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2013 | OriginalPaper | Buchkapitel

3. Ätiologie

verfasst von : S. Blüher, M. Blüher, W. Kiess, A. Hinney, I. Nehring, R. von Kries, R. Ensenauer, W. Langhans, S.C. Schriever, C.X. Yi, P.T. Pfluger, M.H. Tschöp, T.D. Müller, C. Holzapfel, A. Wirth, S. Herpertz, S. Engeli

Erschienen in: Adipositas

Verlag: Springer Berlin Heidelberg

Zusammenfassung

Obwohl die Erblichkeit der Ausprägung des Körpergewichts hoch ist, konnten molekulargenetische Faktoren bislang nur einen kleinen Anteil davon erklären. Es wurden wenige monogene Formen der Adipositas identifiziert, bei denen der Ausfall eines einzelnen Genproduktes bereits zu einer extremen Adipositas führt. So haben funktionell relevante Mutationen im Leptin- oder Leptinrezeptorgen einen monogenen Effekt hinsichtlich der Entwicklung einer Adipositas. Sie finden sich nur bei wenigen Familien weltweit. Funktionell relevante Mutationen im Melanokortin-4-Rezeptorgen (MC4R) finden sich dagegen bei bis zu 6% der extrem adipösen Kinder und Jugendlichen sowie Erwachsenen
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Metadaten
Titel
Ätiologie
verfasst von
S. Blüher
M. Blüher
W. Kiess
A. Hinney
I. Nehring
R. von Kries
R. Ensenauer
W. Langhans
S.C. Schriever
C.X. Yi
P.T. Pfluger
M.H. Tschöp
T.D. Müller
C. Holzapfel
A. Wirth
S. Herpertz
S. Engeli
Copyright-Jahr
2013
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-642-22855-1_3

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