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01.12.2018 | Epidemiology (M Laine, Section Editor) | Ausgabe 4/2018

Current Oral Health Reports 4/2018

Age and Periodontal Health—Immunological View

Current Oral Health Reports > Ausgabe 4/2018
Jeffrey L. Ebersole, D. A. Dawson III, P. Emecen Huja, S. Pandruvada, A. Basu, L. Nguyen, Y. Zhang, O. A. Gonzalez
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s40496-018-0202-2) contains supplementary material, which is available to authorized users.
This article is part of the Topical Collection on Epidemiology


Purpose of the Review

Aging clearly impacts a wide array of systems, in particular the breadth of the immune system leading to immunosenescence, altered immunoactivation, and coincident inflammaging processes. The net result of these changes leads to increased susceptibility to infections, increased neoplastic occurrences, and elevated frequency of autoimmune diseases with aging. However, as the bacteria in the oral microbiome that contribute to the chronic infection of periodontitis is acquired earlier in life, the characteristics of the innate and adaptive immune systems to regulate these members of the autochthonous microbiota across the lifespan remains ill-defined.

Recent Findings

Clear data demonstrate that both cells and molecules of the innate and adaptive immune response are adversely impacted by aging, including in the oral cavity, yielding a reasonable tenet that the increased periodontitis noted in aging populations is reflective of the age-associated immune dysregulation. Additionally, this facet of host-microbe interactions and disease needs to accommodate the population variation in disease onset and progression, which may also reflect an accumulation of environmental stressors and/or decreased protective nutrients that could function at the gene level (i.e., epigenetic) or translational level for production and secretion of immune system molecules.


Finally, the majority of studies of aging and periodontitis have emphasized the increased prevalence/severity of disease with aging, all based upon chronological age. However, evolving areas of study focusing on “biological aging” to help account for population variation in disease expression may suggest that chronic periodontitis represents a co-morbidity that contributes to “gerovulnerability” within the population.

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