nach oben

Erschienen in:

04.01.2024 | Note

Akebia saponin D attenuates allergic airway inflammation through AMPK activation

verfasst von: Lingling Xuan, Song Yang, Lulu Ren, He Liu, Wen Zhang, Yuan Sun, Benshan Xu, Lili Gong, Lihong Liu

Erschienen in: Journal of Natural Medicines | Ausgabe 2/2024

Einloggen, um Zugang zu erhalten

Abstract

Akebia saponin D (ASD) is a bioactive triterpenoid saponin extracted from Dipsacus asper Wall. ex DC.. This study aimed to investigate the effects of ASD on allergic airway inflammation. Human lung epithelial BEAS-2B cells and bone marrow-derived mast cells (BMMCs) were pretreated with ASD (50, 100 and 200 μΜ) and AMPK activator 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) (1 mM), and then stimulated with lipopolysaccharide (LPS) or IL-33. Pretreatment with ASD and AICAR significantly inhibited TNF-α and IL-6 production from BEAS-2B cells, and IL-13 production from BMMCs. Moreover, pretreatment with ASD and AICAR significantly increased p-AMPK expression in BEAS-2B cells. Inhibition of AMPK by siRNA and compound C partly abrogated the suppression effect of ASD on TNF-α, IL-6, and IL-13 production. Asthma murine model was induced by ovalbumin (OVA) challenge and treated with ASD (150 and 300 mg/kg) or AICAR (100 mg/kg). Infiltration of eosinophils, neutrophils, monocytes, and lymphocytes, and production of TNF-α, IL-6, IL-4, and IL-13 were attenuated in ASD and AICAR treated mice. Lung histopathological changes were also ameliorated after ASD and AICAR treatment. Additionally, it showed that treatment with ASD and AICAR increased p-AMPK expression in the lung tissues. In conclusion, ASD exhibited protective effects on allergic airway inflammation through the induction of AMPK activation.

Nur mit Berechtigung zugänglich

GBD Chronic Respiratory Disease Collaborators (2020) Prevalence and attributable health burden of chronic respiratory diseases, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Respir Med 8(6):585–596. https://doi.org/10.1016/S2213-2600(20)30105-3CrossRef

Kardas G, Kuna P, Panek M (2020) Biological therapies of severe asthma and their possible effects on airway remodeling. Front Immunol 11:1134. https://doi.org/10.3389/fimmu.2020.01134CrossRefPubMedPubMedCentral

Palumbo ML, Prochnik A, Wald MR, Genaro AM (2020) Chronic stress and glucocorticoid receptor resistance in asthma. Clin Ther 42(6):993–1006. https://doi.org/10.1016/j.clinthera.2020.03.002CrossRefPubMed

Volmer T, Effenberger T, Trautner C, Buhl R (2018) Consequences of long-term oral corticosteroid therapy and its side-effects in severe asthma in adults: a focused review of the impact data in the literature. Eur Respir J 52(4):1800703. https://doi.org/10.1183/13993003.00703-2018CrossRefPubMed

He Y, Shi J, Nguyen QT, You E, Liu H, Ren X, Wu Z, Li J, Qiu W, Khoo SK, Yang T, Yi W, Sun F, Xi Z, Huang X, Melcher K, Min B, Xu HE (2019) Development of highly potent glucocorticoids for steroid-resistant severe asthma. Proc Natl Acad Sci U S A 116(14):6932–6937. https://doi.org/10.1073/pnas.1816734116ADSCrossRefPubMedPubMedCentral

Heidary Moghaddam R, Samimi Z, Asgary S, Mohammadi P, Hozeifi S, Hoseinzadeh-Chahkandak F, Xu S, Farzaei MH (2022) Natural AMPK activators in cardiovascular disease prevention. Front Pharmacol 12:738420. https://doi.org/10.3389/fphar.2021.738420CrossRefPubMedPubMedCentral

Entezari M, Hashemi D, Taheriazam A, Zabolian A, Mohammadi S, Fakhri F, Hashemi M, Hushmandi K, Ashrafizadeh M, Zarrabi A, Ertas YN, Mirzaei S, Samarghandian S (2022) AMPK signaling in diabetes mellitus, insulin resistance and diabetic complications: a pre-clinical and clinical investigation. Biomed Pharmacother 146:112563. https://doi.org/10.1016/j.biopha.2021.112563CrossRefPubMed

Zhu Y, Wang C, Luo J, Hua S, Li D, Peng L, Liu H, Song L (2021) The protective role of Zingerone in a murine asthma model via activation of the AMPK/Nrf2/HO-1 pathway. Food Funct 12(7):3120–3131. https://doi.org/10.1039/d0fo01583kCrossRefPubMed

Jiang QX, Chen YM, Ma JJ, Wang YP, Li P, Wen XD, Yang J (2022) Effective fraction from Simiao Wan prevents hepatic insulin resistant by inhibition of lipolysis via AMPK activation. Chin J Nat Med 20(3):161–176. https://doi.org/10.1016/S1875-5364(21)60115-2CrossRefPubMed

10.

Wu W, Wang S, Liu Q, Wang X, Shan T, Wang Y (2018) Cathelicidin-WA attenuates LPS-induced inflammation and redox imbalance through activation of AMPK signaling. Free Radic Biol Med 129:338–353. https://doi.org/10.1016/j.freeradbiomed.2018.09.045CrossRefPubMed

11.

Zheng C, Lin JF, Lin ZH, Lin WQ, Thapa S, Lin YZ, Lian H, Liu ZR, Chen JH, Li XW (2018) Sodium houttuyfonate alleviates post-infarct remodeling in rats via AMP-activated protein kinase pathway. Front Pharmacol 9:1092. https://doi.org/10.3389/fphar.2018.01092CrossRefPubMedPubMedCentral

12.

Park CS, Bang BR, Kwon HS, Moon KA, Kim TB, Lee KY, Moon HB, Cho YS (2012) Metformin reduces airway inflammation and remodeling via activation of AMP-activated protein kinase. Biochem Pharmacol 84(12):1660–1670. https://doi.org/10.1016/j.bcp.2012.09.025CrossRefPubMed

13.

Park SJ, Lee KS, Kim SR, Chae HJ, Yoo WH, Kim DI, Jeon MS, Lee YC (2012) AMPK activation reduces vascular permeability and airway inflammation by regulating HIF/VEGFA pathway in a murine model of toluene diisocyanate-induced asthma. Inflamm Res 61(10):1069–1083. https://doi.org/10.1007/s00011-012-0499-6CrossRefPubMed

14.

Lv Y, Wu H, Hong Z, Wei F, Zhao M, Tang R, Li Y, Ge W, Li C, Du W (2023) Exploring active ingredients of anti-osteoarthritis in raw and wine-processed Dipsaci Radix based on spectrum-effect relationship combined with chemometrics. J Ethnopharmacol 309:116281. https://doi.org/10.1016/j.jep.2023.116281CrossRefPubMed

15.

Park JY, Park SD, Koh YJ, Kim DI, Lee JH (2019) Aqueous extract of Dipsacus asperoides suppresses lipopolysaccharide-stimulated inflammatory responses by inhibiting the ERK1/2 signaling pathway in RAW 264.7 macrophages. J Ethnopharmacol 231:253–261. https://doi.org/10.1016/j.jep.2018.11.010CrossRefPubMed

16.

Du W, Lv Y, Wu H, Li Y, Tang R, Zhao M, Wei F, Li C, Ge W (2023) Research on the effect of Dipsaci Radix before and after salt-processed on kidney yang deficiency syndrome rats and the preliminary mechanism study through the BMP-Smad signaling pathway. J Ethnopharmacol 312:116480. https://doi.org/10.1016/j.jep.2023.116480CrossRefPubMed

17.

Tian S, Zou Y, Wang J, Li Y, An BZ, Liu YQ (2022) Protective effect of Du-Zhong-Wan against osteoporotic fracture by targeting the osteoblastogenesis and angiogenesis couple factor SLIT3. J Ethnopharmacol 295:115399. https://doi.org/10.1016/j.jep.2022.115399CrossRefPubMed

18.

Gong LL, Yang S, Zhang W, Han FF, Lv YL, Wan ZR, Liu H, Jia YJ, Xuan LL, Liu LH (2018) Akebia saponin D alleviates hepatic steatosis through BNip3 induced mitophagy. J Pharmacol Sci 136(4):189–195. https://doi.org/10.1016/j.jphs.2017.11.007CrossRefPubMed

19.

Niu Y, Li Y, Huang H, Kong X, Zhang R, Liu L, Sun Y, Wang T, Mei Q (2011) Asperosaponin VI, a saponin component from Dipsacus asper wall, induces osteoblast differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway. Phytother Res 25(11):1700–1706. https://doi.org/10.1002/ptr.3414CrossRefPubMed

20.

Zhang J, Yi S, Li Y, Xiao C, Liu C, Jiang W, Yang C, Zhou T (2020) The antidepressant effects of asperosaponin VI are mediated by the suppression of microglial activation and reduction of TLR4/NF-κB-induced IDO expression. Psychopharmacology 237(8):2531–2545. https://doi.org/10.1007/s00213-020-05553-5CrossRefPubMed

21.

Zhou P, Yang X, Yang Z, Huang W, Kou J, Li F (2019) Akebia saponin D Regulates the metabolome and intestinal microbiota in high fat diet-induced hyperlipidemic rats. Molecules 24(7):1268. https://doi.org/10.3390/molecules24071268CrossRefPubMedPubMedCentral

22.

Wang Y, Shen J, Yang X, Jin Y, Yang Z, Wang R, Zhang F, Linhardt RJ (2018) Akebia saponin D reverses corticosterone hypersecretion in an Alzheimer’s disease rat model. Biomed Pharmacother 107:219–225. https://doi.org/10.1016/j.biopha.2018.07.149CrossRefPubMed

23.

Gong LL, Yang S, Liu H, Zhang W, Ren LL, Han FF, Lv YL, Wan ZR, Liu LH (2019) Anti-nociceptive and anti-inflammatory potentials of Akebia saponin D. Eur J Pharmacol 845:85–90. https://doi.org/10.1016/j.ejphar.2018.11.038CrossRefPubMed

24.

Yang S, Zhang W, Xuan LL, Han FF, Lv YL, Wan ZR, Liu H, Ren LL, Gong LL, Liu LH (2019) Akebia Saponin D inhibits the formation of atherosclerosis in ApoE^-/- mice by attenuating oxidative stress-induced apoptosis in endothelial cells. Atherosclerosis 285:23–30. https://doi.org/10.1016/j.atherosclerosis.2019.04.202CrossRefPubMed

25.

Cho JH, Lee JY, Sim SS, Whang WK, Kim CJ (2010) Inhibitory effects of diterpene acids from root of Aralia cordata on IgE-mediated asthma in guinea pigs. Pulm Pharmacol Ther 23(3):190–199. https://doi.org/10.1016/j.pupt.2009.12.004CrossRefPubMed

26.

Lan YY, Lei N, Zhang XF, Yang RT, Li C, Liu LH (2011) Hypolipidemic function with liver protection of extracts from Dipsacus asper on nonalcoholic fatty liver disease in mice and its activie fractions. Chin Tradit Herbal Drugs 42:2497–2501

27.

Tsvilovskyy V, Solis-Lopez A, Almering J, Richter C, Birnbaumer L, Dietrich A, Freichel M (2020) Analysis of Mrgprb2 receptor-evoked Ca²⁺ signaling in bone marrow derived (BMMC) and peritoneal (PMC) mast cells of TRPC-deficient mice. Front Immunol 11:564. https://doi.org/10.3389/fimmu.2020.00564CrossRefPubMedPubMedCentral

28.

Yang S, Hu T, Liu H, Lv YL, Zhang W, Li H, Xuan LL, Gong LL, Liu LH (2021) Akebia saponin D ameliorates metabolic syndrome (MetS) via remodeling gut microbiota and attenuating intestinal barrier injury. Biomed Pharmacother 138:111441. https://doi.org/10.1016/j.biopha.2021.111441CrossRefPubMed

29.

Xuan LL, Du P, Gong LL, Liu LH (2021) Protective effects of Akebia saponin D on ceramide-induced lung injury. Chin J Clin Pharmacol 37:1363–1366

30.

Gu M, Jin J, Ren C, Chen X, Gao W, Wang X, Wu Y, Tian N, Pan Z, Wu A, Zhou Y, Zhang X (2020) Akebia saponin D suppresses inflammation in chondrocytes via the NRF2/HO-1/NF-κB axis and ameliorates osteoarthritis in mice. Food Funct 11(12):10852–10863. https://doi.org/10.1039/d0fo01909gCrossRefPubMed

31.

Lu C, Fan G, Wang D (2020) Akebia saponin D ameliorated kidney injury and exerted anti-inflammatory and anti-apoptotic effects in diabetic nephropathy by activation of NRF2/HO-1 and inhibition of NF-KB pathway. Int Immunopharmacol 84:106467. https://doi.org/10.1016/j.intimp.2020.106467CrossRefPubMed

32.

Yu X, Wang LN, Du QM, Ma L, Chen L, You R, Liu L, Ling JJ, Yang ZL, Ji H (2012) Akebia saponin D attenuates amyloid β-induced cognitive deficits and inflammatory response in rats: involvement of Akt/NF-κB pathway. Behav Brain Res 235(2):200–209. https://doi.org/10.1016/j.bbr.2012.07.045CrossRefPubMed

33.

Lambrecht BN, Hammad H (2012) The airway epithelium in asthma. Nat Med 18(5):684–692. https://doi.org/10.1038/nm.2737CrossRefPubMed

34.

Heijink IH, Kuchibhotla VNS, Roffel MP, Maes T, Knight DA, Sayers I, Nawijn MC (2020) Epithelial cell dysfunction, a major driver of asthma development. Allergy 75(8):1902–1917. https://doi.org/10.1111/all.14421CrossRefPubMed

35.

Michaeloudes C, Abubakar-Waziri H, Lakhdar R, Raby K, Dixey P, Adcock IM, Mumby S, Bhavsar PK, Chung KF (2022) Molecular mechanisms of oxidative stress in asthma. Mol Aspects Med 85:101026. https://doi.org/10.1016/j.mam.2021.101026CrossRefPubMed

36.

Lambrecht BN, Hammad H (2009) Biology of lung dendritic cells at the origin of asthma. Immunity 31(3):412–424. https://doi.org/10.1016/j.immuni.2009.08.008CrossRefPubMed

37.

Gon Y, Hashimoto S (2018) Role of airway epithelial barrier dysfunction in pathogenesis of asthma. Allergol Int 67(1):12–17. https://doi.org/10.1016/j.alit.2017.08.011CrossRefPubMed

38.

Roan F, Obata-Ninomiya K, Ziegler SF (2019) Epithelial cell-derived cytokines: more than just signaling the alarm. J Clin Invest 129(4):1441–1451. https://doi.org/10.1172/JCI124606CrossRefPubMedPubMedCentral

39.

Kim HY, DeKruyff RH, Umetsu DT (2010) The many paths to asthma: phenotype shaped by innate and adaptive immunity. Nat Immunol 11(7):577–584. https://doi.org/10.1038/ni.1892CrossRefPubMedPubMedCentral

40.

Kuruvilla ME, Lee FE, Lee GB (2019) Understanding asthma phenotypes, endotypes, and mechanisms of disease. Clin Rev Allergy Immunol 56(2):219–233. https://doi.org/10.1007/s12016-018-8712-1CrossRefPubMedPubMedCentral

41.

Pan T, Chang Y, He M, He Z, Jiang J, Ren X, Zhang F (2022) Beta-hydroxyisovalerylshikonin regulates macrophage polarization via the AMPK/Nrf2 pathway and ameliorates sepsis in mice. Pharm Biol 60(1):729–742. https://doi.org/10.1080/13880209.2022.2046111CrossRefPubMedPubMedCentral

42.

He Y, Xu K, Wang Y, Chao X, Xu B, Wu J, Shen J, Ren W, Hu Y (2019) AMPK as a potential pharmacological target for alleviating LPS-induced acute lung injury partly via NLRC4 inflammasome pathway inhibition. Exp Gerontol 125:110661. https://doi.org/10.1016/j.exger.2019.110661CrossRefPubMed

43.

Nassif RM, Chalhoub E, Chedid P, Hurtado-Nedelec M, Raya E, Dang PM, Marie JC, El-Benna J (2022) Metformin inhibits ROS production by human M2 macrophages via the activation of AMPK. Biomedicines 10(2):319. https://doi.org/10.3390/biomedicines10020319CrossRefPubMedPubMedCentral

44.

Rabinovitch RC, Samborska B, Faubert B, Ma EH, Gravel SP, Andrzejewski S, Raissi TC, Pause A, St-Pierre J, Jones RG (2017) AMPK maintains cellular metabolic homeostasis through regulation of mitochondrial reactive oxygen species. Cell Rep 21(1):1–9. https://doi.org/10.1016/j.celrep.2017.09.026CrossRefPubMed

45.

Salminen A, Kaarniranta K (2012) AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network. Ageing Res Rev 11(2):230–241. https://doi.org/10.1016/j.arr.2011.12.005CrossRefPubMed

46.

Liu JQ, Zhang L, Yao J, Yao S, Yuan T (2018) AMPK alleviates endoplasmic reticulum stress by inducing the ER-chaperone ORP150 via FOXO1 to protect human bronchial cells from apoptosis. Biochem Biophys Res Commun 497(2):564–570. https://doi.org/10.1016/j.bbrc.2018.02.095CrossRefPubMed

47.

Mansour HH, Omran MM, Hasan HF, El Kiki SM (2020) Modulation of bleomycin-induced oxidative stress and pulmonary fibrosis by N-acetylcysteine in rats via AMPK/SIRT1/NF-κβ. Clin Exp Pharmacol Physiol 47(12):1943–1952. https://doi.org/10.1111/1440-1681.13378CrossRefPubMed

48.

Zhu L, Chen X, Chong L, Kong L, Wen S, Zhang H, Zhang W, Li C (2019) Adiponectin alleviates exacerbation of airway inflammation and oxidative stress in obesity-related asthma mice partly through AMPK signaling pathway. Int Immunopharmacol 67:396–407. https://doi.org/10.1016/j.intimp.2018.12.030CrossRefPubMed

Titel: Akebia saponin D attenuates allergic airway inflammation through AMPK activation
verfasst von: Lingling Xuan
Song Yang
Lulu Ren
He Liu
Wen Zhang
Yuan Sun
Benshan Xu
Lili Gong
Lihong Liu
Publikationsdatum: 04.01.2024
Verlag: Springer Nature Singapore
Erschienen in: Journal of Natural Medicines / Ausgabe 2/2024
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-023-01762-2

Dihydroartemisinin abolishes cisplatin-induced nephrotoxicity in vivo

Note

Kaempferol-3-O-(2″-O-galloyl-β-d-glucopyranoside): a novel neuroprotective agent from Diospryros kaki against cerebral ischemia—induced brain injury

Original Paper

Phytohemagglutinin from Phaseolus vulgaris enhances the lung cancer cell chemotherapy sensitivity by changing cell membrane permeability

Original Paper

Linderapyrone analogue LPD-01 as a cancer treatment agent by targeting importin7

Original Paper

Upregulation of tumor suppressor PIAS3 by Honokiol promotes tumor cell apoptosis via selective inhibition of STAT3 tyrosine 705 phosphorylation

Original Paper

Improved quantitative analysis of tenuifolin using hydrolytic continuous-flow system to build prediction models for its content based on near-infrared spectroscopy

Original Paper

Springer Medizin

Akebia saponin D attenuates allergic airway inflammation through AMPK activation

Abstract

Weitere Artikel der Ausgabe 2/2024

Dihydroartemisinin abolishes cisplatin-induced nephrotoxicity in vivo

Kaempferol-3-O-(2″-O-galloyl-β-d-glucopyranoside): a novel neuroprotective agent from Diospryros kaki against cerebral ischemia—induced brain injury

Phytohemagglutinin from Phaseolus vulgaris enhances the lung cancer cell chemotherapy sensitivity by changing cell membrane permeability

Linderapyrone analogue LPD-01 as a cancer treatment agent by targeting importin7

Upregulation of tumor suppressor PIAS3 by Honokiol promotes tumor cell apoptosis via selective inhibition of STAT3 tyrosine 705 phosphorylation

Improved quantitative analysis of tenuifolin using hydrolytic continuous-flow system to build prediction models for its content based on near-infrared spectroscopy

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Dihydroartemisinin abolishes cisplatin-induced nephrotoxicity in vivo

Kaempferol-3-O-(2″-O-galloyl-β-d-glucopyranoside): a novel neuroprotective agent from Diospryros kaki against cerebral ischemia—induced brain injury

Phytohemagglutinin from Phaseolus vulgaris enhances the lung cancer cell chemotherapy sensitivity by changing cell membrane permeability

Linderapyrone analogue LPD-01 as a cancer treatment agent by targeting importin7

Upregulation of tumor suppressor PIAS3 by Honokiol promotes tumor cell apoptosis via selective inhibition of STAT3 tyrosine 705 phosphorylation

Improved quantitative analysis of tenuifolin using hydrolytic continuous-flow system to build prediction models for its content based on near-infrared spectroscopy