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28.07.2017 | Original Article

Alcohol flushing is independently associated with lesser degree of carotid atherosclerosis in Japanese type 2 diabetic patients

verfasst von: Norimitsu Murai, Ryo Saiki, Mai Hashizume, Yasuyoshi Kigawa, Go Koizumi, Rie Tadokoro, Kei Endo, Toru Iizaka, Fumiko Otsuka, Masahiko Izumizaki, Shoichiro Nagasaka

Erschienen in: Diabetology International | Ausgabe 1/2018

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Abstract

Background

Type 2 diabetes mellitus is a well-known risk factor for atherosclerosis. Intima media thickness (IMT) of the carotid arteries has been widely used for assessing atherosclerotic changes representing cerebro-cardiovascular disease risk. Previous studies have associated the presence of inactive aldehyde dehydrogenase with progression of atherosclerosis and alcohol flushing. However, reports conflict on whether alcohol flushing could potentially modify the degree of atherosclerosis in type 2 diabetic patients.

Methods

We retrospectively assessed the relationships among alcohol flushing, IMT, and clinical characteristics in 123 consecutive Japanese type 2 diabetic patients. Alcohol flushing was assessed by standardized questionnaires.

Results

Patients with alcohol flushing had lower mean IMT [0.7 (0.65–0.80) vs. 0.8 (0.73–0.90) mm, p < 0.05], despite having higher triglycerides [132 (94–169) vs. 98 (70–139) mg/dL, p < 0.01] and lower high-density lipoprotein cholesterol [52 (44–60) vs. 59 (49–67) mg/dL, p < 0.05] concentration. Patients with alcohol flushing had lower frequency of alcohol intake (45 vs. 76%, p < 0.0001). Mean IMT was positively associated with age and low-density lipoprotein cholesterol concentration, and negatively with alcohol flushing according to stepwise multiple regression analysis. Alcohol flushing was also independently associated with mean IMT by multivariate analysis.

Conclusions

These findings suggest that alcohol flushing is independently associated with lesser degree of carotid atherosclerosis in Japanese type 2 diabetic patients.

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Titel: Alcohol flushing is independently associated with lesser degree of carotid atherosclerosis in Japanese type 2 diabetic patients
verfasst von: Norimitsu Murai
Ryo Saiki
Mai Hashizume
Yasuyoshi Kigawa
Go Koizumi
Rie Tadokoro
Kei Endo
Toru Iizaka
Fumiko Otsuka
Masahiko Izumizaki
Shoichiro Nagasaka
Publikationsdatum: 28.07.2017
Verlag: Springer Japan
Erschienen in: Diabetology International / Ausgabe 1/2018
Print ISSN: 2190-1678
Elektronische ISSN: 2190-1686
DOI: https://doi.org/10.1007/s13340-017-0332-0

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Alcohol flushing is independently associated with lesser degree of carotid atherosclerosis in Japanese type 2 diabetic patients

Abstract

Background

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