Erschienen in:
25.04.2020 | Case Reports
Aggressive Intraosseous Myofibroma of the Maxilla: Report of a Rare Case and Literature Review
verfasst von:
John Lennon Silva Cunha, Carla Isabelly Rodrigues-Fernandes, Ciro Dantas Soares, Celeste Sánchez-Romero, Pablo Agustin Vargas, Cleverson Luciano Trento, Bruno Augusto Benevenuto de Andrade, Sílvia Ferreira de Sousa, Ricardo Luiz Cavalcanti de Albuquerque-Júnior
Erschienen in:
Head and Neck Pathology
|
Ausgabe 1/2021
Einloggen, um Zugang zu erhalten
Abstract
Myofibroma (MF) is a benign mesenchymal myofibroblast-derived tumor, which occurs most frequently in children, and rarely affects the maxilla. We reported a case of an aggressive intraosseous lesion found in the maxilla of a 9-year-old female child. Intraorally, the swelling extended from tooth 12 to 16, causing displacement of teeth 13, 14, and 15. Computed tomography revealed a large osteolytic lesion causing thinning and cortical erosion. Microscopically, the lesion showed a proliferation of spindle-shaped cells, with elongated nuclei and eosinophilic cytoplasm, arranged in interlaced fascicles. The immunohistochemical analysis revealed cytoplasmic positivity for α-SMA and HHF-35, and negativity for desmin, laminin, S-100, β-catenin, and CD34. Ki-67 was positive in 8% of tumor cells. The diagnosis was MF. Herein, we describe an additional case of central MF arising in the maxilla, including clinical, imaging, microscopical, and immunohistochemical features, as well as a review of the literature.