Erschienen in:
22.12.2016 | Brief Report
AKT capture by feline leukemia virus
verfasst von:
Maki Kawamura, Daigo Umehara, Yuka Odahara, Ariko Miyake, Minh Ha Ngo, Yoshiharu Ohsato, Masaharu Hisasue, Masa-aki Nakaya, Shinya Watanabe, Kazuo Nishigaki
Erschienen in:
Archives of Virology
|
Ausgabe 4/2017
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Abstract
Oncogene-containing retroviruses are generated by recombination events between viral and cellular sequences, a phenomenon called “oncogene capture”. The captured cellular genes, referred to as “v-onc” genes, then acquire new oncogenic properties. We report a novel feline leukemia virus (FeLV), designated “FeLV–AKT”, that has captured feline c-AKT1 in feline lymphoma. FeLV–AKT contains a gag–AKT fusion gene that encodes the myristoylated Gag matrix protein and the kinase domain of feline c-AKT1, but not its pleckstrin homology domain. Therefore, it differs structurally from the v-Akt gene of murine retrovirus AKT8. AKT may be involved in the mechanisms underlying malignant diseases in cats.