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Endocrine

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26.11.2021 | Original Article

Aldosterone and renin concentrations were abnormally elevated in a cohort of normotensive pregnant women

verfasst von: Valentina Pastén, Alejandra Tapia-Castillo, Carlos E. Fardella, Andrea Leiva, Cristian A. Carvajal

Erschienen in: Endocrine | Ausgabe 3/2022

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Abstract

Background

During pregnancy, the renin–angiotensin–aldosterone system (RAAS) undergoes major changes to preserve normal blood pressure (BP) and placental blood flow and to ensure a good pregnancy outcome. Abnormal aldosterone–renin metabolism is a risk factor for arterial hypertension and cardiovascular risk, but its association with pathological conditions in pregnancy remains unknown. Moreover, potential biomarkers associated with these pathological conditions should be identified.

Aim

To study a cohort of normotensive pregnant women according to their serum aldosterone and plasma renin levels and assay their small extracellular vesicles (sEVs) and a specific protein cargo (LCN2, AT1R).

Methods

A cohort of 54 normotensive pregnant women at term gestation was included. We determined the BP, serum aldosterone, and plasma renin concentrations. In a subgroup, we isolated their plasma sEVs and semiquantitated two EV proteins (AT1R and LCN2).

Results

We set a normal range of aldosterone and renin based on the interquartile range. We identified 5/54 (9%) pregnant women with elevated aldosterone and low renin levels and 5/54 (9%) other pregnant women with low aldosterone and elevated renin levels. No differences were found in sEV-LCN2 or sEV-AT1R.

Conclusion

We found that 18% of normotensive pregnant women had either high aldosterone or high renin levels, suggesting a subclinical status similar to primary aldosteronism or hyperreninemia, respectively. Both could evolve to pathological conditions by affecting the maternal vascular and renal physiology and further the BP. sEVs and their specific cargo should be further studied to clarify their role as potential biomarkers of RAAS alterations in pregnant women.

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Titel: Aldosterone and renin concentrations were abnormally elevated in a cohort of normotensive pregnant women
verfasst von: Valentina Pastén
Alejandra Tapia-Castillo
Carlos E. Fardella
Andrea Leiva
Cristian A. Carvajal
Publikationsdatum: 26.11.2021
Verlag: Springer US
Erschienen in: Endocrine / Ausgabe 3/2022
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-021-02938-0

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Aldosterone and renin concentrations were abnormally elevated in a cohort of normotensive pregnant women