Skip to main content
Erschienen in:

19.09.2017 | Original Article

Alcohol-Dependent Individuals Make Detrimental Decisions under Ambiguous and Perilous Conditions

verfasst von: Chengjuan Xie, Lili Yuan, Yu Meng, Kai Wang

Erschienen in: International Journal of Mental Health and Addiction | Ausgabe 4/2018

Einloggen, um Zugang zu erhalten

Abstract

The present study assessed the decision-making abilities of patients with alcohol dependence (AD) under ambiguity or risk conditions. Forty-eight AD patients and 50 healthy controls (HC) were subjected to the Mini-Mental State Examination (MMSE), Iowa Gambling Task (IGT), and Game of Dice Task (GDT) systems for evaluating their decision-making ability. Age, duration of education, and MMSE scores were compared between the AD and HC groups. The communication in each block/choice and the group was evaluated along with the relationship between the trial block and choice. The basic characteristics were similar between both groups. Reduced mean net scores (IGT) and frequencies of choice were found for various alternatives (GDT) in AD patients as compared to the healthy controls. The net scores of first block (IGT test) and GDT test in AD patients were associated remarkably. These findings indicated a worse decision-making performance in AD patients compared to HCs under both ambiguity and risk conditions.
Literatur
Zurück zum Zitat American Psychiatric Association (1994). Diagnostic and Statistical Manual of Mental Disorder, 4th ed. Washington, DC: American Psychiatric Press. American Psychiatric Association (1994). Diagnostic and Statistical Manual of Mental Disorder, 4th ed. Washington, DC: American Psychiatric Press.
Zurück zum Zitat Brand, M., Labudda, K., & Markowitsch, H. J. (2006). Neuropsychological correlates of decision-making in ambiguous and risky situations. Neural Networks, 19(8), 1266–1276.CrossRefPubMed Brand, M., Labudda, K., & Markowitsch, H. J. (2006). Neuropsychological correlates of decision-making in ambiguous and risky situations. Neural Networks, 19(8), 1266–1276.CrossRefPubMed
Zurück zum Zitat Brand, M., Recknor, E. C., Grabenhorst, F., & Bechara, A. (2007). Decisions under ambiguity and decisions under risk: correlations with executive functions and comparisons of two different gambling tasks with implicit and explicit rules. Journal of Clinical and Experimental Neuropsychology, 29(1), 86–99.CrossRefPubMed Brand, M., Recknor, E. C., Grabenhorst, F., & Bechara, A. (2007). Decisions under ambiguity and decisions under risk: correlations with executive functions and comparisons of two different gambling tasks with implicit and explicit rules. Journal of Clinical and Experimental Neuropsychology, 29(1), 86–99.CrossRefPubMed
Zurück zum Zitat Brand, M., Roth-Bauer, M., Driessen, M., & Markowitsch, H. J. (2008). Executive functions and risky decision-making in patients with opiate dependence. Drug and Alcohol Dependence, 97(1–2), 64–72.CrossRefPubMed Brand, M., Roth-Bauer, M., Driessen, M., & Markowitsch, H. J. (2008). Executive functions and risky decision-making in patients with opiate dependence. Drug and Alcohol Dependence, 97(1–2), 64–72.CrossRefPubMed
Zurück zum Zitat Brevers, D., Bechara, A., Cleeremans, A., Kornreich, C., Verbanck, P., & Noel, X. (2014). Impaired decision-making under risk in individuals with alcohol dependence. Alcoholism, Clinical and Experimental Research, 38(7), 1924–1931.CrossRefPubMedPubMedCentral Brevers, D., Bechara, A., Cleeremans, A., Kornreich, C., Verbanck, P., & Noel, X. (2014). Impaired decision-making under risk in individuals with alcohol dependence. Alcoholism, Clinical and Experimental Research, 38(7), 1924–1931.CrossRefPubMedPubMedCentral
Zurück zum Zitat Cantrell, H., Finn, P. R., Rickert, M. E., & Lucas, J. (2008). Decision making in alcohol dependence: insensitivity to future consequences and comorbid disinhibitory psychopathology. Alcoholism, Clinical and Experimental Research, 32(8), 1398–1407.CrossRefPubMedPubMedCentral Cantrell, H., Finn, P. R., Rickert, M. E., & Lucas, J. (2008). Decision making in alcohol dependence: insensitivity to future consequences and comorbid disinhibitory psychopathology. Alcoholism, Clinical and Experimental Research, 32(8), 1398–1407.CrossRefPubMedPubMedCentral
Zurück zum Zitat Chen, X., Zhu, C., Li, J., Qiu, L., Zhang, L., Yu, F., et al. (2013). Dissociation of decision making under ambiguity and decision making under risk in breast cancer patients receiving adjuvant chemotherapy: a neuropsychological study. Brain Research, 1533, 63–72.CrossRefPubMed Chen, X., Zhu, C., Li, J., Qiu, L., Zhang, L., Yu, F., et al. (2013). Dissociation of decision making under ambiguity and decision making under risk in breast cancer patients receiving adjuvant chemotherapy: a neuropsychological study. Brain Research, 1533, 63–72.CrossRefPubMed
Zurück zum Zitat Criado, J. R., & Ehlers, C. L. (2010). Event-related oscillations in the parietal cortex of adult alcohol-preferring (P) and alcohol-nonpreferring rats (NP). Alcohol (Fayetteville, NY), 44(4), 335–342.CrossRef Criado, J. R., & Ehlers, C. L. (2010). Event-related oscillations in the parietal cortex of adult alcohol-preferring (P) and alcohol-nonpreferring rats (NP). Alcohol (Fayetteville, NY), 44(4), 335–342.CrossRef
Zurück zum Zitat Cservenka, A., & Nagel, B. J. (2012). Risky decision-making: an FMRI study of youth at high risk for alcoholism. Alcoholism, Clinical and Experimental Research, 36(4), 604–615.CrossRefPubMedPubMedCentral Cservenka, A., & Nagel, B. J. (2012). Risky decision-making: an FMRI study of youth at high risk for alcoholism. Alcoholism, Clinical and Experimental Research, 36(4), 604–615.CrossRefPubMedPubMedCentral
Zurück zum Zitat Dickerson, M. (2007). The future of the alcohol dependence syndrome (ads): possible challenges from more rigorous psychological measurement. Addiction (Abingdon, England), 102(10), 1532–1533 discussion 1537-1538.CrossRef Dickerson, M. (2007). The future of the alcohol dependence syndrome (ads): possible challenges from more rigorous psychological measurement. Addiction (Abingdon, England), 102(10), 1532–1533 discussion 1537-1538.CrossRef
Zurück zum Zitat Dom, G., De Wilde, B., Hulstijn, W., van den Brink, W., & Sabbe, B. (2006). Decision-making deficits in alcohol-dependent patients with and without comorbid personality disorder. Alcoholism, Clinical and Experimental Research, 30(10), 1670–1677.CrossRefPubMed Dom, G., De Wilde, B., Hulstijn, W., van den Brink, W., & Sabbe, B. (2006). Decision-making deficits in alcohol-dependent patients with and without comorbid personality disorder. Alcoholism, Clinical and Experimental Research, 30(10), 1670–1677.CrossRefPubMed
Zurück zum Zitat Ende, G., Hermann, D., Demirakca, T., Hoerst, M., Tunc-Skarka, N., Weber-Fahr, W., et al. (2013). Loss of control of alcohol use and severity of alcohol dependence in non-treatment-seeking heavy drinkers are related to lower glutamate in frontal white matter. Alcoholism, Clinical and Experimental Research, 37(10), 1643–1649.PubMed Ende, G., Hermann, D., Demirakca, T., Hoerst, M., Tunc-Skarka, N., Weber-Fahr, W., et al. (2013). Loss of control of alcohol use and severity of alcohol dependence in non-treatment-seeking heavy drinkers are related to lower glutamate in frontal white matter. Alcoholism, Clinical and Experimental Research, 37(10), 1643–1649.PubMed
Zurück zum Zitat Folstein, M.F., Folstein, S.E., & McHugh PR. (1975). "Mini-mental state" A practical method for grading the cognitive state of patients for the clinician. Journal of psychiatric research, 12(3), 189-198. Folstein, M.F., Folstein, S.E., & McHugh PR. (1975). "Mini-mental state" A practical method for grading the cognitive state of patients for the clinician. Journal of psychiatric research, 12(3), 189-198.
Zurück zum Zitat Goudriaan, A. E., Oosterlaan, J., de Beurs, E., & van den Brink, W. (2005). Decision making in pathological gambling: a comparison between pathological gamblers, alcohol dependents, persons with Tourette syndrome, and normal controls. Brain research. Cognitive Brain Research, 23(1), 137–151.CrossRefPubMed Goudriaan, A. E., Oosterlaan, J., de Beurs, E., & van den Brink, W. (2005). Decision making in pathological gambling: a comparison between pathological gamblers, alcohol dependents, persons with Tourette syndrome, and normal controls. Brain research. Cognitive Brain Research, 23(1), 137–151.CrossRefPubMed
Zurück zum Zitat Huettel, S. A., Stowe, C. J., Gordon, E. M., Warner, B. T., & Platt, M. L. (2006). Neural signatures of economic preferences for risk and ambiguity. Neuron, 49(5), 765–775.CrossRefPubMed Huettel, S. A., Stowe, C. J., Gordon, E. M., Warner, B. T., & Platt, M. L. (2006). Neural signatures of economic preferences for risk and ambiguity. Neuron, 49(5), 765–775.CrossRefPubMed
Zurück zum Zitat Kahkonen, S., Wilenius, J., Nikulin, V. V., Ollikainen, M., & Ilmoniemi, R. J. (2003). Alcohol reduces prefrontal cortical excitability in humans: a combined TMS and EEG study. Neuropsychopharmacology, 28(4), 747–754.CrossRefPubMed Kahkonen, S., Wilenius, J., Nikulin, V. V., Ollikainen, M., & Ilmoniemi, R. J. (2003). Alcohol reduces prefrontal cortical excitability in humans: a combined TMS and EEG study. Neuropsychopharmacology, 28(4), 747–754.CrossRefPubMed
Zurück zum Zitat Kim, Y. T., Sohn, H., & Jeong, J. (2011). Delayed transition from ambiguous to risky decision making in alcohol dependence during Iowa Gambling Task. Psychiatry Research, 190(2–3), 297–303.CrossRefPubMed Kim, Y. T., Sohn, H., & Jeong, J. (2011). Delayed transition from ambiguous to risky decision making in alcohol dependence during Iowa Gambling Task. Psychiatry Research, 190(2–3), 297–303.CrossRefPubMed
Zurück zum Zitat Konrad, A., Vucurevic, G., Lorscheider, M., Bernow, N., Thummel, M., Chai, C., et al. (2012). Broad disruption of brain white matter microstructure and relationship with neuropsychological performance in male patients with severe alcohol dependence. Alcohol and Alcoholism (Oxford, Oxfordshire), 47(2), 118–126.CrossRef Konrad, A., Vucurevic, G., Lorscheider, M., Bernow, N., Thummel, M., Chai, C., et al. (2012). Broad disruption of brain white matter microstructure and relationship with neuropsychological performance in male patients with severe alcohol dependence. Alcohol and Alcoholism (Oxford, Oxfordshire), 47(2), 118–126.CrossRef
Zurück zum Zitat Ma, H., Lv, X., Han, Y., Zhang, F., Ye, R., Yu, F., et al.(2013). Decision-making impairments in patients with Wilson's disease. Journal of Clinical and Experimental Neuropsychology, 35(5), 472-479. Ma, H., Lv, X., Han, Y., Zhang, F., Ye, R., Yu, F., et al.(2013). Decision-making impairments in patients with Wilson's disease. Journal of Clinical and Experimental Neuropsychology, 35(5), 472-479.
Zurück zum Zitat Mainz, V., Druke, B., Boecker, M., Kessel, R., Gauggel, S., & Forkmann, T. (2012). Influence of cue exposure on inhibitory control and brain activation in patients with alcohol dependence. Frontiers in Human Neuroscience, 6, 92.CrossRefPubMedPubMedCentral Mainz, V., Druke, B., Boecker, M., Kessel, R., Gauggel, S., & Forkmann, T. (2012). Influence of cue exposure on inhibitory control and brain activation in patients with alcohol dependence. Frontiers in Human Neuroscience, 6, 92.CrossRefPubMedPubMedCentral
Zurück zum Zitat Makris, N., Oscar-Berman, M., Jaffin, S. K., Hodge, S. M., Kennedy, D. N., Caviness, V. S., et al. (2008). Decreased volume of the brain reward system in alcoholism. Biological Psychiatry, 64(3), 192–202.CrossRefPubMedPubMedCentral Makris, N., Oscar-Berman, M., Jaffin, S. K., Hodge, S. M., Kennedy, D. N., Caviness, V. S., et al. (2008). Decreased volume of the brain reward system in alcoholism. Biological Psychiatry, 64(3), 192–202.CrossRefPubMedPubMedCentral
Zurück zum Zitat Moulton, P. L., Petros, T. V., Apostal, K. J., Park 2nd, R. V., Ronning, E. A., King, B. M., et al. (2005). Alcohol-induced impairment and enhancement of memory: a test of the interference theory. Physiology & Behavior, 85(3), 240–245.CrossRef Moulton, P. L., Petros, T. V., Apostal, K. J., Park 2nd, R. V., Ronning, E. A., King, B. M., et al. (2005). Alcohol-induced impairment and enhancement of memory: a test of the interference theory. Physiology & Behavior, 85(3), 240–245.CrossRef
Zurück zum Zitat Noel, X., Bechara, A., Dan, B., Hanak, C., & Verbanck, P. (2007). Response inhibition deficit is involved in poor decision making under risk in nonamnesic individuals with alcoholism. Neuropsychology, 21(6), 778–786.CrossRefPubMed Noel, X., Bechara, A., Dan, B., Hanak, C., & Verbanck, P. (2007). Response inhibition deficit is involved in poor decision making under risk in nonamnesic individuals with alcoholism. Neuropsychology, 21(6), 778–786.CrossRefPubMed
Zurück zum Zitat Nowakowska, K., Jablkowska, K., & Borkowska, A. (2007). Cognitive dysfunctions in patients with alcohol dependence. Psychiatria Polska, 41(5), 693–702.PubMed Nowakowska, K., Jablkowska, K., & Borkowska, A. (2007). Cognitive dysfunctions in patients with alcohol dependence. Psychiatria Polska, 41(5), 693–702.PubMed
Zurück zum Zitat Rushworth, M. F., & Behrens, T. E. (2008). Choice, uncertainty and value in prefrontal and cingulate cortex. Nature Neuroscience, 11(4), 389–397.CrossRefPubMed Rushworth, M. F., & Behrens, T. E. (2008). Choice, uncertainty and value in prefrontal and cingulate cortex. Nature Neuroscience, 11(4), 389–397.CrossRefPubMed
Zurück zum Zitat Tedstone, D., & Coyle, K. (2004). Cognitive impairments in sober alcoholics: performance on selective and divided attention tasks. Drug and Alcohol Dependence, 75(3), 277–286.CrossRefPubMed Tedstone, D., & Coyle, K. (2004). Cognitive impairments in sober alcoholics: performance on selective and divided attention tasks. Drug and Alcohol Dependence, 75(3), 277–286.CrossRefPubMed
Zurück zum Zitat Xi, C., Zhu, Y., Niu, C., Zhu, C., Lee, T. M., Tian, Y., et al. (2011). Contributions of subregions of the prefrontal cortex to the theory of mind and decision making. Behavioural Brain Research, 221(2), 587–593.CrossRefPubMed Xi, C., Zhu, Y., Niu, C., Zhu, C., Lee, T. M., Tian, Y., et al. (2011). Contributions of subregions of the prefrontal cortex to the theory of mind and decision making. Behavioural Brain Research, 221(2), 587–593.CrossRefPubMed
Metadaten
Titel
Alcohol-Dependent Individuals Make Detrimental Decisions under Ambiguous and Perilous Conditions
verfasst von
Chengjuan Xie
Lili Yuan
Yu Meng
Kai Wang
Publikationsdatum
19.09.2017
Verlag
Springer US
Erschienen in
International Journal of Mental Health and Addiction / Ausgabe 4/2018
Print ISSN: 1557-1874
Elektronische ISSN: 1557-1882
DOI
https://doi.org/10.1007/s11469-017-9810-7

Neu im Fachgebiet Psychiatrie

ADHS-Kranke verlieren sieben Lebensjahre

  • 11.02.2025
  • ADHS
  • Nachrichten

Ein ADHS verkürzt die Lebenserwartung um rund sieben Jahre, bei Frauen sind es sogar fast neun Jahre. Ein Großteil der erhöhten Sterblichkeit lässt sich auf modifizierbare Risikofaktoren wie Alkohol, Rauchen und psychische Begleiterkrankungen zurückführen.

Lagerungsschwindel hält trotz Manöver an: Was steckt dahinter?

Ob sich ein benigner paroxysmaler Lagerungsschwindel erfolgreich behandeln lässt, könnte einem chinesischen Team zufolge auch von psychischen Faktoren abhängen.

Enorme Einschränkungen auch im zweiten Jahr mit Long COVID

Auch mehr als ein Jahr nach einer SARS-CoV-2-Infektion leidet die Mehrheit der Betroffenen, die ein Post-COVID-Syndrom (PCS) entwickelt haben, weiterhin unter eingeschränkter körperlicher Leistungsfähigkeit, Fatigue, kognitiven Beeinträchtigungen und einer reduzierten Lebensqualität. Dies belegt eine Langzeitstudie aus Baden-Württemberg.

Web-basiertes Trainingsprogramm schützt offenbar vor kognitivem Abbau

  • 30.01.2025
  • Demenz
  • Nachrichten

Lässt sich mithilfe eines internetbasierten Trainingsprogramms zur Verbesserung des Lebensstils der kognitive Abbau bremsen? Das Ergebnis einer randomisierten Studie, an der Personen mit erhöhtem Demenzrisiko teilnahmen, lässt dies vermuten.

Update Psychiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.