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Erschienen in:
01.04.2015 | Magnetic Resonance
Age-specific changes in left ventricular diastolic function: A velocity-encoded magnetic resonance imaging study
Erschienen in: European Radiology | Ausgabe 4/2015
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Objectives
Our objectives were to assess the ability of phasecontrast MRI (PC-MRI) to detect sub-clinical age-related variations of left ventricular (LV) diastolic parameters and thus to provide age-related reference ranges currently available for echocardiography but not for MRI-PC, and to identify independent associates of such variations.
Methods
We studied 100 healthy volunteers (age = 42 ± 15years, 50 females) who had MRI with simultaneous blood pressure measurements. LV mass and volumes were assessed. Semiautomated analysis of PC-MRI data provided: 1) early transmitral (Ef) and atrial (Af) peak filling flow-rates (ml/s) and filling volume (FV), 2) deceleration time (DT), isovolumic relaxation time (IVRT), and 3) early myocardial longitudinal (E’) peak velocity.
Results
MRI-PC diastolic parameters were reproducible as reflected by low coefficients of variations (ranged between 0.31 to 6.26 %). Peak myocardial velocity E’ (r = −0.63, p < 0.0001) and flow-rate parameters were strongly and independently associated to age (Ef/Af:r = −0.63, DT:r = 0.46, IVRT:r = 0.44, Ef/FV:r = −0.55, Af/FV:r = 0.56, p < 0.0001). Furthermore, LV relaxation parameters (E’, DT, IVRT), were independently associated to LV remodelling (LV mass/end-diastolic volume) and myocardial wall thickness (p < 0.01).
Conclusions
PC-MRI age-related reference ranges of diastolic parameters are provided. Such parameters might be useful for a fast, reproducible and reliable characterization of diastolic function in patients referred for clinical MRI exam
Key Points
• MRI age-related reference values of left ventricular diastolic parameters are provided.
• MRI diastolic parameters can characterise sub-clinical age-related variations in healthy individuals.
• Diastolic function would complement cardiac MRI exam with currently neglected data.
• Diastolic function would enhance MRI diagnostic value in cardiomyopathy and heartfailure.