phytopharmaka wird im Bereich psychischer Störungen eingesetzt. Am bekanntesten sind vielleicht Baldrian- oder Hopfenpräparate bei Schlafstörungen. In diesem Artikel werden Psychophytopharmaka erörtert, für die eine ausreichende klinische Datenbasis vorliegt, also randomisierte, möglichst placebokontrollierte Studien und auch Metaanalysen.
Literatur
1.
Zurück zum Zitat Auguet M, Clostre F, De Feudis FV. Effects of antidepressants on receptor-activated and Ca2+-activated contractions of rabbit isolated aorta. Gen Pharmacol 2986; 17: 607–610CrossRef Auguet M, Clostre F, De Feudis FV. Effects of antidepressants on receptor-activated and Ca2+-activated contractions of rabbit isolated aorta. Gen Pharmacol 2986; 17: 607–610CrossRef
2.
Zurück zum Zitat Lang F, Hoerr R, Noeldner M, Koch E. Ginkgo biloba extract EGb 761®: From an ancient Asian plant to a modern European herbal medicine product. In: Wagner H, Ulrich- Merzenich G (eds.) Evidence and rational based research on Chinese drugs., Springer, Wien 2013:S. 431-470 Lang F, Hoerr R, Noeldner M, Koch E. Ginkgo biloba extract EGb 761®: From an ancient Asian plant to a modern European herbal medicine product. In: Wagner H, Ulrich- Merzenich G (eds.) Evidence and rational based research on Chinese drugs., Springer, Wien 2013:S. 431-470
3.
Zurück zum Zitat Braquet P. The ginkgolides: potent plateletactivating factor antagonists’ isolated from Ginkgo biloba L. chemistry, pharmacology and clinical applications. Drugs Fut 1987; 12: 643–699 Braquet P. The ginkgolides: potent plateletactivating factor antagonists’ isolated from Ginkgo biloba L. chemistry, pharmacology and clinical applications. Drugs Fut 1987; 12: 643–699
4.
Zurück zum Zitat Koch E. Inhibition of platelet activating factor (PAF)-induced aggregation of human thrombocytes by ginkgolides: considerations on possible bleeding complications after oral intake of Ginkgo biloba extracts. Phytomedicine 2005; 12: 10–16PubMedCrossRef Koch E. Inhibition of platelet activating factor (PAF)-induced aggregation of human thrombocytes by ginkgolides: considerations on possible bleeding complications after oral intake of Ginkgo biloba extracts. Phytomedicine 2005; 12: 10–16PubMedCrossRef
5.
Zurück zum Zitat Kellermann AJ, Kloft C. Is there a risk of bleeding associated with standardized Ginkgo biloba extract therapy? A systematic review and meta-analysis. 2011; 31: 490–502 Kellermann AJ, Kloft C. Is there a risk of bleeding associated with standardized Ginkgo biloba extract therapy? A systematic review and meta-analysis. 2011; 31: 490–502
6.
Zurück zum Zitat Janssens D, Michiels C, Delaive E, Eliarers F, Drieu K, Remacle J. Protection of hypoxiainduced ATP decrease in endothelial cells by Ginkgo biloba extract and Bilobalide. Biochem Pharmacol 1995; 50: 991–999PubMedCrossRef Janssens D, Michiels C, Delaive E, Eliarers F, Drieu K, Remacle J. Protection of hypoxiainduced ATP decrease in endothelial cells by Ginkgo biloba extract and Bilobalide. Biochem Pharmacol 1995; 50: 991–999PubMedCrossRef
7.
Zurück zum Zitat Janssens D, Remacle j, Drieu K, Michiels C. Protection of mitochondrial respiration activity by Bilobalide. Biochem Pharmacol 1999; 58: 109–119PubMedCrossRef Janssens D, Remacle j, Drieu K, Michiels C. Protection of mitochondrial respiration activity by Bilobalide. Biochem Pharmacol 1999; 58: 109–119PubMedCrossRef
8.
Zurück zum Zitat Janssens D, Delaive E, Remacle J, Michiels C. Protection by bilobalide of the ischaemiainduced alterations of the mitochondrial respiratory activity. Fundam Clin Pharmacol 2000; 14: 193–201PubMedCrossRef Janssens D, Delaive E, Remacle J, Michiels C. Protection by bilobalide of the ischaemiainduced alterations of the mitochondrial respiratory activity. Fundam Clin Pharmacol 2000; 14: 193–201PubMedCrossRef
9.
Zurück zum Zitat Longpre F, Garneau P, Christen Y, Ramassamy C. Protection by EGb 761® against betaamyloid-induced neurotoxicity: involvement of NF-kappa B, Sirt1, and MAPKs pathways and inhibition of amyloid fibril formation. Free Radic Biol Med 2006; 41: 1781–1794PubMedCrossRef Longpre F, Garneau P, Christen Y, Ramassamy C. Protection by EGb 761® against betaamyloid-induced neurotoxicity: involvement of NF-kappa B, Sirt1, and MAPKs pathways and inhibition of amyloid fibril formation. Free Radic Biol Med 2006; 41: 1781–1794PubMedCrossRef
10.
Zurück zum Zitat Wu Y, Wu Z, Butko P, Christen Y, Lambert MP, Klein WL, Link CD, Luo Y. Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761® and ginkgolides in transgenic Caenorhabditis elegans. J Neurosci 2006; 26: 13102–13113PubMedCrossRef Wu Y, Wu Z, Butko P, Christen Y, Lambert MP, Klein WL, Link CD, Luo Y. Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761® and ginkgolides in transgenic Caenorhabditis elegans. J Neurosci 2006; 26: 13102–13113PubMedCrossRef
11.
Zurück zum Zitat Yoshitake T, Yoshitake S, Kehr J. The Ginkgo boloba extract EGb 761® and its main constituent flavonoids and ginkgolides increase extracellular dopamine levels in the rat prefrontal cortex. Br J Pharmacol 2010; 159: 659–668PubMedCentralPubMedCrossRef Yoshitake T, Yoshitake S, Kehr J. The Ginkgo boloba extract EGb 761® and its main constituent flavonoids and ginkgolides increase extracellular dopamine levels in the rat prefrontal cortex. Br J Pharmacol 2010; 159: 659–668PubMedCentralPubMedCrossRef
12.
Zurück zum Zitat Müller WE, Abdel-Kader RM, Fehske CJ, Leuner K. Grundlagen der therapeutischen von EGb 761®. Wirkung auf die Kraftwerke der Zellen. Pharm Unserer Zeit 2009; 38: 408–416PubMedCrossRef Müller WE, Abdel-Kader RM, Fehske CJ, Leuner K. Grundlagen der therapeutischen von EGb 761®. Wirkung auf die Kraftwerke der Zellen. Pharm Unserer Zeit 2009; 38: 408–416PubMedCrossRef
13.
Zurück zum Zitat Brondino N, De Silvestri A, Re S, Lanati N, Thiemann P, Verna A, Emanuele E, Politi P. A systematic review and meta-analysis of Ginkgo biloba in neuropsychiatric disorders: From ancient tradition to modern-day medicine. Evidence-Based Complementary and Alternative Medicine [Abk. heraus suchen] 2013, Article ID 915691, 11 pages Brondino N, De Silvestri A, Re S, Lanati N, Thiemann P, Verna A, Emanuele E, Politi P. A systematic review and meta-analysis of Ginkgo biloba in neuropsychiatric disorders: From ancient tradition to modern-day medicine. Evidence-Based Complementary and Alternative Medicine [Abk. heraus suchen] 2013, Article ID 915691, 11 pages
14.
Zurück zum Zitat Weinmann S, Roll S, Schwarzbach C, Vauth C, Willich SN. Effects of Ginkgo biloba in dementia: systematic review and meta-analysis. BMC Geriatr. 2010; 10: 14PubMedCentralPubMedCrossRef Weinmann S, Roll S, Schwarzbach C, Vauth C, Willich SN. Effects of Ginkgo biloba in dementia: systematic review and meta-analysis. BMC Geriatr. 2010; 10: 14PubMedCentralPubMedCrossRef
15.
Zurück zum Zitat Kasper S, Schubert H (2009) Ginkgo-Spezialextrakt EGb 761® in der Behandlung der Demenz: Evidenz für Wirksamkeit und Verträglichkeit. Fortschritte der Neurologie - Psychiatrie 2009; 77: 1–12CrossRef Kasper S, Schubert H (2009) Ginkgo-Spezialextrakt EGb 761® in der Behandlung der Demenz: Evidenz für Wirksamkeit und Verträglichkeit. Fortschritte der Neurologie - Psychiatrie 2009; 77: 1–12CrossRef
16.
Zurück zum Zitat Schwabe. Fachinformation Tebonin® konzent ® 240 mg. 2014a Schwabe. Fachinformation Tebonin® konzent ® 240 mg. 2014a
17.
Zurück zum Zitat Barnes J, Anderson LA, Phillipson JD. St John?s wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties. J Pharm Pharma-col 2001; 53: 583–600CrossRef Barnes J, Anderson LA, Phillipson JD. St John?s wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties. J Pharm Pharma-col 2001; 53: 583–600CrossRef
18.
Zurück zum Zitat Hirano K, Kato Y, Uchida S, Sugimoto Y, Yamada J, Umegaki K, Yamada S. Effects of oral administration of extracts of Hypericum perforatum (St John’s wort) on brain serotonin transporter, serotonin uptake and behaviour in mice. J Pharm Pharmacol 2004; 56: 1589–1595PubMedCrossRef Hirano K, Kato Y, Uchida S, Sugimoto Y, Yamada J, Umegaki K, Yamada S. Effects of oral administration of extracts of Hypericum perforatum (St John’s wort) on brain serotonin transporter, serotonin uptake and behaviour in mice. J Pharm Pharmacol 2004; 56: 1589–1595PubMedCrossRef
19.
Zurück zum Zitat Jakobs D, Hage-Hülsmann A, Prenner L, Kolb C, Weiser D, Häberlein H. Downregulation of α1-adrenergic receptors in rat C6 glioblastoma cells by hyperforin and hyperoside from St John?s wort. J Pharm Pharmacol 2013; 907–915 Jakobs D, Hage-Hülsmann A, Prenner L, Kolb C, Weiser D, Häberlein H. Downregulation of α1-adrenergic receptors in rat C6 glioblastoma cells by hyperforin and hyperoside from St John?s wort. J Pharm Pharmacol 2013; 907–915
20.
Zurück zum Zitat Linde K, Berner MM, Kriston L. St John?s wort for major depression. Cochrane Database Syst Rev. 2008; 8;(4):CD000448 Linde K, Berner MM, Kriston L. St John?s wort for major depression. Cochrane Database Syst Rev. 2008; 8;(4):CD000448
21.
Zurück zum Zitat Gastpar M, Singer A, Zeller K Comparative efficacy and safety of a once-daily dosage of hypericum extract STW3-VI and citalopram in patients with moderate depression: a double-blind, randomised, multicentre, placebo-controlled study. Pharmacopsychiatry 2006; 39: 66–75PubMedCrossRef Gastpar M, Singer A, Zeller K Comparative efficacy and safety of a once-daily dosage of hypericum extract STW3-VI and citalopram in patients with moderate depression: a double-blind, randomised, multicentre, placebo-controlled study. Pharmacopsychiatry 2006; 39: 66–75PubMedCrossRef
22.
Zurück zum Zitat Kasper S, Gastpar M, Möller HJ, Müller WE, Volz HP, Dienel A, Kieser M. Better tolerability of St. John?s wort extract WS 5570 compared to treatment with SSRIs: a reanalysis of data from controlled clinical trials in acute major depression. Int Clin Psychopharmacol 2010c; 25: 204–213CrossRef Kasper S, Gastpar M, Möller HJ, Müller WE, Volz HP, Dienel A, Kieser M. Better tolerability of St. John?s wort extract WS 5570 compared to treatment with SSRIs: a reanalysis of data from controlled clinical trials in acute major depression. Int Clin Psychopharmacol 2010c; 25: 204–213CrossRef
23.
Zurück zum Zitat Szegedi A, Kohnen R, Dienel A, Kieser M. Acute treatment of moderate to severe depression with hypericum extract WS 5570 (St John?s wort): randomised controlled double blind non-inferiority trial versus paroxetine. BMJ. 2005; 330: 503–506PubMedCentralPubMedCrossRef Szegedi A, Kohnen R, Dienel A, Kieser M. Acute treatment of moderate to severe depression with hypericum extract WS 5570 (St John?s wort): randomised controlled double blind non-inferiority trial versus paroxetine. BMJ. 2005; 330: 503–506PubMedCentralPubMedCrossRef
24.
Zurück zum Zitat Lecrubier Y, Clerc G, Didi R, Kieser M. Efficacy of St. John?s wort extract WS 5570 in major depression: a double-blind, placebocontrolled trial. Am J Psychiatry 2002; 159: 1361–1366PubMedCrossRef Lecrubier Y, Clerc G, Didi R, Kieser M. Efficacy of St. John?s wort extract WS 5570 in major depression: a double-blind, placebocontrolled trial. Am J Psychiatry 2002; 159: 1361–1366PubMedCrossRef
25.
Zurück zum Zitat Kasper S, Anghelescu IG, Szegedi A, Dienel A, Kieser M. Superior efficacy of St John?s wort extract WS 5570 compared to placebo in patients with major depression: a randomized, double-blind, placebo-controlled, multi-center trial [ISRCTN77277298]. BMC Med 2006; 4: 14PubMedCentralPubMedCrossRef Kasper S, Anghelescu IG, Szegedi A, Dienel A, Kieser M. Superior efficacy of St John?s wort extract WS 5570 compared to placebo in patients with major depression: a randomized, double-blind, placebo-controlled, multi-center trial [ISRCTN77277298]. BMC Med 2006; 4: 14PubMedCentralPubMedCrossRef
26.
Zurück zum Zitat Kasper S, Volz HP, Möller HJ, Dienel A, Kieser M. Continuation and long-term maintenance treatment with Hypericum extract WS 5570 after recovery from an acute episode of moderate depression - a doubleblind, randomized, placebo controlled long-term trial. Eur Neuropsychopharmacol 2008; 18: 803–813PubMedCrossRef Kasper S, Volz HP, Möller HJ, Dienel A, Kieser M. Continuation and long-term maintenance treatment with Hypericum extract WS 5570 after recovery from an acute episode of moderate depression - a doubleblind, randomized, placebo controlled long-term trial. Eur Neuropsychopharmacol 2008; 18: 803–813PubMedCrossRef
27.
Zurück zum Zitat Schwabe. Fachinformation Neuroplant® aktiv. 2014b Schwabe. Fachinformation Neuroplant® aktiv. 2014b
28.
Zurück zum Zitat Steigerwald. Fachinformation Laif 900®, 2014 Steigerwald. Fachinformation Laif 900®, 2014
29.
Zurück zum Zitat Schuwald AM, Nöldner M, Wilmes T, Klugbauer N, Leuner K, Müller WE. Lavender oil-potent anxiolytic properties via modulating voltage dependent calcium channels. PLoS One 2013; 8(4): e59998PubMedCentralPubMedCrossRef Schuwald AM, Nöldner M, Wilmes T, Klugbauer N, Leuner K, Müller WE. Lavender oil-potent anxiolytic properties via modulating voltage dependent calcium channels. PLoS One 2013; 8(4): e59998PubMedCentralPubMedCrossRef
30.
Zurück zum Zitat Uehleke B, Schaper S, Dienel A, Schlaefke S, Stange R. Phase II trial on the effects of Silexan in patients with neurasthenia, posttraumatic stress disorder or somatization disorder. Phytomedicine 2012; 19: 665–671PubMedCrossRef Uehleke B, Schaper S, Dienel A, Schlaefke S, Stange R. Phase II trial on the effects of Silexan in patients with neurasthenia, posttraumatic stress disorder or somatization disorder. Phytomedicine 2012; 19: 665–671PubMedCrossRef
31.
Zurück zum Zitat Kasper S, Gastpar M, Müller WE, Volz HP, Möller HJ, Dienel A, Schläfke S. Silexan, an orally administered Lavandula oil preparation, is effective in the treatment of ?subsyndromal? anxiety disorder: a randomized, double-blind, placebo controlled trial. Int Clin Psychopharmacol 2010a; 25: 277–287CrossRef Kasper S, Gastpar M, Müller WE, Volz HP, Möller HJ, Dienel A, Schläfke S. Silexan, an orally administered Lavandula oil preparation, is effective in the treatment of ?subsyndromal? anxiety disorder: a randomized, double-blind, placebo controlled trial. Int Clin Psychopharmacol 2010a; 25: 277–287CrossRef
32.
Zurück zum Zitat Volz HP, Gastpar M, Kasper S, Möller HJ, Müller WE. Subsyndromale Angststörungen: Definition, Messparameter, Epidemiologie. J Neurol Neurochir Psychiatr 2011; 12: 162–167 Volz HP, Gastpar M, Kasper S, Möller HJ, Müller WE. Subsyndromale Angststörungen: Definition, Messparameter, Epidemiologie. J Neurol Neurochir Psychiatr 2011; 12: 162–167
33.
Zurück zum Zitat Kasper S, Anghelescu I, Dienel A. Efficacy of Silexan (WS® 1265) in patients with restlessness and sleep disturbance. Poster präsentiert im Rahmen des Jahrestreffens der DGPPN, Berlin, 2010b Kasper S, Anghelescu I, Dienel A. Efficacy of Silexan (WS® 1265) in patients with restlessness and sleep disturbance. Poster präsentiert im Rahmen des Jahrestreffens der DGPPN, Berlin, 2010b
34.
Zurück zum Zitat Woelk H, Schläfke S. A multi-center, doubleblind, randomised study of the Lavender oil preparation Silexan in comparison to Lorazepam for generalized anxiety disorder. Phytomedicine. 2010; 17: 94–99PubMedCrossRef Woelk H, Schläfke S. A multi-center, doubleblind, randomised study of the Lavender oil preparation Silexan in comparison to Lorazepam for generalized anxiety disorder. Phytomedicine. 2010; 17: 94–99PubMedCrossRef
35.
Zurück zum Zitat Kasper S, Gastpar M, Müller WE, Volz HP, Möller HJ, Dienel A, Schläfke S. Efficacy and safety of silexan, a new, orally administered lavender oil preparation, in subthreshold anxiety disorder - evidence from clinical trials. Wien Med Wochenschr 2010d; 160: 547–556CrossRef Kasper S, Gastpar M, Müller WE, Volz HP, Möller HJ, Dienel A, Schläfke S. Efficacy and safety of silexan, a new, orally administered lavender oil preparation, in subthreshold anxiety disorder - evidence from clinical trials. Wien Med Wochenschr 2010d; 160: 547–556CrossRef
36.
Zurück zum Zitat Kasper S, Gastpar M, Müller WE, Volz HP, Möller HJ, Schläfke S, Dienel A. Lav-ender oil preparation Silexan is effective in generalized anxiety disorder - a randomized, double-blind comparison to placebo and paroxetine. Int J Neuropsychopharmacol 2014; 17: 859–869PubMedCrossRef Kasper S, Gastpar M, Müller WE, Volz HP, Möller HJ, Schläfke S, Dienel A. Lav-ender oil preparation Silexan is effective in generalized anxiety disorder - a randomized, double-blind comparison to placebo and paroxetine. Int J Neuropsychopharmacol 2014; 17: 859–869PubMedCrossRef
37.
Zurück zum Zitat Schwabe. Fachinformation Lasea®. 2014c Schwabe. Fachinformation Lasea®. 2014c
38.
Zurück zum Zitat Doroshyenko O, Rokitta D, Zadoyan G, Klement S, Schläfke S, Dienel A, Gra-matté T, Lück H, Fuhr U. Drug cocktail interaction study on the effect of the orally administered lavender oil preparation silexan on cytochrome P450 enzymes in healthy volunteers. Drug Metab Dispos 2013; 41: 987–993PubMedCrossRef Doroshyenko O, Rokitta D, Zadoyan G, Klement S, Schläfke S, Dienel A, Gra-matté T, Lück H, Fuhr U. Drug cocktail interaction study on the effect of the orally administered lavender oil preparation silexan on cytochrome P450 enzymes in healthy volunteers. Drug Metab Dispos 2013; 41: 987–993PubMedCrossRef
39.
Zurück zum Zitat Kasper S, Dienel A. Effects of Silexan® on human cytochrome P450 activity and contraceptive efficacy of a combined oral contraceptive. Poster präsentiert im Rahmen des Jahrestreffens der DGPPN, Berlin, 2011 Kasper S, Dienel A. Effects of Silexan® on human cytochrome P450 activity and contraceptive efficacy of a combined oral contraceptive. Poster präsentiert im Rahmen des Jahrestreffens der DGPPN, Berlin, 2011
40.
Zurück zum Zitat De Mey C, Dienel A. Silexan ist sicher bei eingeschränkter Nierenfunktion [Abstract]. NeuroGeriartrie 2013; 10: S41 De Mey C, Dienel A. Silexan ist sicher bei eingeschränkter Nierenfunktion [Abstract]. NeuroGeriartrie 2013; 10: S41
41.
Zurück zum Zitat Preskorn SH. Clinical pharmacology of selective serotonin reuptake inhibitors. Caddo, OK: Professional communications, 1996 Preskorn SH. Clinical pharmacology of selective serotonin reuptake inhibitors. Caddo, OK: Professional communications, 1996
42.
Zurück zum Zitat Preskorn SH. The adverse effect profiles of the selective serotonin reuptake inhibitors: relationship to in vitro pharmacology. J Psychiatr Pract 2000; 6: 153–157 Preskorn SH. The adverse effect profiles of the selective serotonin reuptake inhibitors: relationship to in vitro pharmacology. J Psychiatr Pract 2000; 6: 153–157
Metadaten
Titel
Psychophytopharmaka
Ähnlich stark wirksam wie synthetische Stoffe und besser verträglich?
verfasst von
Prof. Dr. med. Hans-Peter Volz
Prof. Dr. med. Dr. h.c. mult. Siegfried Kasper
Publikationsdatum
19.01.2015
Verlag
Urban & Vogel
Erschienen in
DNP – Die Neurologie & Psychiatrie / Ausgabe 1/2015
Print ISSN: 2731-8168
Elektronische ISSN: 2731-8176
DOI
https://doi.org/10.1007/s15202-015-0609-8

Weitere Artikel der Ausgabe 1/2015

DNP - Der Neurologe & Psychiater 1/2015 Zur Ausgabe

Medizin aktuell

Mädchen gefährdeter