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Erschienen in: Journal of Neurology 8/2019

28.08.2018 | Review

Alcohol consumption and risk for Parkinson’s disease: a systematic review and meta-analysis

verfasst von: Félix Javier Jiménez-Jiménez, Hortensia Alonso-Navarro, Elena García-Martín, José A. G. Agúndez

Erschienen in: Journal of Neurology | Ausgabe 8/2019

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Abstract

The possibility that alcohol consumption should be considered as a “protective factor” for Parkinson’s disease (PD) has been suggested by several case–control studies. However, other case–control studies and data from prospective longitudinal cohort studies have been inconclusive. We carried out a systematic review which included all the eligible studies published on PD risk related with alcohol consumption, and conducted a meta-analysis according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. The systematic review was performed using two databases, and the meta-analysis of the eligible studies with the software Meta-Disc1.1.1. Heterogeneity between studies was tested with the Q-statistic. The meta-analysis included 26 eligible retrospective case–control studies (8798 PD patients, 15,699 controls) and 5 prospective longitudinal cohort studies (2404 PD patients, 600,592 controls) on alcohol consumption and PD. In retrospective case–control studies the frequency of PD patients never drinkers was higher and the frequency of heavy + moderate drinkers was lower [diagnostic OR (95% CI) 1.33(1.20–1.48) and 0.74(0.64–0.85)], respectively, when compared to healthy controls. In contrast, in prospective studies, the differences were not significant with the exception of a trend towards a higher frequency of non-drinkers in PD women and a significantly lower frequency of moderate + heavy drinkers in PD men in those studies which stratified data by gender. The present meta-analysis suggests an inverse association between alcohol consumption and PD, which is supported by the results of case–control studies but not clearly by prospective ones.
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Metadaten
Titel
Alcohol consumption and risk for Parkinson’s disease: a systematic review and meta-analysis
verfasst von
Félix Javier Jiménez-Jiménez
Hortensia Alonso-Navarro
Elena García-Martín
José A. G. Agúndez
Publikationsdatum
28.08.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Journal of Neurology / Ausgabe 8/2019
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-018-9032-3

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