nach oben

Erschienen in:

01.01.2015 | Original Article

Age-related differences in the activity of arterial mineral deposition and regional bone metabolism: a ¹⁸F-sodium fluoride positron emission tomography study

verfasst von: T. Derlin, T. Janssen, J. Salamon, S. Veldhoen, J. D. Busch, G. Schön, J. Herrmann, F. O. Henes, P. Bannas, G. Adam

Erschienen in: Osteoporosis International | Ausgabe 1/2015

Einloggen, um Zugang zu erhalten

Abstract

Summary

Functional ¹⁸F-fluoride PET demonstrated an inverse relationship between the activity of arterial mineral deposition and regional bone metabolism. While bone metabolism decreases with age, the activity of arterial mineral deposition increases.

Introduction

The extent of arterial calcification increases with age, whereas bone mineral density decreases, evidencing a well-known inverse correlation on morphological basis. The aim of this study was to evaluate the functional relationship between the activity of arterial mineral deposition and regional bone metabolism as assessed by ¹⁸F-sodium fluoride (NaF) PET/CT.

Methods

Three hundred four subjects were examined by ¹⁸F-NaF PET/CT. Tracer accumulation in the femoral arteries was analyzed both qualitatively and semiquantitatively by measuring the blood-pool-corrected standardized uptake value (target-to-background ratio). Uptake was compared with cardiovascular risk factors (RFs), calcified plaque burden, and regional bone metabolism as assessed by PET/CT.

Results

The activity of arterial mineral deposition significantly increased with age (p < 0.001), whereas regional bone metabolism significantly decreased (p < 0.001). There was a significant inverse correlation between bone metabolism and arterial mineral deposition (unadjusted, p < 0.001); that association was not significant (p = 0.79) when controlled for age and other RFs. Both high activity of arterial mineral deposition and low bone metabolism were significantly associated with cardiovascular events and other RFs.

Conclusion

¹⁸F-NaF PET/CT provides a tool to visualize and quantify the activity of arterial mineral deposition and regional bone metabolism. In this study, we observed an inverse correlation between the activity of arterial mineral deposition and regional bone metabolism. While the activity of arterial mineral deposition significantly increases with age, regional bone metabolism decreases.

Hofbauer LC, Brueck CC, Shanahan CM, Schoppet M, Dobnig H (2007) Vascular calcification and osteoporosis—from clinical observation towards molecular understanding. Osteoporos Int 18:251–259PubMedCrossRef

Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Iida A, Shiraki-Iida T, Nishikawa S, Nagai R, Nabeshima YI (1997) Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390:45–51PubMedCrossRef

Demer LL, Tintut Y (2008) Vascular calcification: pathobiology of a multifaceted disease. Circulation 117:2938–2948PubMedCrossRef

Kiel DP, Kauppila LI, Cupples LA, Hannan MT, O’Donnell CJ, Wilson PW (2001) Bone loss and the progression of abdominal aortic calcification over a 25 year period: the Framingham Heart Study. Calcif Tissue Int 68:271–276PubMedCrossRef

Bagger YZ, Tanko LB, Alexandersen P, Qin G, Christiansen C (2006) Radiographic measure of aorta calcification is a site-specific predictor of bone loss and fracture risk at the hip. J Intern Med 259:598–605PubMedCrossRef

Schulz E, Arfai K, Liu X, Sayre J, Gilsanz V (2004) Aortic calcification and the risk of osteoporosis and fractures. J Clin Endocrinol Metab 89:4246–4253PubMedCrossRef

Doherty TM, Asotra K, Fitzpatrick LA, Qiao JH, Wilkin DJ, Detrano RC, Dunstan CR, Shah PK, Rajavashisth TB (2003) Calcification in atherosclerosis: bone biology and chronic inflammation at the arterial crossroads. Proc Natl Acad Sci U S A 100:11201–11206PubMedCentralPubMedCrossRef

Doherty TM, Fitzpatrick LA, Inoue D, Qiao JH, Fishbein MC, Detrano RC, Shah PK, Rajavashisth TB (2004) Molecular, endocrine, and genetic mechanisms of arterial calcification. Endocr Rev 25:629–672PubMedCrossRef

Schinke T, Karsenty G (2000) Vascular calcification—a passive process in need of inhibitors. Nephrol Dial Transplant 15:1272–1274PubMedCrossRef

10.

Bucay N, Sarosi I, Dunstan CR, Morony S, Tarpley J, Capparelli C, Scully S, Tan HL, Xu W, Lacey DL, Boyle WJ, Simonet WS (1998) Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev 12:1260–1268PubMedCentralPubMedCrossRef

11.

Grant FD, Fahey FH, Packard AB, Davis RT, Alavi A, Treves ST (2008) Skeletal PET with ¹⁸F-fluoride: applying new technology to an old tracer. J Nucl Med 49:68–78PubMedCrossRef

12.

Blau M, Ganatra R, Bender MA (1972) ¹⁸F-fluoride for bone imaging. Semin Nucl Med 2:31–37PubMedCrossRef

13.

Piert M, Zittel TT, Becker GA, Jahn M, Stahlschmidt A, Maier G, Machulla HJ, Bares R (2001) Assessment of porcine bone metabolism by dynamic. J Nucl Med 42:1091–1100PubMed

14.

Frost ML, Fogelman I, Blake GM, Marsden PK, Cook G Jr (2004) Dissociation between global markers of bone formation and direct measurement of spinal bone formation in osteoporosis. J Bone Miner Res 19:1797–1804PubMedCrossRef

15.

Uchida K, Nakajima H, Miyazaki T, Yayama T, Kawahara H, Kobayashi S, Tsuchida T, Okazawa H, Fujibayashi Y, Baba H (2009) Effects of alendronate on bone metabolism in glucocorticoid-induced osteoporosis measured by ¹⁸F-fluoride PET: a prospective study. J Nucl Med 50:1808–1814PubMedCrossRef

16.

Puri T, Frost ML, Curran KM, Siddique M, Moore AE, Cook GJ, Marsden PK, Fogelman I, Blake GM Differences in regional bone metabolism at the spine and hip: a quantitative study using (18)F-fluoride positron emission tomography. Osteoporos Int 24:633–639

17.

Derlin T, Toth Z, Papp L, Wisotzki C, Apostolova I, Habermann CR, Mester J, Klutmann S (2011) Correlation of inflammation assessed by ¹⁸F-FDG PET, active mineral deposition assessed by ¹⁸F-fluoride PET, and vascular calcification in atherosclerotic plaque: a dual-tracer PET/CT study. J Nucl Med 52:1020–1027PubMedCrossRef

18.

Derlin T, Richter U, Bannas P, Begemann P, Buchert R, Mester J, Klutmann S (2010) Feasibility of ¹⁸F-sodium fluoride PET/CT for imaging of atherosclerotic plaque. J Nucl Med 51:862–865PubMedCrossRef

19.

Derlin T, Wisotzki C, Richter U, Apostolova I, Bannas P, Weber C, Mester J, Klutmann S (2011) In vivo imaging of mineral deposition in carotid plaque using ¹⁸F-sodium fluoride PET/CT: correlation with atherogenic risk factors. J Nucl Med 52:362–368PubMedCrossRef

20.

Joshi NV, Vesey AT, Williams MC, Shah AS, Calvert PA, Craighead FH, Yeoh SE, Wallace W, Salter D, Fletcher AM, van Beek EJ, Flapan AD, Uren NG, Behan MW, Cruden NL, Mills NL, Fox KA, Rudd JH, Dweck MR, Newby DE (2014) ¹⁸F-fluoride positron emission tomography for identification of ruptured and high-risk coronary atherosclerotic plaques: a prospective clinical trial. Lancet 383:705–713PubMedCrossRef

21.

Janssen T, Bannas P, Herrmann J, Veldhoen S, Busch JD, Treszl A, Munster S, Mester J, Derlin T (2013) Association of linear (1)(8)F-sodium fluoride accumulation in femoral arteries as a measure of diffuse calcification with cardiovascular risk factors: a PET/CT study. J Nucl Cardiol 20:569–577PubMedCrossRef

22.

Luo G, Ducy P, McKee MD, Pinero GJ, Loyer E, Behringer RR, Karsenty G (1997) Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature 386:78–81PubMedCrossRef

23.

Kurata S, Shizukuishi K, Tateishi U, Yoneyama T, Hino A, Ishibashi M, Inoue T (2012) Age-related changes in pre- and postmenopausal women investigated with ¹⁸F-fluoride PET—a preliminary study. Skelet Radiol 41:947–953CrossRef

24.

Dweck MR, Chow MW, Joshi NV, Williams MC, Jones C, Fletcher AM, Richardson H, White A, McKillop G, van Beek EJ, Boon NA, Rudd JH, Newby DE (2012) Coronary arterial ¹⁸F-sodium fluoride uptake: a novel marker of plaque biology. J Am Coll Cardiol 59:1539–1548PubMedCrossRef

25.

Beheshti M, Saboury B, Mehta NN, Torigian DA, Werner T, Mohler E, Wilensky R, Newberg AB, Basu S, Langsteger W, Alavi A (2011) Detection and global quantification of cardiovascular molecular calcification by fluoro18-fluoride positron emission tomography/computed tomography—a novel concept. Hellén J Nucl Med 14:114–120

26.

Dweck MR, Khaw HJ, Sng GK, Luo EL, Baird A, Williams MC, Makiello P, Mirsadraee S, Joshi NV, van Beek EJ, Boon NA, Rudd JH, Newby DE (2013) Aortic stenosis, atherosclerosis, and skeletal bone: is there a common link with calcification and inflammation? Eur Heart J 34:1567–1574PubMedCrossRef

27.

Bural GG, Torigian DA, Chamroonrat W, Houseni M, Chen W, Basu S, Kumar R, Alavi A (2008) FDG-PET is an effective imaging modality to detect and quantify age-related atherosclerosis in large arteries. Eur J Nucl Med Mol Imaging 35:562–569PubMedCrossRef

28.

Tanko LB, Christiansen C, Cox DA, Geiger MJ, McNabb MA, Cummings SR (2005) Relationship between osteoporosis and cardiovascular disease in postmenopausal women. J Bone Miner Res 20:1912–1920PubMedCrossRef

29.

Schwartz AV, Sellmeyer DE, Strotmeyer ES, Tylavsky FA, Feingold KR, Resnick HE, Shorr RI, Nevitt MC, Black DM, Cauley JA, Cummings SR, Harris TB (2005) Diabetes and bone loss at the hip in older black and white adults. J Bone Miner Res 20:596–603PubMedCrossRef

30.

Yamaguchi T, Sugimoto T, Yano S, Yamauchi M, Sowa H, Chen Q, Chihara K (2002) Plasma lipids and osteoporosis in postmenopausal women. Endocr J 49:211–217PubMedCrossRef

31.

Rajzbaum G, Bezie Y (2006) Postmenopausal osteoporosis and atheroma. Joint Bone Spine 73:661–666PubMedCrossRef

32.

Bagger YZ, Rasmussen HB, Alexandersen P, Werge T, Christiansen C, Tanko LB (2007) Links between cardiovascular disease and osteoporosis in postmenopausal women: serum lipids or atherosclerosis per se? Osteoporos Int 18:505–512PubMedCentralPubMedCrossRef

33.

Laroche M, Pouilles JM, Ribot C, Bendayan P, Bernard J, Boccalon H, Mazieres B (1994) Comparison of the bone mineral content of the lower limbs in men with ischaemic atherosclerotic disease. Clin Rheumatol 13:611–614PubMedCrossRef

34.

Boellaard R (2009) Standards for PET image acquisition and quantitative data analysis. J Nucl Med 50:11S–20SPubMedCrossRef

35.

Blomberg BA, Thomassen A, Takx RA, Vilstrup MH, Hess S, Nielsen AL, Diederichsen AC, Mickley H, Alavi A, Høilund-Carlsen PF (2014) Delayed sodium 18F-fluoride PET/CT imaging does not improve quantification of vascular calcification metabolism: results from the CAMONA study. J Nucl Cardiol 21:293–304PubMedCrossRef

Titel: Age-related differences in the activity of arterial mineral deposition and regional bone metabolism: a 18F-sodium fluoride positron emission tomography study
verfasst von: T. Derlin
T. Janssen
J. Salamon
S. Veldhoen
J. D. Busch
G. Schön
J. Herrmann
F. O. Henes
P. Bannas
G. Adam
Publikationsdatum: 01.01.2015
Verlag: Springer London
Erschienen in: Osteoporosis International / Ausgabe 1/2015
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-014-2839-6

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen.
» Jetzt entdecken

Neu im Fachgebiet Orthopädie und Unfallchirurgie

23.04.2024 | Leitsymptom Rückenschmerzen | Nachrichten

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Age-related differences in the activity of arterial mineral deposition and regional bone metabolism: a ¹⁸F-sodium fluoride positron emission tomography study

Abstract

Summary

Introduction

Methods

Results

Conclusion

Arthropedia

Neu im Fachgebiet Orthopädie und Unfallchirurgie

Ärztliche Empathie hilft gegen Rückenschmerzen

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Vorsicht mit hohen NSAR-Dosen bei ankylosierender Spondylitis!

Brustkrebs in der Vorgeschichte macht Gelenkersatz komplikationsträchtiger

Update Orthopädie und Unfallchirurgie

Springer Medizin

Abstract

Summary

Introduction

Methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2015

Preservation of volumetric bone density and geometry in trans women during cross-sex hormonal therapy: a prospective observational study

Single and combined effect of high-frequency loading and bisphosphonate treatment on the bone micro-architecture of ovariectomized rats

Polymorphisms in genes in the RANKL/RANK/OPG pathway are associated with bone mineral density at different skeletal sites in post-menopausal women

Postpartum osteoporosis and vertebral fractures in two patients treated with enoxaparin during pregnancy

Effects of long-term alendronate treatment on postmenopausal osteoporosis bone material properties

Alendronate-induced unmasking or deterioration of coeliac disease: a case series

Arthropedia

Neu im Fachgebiet Orthopädie und Unfallchirurgie

Ärztliche Empathie hilft gegen Rückenschmerzen

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Vorsicht mit hohen NSAR-Dosen bei ankylosierender Spondylitis!

Brustkrebs in der Vorgeschichte macht Gelenkersatz komplikationsträchtiger

Update Orthopädie und Unfallchirurgie