Background
It is well documented that depressive disorders are associated with cognitive deficits, including problems with attention, executive functions, and memory [
1‐
4]. Cognitive symptoms are often considered by-products of depression, and expected to diminish with clinical improvement. For many patients, however, cognitive impairments represent a primary concern and are noted to chronically impair activities of daily living [
5]. For example, visuospatial neglect can interfere with navigation in space - one of our clinical cases reported falling into the installation pit of his workshop when passing on the right-hand side. In this individual, in addition to hemineglect, moderate to severe depressive scores were reported, and then, with remission of the depression, neuropsychological deficits also subsided. In the present study, we focused on visuospatial deficits in depression and its relation to alertness and mood symptoms.
With regard to visuospatial attention, behavioural studies have reported left visual field impairments in depressive patients [
6,
7], as well as in healthy subjects during conditions of induced sadness [
8‐
10]. Different interpretations have been offered to explain these lateralization effects. According to Banich and colleagues, depression might be associated with hyperactivity in right frontal regions and hypoactivity in posterior regions, resulting in attention problems [
10]. Higher activation in the right hemisphere, particularly in frontal regions, was found to be indicator of negative affect in healthy populations [
11]. Liotti and Mayberg suggested a model in which limbic activation in sadness leads to deactivation of cortical sites involved in the processing of attention stimuli, such as dorsolateral prefrontal cortex and inferior parietal cortex. In fact, depression was found to interact with right-hemisphere dorsal cortico-limbic networks mediating space processing and externally directed attention and arousal [
3].
Classically, visuospatial neglect has been observed after brain lesions, predominantly in the left visual field after right-hemisphere lesions. Patients "ignore" stimuli in the visual field contralateral to the lesion and, as such, they fail to properly interact with and navigate their environment. In laboratory measures, visuospatial neglect is reflected by prolonged reaction time to and omissions of laterally presented stimuli in the affected visual field [
12,
13]. Current neuropsychological models of visuospatial neglect are based on a strong association of alertness with visuospatial impairments [
14]. Evidence was also provided by Thimm and colleagues who showed that alertness training in patients with right-hemisphere lesions and left-sided visuospatial neglect resulted in a transient amelioration of neglect symptoms on the behavioural level as well as to reactivation of associated brain areas. Thus, alertness seems to be a necessary but not sufficient factor of normal functioning of visuospatial attention [
15]. Sturm and colleagues investigated the functional anatomy in an intrinsic alertness and a visuospatial attention task and found a combined right-hemispheric network in the prefrontal and inferior parietal cortex [
16]. This functional connection may account for the finding that lesions in these areas elicit an alertness deficit associated with visuospatial deficits. However, it is unknown if this mechanism applies in depression as well.
The aim of the present study was to investigate the relation of visuospatial attention in depression to sad mood and alertness deficits, examining performance on standard computer measures for visuospatial attention and alertness in a group of patients diagnosed with depression and in a group of matched controls (see methods section). Sad mood was assessed using the Beck Depression Inventory (BDI) [
17]. Based on the literature, our first goal was to confirm left hemifield visuospatial impairments in individuals with depression (reflected as a rightward spatial bias). Our second goal was to measure whether alertness deficits or sad mood would enhance such an attention bias.
Results
Comparisons of the neglect tests concerning omissions as well as reaction time and of the alertness test yielded no significant differences between depressive patients and healthy controls.
The difference scores of omissions in the left visual field and those in the right visual field, however, yielded higher values in the depression group in all three tests, indicating a bias in the direction of the right visual field. Table
2 shows the comparisons in detail. Concerning omissions in TAP Neglect, depressive patients were biased to the right visual field and healthy controls to the left visual field. In the TAP Visual Scanning task, depressive patients and healthy control subjects both showed negative values for omissions, indicating a bias to the left hemispace. In the WAF Extinction-Neglect subtest, depressive patients had a rightward bias (higher omission rate in the left visual field) whereas omissions tended to a value of zero in controls. Reaction time in WAF alertness showed no significant difference between depressive patients and healthy controls, although an increased variance in the depression group is notable.
Table 2
Visual field difference of number of omissions and Alertness performance (mean ± SD)
TAP Neglect |
Omissions (LVF-RVF) | 0.19 ± 0.75 | -0.21 ± 0.89 | 1.24 | .234 | .458 | .019 | β1: .67 β2: -.12 | 3.27 -0.59 | .006* .564 |
TAP Visual Scanning |
Omissions (LVF-RVF) | -0.25 ± 2.27 | -0.71 ± 2.59 | 0.48 | .638 | .047 | .731 | β1: -.19 β2: .10 | -0.71 0.38 | .491 .707 |
WAF Extinction-Neglect |
Omissions (LVF-RVF) | 0.50 ± 1.10 | 0.06 ± 0.93 | 1.39 | .186 | .369 | .050 | β1: .40 β2: .45 | 1.80 2.06 | .095 .060 |
WAF Alertness |
(RT in ms) | 278.8 ± 100.3 | 261.0 ± 29.2 | 0.68 | .510 | - | - | - | - | - |
The results of the linear regression analysis showed that the combination of alertness performance and subjective rating of sad mood predicted performance on visuospatial attention tests. The factor WAF Alertness had a significant influence on the omissions in TAP Neglect, with longer reaction times predicting a rightward bias (β1 = .67, T
13 = 3.27, p < .006). The relation of alertness and rightward bias in WAF Extinction-Neglect showed a trend in the same direction (β1 = .40, T
13 = 1.80, p < .095). In the TAP Visual Scanning subtest, neither alertness nor sad mood influenced the number of omissions. Omissions in TAP Neglect were not influenced by sad mood. Sad mood in the BDI showed a trend towards predicting a rightward bias in WAF Extinction-Neglect (β2 = .45, T
13 = 2.06, p < .060). For detailed results see Table
2.
Arguing against a speed-accuracy trade-off, the mean reaction time differences of left and right visual field (± SD, in ms) revealed similar tendencies in both groups in contrast to omission differences. Slightly longer reaction times emerged in the left visual field during the TAP Neglect test (depression: 8.19 ± 53.19, control: 24.86 ± 95.14) and shorter reaction times in the left visual field during both TAP Visual Scanning (depression: -373.88 ± 1274.87, control: -350.64 ± 1169.09) and WAF Extinction-Neglect (depression: -33.44 ± 50.53, control: -31.71 ± 29.10). Reflecting the increased variability of the natural sample, high variances were noted in both groups. Testing for further covariates, no significant effect emerged concerning the influence of gender on performance in alertness and visuospatial attention tests (F [
7,
6] = 0.568, p < .762).
Discussion
The first hypothesis predicted visuospatial impairments in the left visual field in individuals with depression, reflected as a bias to the right visual field. A statistically significant difference of lateralized attention in patients versus controls, however, was not established. Our second hypothesis predicted a relationship between sad mood, alertness and a left visuospatial attention deficit in depressive patients. Our data supported the view that alertness deficits in depression promote visuospatial impairment in the left hemifield, reflected as a rightward bias of spatial attention, whereas sad mood showed a trend in the same direction. The influence of alertness on visuospatial attention was hypothesized, based on the model of a combined network of alertness and visuospatial attention [
15,
16]. Moreover, the effect of mood - although weak - also supports the hypothesis that sadness inhibits visuospatial attention processing in the right hemisphere and therefore favours left visual field impairment [
3].
Our patient sample yielded a trend towards left-sided visuospatial deficits, seen as positive values in the number of omissions in two of the three neglect tests (i.e., an attention bias towards the right visual field). Since reaction times revealed no group difference concerning the visual field bias in all three tests, speed-accuracy trade-off could not account for different tendencies in omission scores. Moreover, reaction times must be considered as possible confounds of alertness differences in both groups and should therefore not be interpreted with regard to our hypotheses.
There are, indeed, several reasons that may explain the absence of stronger (and significant) cognitive deficits in the group as a whole. In the present study, mean treatment duration of the patients was longer than two months at testing time. Cognitive disturbances thus may have been reduced by antidepressant medication. When testing acutely depressed patients, a different cognitive profile may be expected. Grant and co-workers administered a neuropsychological test battery to a group of unmedicated middle-aged mildly depressed patients and showed that reaction time was positively correlated to illness severity and that there was a moderate relationship of illness severity and performance deficit in attention shifting [
31]. As our sample comprised mildly to moderate depressed patients, low illness severity may explain the lack of significant differences between depressive patients and healthy controls.
Concerning arousal, whereas depression is commonly associated with low arousal, anxiety is associated with high arousal. On the neural level, the right posterior region is hypothesized to exhibit lower activation in depression and higher activation in anxiety [
11]. According to the spatial attention network model, these different levels of arousal may influence anterior regions in the same way [
16]. Comorbid anxiety in depression may therefore abolish the low arousal and lead to increased activity in the attention network. The fact that depressive patients scored significantly higher in state and trait anxiety than our healthy subjects may have contributed to the relative high values of arousal and consequently may have prevented observing a more pronounced visuospatial attention deficit in the current sample.
Omission scores on the TAP Neglect subtest were predicted by alertness. In the WAF Extinction-Neglect subtest, alertness and sad mood influenced omission scores at a trend-level. Using three different tests and a conservative correction for multiple testing reduced the statistical power in the current study. Furthermore, we noted a degree of variability across the tests.
It has to be taken into account that different visuospatial attention measures differ in sensitivity and recruitment of processing resources. Reviewing several studies on cognitive impairment in depression, Levin and colleagues concluded that the problems arise from using a different strategy in the allocation of resources [
32]. In the present study, this finding may be reflected by a more rightward attention bias in the TAP Neglect and WAF Extinction-Neglect subtests in depressive patients. These two tests comprised a restriction for the time to answer a stimulus, whereas in TAP Visual Scanning the participant was instructed to answer as fast as possible but nevertheless stimulus set changed with the participants' button press. More time could be taken to scan the stimulus set and thus less processing resources may have been needed.
The leftward bias in control subjects observed in two of the three neglect tests may reflect a phenomenon termed pseudoneglect, originally investigated in line bisection tasks and inducing a leftward bias in neurologically healthy subjects. This effect seems to be substantially dependent on the scanning strategy (left-to-right or right-to-left) [
33], and could thereby be another explanation for the leftward bias of depressive patients in the visual scanning task, where a left-to-right scanning strategy is part of the task. The cognitive control of attention distribution is also an important factor in the rehabilitation of visuospatial neglect in stroke patients [
34,
35]. Accordingly, the use of a left-to-right scanning strategy in the subtest TAP Visual Scanning may explain the absence of a comparable trend to a rightward bias seen in the other two tests in depressive patients.
The rather small effect of sad mood on the attention bias may be explained by the restricted validity of the sad mood item of the BDI. When considering the complete BDI score - a well established measure of depressiveness - a stronger effect concerning the relation of attention and depressiveness may have occurred. In our hypothesis, however, we emphasized the influence of sad mood on alertness and spatial attention deficits. Depressiveness includes a wide range of symptoms, including feelings of guilt, reduced drive and suicidal thoughts, thus not only negative emotion as relevant for our hypothesis. A questionnaire measuring negative emotions such as the Positive and Negative Affect Schedule (PANAS) [
36] may be a more useful tool in future studies to investigate the influence of negative emotion on cognitive functioning in depressive disorder.
Conclusions
In our sample, depressive patients did not show significant spatial attention deficits in the left visual field as compared to controls. However, we confirmed the hypothesis that alertness deficits and at a trend level subjectively experienced sadness in depression enhanced a rightward bias of spatial attention. We suggest that reduced alertness is a mechanism that can lead to visuospatial impairments in depression. Stimulus-driven spatial attention tasks seem to be more suitable for the analysis of visuospatial impairments in depressive patients as compared to tasks involving strategy use. Since cognitive deficits, particularly attention impairments, can substantially reduce quality of life, future studies should also investigate impaired attention and the underlying mechanisms in psychiatric disorders. Importantly, the interaction between attention mechanisms and disturbed emotions requires further analysis.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
LS participated in setting up the design, collected the data, conducted statistical analysis and drafted the manuscript. MS participated in data collection and helped to draft the manuscript. WS set up the design, participated in statistical analysis and helped to draft the manuscript. KM set up the design, participated in statistical analysis and helped to draft the manuscript. All authors read and approved the final manuscript.