Skip to main content
Erschienen in: Journal of Medical Case Reports 1/2014

Open Access 01.12.2014 | Case report

Aggressive middle turbinate osteoblastoma with intracranial extension: a case report

verfasst von: Draško Cikojević, Zaviša Čolović, Bernarda Lozić, Marisa Klančnik

Erschienen in: Journal of Medical Case Reports | Ausgabe 1/2014

download
DOWNLOAD
print
DRUCKEN
insite
SUCHEN

Abstract

Introduction

Osteoblastoma is an uncommon benign bone tumor that accounts for 1 percent of all primary bone tumors. About 30 to 40 percent of all osteoblastoma cases involve the spine. Osteoblastoma involving the nasal cavity is rare, with only 11 reported cases in the English-language literature, while only four cases of turbinate osteoblastoma have been described.

Case presentation

We report an unusual case of middle turbinate osteoblastoma associated with right-sided nasal obstruction and severe headache in a 14-year-old Caucasian girl. The tumor involved the right middle turbinate, complete anterior and incomplete posterior ethmoidal cells, and the frontal sinus ostium. Cribriform lamina was, in the most part, consumed by the tumor growth, while the skull base was mostly of normal bone structure.

Conclusions

To the best of our knowledge, this is the first case of middle turbinate osteoblastoma with intracranial spread. Surgical treatment is the only therapeutic option for osteoblastoma.
Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1752-1947-8-161) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

DC was the surgeon, participated in the sequence alignment and drafted the manuscript. ZC participated in the sequence alignment. BL participated in the design of the study and performed the statistical analysis. MK conceived of the study, and participated in its design and coordination and helped to draft the manuscript. All authors read and approved the final manuscript.

Introduction

Osteoblastoma is an uncommon benign bone tumor that accounts for 1 percent of all primary bone tumors [1, 2]. The term 'benign osteoblastoma' was independently proposed by Jaffe and Lichtenstein to define a vascular osteoid and bone-forming tumor containing numerous osteoblasts and rich vascularized delicate fibrous stroma with a benign appearance [3, 4].
About 30 to 40 percent of all osteoblastoma cases involve the spine [5, 6]. The most common area of involvement is the cervical spine (20 to 40 percent), followed by the lumbar spine. Approximately 10 to 15 percent arise within the bones of the craniofacial skeleton [7, 8]. The most common location is the mandible, followed by the maxilla. Osteoblastoma involving the nasal cavity is rare, with only 11 reported cases in the English-language literature [9, 10], while only four cases of turbinate osteoblastoma have been described [1113]. Most nasal cavity cases originate from the ethmoid sinus and spread to involve the nasal cavity. Osteoblastomas usually occur in patients aged <30, with a peak incidence in the second decade of life, age range 3 to 78 years. The tumor shows a predilection for male gender (M [male]:F [female], 2.5:1). Most osteoblastomas measure between 2 and 5cm, and are solid and dark red due to rich vascularity. The tumors have poorly defined margins.
Differential diagnosis of osteoblastoma includes osteoma, osteoid osteoma, chronic osteomyelitis (Brodie's abscess) and osteosarcoma. The treatment of osteoblastoma is principally surgical excision. En bloc resection is usually curative, however, curettage results in a local recurrence rate of approximately 20 percent. Malignant transformation of osteoblastoma to osteosarcoma is exceptionally rare (<1 percent).We report an unusual case of middle turbinate osteoblastoma associated with a right-sided nasal obstruction and severe headache in a 14-year-old Caucasian girl (Figure 1). To the best of our knowledge, this is the first case of middle turbinate osteoblastoma with intracranial spread.

Case presentation

A 14-year-old Caucasian girl presented with a right-sided nasal obstruction and severe headache, which was most pronounced in the right forehead region. Our patient reported a headache persisting for three years, however, in the past three months, its intensity prevented her from attending school. In addition to difficult breathing on the right turbinate, she reported anosmia and occasional epistaxis on the same nostril. On several occasions, our patient was seen by a pediatrician, who considered her headaches to be related to puberty. When her headache turned so severe to prevent her attending school, a magnetic resonance imaging (MRI) scan of her brain was recommended to reveal a tumor of the right middle turbinate. A multislice computed tomography (MSCT) scan of her paranasal sinuses, taken for better visualization of the bone structure, showed a clearly delineated, heterogeneous (hyperechoic) tumor growth, which corresponded to the finding of a bone tumor with a inhomogeneous central portion and marginal mineralization (Figures 2 and 3). The tumor involved the right middle turbinate, complete anterior and incomplete posterior ethmoidal cells, and the frontal sinus ostium. Cribriform lamina was, in the most part, consumed by the tumor growth, while the skull base was mostly of normal bone structure. Lamina papyracea was free and clearly demarcated from the tumor. There was septum shift to the left, without septum perforation. The tumor was removed in toto by endoscopic technique (Figure 4) and pathohistological analysis showed the osteoblastoma (Figure 5). As it was a bone tumor, it could not be excised en bloc, instead, the tumor was first cut by a bur in the region of the middle turbinate base, then the rest of the tumor was removed by diamond bur abrasion of the bone with removal of the most part of the cribriform lamina. On endoscopy, there was a clear margin between the healthy bone, which was white and compact, and osteoblastoma, which was of a honeycomb structure, reddish and more vascularized. Postoperatively, our patient denied headache, breathed normally through her nose and attended school regularly. But the six-month follow-up computed tomography (CT) scan showed a recurrence and we had to do an en bloc resection of the tumor. The CT scan one year later showed normal findings without recurrence and our patient did not have her headache any more (Figures 6, 7 and 8).

Discussion

Osteoblastoma is a rare bone tumor and accounts for approximately 1 percent of all primary bone tumors. On differential diagnosis, it is important to differentiate osteoblastoma from osteoma, osteoid osteoma and osteosarcoma.
Osteomas are benign, slow-growing tumors that rarely occur in children. They usually arise on the surface of the cranial vault, jaw, paranasal sinuses and orbit [14]. Osteomas are often asymptomatic and are frequently an incidental finding. They are round, oval, white, well circumscribed and attached to the underlying bone by a broad base, or occasionally by a small stalk. On bisection, they are dense or sclerotic, with narrow (compact type) or prominent (spongiotic) intertrabecular spaces. Recurrences are very rare, even in incompletely excised lesions. Malignant transformation has not been reported.
Osteoid osteoma is 1 to 2cm in diameter, and morphologically similar lesions larger than 2cm are classified as osteoblastomas [1, 5]. It accounts for approximately 12 percent of benign bone tumors and, similar to osteoblastoma, it predominantly affects children and young adults, particularly female. Clinically, osteoid osteoma most commonly occurs in the long bones (for example, femur, tibia). The lesions cause night pain that is relieved with nonsteroidal anti-inflammatory drugs (NSAIDs). On radiography, osteoid osteomas exhibit a central lucency (the nidus) with patchy mineralization located centrally. Osteoid osteoma may be managed nonsurgically with NSAIDs.
Osteosarcoma is the most common primary malignant tumor of bone. In the craniofacial region, osteosarcoma mostly affects jaw bones, with approximately 6 percent of all [15]. The majority of patients are older than 30 years of age. On radiography, osteosarcoma shows a poorly defined destructive lesion that can be sclerotic, lytic or mixed.
Osteoblastoma occurs predominantly in young adults. It develops most frequently in the posterior element of the vertebrae and in long bone metaphyses. Patients present with a painful mass and craniofacial tumors may produce headache, tooth impaction and epistaxis. The pain does not get worse at night and is less likely to be relieved with NSAIDs. Most osteoblastomas measure between 2 and 5cm and are solid, dark red, due to the rich vascularity, tan-white and gritty. Some tumors have more poorly defined margins. On radiography, osteoblastomas arise in the medullary cavity or on the surface of the bone. The intralesional mineralization is very variable and may be minimal or extensive, but is greatest centrally. The intertrabecular space is filled with richly vascular loose connective tissue. The treatment of osteoblastoma is principally surgical excision. En bloc resection is usually curative, however, curettage results in a local recurrence rate of approximately 20 percent. Malignant transformation of osteoblastoma to osteosarcoma is exceptionally rare (<1 percent).
Reliable preoperative diagnosis is of utmost importance, which is rather difficult in bone tumors because cytologic biopsy is impossible due to the hard tumor structure. Biopsy can be done in osteoblastoma, however, hemorrhage may occur because of rich tumor vascularization. It is crucial to differentiate osteoid osteoma from osteoblastoma because the former can be managed by medicamentous therapy (NSAIDs), whereas surgical treatment is the only therapeutic option for osteoblastoma.

Conclusions

To the best of our knowledge, this is the first case of middle turbinate osteoblastoma with intracranial spread. Surgical treatment is the only therapeutic option for osteoblastoma.
Written informed consent was obtained from the patient’s parents for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://​creativecommons.​org/​licenses/​by/​2.​0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://​creativecommons.​org/​publicdomain/​zero/​1.​0/​) applies to the data made available in this article, unless otherwise stated.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

DC was the surgeon, participated in the sequence alignment and drafted the manuscript. ZC participated in the sequence alignment. BL participated in the design of the study and performed the statistical analysis. MK conceived of the study, and participated in its design and coordination and helped to draft the manuscript. All authors read and approved the final manuscript.

Unsere Produktempfehlungen

e.Med Interdisziplinär

Kombi-Abonnement

Für Ihren Erfolg in Klinik und Praxis - Die beste Hilfe in Ihrem Arbeitsalltag

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de.

© Springer Medizin

Bis 11. April 2024 bestellen und im ersten Jahr 50 % sparen!

e.Med Allgemeinmedizin

Kombi-Abonnement

Mit e.Med Allgemeinmedizin erhalten Sie Zugang zu allen CME-Fortbildungen und Premium-Inhalten der allgemeinmedizinischen Zeitschriften, inklusive einer gedruckten Allgemeinmedizin-Zeitschrift Ihrer Wahl.

© Springer Medizin

Bis 11. April 2024 bestellen und im ersten Jahr 50 % sparen!

Literatur
1.
Zurück zum Zitat Atesok KI, Alman BA, Schemitsch EH, Peyser A, Mankin H: Osteoid osteoma and osteoblastoma. J Am Acad Orthop Surg. 2011, 19: 678-689.CrossRefPubMed Atesok KI, Alman BA, Schemitsch EH, Peyser A, Mankin H: Osteoid osteoma and osteoblastoma. J Am Acad Orthop Surg. 2011, 19: 678-689.CrossRefPubMed
4.
Zurück zum Zitat Jaffe HL: Benign osteoblastoma. Bull Hosp J Orthop Inst. 1956, 17: 141-151. Jaffe HL: Benign osteoblastoma. Bull Hosp J Orthop Inst. 1956, 17: 141-151.
5.
Zurück zum Zitat Janin Y, Epstein JA, Carras R, Khan A: Osteoid osteomas and osteoblastoma of the spine. Neurosurgery. 1981, 8: 31-38.CrossRefPubMed Janin Y, Epstein JA, Carras R, Khan A: Osteoid osteomas and osteoblastoma of the spine. Neurosurgery. 1981, 8: 31-38.CrossRefPubMed
6.
Zurück zum Zitat Myles ST, MacRae ME: Benign osteoblastoma of the spine in childhood. J Neurosurg. 1988, 68: 884-888.CrossRefPubMed Myles ST, MacRae ME: Benign osteoblastoma of the spine in childhood. J Neurosurg. 1988, 68: 884-888.CrossRefPubMed
8.
Zurück zum Zitat Yong GL, Chang WC: Benign osteoblastoma located in the parietal bone. J Korean Neurosurg Soc. 2010, 48: 170-172.CrossRef Yong GL, Chang WC: Benign osteoblastoma located in the parietal bone. J Korean Neurosurg Soc. 2010, 48: 170-172.CrossRef
9.
Zurück zum Zitat Young E, Dabrowski M, Brelsford K: Osteoblastoma of the nasal septum. J Laryngol Otol. 2011, 125: 1062-1066.CrossRefPubMed Young E, Dabrowski M, Brelsford K: Osteoblastoma of the nasal septum. J Laryngol Otol. 2011, 125: 1062-1066.CrossRefPubMed
10.
Zurück zum Zitat Jeong YJ, Sohn MH, Lim ST, Kim DW, Jeong HJ, Jang KY, Yim CY: Osteoblastoma in the nasal cavity: F-18 FDG PET/CT and Tc-99 m MDP 3-phase bone scan findings with pathologic correlation. Clin Nucl Med. 2011, 36: 214-217.CrossRefPubMed Jeong YJ, Sohn MH, Lim ST, Kim DW, Jeong HJ, Jang KY, Yim CY: Osteoblastoma in the nasal cavity: F-18 FDG PET/CT and Tc-99 m MDP 3-phase bone scan findings with pathologic correlation. Clin Nucl Med. 2011, 36: 214-217.CrossRefPubMed
11.
Zurück zum Zitat Ducastelle T, Dehesdin D, Hemet J, Andrieu-Guitrancourt J: Benign subperiostealosteoblastoma of the nasal cavity, histological and ultrastructural study of a case. Ann Pathol. 1985, 5: 131-136.PubMed Ducastelle T, Dehesdin D, Hemet J, Andrieu-Guitrancourt J: Benign subperiostealosteoblastoma of the nasal cavity, histological and ultrastructural study of a case. Ann Pathol. 1985, 5: 131-136.PubMed
12.
Zurück zum Zitat Chang YK, Chen PR, Su B, Lee CL: Osteoblastoma of the inferior turbinate. Otolaryngol Head Neck Surg. 2011, 145: 517-518.CrossRefPubMed Chang YK, Chen PR, Su B, Lee CL: Osteoblastoma of the inferior turbinate. Otolaryngol Head Neck Surg. 2011, 145: 517-518.CrossRefPubMed
15.
Zurück zum Zitat Klein MJ, Siegal GP: Osteosarcoma: anatomic and histologic variants. Am J Clin Pathol. 2006, 125: 555-581.CrossRefPubMed Klein MJ, Siegal GP: Osteosarcoma: anatomic and histologic variants. Am J Clin Pathol. 2006, 125: 555-581.CrossRefPubMed
Metadaten
Titel
Aggressive middle turbinate osteoblastoma with intracranial extension: a case report
verfasst von
Draško Cikojević
Zaviša Čolović
Bernarda Lozić
Marisa Klančnik
Publikationsdatum
01.12.2014
Verlag
BioMed Central
Erschienen in
Journal of Medical Case Reports / Ausgabe 1/2014
Elektronische ISSN: 1752-1947
DOI
https://doi.org/10.1186/1752-1947-8-161

Weitere Artikel der Ausgabe 1/2014

Journal of Medical Case Reports 1/2014 Zur Ausgabe