nach oben

Der Nervenarzt

Erschienen in:

22.12.2016 | Affektive Störungen | CME

Ernährung und psychische Erkrankungen

Schwerpunkt depressive Störungen

verfasst von: Prof. Dr. oec.troph. L. Libuda, J. Antel, J. Hebebrand, M. Föcker

Erschienen in: Der Nervenarzt | Ausgabe 1/2017

Einloggen, um Zugang zu erhalten

Zusammenfassung

Gegenwärtig wird ein möglicher Einsatz ernährungsbasierter Interventionen als ergänzende Maßnahme im Rahmen der Therapie psychischer Störungen diskutiert. Zugrunde liegende pathobiologische Mechanismen sind derzeit nicht abschließend geklärt. Plausibel ist ein Einfluss von Nährstoffen und Ernährungsmustern auf immun- und inflammatorische Prozesse, das Mikrobiom, die Leptin-melanokortinerge- und Hypothalamus-Hypophysen-Nebennierenrinden-Achse sowie auf Neurotransmitter des cholinergen, noradrenergen, dopaminergen bzw. serotonergen Systems und Neurotrophine.

In Beobachtungsstudien erwiesen sich traditionelle Ernährungsmuster wie die mediterrane Ernährung als protektiv für die seelische Gesundheit. In Bezug auf einzelne Nährstoffe zeigten Interventionsstudien bei Supplementation mit langkettigen, mehrfach ungesättigten Omega-3-Fettsäuren bei Depressionen kleine, aber signifikante Effekte. Die Studienlage bezüglich einer antidepressiven Wirkung einer Vitamin-D-Supplementation ist bislang insgesamt inkonsistent.

Jacobi F, Hofler M, Strehle J et al (2015) Twelve-months prevalence of mental disorders in the German Health Interview and Examination Survey for Adults – Mental Health Module (DEGS1-MH): a methodological addendum and correction. Int J Methods Psychiatr Res 24(4):305–313PubMedCrossRef

Statistisches Bundesamt (2010) Fachserie 12 Reihe 7.2 Gesundheit, Krankheitskosten, 2002, 2004, 2006, 2008. Statistisches Bundesamt, Wiesbaden

Sarris J, Logan AC, Akbaraly TN et al (2015) Nutritional medicine as mainstream in psychiatry. Lancet Psychiatry 2(3):271–274PubMedCrossRef

Berthoud HR, Morrison C (2008) The brain, appetite, and obesity. Annu Rev Psychol 59:55–92PubMedCrossRef

Berthoud HR (2011) Metabolic and hedonic drives in the neural control of appetite: who is the boss? Curr Opin Neurobiol 21(6):888–896PubMedPubMedCentralCrossRef

Egecioglu E, Skibicka KP, Hansson C et al (2011) Hedonic and incentive signals for body weight control. Rev Endocr Metab Disord 12(3):141–151PubMedPubMedCentralCrossRef

Yeomans MR, Coughlan E (2009) Mood-induced eating. Interactive effects of restraint and tendency to overeat. Appetite 52(2):290–298PubMedCrossRef

Gibson EL (2006) Emotional influences on food choice: sensory, physiological and psychological pathways. Physiol Behav 89(1):53–61PubMedCrossRef

Volkow ND, Wang GJ, Tomasi D et al (2013) The addictive dimensionality of obesity. Biol Psychiatry 73(9):811–818PubMedPubMedCentralCrossRef

10.

Volkow ND, Wang GJ, Tomasi D et al (2013) Obesity and addiction: neurobiological overlaps. Obes Rev 14(1):2–18PubMedCrossRef

11.

Barsh GS, Schwartz MW (2002) Genetic approaches to studying energy balance: perception and integration. Nat Rev Genet 3(8):589–600PubMed

12.

Cone RD (2005) Anatomy and regulation of the central melanocortin system. Nat Neurosci 8(5):571–578PubMedCrossRef

13.

O’Rahilly S, Yeo GS, Farooqi IS (2004) Melanocortin receptors weigh in. Nat Med 10(4):351–352PubMedCrossRef

14.

Hinney A, Volckmar AL, Knoll N (2013) Melanocortin-4 receptor in energy homeostasis and obesity pathogenesis. Prog Mol Biol Transl Sci 114:147–191PubMedCrossRef

15.

Lim BK, Huang KW, Grueter BA et al (2012) Anhedonia requires MC4R–mediated synaptic adaptations in nucleus accumbens. Nature 487(7406):183–189PubMedPubMedCentralCrossRef

16.

Liu J, Garza JC, Truong HV et al (2007) The melanocortinergic pathway is rapidly recruited by emotional stress and contributes to stress-induced anorexia and anxiety-like behavior. Endocrinology 148(11):5531–5540PubMedPubMedCentralCrossRef

17.

Wang GJ, Volkow ND, Fowler JS (2002) The role of dopamine in motivation for food in humans: implications for obesity. Expert Opin Ther Targets 6(5):601–609PubMedCrossRef

18.

Fehm HL, Kern W, Peters A (2006) The selfish brain: competition for energy resources. Prog Brain Res 153:129–140PubMedCrossRef

19.

Berridge KC, Ho CY, Richard JM et al (2010) The tempted brain eats: pleasure and desire circuits in obesity and eating disorders. Brain Res 1350:43–64PubMedPubMedCentralCrossRef

20.

Weltens N, Zhao D, Van Oudenhove L (2014) Where is the comfort in comfort foods? Mechanisms linking fat signaling, reward, and emotion. Neurogastroenterol Motil 26(3):303–315PubMedCrossRef

21.

Berridge KC (2009) „Liking“ and „wanting“ food rewards: brain substrates and roles in eating disorders. Physiol Behav 97(5):537–550PubMedPubMedCentralCrossRef

22.

Opland DM, Leinninger GM, Myers MG Jr. (2010) Modulation of the mesolimbic dopamine system by leptin. Brain Res 1350:65–70PubMedPubMedCentralCrossRef

23.

van Zessen R, van der Plasse G, Adan RA (2012) Contribution of the mesolimbic dopamine system in mediating the effects of leptin and ghrelin on feeding. Proc Nutr Soc 71(4):435–445PubMedCrossRef

24.

Meye FJ, Adan RA (2014) Feelings about food: the ventral tegmental area in food reward and emotional eating. Trends Pharmacol Sci 35(1):31–40PubMedCrossRef

25.

Zheng H, Lenard NR, Shin AC et al (2009) Appetite control and energy balance regulation in the modern world: reward-driven brain overrides repletion signals. Int J Obes (Lond) 33(Suppl 2):S8–13CrossRef

26.

Hebebrand J, Albayrak O, Adan R et al (2014) „Eating addiction“, rather than „food addiction“, better captures addictive-like eating behavior. Neurosci Biobehav Rev 47:295–306PubMedCrossRef

27.

Menzies JR, Skibicka KP, Leng G et al (2013) Ghrelin, reward and motivation. Endocr Dev 25:101–111PubMed

28.

Domingos AI, Vaynshteyn J, Voss HU et al (2011) Leptin regulates the reward value of nutrient. Nat Neurosci 14(12):1562–1568PubMedPubMedCentralCrossRef

29.

Frank S, Heni M, Moss A et al (2013) Long-term stabilization effects of leptin on brain functions in a leptin-deficient patient. PLOS ONE 8(6):e65893PubMedPubMedCentralCrossRef

30.

Haroon E, Raison CL, Miller AH (2012) Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior. Neuropsychopharmacology 37(1):137–162PubMedCrossRef

31.

Fritsche KL (2015) The science of fatty acids and inflammation. Adv Nutr 6(3):293–301CrossRef

32.

Berk M, Williams LJ, Jacka FN et al (2013) So depression is an inflammatory disease, but where does the inflammation come from? BMC Med 11:200PubMedPubMedCentralCrossRef

33.

Muhlig Y, Antel J, Focker M et al (2016) Are bidirectional associations of obesity and depression already apparent in childhood and adolescence as based on high-quality studies? A systematic review. Obes Rev 17(3):235–249PubMedCrossRef

34.

Mooney SJ, El-Sayed AM (2016) Stigma and the etiology of depression among the obese: An agent-based exploration. Soc Sci Med 148:1–7PubMedCrossRef

35.

Shelton RC, Miller AH (2011) Inflammation in depression: is adiposity a cause? Dialogues Clin Neurosci 13(1):41–53PubMed

36.

Luppino FS, de Wit LM, Bouvy PF et al (2010) Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Arch Gen Psychiatry 67(3):220–229PubMedCrossRef

37.

Messay B, Lim A, Marsland AL (2012) Current understanding of the bi-directional relationship of major depression with inflammation. Biol Mood Anxiety Disord 2(1):4PubMedPubMedCentralCrossRef

38.

Penninx BW, Milaneschi Y, Lamers F et al (2013) Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile. BMC Med 11:129PubMedPubMedCentralCrossRef

39.

Sperner-Unterweger B, Kohl C, Fuchs D (2014) Immune changes and neurotransmitters: possible interactions in depression? Prog Neuropsychopharmacol Biol Psychiatry 48:268–276PubMedCrossRef

40.

Catena-Dell’Osso M, Rotella F, Dell’Osso A et al (2013) Inflammation, serotonin and major depression. Curr Drug Targets 14(5):571–577PubMedCrossRef

41.

Powell TR, McGuffin P, D’Souza UM et al (2014) Putative transcriptomic biomarkers in the inflammatory cytokine pathway differentiate major depressive disorder patients from control subjects and bipolar disorder patients. PLOS ONE 9(3):e91076PubMedPubMedCentralCrossRef

42.

Appelhans BM, Whited MC, Schneider KL et al (2012) Depression severity, diet quality, and physical activity in women with obesity and depression. J Acad Nutr Diet 112(5):693–698PubMedPubMedCentralCrossRef

43.

Shoelson SE, Herrero L, Naaz A (2007) Obesity, inflammation, and insulin resistance. Gastroenterology 132(6):2169–2180PubMedCrossRef

44.

Zeevi D, Korem T, Segal E (2016) Talking about cross-talk: the immune system and the microbiome. Genome Biol 17:50PubMedPubMedCentralCrossRef

45.

Fond G, Boukouaci W, Chevalier G et al (2015) The „psychomicrobiotic“: targeting microbiota in major psychiatric disorders: a systematic review. Pathol Biol 63(1):35–42PubMedCrossRef

46.

Pusceddu MM, El Aidy S, Crispie F et al (2015) N‑3 Polyunsaturated Fatty Acids (PUFAs) reverse the impact of early-life stress on the gut microbiota. PLOS ONE 10(10):e0139721PubMedPubMedCentralCrossRef

47.

Brennan SL, Henry MJ, Nicholson GC et al (2009) Socioeconomic status and risk factors for obesity and metabolic disorders in a population-based sample of adult females. Prev Med 49(2–3):165–171PubMedCrossRef

48.

U.S.-Department-of-Health-and-Human-Services, Dietary Patterns, Foods and Nutrients, and Health Outcomes, U.S.D.o.H.a.H. Services, Editor. 2015, U.S. Department of Health and Human Services.

49.

Saez-Almendros S, Obrador B, Bach-Faig A et al (2013) Environmental footprints of Mediterranean versus Western dietary patterns: beyond the health benefits of the Mediterranean diet. Environ Health 12:118PubMedPubMedCentralCrossRef

50.

Hu FB (2002) Dietary pattern analysis: a new direction in nutritional epidemiology. Curr Opin Lipidol 13(1):3–9PubMedCrossRef

51.

Rahe C, Unrath M, Berger K (2014) Dietary patterns and the risk of depression in adults: a systematic review of observational studies. Eur J Nutr 53(4):997–1013PubMedCrossRef

52.

Trichopoulou A, Costacou T, Bamia C et al (2003) Adherence to a Mediterranean diet and survival in a Greek population. N Engl J Med 348(26):2599–2608PubMedCrossRef

53.

Ferrari R, Rapezzi C (2011) The Mediterranean diet: a cultural journey. Lancet 377(9779):1730–1731PubMedCrossRef

54.

Estruch R (2010) Anti-inflammatory effects of the Mediterranean diet: the experience of the PREDIMED study. Proc Nutr Soc 69(3):333–340PubMedCrossRef

55.

Estruch R, Ros E, Salas-Salvado J et al (2013) Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med 368(14):1279–1290PubMedCrossRef

56.

Esposito K, Marfella R, Ciotola M et al (2004) Effect of a mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial. JAMA 292(12):1440–1446PubMedCrossRef

57.

Giacosa A, Barale R, Bavaresco L et al (2013) Cancer prevention in Europe: the Mediterranean diet as a protective choice. Eur J Cancer Prev 22(1):90–95PubMedCrossRef

58.

Esposito K, Di Palo C, Maiorino MI et al (2011) Long-term effect of mediterranean-style diet and calorie restriction on biomarkers of longevity and oxidative stress in overweight men. Cardiol Res Pract 2011:293916. doi:10.4061/2011/293916

59.

Knoops KT, de Groot LC, Kromhout D et al (2004) Mediterranean diet, lifestyle factors, and 10-year mortality in elderly European men and women: the HALE project. JAMA 292(12):1433–1439PubMedCrossRef

60.

Willett WC, Sacks F, Trichopoulou A et al (1995) Mediterranean diet pyramid: a cultural model for healthy eating. Am J Clin Nutr 61(6 Suppl):1402–1406

61.

Estruch R, Martinez-Gonzalez MA, Corella D et al (2006) Effects of a Mediterranean-style diet on cardiovascular risk factors: a randomized trial. Ann Intern Med 145(1):1–11PubMedCrossRef

62.

Sofi F, Abbate R, Gensini GF et al (2010) Accruing evidence on benefits of adherence to the Mediterranean diet on health: an updated systematic review and meta-analysis. Am J Clin Nutr 92(5):1189–1196PubMedCrossRef

63.

Knopman DS (2009) Mediterranean diet and late-life cognitive impairment: a taste of benefit. JAMA 302(6):686–687PubMedPubMedCentralCrossRef

64.

Vernaglione L (2009) The Mediterranean diet: a matter of history, tradition, culture and health. J Nephrol 22(Suppl 14):149–158PubMed

65.

Lai JS, Hiles S, Bisquera A et al (2014) A systematic review and meta-analysis of dietary patterns and depression in community-dwelling adults. Am J Clin Nutr 99(1):181–197PubMedCrossRef

66.

Quirk SE, Williams LJ, O’Neil A et al (2013) The association between diet quality, dietary patterns and depression in adults: a systematic review. BMC Psychiatry 13:175PubMedPubMedCentralCrossRef

67.

Psaltopoulou T, Sergentanis TN, Panagiotakos DB et al (2013) Mediterranean diet, stroke, cognitive impairment, and depression: a meta-analysis. Ann Neurol 74(4):580–591PubMedCrossRef

68.

O’Neil A, Berk M, Itsiopoulos C et al (2013) A randomised, controlled trial of a dietary intervention for adults with major depression (the „SMILES“ trial): study protocol. BMC Psychiatry 13:114PubMedPubMedCentralCrossRef

69.

Sanchez-Villegas A, Martinez-Gonzalez MA, Estruch R et al (2013) Mediterranean dietary pattern and depression: the PREDIMED randomized trial. BMC Med 11:208PubMedPubMedCentralCrossRef

70.

Sanchez-Villegas A, Martinez-Gonzalez MA (2013) Diet, a new target to prevent depression? BMC Med 11:3PubMedPubMedCentralCrossRef

71.

Arterburn LM, Hall EB, Oken H (2006) Distribution, interconversion, and dose response of n‑3 fatty acids in humans. Am J Clin Nutr 83(6 Suppl):1467–1476

72.

Harris WS, Von Schacky C (2004) The Omega-3 Index: a new risk factor for death from coronary heart disease? Prev Med 39(1):212–220PubMedCrossRef

73.

Bradbury J (2011) Docosahexaenoic acid (DHA): an ancient nutrient for the modern human brain. Nutrients 3(5):529–554PubMedPubMedCentralCrossRef

74.

Janssen CI, Kiliaan AJ (2014) Long-chain polyunsaturated fatty acids (LCPUFA) from genesis to senescence: the influence of LCPUFA on neural development, aging, and neurodegeneration. Prog Lipid Res 53:1–17PubMedCrossRef

75.

Schmitz G, Ecker J (2008) The opposing effects of n‑3 and n‑6 fatty acids. Prog Lipid Res 47(2):147–155PubMedCrossRef

76.

Deutsche Gesellschaft für Ernährung (DGE), Österreichische Gesellschaft für Ernährung (ÖGE), Schweizerische Gesellschaft für Ernährung (2015) Referenzwerte für die Nährstoffzufuhr. Vol. 2, 1. Aufl. DGE, Bonn

77.

Abedi E, Sahari MA (2014) Long-chain polyunsaturated fatty acid sources and evaluation of their nutritional and functional properties. Food Sci Nutr 2(5):443–463PubMedPubMedCentralCrossRef

78.

Jungvogel A, Wendt I, Schäbethal K et al (2013) Überarbeitet: Die 10 Regeln der DGE. Ernährungs Umsch 11:M644–M645

79.

Krems C, Walter C, Heuer T et al (2012) Lebensmittelverzehr und Nährstoffzufuhr – Ergebnisse der Nationalen Verzehrsstudie II. In: Deutsche Gesellschaft für Ernährung (Hrsg) Ernährungsbericht 2012. Deutsche Gesellschaft für Ernährung, Bonn

80.

Krems C, Walter CH, Hoffmann T (2013) I. Nationale Verzehrsstudie II. Lebensmittelverzehr und Nährstoffzufuhr auf Basis von 24 h-Recalls. http://www.mri.bund.de/fileadmin/MRI/Institute/EV/Lebensmittelverzehr_N%C3%A4hrstoffzufuhr_24h-recalls-neu.pdf. Zugegriffen: 15.12.2016

81.

Hibbeln JR (1998) Fish consumption and major depression. Lancet 351(9110):1213PubMedCrossRef

82.

Peet M (2004) International variations in the outcome of schizophrenia and the prevalence of depression in relation to national dietary practices: an ecological analysis. Br J Psychiatry 184:404–408PubMedCrossRef

83.

Lin PY, Huang SY, Su KP (2010) A meta-analytic review of polyunsaturated fatty acid compositions in patients with depression. Biol Psychiatry 68(2):140–147PubMedCrossRef

84.

Pottala JV, Talley JA, Churchill SW et al (2012) Red blood cell fatty acids are associated with depression in a case-control study of adolescents. Prostaglandins Leukot Essent Fatty Acids 86(4–5):161–165PubMedCrossRef

85.

Hawkey E, Nigg JT (2014) Omega-3 fatty acid and ADHD: blood level analysis and meta-analytic extension of supplementation trials. Clin Psychol Rev 34(6):496–505PubMedPubMedCentralCrossRef

86.

Al-Farsi YM, Waly MI, Deth RC et al (2013) Impact of nutrition on serum levels of docosahexaenoic acid among Omani children with autism. Nutrition 29(9):1142–1146PubMedCrossRef

87.

Brigandi SA, Shao H, Qian SY et al (2015) Autistic children exhibit decreased levels of essential Fatty acids in red blood cells. Int J Mol Sci 16(5):10061–10076PubMedPubMedCentralCrossRef

88.

Appleton KM, Sallis HM, Perry R et al (2016) Omega-3 Fatty acids for major depressive disorder in adults: an abridged Cochrane review. BMJ Open 6(3):e010172PubMedPubMedCentralCrossRef

89.

Grosso G, Pajak A, Marventano S et al (2014) Role of omega-3 fatty acids in the treatment of depressive disorders: a comprehensive meta-analysis of randomized clinical trials. PLOS ONE 9(5):e96905PubMedPubMedCentralCrossRef

90.

Mocking RJ, Harmsen I, Assies J et al (2016) Meta-analysis and meta-regression of omega-3 polyunsaturated fatty acid supplementation for major depressive disorder. Transl Psychiatry 6:e756PubMedPubMedCentralCrossRef

91.

Nemets H, Nemets B, Apter A et al (2006) Omega-3 treatment of childhood depression: a controlled, double-blind pilot study. Am J Psychiatry 163(6):1098–1100PubMedCrossRef

92.

Rapaport MH, Nierenberg AA, Schettler PJ et al (2016) Inflammation as a predictive biomarker for response to omega-3 fatty acids in major depressive disorder: a proof-of-concept study. Mol Psychiatry 21(1):71–79PubMedCrossRef

93.

von Schacky C (2014) Omega-3 index and cardiovascular health. Nutrients 6(2):799–814CrossRef

94.

Vieth R (2004) Why „Vitamin D“ is not a hormone, and not a synonym for 1,25-dihydroxy-vitamin D, its analogs or deltanoids. J Steroid Biochem Mol Biol 89–90(1–5):571–573PubMedCrossRef

95.

Ryan JW, Anderson PH, Morris HA (2015) Pleiotropic activities of vitamin D receptors – adequate activation for multiple health outcomes. Clin Biochem Rev 36(2):53–61PubMedPubMedCentral

96.

Pike JW, Meyer MB, Martowicz ML et al (2010) Emerging regulatory paradigms for control of gene expression by 1,25-dihydroxyvitamin D3. J Steroid Biochem Mol Biol 121(1–2):130–135PubMedPubMedCentralCrossRef

97.

Eyles DW, Smith S, Kinobe R et al (2005) Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J Chem Neuroanat 29(1):21–30PubMedCrossRef

98.

Binkley N, Wiebe D (2013) Clinical controversies in vitamin D: 25(OH)D measurement, target concentration, and supplementation. J Clin Densitom 16(4):402–408PubMedCrossRef

99.

Holick MF (2007) Vitamin D deficiency. N Engl J Med 357(3):266–281PubMedCrossRef

100.

Deutsche Gesellschaft f. Ernährung (DGE), Österreichische Gesellschaft f. Ernährung (ÖGE), Schweizerische Gesellschaft f. Ernährungsforschung (SGE), Schweizerische Gesellschaft f. Ernährungsforschung (SGE), et al (2008) Referenzwerte für die Nährstoffzufuhr, ed. Deutsche Gesellschaft f. Ernährung. Umschau, Neustadt an der Weinstraße

101.

Binkley N, Sempos CT, Vitamin D Standardization Program (2014) Standardizing vitamin D assays: the way forward. J Bone Miner Res 29(8):1709–1714PubMedCrossRef

102.

Committee to Review Dietary Reference Intakes for Vitamin D and Calcium, Institute of Medicine (2011) Dietary reference intakes for calcium and vitamin D

103.

Linseisen J, Bechthold A, Bischoff-Ferrari HA et al (2011) DGE-Stellungnahme: Vitamin D und Prävention ausgewählter chronischer Krankheiten. https://www.dge.de/fileadmin/public/doc/ws/stellungnahme/DGE-Stellungnahme-VitD-111220.pdf. Zugegriffen: 15.12.2016

104.

Bener A, Kamal M (2014) Predict attention deficit hyperactivity disorder? Evidence – based medicine. Glob J Health Sci 6(2):47–57

105.

Bener A, Khattab AO, Al-Dabbagh MM (2014) Is high prevalence of vitamin D deficiency evidence for autism disorder?: In a highly endogamous population. J Pediatr Neurosci 9(3):227–233PubMedPubMedCentralCrossRef

106.

Goksugur SB, Tufan AE, Semiz M et al (2014) Vitamin D status in children with attention-deficit-hyperactivity disorder. Pediatr Int 56(4):515–519PubMedCrossRef

107.

Kamal M, Bener A, Ehlayel MS (2014) Is high prevalence of vitamin D deficiency a correlate for attention deficit hyperactivity disorder? Atten Defic Hyperact Disord 6(2):73–78PubMedCrossRef

108.

Eyles DW, Burne TH, McGrath JJ (2013) Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease. Front Neuroendocrinol 34(1):47–64PubMedCrossRef

109.

Verduijn J, Milaneschi Y, Schoevers RA et al (2015) Pathophysiology of major depressive disorder: mechanisms involved in etiology are not associated with clinical progression. Transl Psychiatry 5:e649PubMedCrossRef

110.

Zhu DM, Liu Y, Zhang AG et al (2015) High levels of vitamin D in relation to reduced risk of schizophrenia with elevated C‑reactive protein. Psychiatry Res 228(3):565–570PubMedCrossRef

111.

Fernell E, Bejerot S, Westerlund J et al (2015) Autism spectrum disorder and low vitamin D at birth: a sibling control study. Mol Autism 6:3PubMedPubMedCentralCrossRef

112.

Gong ZL, Luo CM, Wang L et al (2014) Serum 25-hydroxyvitamin D levels in Chinese children with autism spectrum disorders. Neuroreport 25(1):23–27PubMed

113.

Saad K, Abdel-Rahman AA, Elserogy YM et al (2015) Vitamin D status in autism spectrum disorders and the efficacy of vitamin D supplementation in autistic children. Nutr Neurosci 19:346. doi:10.1179/1476830515y.0000000019 PubMedCrossRef

114.

Milaneschi Y, Hoogendijk W, Lips P et al (2014) The association between low vitamin D and depressive disorders. Mol Psychiatry 19(4):444–451PubMedCrossRef

115.

Jozefowicz O, Rabe-Jablonska J, Wozniacka A et al (2014) Analysis of vitamin D status in major depression. J Psychiatr Pract 20(5):329–337PubMedCrossRef

116.

Belzeaux R, Boyer L, Ibrahim EC et al (2015) Mood disorders are associated with a more severe hypovitaminosis D than schizophrenia. Psychiatry Res 229:613. doi:10.1016/j.psychres.2015.04.039 PubMedCrossRef

117.

Jaaskelainen T, Knekt P, Suvisaari J et al (2015) Higher serum 25-hydroxyvitamin D concentrations are related to a reduced risk of depression. Br J Nutr 113(9):1418–1426PubMedCrossRef

118.

Jaddou HY, Batieha AM, Khader YS et al (2012) Depression is associated with low levels of 25-hydroxyvitamin D among Jordanian adults: results from a national population survey. Eur Arch Psychiatry Clin Neurosci 262(4):321–327PubMedCrossRef

119.

Brouwer-Brolsma EM, Feskens EJ, Steegenga WT et al (2013) Associations of 25-hydroxyvitamin D with fasting glucose, fasting insulin, dementia and depression in European elderly: the SENECA study. Eur J Nutr 52(3):917–925PubMedCrossRef

120.

Gowda U, Mutowo MP, Smith BJ et al (2015) Vitamin D supplementation to reduce depression in adults: meta-analysis of randomized controlled trials. Nutrition 31(3):421–429PubMedCrossRef

121.

Spedding S (2014) Vitamin D and depression: a systematic review and meta-analysis comparing studies with and without biological flaws. Nutrients 6(4):1501–1518PubMedPubMedCentralCrossRef

122.

Li G, Mbuagbaw L, Samaan Z et al (2014) Efficacy of vitamin D supplementation in depression in adults: a systematic review. J Clin Endocrinol Metab 99(3):757–767PubMedCrossRef

123.

Shaffer JA, Edmondson D, Wasson LT et al (2014) Vitamin D supplementation for depressive symptoms: a systematic review and meta-analysis of randomized controlled trials. Psychosom Med 76(3):190–196PubMedPubMedCentralCrossRef

124.

Sherrington C, Herbert RD, Maher CG et al (2000) PEDro. A database of randomized trials and systematic reviews in physiotherapy. Man Ther 5(4):223–226PubMedCrossRef

125.

Khoraminya N, Tehrani-Doost M, Jazayeri S et al (2013) Therapeutic effects of vitamin D as adjunctive therapy to fluoxetine in patients with major depressive disorder. Aust N Z J Psychiatry 47(3):271–275PubMedCrossRef

126.

Mozaffari-Khosravi H, Nabizade L, Yassini-Ardakani SM et al (2013) The effect of 2 different single injections of high dose of vitamin D on improving the depression in depressed patients with vitamin D deficiency: a randomized clinical trial. J Clin Psychopharmacol 33(3):378–385PubMedCrossRef

127.

Straßburg A (2010) Ernährungserhebungen: Methoden und Instrumente. Ernährungs Umsch 8:422–430

Titel: Ernährung und psychische Erkrankungen
Schwerpunkt depressive Störungen
verfasst von: Prof. Dr. oec.troph. L. Libuda
J. Antel
J. Hebebrand
M. Föcker
Publikationsdatum: 22.12.2016
Verlag: Springer Medizin
Schlagwörter: Affektive Störungen
Affektive Störungen
Ernährung
Erschienen in: Der Nervenarzt / Ausgabe 1/2017
Print ISSN: 0028-2804
Elektronische ISSN: 1433-0407
DOI: https://doi.org/10.1007/s00115-016-0262-2

Springer Medizin

Zusammenfassung

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2017

„Kein Wunder, aber beachtliche Wirkung“?

„Schizophrenie“: Pars pro toto der Psychiatrie?

Dissemination psychotherapeutischer Module für traumatisierte Geflüchtete

Elektrokonvulsionstherapie gegen den natürlichen Patientenwillen

Memantin als Add-on-Medikation zur Acetylcholinesteraseinhibitor-Therapie bei Alzheimer-Demenz

Psychische Versorgung von Flüchtlingen in Deutschland