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Current Allergy and Asthma Reports

Erschienen in:

01.07.2020 | Rhinosinusitis (J Mullol, Section Editor)

Allergen Immunotherapy for Local Respiratory Allergy

verfasst von: I. Eguiluz-Gracia, A. Ariza, A. Testera-Montes, C. Rondón, P. Campo

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 7/2020

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Abstract

Purpose of Reviesw

Local respiratory allergy (LRA) is an eosinophilic phenotype of chronic airway disease. Three entities have been described within the LRA spectrum: local allergic rhinitis (LAR) and local allergic asthma (LAA) in non-atopic patients, and dual allergic rhinitis (DAR) in atopic patients (coexistence of LAR and allergic rhinitis). In this article, we aim to review the current evidence on the therapeutic options for LRA.

Recent Findings

No controlled study has assessed the effect of standard therapy (oral antihistamines, intranasal or inhaled corticosteroids, bronchodilators) in LRA subjects. Three randomized clinical trials and one observational study demonstrated that allergen immunotherapy (AIT) is able to control nasal and ocular symptoms, decrease the need for rescue medication, and improve quality of life in LAR individuals.

Summary

Nasal or inhaled steroids can be expected to improve eosinophilic inflammation in LRA patients but cannot change the natural course of the disease. Moreover, the long-term and disease-modifying effects of AIT in LRA subjects need to be investigated.

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Titel: Allergen Immunotherapy for Local Respiratory Allergy
verfasst von: I. Eguiluz-Gracia
A. Ariza
A. Testera-Montes
C. Rondón
P. Campo
Publikationsdatum: 01.07.2020
Verlag: Springer US
Erschienen in: Current Allergy and Asthma Reports / Ausgabe 7/2020
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI: https://doi.org/10.1007/s11882-020-00920-w

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Allergen Immunotherapy for Local Respiratory Allergy

Abstract

Purpose of Reviesw

Recent Findings

Summary

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