Background
Methods
Study setting and participants
Measures
Analysis
Results
Overall n = 1,388 | Women n = 958 | Men n = 430 | Odds-ratioa(95 % CI) |
p-value | Adjusted odds-ratiob(95 % CI) | Adjusted p-valueb
| ||
---|---|---|---|---|---|---|---|---|
Median age (IQR) | 43.6 (34.5–53.5) | 43.6 (34.5–53.5) | 40.8 (32.4–51.4) | <0.001 | . | . | ||
Alcohol consumption | Yes | 268 (19.3 %) | 134 (14.0 %) | 134 (31.2 %) | 0.35 (0.27-0.47) | <0.001 | 0.37 (0.28-0.50) | <0.001 |
No | 1,120 (80.7 %) | 824 (86.0 %) | 296 (68.8 %) | |||||
Mean AUDIT Score (SD) among drinkers | 5.9 (5.4) | 5.7 (5.8) | 6.2 (4.9) | . | 0.454 | . | 0.491 | |
Hazardous consumption (AUDIT ≥ 8) | Yes | 88 (6.3 %) | 42 (4.4 %) | 46 (10.7 %) | 0.38 (0.25-0.59) | <0.001 | 0.39 (0.25-0.60) | <0.001 |
No | 1,300 (93.7 %) | 916 (95.6 %) | 384 (89.3 %) | |||||
Alcohol dependence (AUDIT ≥ 20) | Yes | 4 (0.3 %) | 3 (0.3 %) | 1 (0.2 %) | . | . | . | . |
No | 1,384 (99.7 %) | 955 (99.7 %) | 429 (99.8 %) | |||||
Mean PHQ Score (SD) | 6.6 (5.8) | 7.1 (5.8) | 5.5 (5.6) | . | <0.001 | . | <0.001 | |
Moderate to severe depression (PHQ-9 ≥ 10) | Yes | 400 (28.8 %) | 313 (32.7 %) | 87 (20.2 %) | 1.89 (1.45-2.49) | <0.001 | 1.92 (1.45-2.54) | <0.001 |
No | 988 (71.2 %) | 645 (67.3 %) | 343 (79.8 %) | |||||
Mean VAS (SD) | 92.0 (12.2) | 91.9 (12.3) | 92.2 (12.0) | . | 0.713 | . | 0.701 | |
Low VAS (≤95 %) | Yes | 610 (44.7 %) | 419 (44.6 %) | 191 (45.0 %) | 0.97 (0.77-1.23) | 0.823 | 0.97 (0.76-1.23) | 0.780 |
No | 754 (55.3 %) | 521 (55.4 %) | 233 (55.0 %) | |||||
Mean pill count Score (SD) | 96.9 (8.3) | 97.1 (8.1) | 96.6 (8.6) | . | 0.333 | . | 0.380 | |
Low pill count (≤95 %) | Yes | 301 (22.6 %) | 196 (21.3 %) | 105 (25.5 %) | 0.79 (0.60-1.04) | 0.093 | 0.81 (0.61-1.08) | 0.148 |
No | 1,029 (77.4 %) | 723 (78.7 %) | 306 (74.5 %) | |||||
Viral Suppression (≤80 copies/m) | Yes | 1,270 (91.5 %) | 883 (92.2 %) | 387(90.0 %) | 1.31 (0.88-1.94) | 0.187 | 1.43 (0.96-2.16) | 0.088 |
No | 118 (8.5 %) | 75 (7.8 %) | 43 (10.0 %) |
Alcohol use
Depressive symptoms
Virologic suppression
Viral load <80 c/mL | ≥80 c/mL | Odds-ratio viral suppression (95 % CI) |
p-value | ||
---|---|---|---|---|---|
Male | 387 (90.0 %) | 43 (10.0 %) | 1 | ||
Female | 883 (92.2 %) | 75 (7.8 %) | 1.33 (0.90-2.00) | 0.158 | |
Median age (IQR) | 43.6 (34.5–53.9) | 41.4 (33.2–50.2) | 0.181a
| ||
Age <35 years | 334 (90.3 %) | 36 (9.7 %) | 1 | 0.329 | |
≥35 years | 936 (91.9 %) | 82 (8.1 %) | 1.23 (0.81-1.86) | ||
Median wealth index (IQR) | −0.52 (−1.66-1.25) | −0.90 (−1.76-1.13) | 0.180a
| ||
Wealth index | Q1b
| 253 (90.7 %) | 26 (9.3 %) | 1 | 0.293 |
Q2 | 249 (88.9 %) | 31 (11.1 %) | 0.83 (0.41-1.64) | ||
Q3 | 250 (92.6 %) | 20 (7.4 %) | 1.28 (0.60-2.75) | ||
Q4 | 258 (93.8 %) | 17 (6.2 %) | 1.56 (0.70-3.46) | ||
Q5 | 260 (91.5 %) | 24 (8.5 %) | 1.11 (0.54-2.31) | ||
Type of facility | Center | 768 (91.9 %) | 68 (8.1 %) | 1 | 0.547 |
Hospital | 502 (90.9 %) | 50 (9.1 %) | 0.89 (0.61-1.30) | ||
NRTI backbone | AZTc/3TCd
| 418 (87.8 %) | 58 (12.2 %) | 0.52 (0.34-0.80) | 0.004 |
TDFe/3TCd
| 819 (93.3 %) | 59 (6.7 %) | 1 | ||
ABCf/3TCd
| 13 (92.9 %) | 1 (7.1 %) | 0.94 (0.09-9.80) | ||
NNRTI | EFVg
| 959 (92.2 %) | 81 (7.8 %) | 1 | 0.056 |
NVPh
| 291 (88.7 %) | 37 (11.3 %) | 0.66 (0.44-1.00) | ||
Median AUDIT Score (IQR) | 0 (0–0) | 0 (0–1.0) | 0.384a
| ||
Hazardous consumption | Yes | 79 (89.8 %) | 9 (10.2 %) | 0.80 (0.39-1.65) | 0.559 |
(AUDIT ≥ 8) | No | 1’191(91.6 %) | 109(8.4 %) | 1 | |
Median PHQ-9 Score (IQR) | 6 (1–10) | 6 (1–9) | 0.423a
| ||
Moderate to severe depression (PHQ-9 ≥ 10) | Yes | 371 (92.8 %) | 29 (7.3 %) | 1.27 (0.82-1.96) | 0.281 |
No | 899 (91.0 %) | 89 (9.0 %) | 1 | ||
VAS (IQR) | 96 (91–99) | 96 (90–100) | 0.424a
| ||
Low adherence VAS (≤95 %) | Yes | 558 (91.5 %) | 52 (8.5 %) | 1.02 (0.70-1.50) | 0.818 |
No | 691 (91.6 %) | 63 (8.4 %) | 1 | ||
Pill count’s tool (IQR) | 100 (96–100) | 100 (96–100) | 0.851a
| ||
Low pill count’s tool (≤95 %) | Yes | 275 (91.4 %) | 26 (8.6 %) | 0.99 (0.63-1.56) | 0.999 |
No | 941 (91.4 %) | 88 (8.6 %) | 1 |