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Erschienen in: Clinical Rheumatology 1/2017

17.11.2016 | Original Article

Age of onset influences on clinical and laboratory profile of patients with systemic lupus erythematosus

verfasst von: Rafael Hennemann Sassi, Jordana Vaz Hendler, Giovana Fagundes Piccoli, Andrese Aline Gasparin, Rafael Mendonça da Silva Chakr, João Carlos Tavares Brenol, Odirlei André Monticielo

Erschienen in: Clinical Rheumatology | Ausgabe 1/2017

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Abstract

The present study aims to evaluate differences in clinical and laboratory manifestations and medication use in the different ages of disease onset in patients with systemic lupus erythematosus (SLE). This cross-sectional study consisted of 598 SLE patients (550 female and 48 male), who attended the Rheumatology Clinic of the Hospital de Clínicas de Porto Alegre between 2003 and 2015. Demographic, clinical and laboratory data were collected. The patients were classified into three groups according to their ages at disease diagnosis. Mean age of diagnosis was 33.6 ± 14.3 years, and the median (25th–75th percentile) disease duration was 13 (7–20) years. Among the patients studied, 419 (70%) were adult-onset (aSLE), 90 (14.8%) were late-onset (lSLE) and 89 (14.8%) were childhood-onset (cSLE). The female to male ratio was higher in aSLE (18:1) compared to the other groups (p = 0.001). Arthritis was predominantly found in aSLE (78.5%) when compared with lSLE (57.7%) (p < 0.001). Nephritis was more common in cSLE (60.6%) than in lSLE (26.6%) (p < 0.001). Median (25th–75th percentile) of SLE disease activity index (SLEDAI) was higher in the cSLE group [2 (0–5)] when compared to the lSLE group [0 (0–4)] (p = 0.045). Childhood-onset SLE showed a more severe disease due to the higher incidence of nephritis and needed a more aggressive treatment with immunosuppressive drugs.
Literatur
1.
Zurück zum Zitat Monticielo OA, Mucenic T, Xavier RM et al (2008) The role of mannose-binding lectin in systemic lupus erythematosus. Clin Rheumatol 27(4):413–419PubMedCrossRef Monticielo OA, Mucenic T, Xavier RM et al (2008) The role of mannose-binding lectin in systemic lupus erythematosus. Clin Rheumatol 27(4):413–419PubMedCrossRef
2.
Zurück zum Zitat Boddaert J, Huong DL, Amoura Z et al (2004) Late-onset systemic lupus erythematosus: a personal series of 47 patients and pooled analysis of 714 cases in the literature. Medicine (Baltimore) 83(6):348–359CrossRef Boddaert J, Huong DL, Amoura Z et al (2004) Late-onset systemic lupus erythematosus: a personal series of 47 patients and pooled analysis of 714 cases in the literature. Medicine (Baltimore) 83(6):348–359CrossRef
3.
Zurück zum Zitat Ballou SP, Khan MA, Kushner I (1982) Clinical features of systemic lupus erythematosus: differences related to race and age of onset. Arthritis Rheum 25(1):55–60PubMedCrossRef Ballou SP, Khan MA, Kushner I (1982) Clinical features of systemic lupus erythematosus: differences related to race and age of onset. Arthritis Rheum 25(1):55–60PubMedCrossRef
4.
Zurück zum Zitat Alonso MD, Martinez-Vazquez F, de Teran TD et al (2012) Late-onset systemic lupus erythematosus in northwestern Spain: differences with early-onset systemic lupus erythematosus and literature review. Lupus 21(10):1135–1148PubMedCrossRef Alonso MD, Martinez-Vazquez F, de Teran TD et al (2012) Late-onset systemic lupus erythematosus in northwestern Spain: differences with early-onset systemic lupus erythematosus and literature review. Lupus 21(10):1135–1148PubMedCrossRef
5.
Zurück zum Zitat Bertoli AM, Alarcon GS, Calvo-Alen J et al (2006) Systemic lupus erythematosus in a multiethnic US cohort. XXXIII. Clinical [corrected] features, course, and outcome in patients with late-onset disease. Arthritis Rheum 54(5):1580–1587PubMedCrossRef Bertoli AM, Alarcon GS, Calvo-Alen J et al (2006) Systemic lupus erythematosus in a multiethnic US cohort. XXXIII. Clinical [corrected] features, course, and outcome in patients with late-onset disease. Arthritis Rheum 54(5):1580–1587PubMedCrossRef
7.
Zurück zum Zitat Chen YM, Lin CH, Chen HH et al (2014) Onset age affects mortality and renal outcome of female systemic lupus erythematosus patients: a nationwide population-based study in Taiwan. Rheumatology (Oxford) 53(1):180–185CrossRef Chen YM, Lin CH, Chen HH et al (2014) Onset age affects mortality and renal outcome of female systemic lupus erythematosus patients: a nationwide population-based study in Taiwan. Rheumatology (Oxford) 53(1):180–185CrossRef
8.
Zurück zum Zitat Feng X, Zou Y, Pan W et al (2014) Associations of clinical features and prognosis with age at disease onset in patients with systemic lupus erythematosus. Lupus 23(3):327–334PubMedCrossRef Feng X, Zou Y, Pan W et al (2014) Associations of clinical features and prognosis with age at disease onset in patients with systemic lupus erythematosus. Lupus 23(3):327–334PubMedCrossRef
9.
Zurück zum Zitat Watson L, Leone V, Pilkington C et al (2012) Disease activity, severity, and damage in the UK juvenile-onset systemic lupus erythematosus cohort. Arthritis Rheum 64(7):2356–2365PubMedCrossRef Watson L, Leone V, Pilkington C et al (2012) Disease activity, severity, and damage in the UK juvenile-onset systemic lupus erythematosus cohort. Arthritis Rheum 64(7):2356–2365PubMedCrossRef
10.
Zurück zum Zitat Brunner HI, Gladman DD, Ibanez D et al (2008) Difference in disease features between childhood-onset and adult-onset systemic lupus erythematosus. Arthritis Rheum 58(2):556–562PubMedCrossRef Brunner HI, Gladman DD, Ibanez D et al (2008) Difference in disease features between childhood-onset and adult-onset systemic lupus erythematosus. Arthritis Rheum 58(2):556–562PubMedCrossRef
11.
Zurück zum Zitat Lazaro D (2007) Elderly-onset systemic lupus erythematosus: prevalence, clinical course and treatment. Drugs Aging 24(9):701–715PubMedCrossRef Lazaro D (2007) Elderly-onset systemic lupus erythematosus: prevalence, clinical course and treatment. Drugs Aging 24(9):701–715PubMedCrossRef
12.
Zurück zum Zitat Rovensky J, Tuchynova A (2008) Systemic lupus erythematosus in the elderly. Autoimmun Rev 7(3):235–239PubMedCrossRef Rovensky J, Tuchynova A (2008) Systemic lupus erythematosus in the elderly. Autoimmun Rev 7(3):235–239PubMedCrossRef
13.
Zurück zum Zitat das Chagas Medeiros MM, Bezerra MC, Braga FN et al (2016) Clinical and immunological aspects and outcome of a Brazilian cohort of 414 patients with systemic lupus erythematosus (SLE): comparison between childhood-onset, adult-onset, and late-onset SLE. Lupus 25(4):355–363PubMedCrossRef das Chagas Medeiros MM, Bezerra MC, Braga FN et al (2016) Clinical and immunological aspects and outcome of a Brazilian cohort of 414 patients with systemic lupus erythematosus (SLE): comparison between childhood-onset, adult-onset, and late-onset SLE. Lupus 25(4):355–363PubMedCrossRef
14.
Zurück zum Zitat Costallat LT, Coimbra AM (1994) Systemic lupus erythematosus: clinical and laboratory aspects related to age at disease onset. Clin Exp Rheumatol 12(6):603–607PubMed Costallat LT, Coimbra AM (1994) Systemic lupus erythematosus: clinical and laboratory aspects related to age at disease onset. Clin Exp Rheumatol 12(6):603–607PubMed
15.
Zurück zum Zitat Sato VA, Marques ID, Goldenstein PT, et al. (2012) Lupus nephritis is more severe in children and adolescents than in older adults. 21(9):978–983 Sato VA, Marques ID, Goldenstein PT, et al. (2012) Lupus nephritis is more severe in children and adolescents than in older adults. 21(9):978–983
16.
Zurück zum Zitat Borba EF, Araujo DB, Bonfa E et al (2013) Clinical and immunological features of 888 Brazilian systemic lupus patients from a monocentric cohort: comparison with other populations. Lupus 22(7):744–749PubMedCrossRef Borba EF, Araujo DB, Bonfa E et al (2013) Clinical and immunological features of 888 Brazilian systemic lupus patients from a monocentric cohort: comparison with other populations. Lupus 22(7):744–749PubMedCrossRef
17.
Zurück zum Zitat Chahade WH, Sato EI, Moura JE Jr et al (1995) Systemic lupus erythematosus in Sao Paulo/Brazil: a clinical and laboratory overview. Lupus 4(2):100–103PubMedCrossRef Chahade WH, Sato EI, Moura JE Jr et al (1995) Systemic lupus erythematosus in Sao Paulo/Brazil: a clinical and laboratory overview. Lupus 4(2):100–103PubMedCrossRef
18.
Zurück zum Zitat Nakashima CA, Galhardo AP, Silva JF et al (2011) Incidence and clinical-laboratory aspects of systemic lupus erythematosus in a southern Brazilian city. Rev Bras Reumatol 51(3):231–239PubMedCrossRef Nakashima CA, Galhardo AP, Silva JF et al (2011) Incidence and clinical-laboratory aspects of systemic lupus erythematosus in a southern Brazilian city. Rev Bras Reumatol 51(3):231–239PubMedCrossRef
19.
Zurück zum Zitat Vilar MJ, Sato EI (2002) Estimating the incidence of systemic lupus erythematosus in a tropical region (Natal, Brazil). Lupus 11(8):528–532PubMedCrossRef Vilar MJ, Sato EI (2002) Estimating the incidence of systemic lupus erythematosus in a tropical region (Natal, Brazil). Lupus 11(8):528–532PubMedCrossRef
20.
Zurück zum Zitat Tan EM, Cohen AS, Fries JF et al (1982) The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 25(11):1271–1277PubMedCrossRef Tan EM, Cohen AS, Fries JF et al (1982) The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 25(11):1271–1277PubMedCrossRef
21.
Zurück zum Zitat Hochberg MC (1997) Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40(9):1725PubMedCrossRef Hochberg MC (1997) Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40(9):1725PubMedCrossRef
22.
Zurück zum Zitat Monticielo OA, Brenol JC, Chies JA et al (2012) The role of BsmI and FokI vitamin D receptor gene polymorphisms and serum 25-hydroxyvitamin D in Brazilian patients with systemic lupus erythematosus. Lupus 21(1):43–52PubMedCrossRef Monticielo OA, Brenol JC, Chies JA et al (2012) The role of BsmI and FokI vitamin D receptor gene polymorphisms and serum 25-hydroxyvitamin D in Brazilian patients with systemic lupus erythematosus. Lupus 21(1):43–52PubMedCrossRef
23.
Zurück zum Zitat Santos NPC, Ribeiro-Rodrigues EM, Ribeiro-dos-Santos Andrea KC et al (2010) Assessing individual interethnic admixture and population substructure using a 48-insertion-deletion (INSEL) ancestry-informative marker (AIM) panel. Hum Mutat 31(2):184–190PubMedCrossRef Santos NPC, Ribeiro-Rodrigues EM, Ribeiro-dos-Santos Andrea KC et al (2010) Assessing individual interethnic admixture and population substructure using a 48-insertion-deletion (INSEL) ancestry-informative marker (AIM) panel. Hum Mutat 31(2):184–190PubMedCrossRef
24.
Zurück zum Zitat Cervera R, Khamashta MA, Font J et al (1993) Systemic lupus erythematosus: clinical and immunologic patterns of disease expression in a cohort of 1,000 patients. The European Working Party on Systemic Lupus Erythematosus. Medicine (Baltimore) 72(2):113–124CrossRef Cervera R, Khamashta MA, Font J et al (1993) Systemic lupus erythematosus: clinical and immunologic patterns of disease expression in a cohort of 1,000 patients. The European Working Party on Systemic Lupus Erythematosus. Medicine (Baltimore) 72(2):113–124CrossRef
25.
Zurück zum Zitat Feng JB, Ni JD, Yao X et al (2010) Gender and age influence on clinical and laboratory features in Chinese patients with systemic lupus erythematosus: 1,790 cases. Rheumatol Int 30(8):1017–1023PubMedCrossRef Feng JB, Ni JD, Yao X et al (2010) Gender and age influence on clinical and laboratory features in Chinese patients with systemic lupus erythematosus: 1,790 cases. Rheumatol Int 30(8):1017–1023PubMedCrossRef
26.
Zurück zum Zitat Silva CA, Avcin T, Brunner HI (2012) Taxonomy for systemic lupus erythematosus with onset before adulthood. Arthritis Care Res (Hoboken) 64(12):1787–1793CrossRef Silva CA, Avcin T, Brunner HI (2012) Taxonomy for systemic lupus erythematosus with onset before adulthood. Arthritis Care Res (Hoboken) 64(12):1787–1793CrossRef
27.
Zurück zum Zitat Wilson WA, Gharavi AE, Koike T et al (1999) International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: report of an international workshop. Arthritis Rheum 42(7):1309–1311PubMedCrossRef Wilson WA, Gharavi AE, Koike T et al (1999) International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: report of an international workshop. Arthritis Rheum 42(7):1309–1311PubMedCrossRef
28.
Zurück zum Zitat Vitali C, Bombardieri S, Jonsson R et al (2002) Classification criteria for Sjogren’s syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 61(6):554–558PubMedPubMedCentralCrossRef Vitali C, Bombardieri S, Jonsson R et al (2002) Classification criteria for Sjogren’s syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 61(6):554–558PubMedPubMedCentralCrossRef
30.
Zurück zum Zitat Miyakis S, Lockshin MD, Atsumi T et al (2006) International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 4(2):295–306PubMedCrossRef Miyakis S, Lockshin MD, Atsumi T et al (2006) International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 4(2):295–306PubMedCrossRef
31.
Zurück zum Zitat Bombardier C, Gladman DD, Urowitz MB et al (1992) Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE. Arthritis Rheum 35(6):630–640PubMedCrossRef Bombardier C, Gladman DD, Urowitz MB et al (1992) Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE. Arthritis Rheum 35(6):630–640PubMedCrossRef
32.
Zurück zum Zitat Gladman D, Ginzler E, Goldsmith C et al (1996) The development and initial validation of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage index for systemic lupus erythematosus. Arthritis Rheum 39(3):363–369PubMedCrossRef Gladman D, Ginzler E, Goldsmith C et al (1996) The development and initial validation of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage index for systemic lupus erythematosus. Arthritis Rheum 39(3):363–369PubMedCrossRef
33.
Zurück zum Zitat Romero-Diaz J, Isenberg D, Ramsey-Goldman R (2011) Measures of adult systemic lupus erythematosus: updated version of British Isles Lupus Assessment Group (BILAG 2004), European Consensus Lupus Activity Measurements (ECLAM), Systemic Lupus Activity Measure, Revised (SLAM-R), Systemic Lupus Activity Questionnaire for Population Studies (SLAQ), Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K), and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI). Arthritis Care Res (Hoboken) 63 Suppl 11:S37–S46CrossRef Romero-Diaz J, Isenberg D, Ramsey-Goldman R (2011) Measures of adult systemic lupus erythematosus: updated version of British Isles Lupus Assessment Group (BILAG 2004), European Consensus Lupus Activity Measurements (ECLAM), Systemic Lupus Activity Measure, Revised (SLAM-R), Systemic Lupus Activity Questionnaire for Population Studies (SLAQ), Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K), and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI). Arthritis Care Res (Hoboken) 63 Suppl 11:S37–S46CrossRef
34.
Zurück zum Zitat Griffiths B, Mosca M, Gordon C (2005) Assessment of patients with systemic lupus erythematosus and the use of lupus disease activity indices. Best Pract Res Clin Rheumatol 19(5):685–708PubMedCrossRef Griffiths B, Mosca M, Gordon C (2005) Assessment of patients with systemic lupus erythematosus and the use of lupus disease activity indices. Best Pract Res Clin Rheumatol 19(5):685–708PubMedCrossRef
35.
Zurück zum Zitat Font J, Cervera R, Navarro M et al (1992) Systemic lupus erythematosus in men: clinical and immunological characteristics. Ann Rheum Dis 51(9):1050–1052PubMedPubMedCentralCrossRef Font J, Cervera R, Navarro M et al (1992) Systemic lupus erythematosus in men: clinical and immunological characteristics. Ann Rheum Dis 51(9):1050–1052PubMedPubMedCentralCrossRef
36.
Zurück zum Zitat Formiga F, Moga I, Pac M et al (1999) Mild presentation of systemic lupus erythematosus in elderly patients assessed by SLEDAI. SLE Disease Activity Index. Lupus 8(6):462–465PubMedCrossRef Formiga F, Moga I, Pac M et al (1999) Mild presentation of systemic lupus erythematosus in elderly patients assessed by SLEDAI. SLE Disease Activity Index. Lupus 8(6):462–465PubMedCrossRef
37.
Zurück zum Zitat Lalani S, Pope J, de Leon F et al (2010) Clinical features and prognosis of late-onset systemic lupus erythematosus: results from the 1000 faces of lupus study. J Rheumatol 37(1):38–44PubMedCrossRef Lalani S, Pope J, de Leon F et al (2010) Clinical features and prognosis of late-onset systemic lupus erythematosus: results from the 1000 faces of lupus study. J Rheumatol 37(1):38–44PubMedCrossRef
38.
Zurück zum Zitat Webb R, Kelly JA, Somers EC et al (2011) Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients. Ann Rheum Dis 70(1):151–156PubMedCrossRef Webb R, Kelly JA, Somers EC et al (2011) Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients. Ann Rheum Dis 70(1):151–156PubMedCrossRef
39.
Zurück zum Zitat Catoggio LJ, Soriano ER, Imamura PM et al (2015) Late-onset systemic lupus erythematosus in Latin Americans: a distinct subgroup? Lupus 24(8):788–795PubMedCrossRef Catoggio LJ, Soriano ER, Imamura PM et al (2015) Late-onset systemic lupus erythematosus in Latin Americans: a distinct subgroup? Lupus 24(8):788–795PubMedCrossRef
40.
Zurück zum Zitat Achour A, Mankai A, Thabet Y et al (2012) Systemic lupus erythematosus in the elderly. Rheumatol Int 32(5):1225–1229PubMedCrossRef Achour A, Mankai A, Thabet Y et al (2012) Systemic lupus erythematosus in the elderly. Rheumatol Int 32(5):1225–1229PubMedCrossRef
41.
Zurück zum Zitat Koh ET, Boey ML (1994) Late onset lupus: a clinical and immunological study in a predominantly Chinese population. J Rheumatol 21(8):1463–1467PubMed Koh ET, Boey ML (1994) Late onset lupus: a clinical and immunological study in a predominantly Chinese population. J Rheumatol 21(8):1463–1467PubMed
42.
Zurück zum Zitat Padovan M, Govoni M, Castellino G et al (2007) Late onset systemic lupus erythematosus: no substantial differences using different cut-off ages. Rheumatol Int 27(8):735–741PubMedCrossRef Padovan M, Govoni M, Castellino G et al (2007) Late onset systemic lupus erythematosus: no substantial differences using different cut-off ages. Rheumatol Int 27(8):735–741PubMedCrossRef
43.
Zurück zum Zitat McMurray RW, May W (2003) Sex hormones and systemic lupus erythematosus: review and meta-analysis. Arthritis Rheum 48(8):2100–2110PubMedCrossRef McMurray RW, May W (2003) Sex hormones and systemic lupus erythematosus: review and meta-analysis. Arthritis Rheum 48(8):2100–2110PubMedCrossRef
44.
Zurück zum Zitat Cartella S, Cavazzana I, Ceribelli A et al (2013) Evaluation of mortality, disease activity, treatment, clinical and immunological features of adult and late onset systemic lupus erythematosus. Autoimmunity 46(6):363–368PubMedCrossRef Cartella S, Cavazzana I, Ceribelli A et al (2013) Evaluation of mortality, disease activity, treatment, clinical and immunological features of adult and late onset systemic lupus erythematosus. Autoimmunity 46(6):363–368PubMedCrossRef
45.
Zurück zum Zitat Costenbader KH, Feskanich D, Stampfer MJ et al (2007) Reproductive and menopausal factors and risk of systemic lupus erythematosus in women. Arthritis Rheum 56(4):1251–1262PubMedCrossRef Costenbader KH, Feskanich D, Stampfer MJ et al (2007) Reproductive and menopausal factors and risk of systemic lupus erythematosus in women. Arthritis Rheum 56(4):1251–1262PubMedCrossRef
46.
Zurück zum Zitat Livingston B, Bonner A, Pope J (2011) Differences in clinical manifestations between childhood-onset lupus and adult-onset lupus: a meta-analysis. Lupus 20(13):1345–1355PubMedCrossRef Livingston B, Bonner A, Pope J (2011) Differences in clinical manifestations between childhood-onset lupus and adult-onset lupus: a meta-analysis. Lupus 20(13):1345–1355PubMedCrossRef
47.
Zurück zum Zitat Gómez LAR, Uribe OU, Uribe OO et al (2008) Childhood systemic lupus erythematosus in Latin America. The GLADEL experience in 230 children. Lupus 17(6):596–604PubMedCrossRef Gómez LAR, Uribe OU, Uribe OO et al (2008) Childhood systemic lupus erythematosus in Latin America. The GLADEL experience in 230 children. Lupus 17(6):596–604PubMedCrossRef
49.
Zurück zum Zitat Hochberg MC, Boyd RE, Ahearn JM et al (1985) Systemic lupus erythematosus: a review of clinico-laboratory features and immunogenetic markers in 150 patients with emphasis on demographic subsets. Medicine (Baltimore) 64(5):285–295CrossRef Hochberg MC, Boyd RE, Ahearn JM et al (1985) Systemic lupus erythematosus: a review of clinico-laboratory features and immunogenetic markers in 150 patients with emphasis on demographic subsets. Medicine (Baltimore) 64(5):285–295CrossRef
50.
Zurück zum Zitat Jonsson H, Nived O, Sturfelt G (1988) The effect of age on clinical and serological manifestations in unselected patients with systemic lupus erythematosus. J Rheumatol 15(3):505–509PubMed Jonsson H, Nived O, Sturfelt G (1988) The effect of age on clinical and serological manifestations in unselected patients with systemic lupus erythematosus. J Rheumatol 15(3):505–509PubMed
51.
Zurück zum Zitat Franceschini F, Cavazzana I (2005) Anti-Ro/SSA and La/SSB antibodies. Autoimmunity 38(1):55–63PubMedCrossRef Franceschini F, Cavazzana I (2005) Anti-Ro/SSA and La/SSB antibodies. Autoimmunity 38(1):55–63PubMedCrossRef
52.
Zurück zum Zitat Catoggio LJ, Skinner RP, Smith G et al (1984) Systemic lupus erythematosus in the elderly: clinical and serological characteristics. J Rheumatol 11(2):175–181PubMed Catoggio LJ, Skinner RP, Smith G et al (1984) Systemic lupus erythematosus in the elderly: clinical and serological characteristics. J Rheumatol 11(2):175–181PubMed
53.
Zurück zum Zitat Mak SK, Lam EK, Wong AK (1998) Clinical profile of patients with late-onset SLE: not a benign subgroup. Lupus 7(1):23–28PubMedCrossRef Mak SK, Lam EK, Wong AK (1998) Clinical profile of patients with late-onset SLE: not a benign subgroup. Lupus 7(1):23–28PubMedCrossRef
54.
Zurück zum Zitat Hashimoto H, Tsuda H, Hirano T et al (1987) Differences in clinical and immunological findings of systemic lupus erythematosus related to age. J Rheumatol 14(3):497–501PubMed Hashimoto H, Tsuda H, Hirano T et al (1987) Differences in clinical and immunological findings of systemic lupus erythematosus related to age. J Rheumatol 14(3):497–501PubMed
55.
Zurück zum Zitat Descloux E, Durieu I, Cochat P et al (2009) Influence of age at disease onset in the outcome of paediatric systemic lupus erythematosus. Rheumatology (Oxford) 48(7):779–784CrossRef Descloux E, Durieu I, Cochat P et al (2009) Influence of age at disease onset in the outcome of paediatric systemic lupus erythematosus. Rheumatology (Oxford) 48(7):779–784CrossRef
56.
Zurück zum Zitat Malattia C, Martini A (2013) Paediatric-onset systemic lupus erythematosus. Best Pract Res Clin Rheumatol 27(3):351–362PubMedCrossRef Malattia C, Martini A (2013) Paediatric-onset systemic lupus erythematosus. Best Pract Res Clin Rheumatol 27(3):351–362PubMedCrossRef
57.
Zurück zum Zitat Livingston B, Bonner A, Pope J (2012) Differences in autoantibody profiles and disease activity and damage scores between childhood- and adult-onset systemic lupus erythematosus: a meta-analysis. Semin Arthritis Rheum 42(3):271–280PubMedCrossRef Livingston B, Bonner A, Pope J (2012) Differences in autoantibody profiles and disease activity and damage scores between childhood- and adult-onset systemic lupus erythematosus: a meta-analysis. Semin Arthritis Rheum 42(3):271–280PubMedCrossRef
58.
Zurück zum Zitat Marks SD, Tullus K (2010) Modern therapeutic strategies for paediatric systemic lupus erythematosus and lupus nephritis. Acta Paediatr 99(7):967–974PubMedCrossRef Marks SD, Tullus K (2010) Modern therapeutic strategies for paediatric systemic lupus erythematosus and lupus nephritis. Acta Paediatr 99(7):967–974PubMedCrossRef
59.
Zurück zum Zitat Ruiz-Irastorza G, Danza A, Khamashta M (2013) Treatment of systemic lupus erythematosus: myths, certainties and doubts. Med Clin (Barc) 141(12):533–542CrossRef Ruiz-Irastorza G, Danza A, Khamashta M (2013) Treatment of systemic lupus erythematosus: myths, certainties and doubts. Med Clin (Barc) 141(12):533–542CrossRef
Metadaten
Titel
Age of onset influences on clinical and laboratory profile of patients with systemic lupus erythematosus
verfasst von
Rafael Hennemann Sassi
Jordana Vaz Hendler
Giovana Fagundes Piccoli
Andrese Aline Gasparin
Rafael Mendonça da Silva Chakr
João Carlos Tavares Brenol
Odirlei André Monticielo
Publikationsdatum
17.11.2016
Verlag
Springer London
Erschienen in
Clinical Rheumatology / Ausgabe 1/2017
Print ISSN: 0770-3198
Elektronische ISSN: 1434-9949
DOI
https://doi.org/10.1007/s10067-016-3478-4

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