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Erschienen in: Canadian Journal of Anesthesia/Journal canadien d'anesthésie 7/2022

04.04.2022 | Reports of Original Investigations

Albumin use for fluid resuscitation in cardiac surgical patients: a survey of Canadian perioperative care providers

verfasst von: Laura Liu, HBSc, Stuart A. McCluskey, MD, FRCPC, PhD, Michael Law, MD, FRCPC, Lusine Abrahamyan, MD, PhD, Miki Peer, PhD, Gordon Tait, PhD, Vivek Rao, MD, FRCPC, Duminda N. Wijeysundera, MD, PhD, FRCPC, Damon C. Scales, MD, PhD, FRCPC, Jeannie Callum, MD, FRCPC, Keyvan Karkouti, MD, MSc, FRCPC, Justyna Bartoszko, MD, MSc, FRCPC

Erschienen in: Canadian Journal of Anesthesia/Journal canadien d'anesthésie | Ausgabe 7/2022

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Abstract

Purpose

To evaluate the perceptions and practices of Canadian cardiovascular anesthesiologists and intensivists towards intravenous albumin as a resuscitation fluid in patients undergoing cardiac surgery.

Methods

We conducted a cross-sectional survey of cardiac anesthesiologists and intensivists involved in the care of cardiac surgical patients. The 22-item survey included seven open-ended questions and assessed practice patterns and attitudes towards albumin. Descriptive statistics were analyzed using counts and proportions. Qualitative data were analyzed to identify themes describing albumin use patterns in Canada.

Results

A total of 133 respondents from seven provinces participated, with 83 (62%) using albumin perioperatively. The majority of respondents (77%) felt a low fluid balance in cardiac surgical patients was important, and that supplementing crystalloids with albumin was helpful for this objective (67%). There was poor agreement among survey respondents regarding the role of albumin for faster vasopressor weaning or intensive care discharge, and ≥ 90% did not feel albumin reduced mortality, renal injury, or coagulopathy. Nevertheless, cardiac surgical patients were identified as a distinct population where albumin may help to minimize fluid balance. There was an acknowledged paucity of formal evidence supporting possible benefits. Fewer than 10% of respondents could identify institutional or national guidelines for albumin use. A lack of evidence supporting albumin use in cardiac surgical patients, especially those at highest risk of complications, was a frequently identified concern.

Conclusions

The majority of Canadian anesthesiologists and intensivists (62%) use albumin in cardiac surgical patients. There is clinical equipoise regarding its utility, and an acknowledged need for higher quality evidence to guide practice.
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Literatur
1.
Zurück zum Zitat Grundmann R, Heistermann S. Postoperative albumin infusion therapy based on colloid osmotic pressure: a prospectively randomized trial. Arch Surg 1985; 120: 911-5.CrossRef Grundmann R, Heistermann S. Postoperative albumin infusion therapy based on colloid osmotic pressure: a prospectively randomized trial. Arch Surg 1985; 120: 911-5.CrossRef
2.
Zurück zum Zitat Miller TE, Myles PS. Perioperative fluid therapy for major surgery. Anesthesiology 2019; 130: 825-32.CrossRef Miller TE, Myles PS. Perioperative fluid therapy for major surgery. Anesthesiology 2019; 130: 825-32.CrossRef
4.
Zurück zum Zitat Lyu PF, Murphy DJ. Economics of fluid therapy in critically ill patients. Curr Opin Crit Care 2014; 20: 402-7.CrossRef Lyu PF, Murphy DJ. Economics of fluid therapy in critically ill patients. Curr Opin Crit Care 2014; 20: 402-7.CrossRef
5.
Zurück zum Zitat Barron ME, Wilkes MM, Navickis RJ. A systematic review of the comparative safety of colloids. Arch Surg 2004; 139: 552-63.CrossRef Barron ME, Wilkes MM, Navickis RJ. A systematic review of the comparative safety of colloids. Arch Surg 2004; 139: 552-63.CrossRef
6.
Zurück zum Zitat Hanley C, Callum J, Karkouti K, Bartoszko J. Albumin in adult cardiac surgery: a narrative review. Can J Anesth 2021; 68: 1197-213.CrossRef Hanley C, Callum J, Karkouti K, Bartoszko J. Albumin in adult cardiac surgery: a narrative review. Can J Anesth 2021; 68: 1197-213.CrossRef
8.
Zurück zum Zitat Hanley C, Callum J, McCluskey S, Karkouti K, Bartoszko J. Albumin use in bleeding cardiac surgical patients and associated patient outcomes. Can J Anesth 2021; 68: 1514-26.CrossRef Hanley C, Callum J, McCluskey S, Karkouti K, Bartoszko J. Albumin use in bleeding cardiac surgical patients and associated patient outcomes. Can J Anesth 2021; 68: 1514-26.CrossRef
9.
Zurück zum Zitat Protsyk V, Rasmussen BS, Guarracino F, Erb J, Turton E, Ender J. Fluid management in cardiac surgery: results of a survey in European cardiac anesthesia departments. J Cardiothorac Vasc Anesth 2017; 31: 1624-9.CrossRef Protsyk V, Rasmussen BS, Guarracino F, Erb J, Turton E, Ender J. Fluid management in cardiac surgery: results of a survey in European cardiac anesthesia departments. J Cardiothorac Vasc Anesth 2017; 31: 1624-9.CrossRef
11.
Zurück zum Zitat Dillman DA, Smyth JD, Christian LM. Internet, Phone, Mail, and Mixed Mode Surveys: The Tailored Design Method, 4th ed. Hoboken, NJ: John Wiley & Sons Inc; 2014. Dillman DA, Smyth JD, Christian LM. Internet, Phone, Mail, and Mixed Mode Surveys: The Tailored Design Method, 4th ed. Hoboken, NJ: John Wiley & Sons Inc; 2014.
14.
Zurück zum Zitat Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform 2009; 42: 377-81.CrossRef Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform 2009; 42: 377-81.CrossRef
17.
Zurück zum Zitat China L, Freemantle N, Forrest E, et al. A randomized trial of albumin infusions in hospitalized patients with cirrhosis. N Engl J Med 2021; 384: 808-17.CrossRef China L, Freemantle N, Forrest E, et al. A randomized trial of albumin infusions in hospitalized patients with cirrhosis. N Engl J Med 2021; 384: 808-17.CrossRef
18.
Zurück zum Zitat Finfer S, Bellomo R, Boyce N, et al. A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med 2004; 350: 2247-56.CrossRef Finfer S, Bellomo R, Boyce N, et al. A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med 2004; 350: 2247-56.CrossRef
20.
Zurück zum Zitat Caironi P, Tognoni G, Masson S, et al. Albumin replacement in patients with severe sepsis or septic shock. N Engl J Med 2014; 370: 1412-21.CrossRef Caironi P, Tognoni G, Masson S, et al. Albumin replacement in patients with severe sepsis or septic shock. N Engl J Med 2014; 370: 1412-21.CrossRef
21.
Zurück zum Zitat Van der Linden P, De Villé A, Hofer A, Heschl M, Gombotz H. Six percent hydroxyethyl starch 130/0.4 (Voluven®) versus 5% human serum albumin for volume replacement therapy during elective open-heart surgery in pediatric patients. Anesthesiology 2013; 119: 1296-309.CrossRef Van der Linden P, De Villé A, Hofer A, Heschl M, Gombotz H. Six percent hydroxyethyl starch 130/0.4 (Voluven®) versus 5% human serum albumin for volume replacement therapy during elective open-heart surgery in pediatric patients. Anesthesiology 2013; 119: 1296-309.CrossRef
22.
Zurück zum Zitat Tigchelaar I, Gallandat Huet RC, Boonstra PW, van Oeveren W. Comparison of three plasma expanders used as priming fluids in cardiopulmonary bypass patients. Perfusion 1998; 13: 297-303.CrossRef Tigchelaar I, Gallandat Huet RC, Boonstra PW, van Oeveren W. Comparison of three plasma expanders used as priming fluids in cardiopulmonary bypass patients. Perfusion 1998; 13: 297-303.CrossRef
23.
Zurück zum Zitat Skillman JJ, Restall DS, Salzman EW. Randomized trial of albumin vs. electrolyte solutions during abdominal aortic operations. Surgery 1975; 78: 291-303.PubMed Skillman JJ, Restall DS, Salzman EW. Randomized trial of albumin vs. electrolyte solutions during abdominal aortic operations. Surgery 1975; 78: 291-303.PubMed
24.
Zurück zum Zitat Skhirtladze K, Base EM, Lassnigg A, et al. Comparison of the effects of albumin 5%, hydroxyethyl starch 130/0.4 6%, and Ringer's lactate on blood loss and coagulation after cardiac surgery. Br J Anaesth 2014; 112: 255-64.CrossRef Skhirtladze K, Base EM, Lassnigg A, et al. Comparison of the effects of albumin 5%, hydroxyethyl starch 130/0.4 6%, and Ringer's lactate on blood loss and coagulation after cardiac surgery. Br J Anaesth 2014; 112: 255-64.CrossRef
25.
Zurück zum Zitat Scott DA, Hore PJ, Cannata J, Masson K, Treagus B, Mullaly J. A comparison of albumin, polygeline and crystalloid priming solutions for cardiopulmonary bypass in patients having coronary artery bypass graft surgery. Perfusion 1995; 10: 415-24.CrossRef Scott DA, Hore PJ, Cannata J, Masson K, Treagus B, Mullaly J. A comparison of albumin, polygeline and crystalloid priming solutions for cardiopulmonary bypass in patients having coronary artery bypass graft surgery. Perfusion 1995; 10: 415-24.CrossRef
26.
Zurück zum Zitat Saunders CR, Carlisle L, Bick RL. Hydroxyethyl starch versus albumin in cardiopulmonary bypass prime solutions. Ann Thorac Surg 1983; 36: 532-9.CrossRef Saunders CR, Carlisle L, Bick RL. Hydroxyethyl starch versus albumin in cardiopulmonary bypass prime solutions. Ann Thorac Surg 1983; 36: 532-9.CrossRef
27.
Zurück zum Zitat Sade RM, Stroud MR, Crawford FA Jr, Kratz JM, Dearing JP, Bartles DM. A prospective randomized study of hydroxyethyl starch, albumin, and lactated Ringer’s solution as priming fluid for cardiopulmonary bypass. J Thorac Cardiovasc Surg 1985; 89: 713-22.CrossRef Sade RM, Stroud MR, Crawford FA Jr, Kratz JM, Dearing JP, Bartles DM. A prospective randomized study of hydroxyethyl starch, albumin, and lactated Ringer’s solution as priming fluid for cardiopulmonary bypass. J Thorac Cardiovasc Surg 1985; 89: 713-22.CrossRef
28.
Zurück zum Zitat Riegger LQ, Voepel-Lewis T, Kulik TJ, et al. Albumin versus crystalloid prime solution for cardiopulmonary bypass in young children. Crit Care Med 2002; 30: 2649-54.CrossRef Riegger LQ, Voepel-Lewis T, Kulik TJ, et al. Albumin versus crystalloid prime solution for cardiopulmonary bypass in young children. Crit Care Med 2002; 30: 2649-54.CrossRef
29.
Zurück zum Zitat Rex S, Scholz M, Weyland A, Busch T, Schorn B, Buhre W. Intra- and extravascular volume status in patients undergoing mitral valve replacement: crystalloid vs. colloid priming of cardiopulmonary bypass. Eur J Anaesthesiol 2006; 23: 1-9.CrossRef Rex S, Scholz M, Weyland A, Busch T, Schorn B, Buhre W. Intra- and extravascular volume status in patients undergoing mitral valve replacement: crystalloid vs. colloid priming of cardiopulmonary bypass. Eur J Anaesthesiol 2006; 23: 1-9.CrossRef
30.
Zurück zum Zitat Palanzo DA, Parr GV, Bull AP, Williams DR, O’Neill MJ, Waldhausen JA. Hetastarch as a prime for cardiopulmonary bypass. Ann Thorac Surg 1982; 34: 680-3.CrossRef Palanzo DA, Parr GV, Bull AP, Williams DR, O’Neill MJ, Waldhausen JA. Hetastarch as a prime for cardiopulmonary bypass. Ann Thorac Surg 1982; 34: 680-3.CrossRef
31.
Zurück zum Zitat Ohqvist G, Settergren G, Lundberg S. Pulmonary oxygenation, central haemodynamics and glomerular filtration following cardiopulmonary bypass with colloid or non-colloid priming solution. Scand J Thorac Cardiovasc Surg 1981; 15: 257-62.CrossRef Ohqvist G, Settergren G, Lundberg S. Pulmonary oxygenation, central haemodynamics and glomerular filtration following cardiopulmonary bypass with colloid or non-colloid priming solution. Scand J Thorac Cardiovasc Surg 1981; 15: 257-62.CrossRef
32.
Zurück zum Zitat Niemi TT, Suojaranta-Ylinen RT, Kukkonen SI, Kuitunen AH. Gelatin and hydroxyethyl starch, but not albumin, impair hemostasis after cardiac surgery. Anesth Analg 2006; 102: 998-1006.CrossRef Niemi TT, Suojaranta-Ylinen RT, Kukkonen SI, Kuitunen AH. Gelatin and hydroxyethyl starch, but not albumin, impair hemostasis after cardiac surgery. Anesth Analg 2006; 102: 998-1006.CrossRef
33.
Zurück zum Zitat Mastroianni L, Low HB, Rollman J, Wagle M, Bleske B, Chow MS. A comparison of 10% pentastarch and 5% albumin in patients undergoing open-heart surgery. J Clin Pharmacol 1994; 34: 34-40.CrossRef Mastroianni L, Low HB, Rollman J, Wagle M, Bleske B, Chow MS. A comparison of 10% pentastarch and 5% albumin in patients undergoing open-heart surgery. J Clin Pharmacol 1994; 34: 34-40.CrossRef
34.
Zurück zum Zitat Marelli D, Paul A, Samson R, Edgell D, Angood P, Chiu RC. Does the addition of albumin to the prime solution in cardiopulmonary bypass affect clinical outcome? A prospective randomized study. J Thorac Cardiovasc Surg 1989; 98: 751-6.CrossRef Marelli D, Paul A, Samson R, Edgell D, Angood P, Chiu RC. Does the addition of albumin to the prime solution in cardiopulmonary bypass affect clinical outcome? A prospective randomized study. J Thorac Cardiovasc Surg 1989; 98: 751-6.CrossRef
35.
Zurück zum Zitat London MJ, Franks M, Verrier ED, Merrick SH, Levin J, Mangano DT. The safety and efficacy of ten percent pentastarch as a cardiopulmonary bypass priming solution. A randomized clinical trial. J Thorac Cardiovasc Surg 1992; 104: 284-96.CrossRef London MJ, Franks M, Verrier ED, Merrick SH, Levin J, Mangano DT. The safety and efficacy of ten percent pentastarch as a cardiopulmonary bypass priming solution. A randomized clinical trial. J Thorac Cardiovasc Surg 1992; 104: 284-96.CrossRef
36.
Zurück zum Zitat London MJ, Ho JS, Triedman JK, et al. A randomized clinical trial of 10% pentastarch (low molecular weight hydroxyethyl starch) versus 5% albumin for plasma volume expansion after cardiac operations. J Thorac Cardiovasc Surg 1989; 97: 785-97.CrossRef London MJ, Ho JS, Triedman JK, et al. A randomized clinical trial of 10% pentastarch (low molecular weight hydroxyethyl starch) versus 5% albumin for plasma volume expansion after cardiac operations. J Thorac Cardiovasc Surg 1989; 97: 785-97.CrossRef
37.
Zurück zum Zitat Liou HL, Shih CC, Chao YF, et al. “Inflammatory response to colloids compared to crystalloid priming in cardiac surgery patients with cardiopulmonary bypass.” Chin J Physiol 2012; 55: 210-8.CrossRef Liou HL, Shih CC, Chao YF, et al. “Inflammatory response to colloids compared to crystalloid priming in cardiac surgery patients with cardiopulmonary bypass.” Chin J Physiol 2012; 55: 210-8.CrossRef
38.
Zurück zum Zitat Lee EH, Kim WJ, Kim JY, et al. Effect of exogenous albumin on the incidence of postoperative acute kidney injury in patients undergoing off-pump coronary artery bypass surgery with a preoperative albumin level of less than 4.0 g/dl. Anesthesiology 2016; 124: 1001-11.CrossRef Lee EH, Kim WJ, Kim JY, et al. Effect of exogenous albumin on the incidence of postoperative acute kidney injury in patients undergoing off-pump coronary artery bypass surgery with a preoperative albumin level of less than 4.0 g/dl. Anesthesiology 2016; 124: 1001-11.CrossRef
39.
Zurück zum Zitat Jenkins IR, Curtis AP. The combination of mannitol and albumin in the priming solution reduces positive intraoperative fluid balance during cardiopulmonary bypass. Perfusion 1995; 10: 301-5.CrossRef Jenkins IR, Curtis AP. The combination of mannitol and albumin in the priming solution reduces positive intraoperative fluid balance during cardiopulmonary bypass. Perfusion 1995; 10: 301-5.CrossRef
42.
Zurück zum Zitat Spence J, Belley-Côté E, Devereaux PJ, et al. Benzodiazepine administration during adult cardiac surgery: a survey of current practice among Canadian anesthesiologists working in academic centres. Can J Anesth 2018; 65: 263-71.CrossRef Spence J, Belley-Côté E, Devereaux PJ, et al. Benzodiazepine administration during adult cardiac surgery: a survey of current practice among Canadian anesthesiologists working in academic centres. Can J Anesth 2018; 65: 263-71.CrossRef
Metadaten
Titel
Albumin use for fluid resuscitation in cardiac surgical patients: a survey of Canadian perioperative care providers
verfasst von
Laura Liu, HBSc
Stuart A. McCluskey, MD, FRCPC, PhD
Michael Law, MD, FRCPC
Lusine Abrahamyan, MD, PhD
Miki Peer, PhD
Gordon Tait, PhD
Vivek Rao, MD, FRCPC
Duminda N. Wijeysundera, MD, PhD, FRCPC
Damon C. Scales, MD, PhD, FRCPC
Jeannie Callum, MD, FRCPC
Keyvan Karkouti, MD, MSc, FRCPC
Justyna Bartoszko, MD, MSc, FRCPC
Publikationsdatum
04.04.2022
Verlag
Springer International Publishing
Erschienen in
Canadian Journal of Anesthesia/Journal canadien d'anesthésie / Ausgabe 7/2022
Print ISSN: 0832-610X
Elektronische ISSN: 1496-8975
DOI
https://doi.org/10.1007/s12630-022-02237-w

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