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Erschienen in: Metabolic Brain Disease 1/2019

04.10.2018 | Review Article

Alkaline phosphatase: a potential biomarker for stroke and implications for treatment

verfasst von: Allison L. Brichacek, Candice M. Brown

Erschienen in: Metabolic Brain Disease | Ausgabe 1/2019

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Abstract

Stroke is the fifth leading cause of death in the U.S., with more than 100,000 deaths annually. There are a multitude of risks associated with stroke, including aging, cardiovascular disease, hypertension, Alzheimer’s disease (AD), and immune suppression. One of the many challenges, which has so far proven to be unsuccessful, is the identification of a cost-effective diagnostic or prognostic biomarker for stroke. Alkaline phosphatase (AP), an enzyme first discovered in the 1920s, has been evaluated as a potential biomarker in many disorders, including many of the co-morbidities associated with stroke. This review will examine the basic biology of AP, and its most common isoenzyme, tissue nonspecific alkaline phosphatase (TNAP), with a specific focus on the central nervous system. It examines the preclinical and clinical evidence which supports a potential role for AP in stroke and suggests potential mechanism(s) of action for AP isoenzymes in stroke. Lastly, the review speculates on the clinical utility of AP isoenzymes as potential blood biomarkers for stroke or as AP-targeted treatments for stroke patients.
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Metadaten
Titel
Alkaline phosphatase: a potential biomarker for stroke and implications for treatment
verfasst von
Allison L. Brichacek
Candice M. Brown
Publikationsdatum
04.10.2018
Verlag
Springer US
Erschienen in
Metabolic Brain Disease / Ausgabe 1/2019
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI
https://doi.org/10.1007/s11011-018-0322-3

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