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Erschienen in: Im Fokus Onkologie 12/2012

03.01.2013 | Zertifizierte Fortbildung

Aktuelle Empfehlungen zur medikamentösen Therapie

Gastrointestinale Stromatumoren

verfasst von: Annette Reichardt, PD Dr. med. Peter Reichardt

Erschienen in: Im Fokus Onkologie | Ausgabe 12/2012

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Zusammenfassung

Im September 2012 publizierte die European Society for Medical Oncology (ESMO) neue europäische Leitlinien zur Diagnostik, Therapie und Nachsorge gastrointestinaler Stromatumoren (GIST) [1]. Nun gibt es aktuelle Empfehlungen.

Literatur
  1. The ESMO / European Sarcoma Network Working Group. Gastrointestinal stromal tumors: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2012;23 Suppl 7:vii49–55.
  2. Miettinen M, Lasota J. Gastrointestinal stromal tumors: Pathology and prognosis at different sites. Semin Diagn Pathol. 2006;23(2):70–83.PubMedView Article
  3. Demetri GD et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med. 2002;347(7):472–480.PubMedView Article
  4. Blanke CD et al. Long-term results from a randomized phase II trial of standard versus higher-dose imatinib mesylate for patients with unresectable or metastatic gastrointestinal stromal tumors expressing KIT. J Clin Oncol. 2008;26(4):620–625.PubMedView Article
  5. von Mehren M et al. Follow-up results after 9 years (yrs) of the ongoing, phase II B2222 trial of imatinib mesylate (IM) in patients (pts) with metastatic or unresectable KIT+ gastrointestinal stromal tumors (GIST). J Clin Oncol. 2011;29:(suppl:abstr. 10016).
  6. Verweij J et al. Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomized trial. Lancet. 2004;364(9440):1127–1134.PubMedView Article
  7. Blanke CD et al. Phase III randomized, intergroup trial assessing imatinib mesylate at two dose levels in patients with unresectable or metastatic gastrointestinal stromal tumours expressing the KIT receptor tyrosine kinase: S0033. J Clin Oncol. 2008;26(4):626–632.PubMedView Article
  8. Gastrointestinal Stromal Tumor Meta-Analysis Group (MetaGIST). Comparison of two doses of imatinib for the treatment of unresectable or metastatic gastrointestinal stromal tumors (GIST): A meta-analysis based on 1,640 patients. J Clin Oncol. 2010;28(7):1247–1253.View Article
  9. Blay JY et al. Prospective multicentric randomized phase III study of imatinib in patients with advanced gastrointestinal stromal tumours comparing interruption versus continuation of treatment beyond 1 year: the French Sarcoma Group. J Clin Oncol. 2007;25(9):1107–1113.PubMedView Article
  10. Le Cesne A et al. Discontinuation of imatinib in patients with advanced gastrointestinal stromal tumours after 3 years of treatment: an open-label multicentre randomised phase 3 trial. Lancet Oncol. 2010;11(10):942–949.View Article
  11. Ray-Coquard IL et al. Risk of relapse with imatinib (IM) discontinuation at 5 years in advanced GIST patients: Results of the prospective BFR14 randomized phase III study comparing interruption versus continuation of IM at 5 years of treatment: A French Sarcoma Group Study. J Clin Oncol. 2012;28:15s(suppl:abstr. 10032)
  12. Demetri GD et al. Imatinib Plasma Levels Are Correlated With Clinical Benefit in Patients With Unresectable/Metastatic Gastrointestinal Stromal Tumors. J Clin Oncol. 2009;27(19):3141–3147.PubMedView Article
  13. Joensuu H et al. Practical management of tyrosine kinase inhibitor-associated side effects in GIST. Cancer Treat Rev. 2011;37(1):75–88.PubMedView Article
  14. Zalcberg JR et al. Outcome of patients with advanced gastro-intestinal stromal tumours crossing over to a daily imatinib dose of 800 mg after progression on 400 mg. Eur J Cancer. 2005;41(12):1751–1757.PubMedView Article
  15. Demetri GD et al. Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet. 2006;368(9544):1329–1338.PubMedView Article
  16. Reichardt P et al. Detailed analysis of survival and safety with sunitinib (SU) in a worldwide treatment-use trial of patients with advanced GIST. J Clin Oncol. 2008;26(May 20 suppl:abstr. 10548).
  17. George S et al. Clinical evaluation of continuous daily dosing of sunitinib malate in patients with advanced gastrointestinal stromal tumour after imatinib failure. Eur J Cancer. 2009;45(11):1959–1968.PubMedView Article
  18. Reichardt P et al. Randomisierte Phase III-Studie von Regorafenib bei Patienten mit metastasiertem und/oder nicht-resektablem gastrointestinalen Stromatumor (GIST) nach Progression von Imatinib und Sunitinib — GRID-Studie. Onkologie. 2012; 35(suppl 6):168
  19. Eisenberg BL, Harris J, Blanke CD et al. Phase II trial of neoadjuvant/adjuvant imatinib mesylate (IM) for advanced primary and metastatic/recurrent operable gastrointestinal stromal tumor (GIST): early results of RTOG 0132/ACRIN 6665. J Surg Oncol. 2009;99(1):42–47.PubMedView Article
  20. Fiore M et al. Preoperative imatinib mesylate for unresectable or locally advanced primary gastrointestinal stromal tumors (GIST). Eur J Surg Oncol. 2009;35(7):739–745.PubMedView Article
  21. DeMatteo RP et al. Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial. Lancet. 2009;373(9669):1097–1104.PubMedView Article
  22. Joensuu H et al. One vs Three Years of adjuvant Imatinib for Operable Gastrointestinal Stromal Tumor. A Randomized Trial. JAMA. 2012;307(12):1265–1272.PubMedView Article
  23. Reichardt P et al. Adjuvant therapy in primary GIST: state-of-the-art. Ann Oncol. 2012;23(11):2776–2781.PubMedView Article
  24. Corless CL et al. Relation of tumor pathologic and molecular features to outcome after surgical resection of localized primary gastrointestinal stromal tumor (GIST): Results of the intergroup phase III trial ACOSOG Z9001. J Clin Oncol 2010;28:15s(suppl:abstr. 10006).View Article
  25. Gouveia AM et al. Surgical margin status and prognosis of gastrointestinal stromal tumor. World J Surg. 2008;32(11):2375–2382.PubMedView Article
  26. Hohenberger P et al. Pattern of recurrence in patients with ruptured primary gastrointestinal stromal tumour. Br J Surg. 2010;97(12):1854–1859.PubMedView Article
Metadaten
Titel
Aktuelle Empfehlungen zur medikamentösen Therapie
Gastrointestinale Stromatumoren
verfasst von
Annette Reichardt
PD Dr. med. Peter Reichardt
Publikationsdatum
03.01.2013
Verlag
Urban and Vogel
Erschienen in
Im Fokus Onkologie / Ausgabe 12/2012
Print ISSN: 1435-7402
Elektronische ISSN: 2192-5674
DOI
https://doi.org/10.1007/s15015-012-0646-5

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