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Erschienen in: ästhetische dermatologie & kosmetologie 5/2018

12.10.2018 | Alopezie | cme fortbildung

Ein Haarausfall mit vielen Facetten

Alopecia androgenetica der Frau

verfasst von: PD Dr. med. Gerhard Lutz

Erschienen in: ästhetische dermatologie & kosmetologie | Ausgabe 5/2018

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Zusammenfassung

Aufgrund der Vielgestaltigkeit der Ausfallsmuster und der zahlreichen möglichen Ursachen betrachten viele Ärzte Haarausfall bei Frauen als crux medicorum. Doch das Problem ist beherrschbar. Grundsätzlich ist zu unterscheiden, ob der Haarausfall durch hormonelle oder nicht hormonelle Ursachen bedingt ist und ob im Fall einer androgenetischen Alopezie eine manifeste Hyperandrogenämie oder nur eine erhöhte Sensitivität der Haarfollikel gegenüber Androgenen vorliegt.
Literatur
1.
Zurück zum Zitat Ludwig E. Classification of the types of androgenetic alopecia (common baldness) occurring in the female sex. Br J Dermatol 1977; 97: 247–54 CrossRef Ludwig E. Classification of the types of androgenetic alopecia (common baldness) occurring in the female sex. Br J Dermatol 1977; 97: 247–54 CrossRef
2.
Zurück zum Zitat Rojhirunsakool S, Suchonwanit P. Parietal scalp is another affected area in female pattern hair loss: an analysis of hair density and hair diameter. Clin Cosmet Investig Dermatol 2017; 11: 7–12 CrossRef Rojhirunsakool S, Suchonwanit P. Parietal scalp is another affected area in female pattern hair loss: an analysis of hair density and hair diameter. Clin Cosmet Investig Dermatol 2017; 11: 7–12 CrossRef
3.
Zurück zum Zitat Harries M et al. Towards a consensus on how to diagnose and quantify female pattern hair loss — The ‚Female Pattern Hair Loss Severity Index (FPHL-SI)‘. J Eur Acad Dermatol Venereol 2016; 30: 667–76 CrossRef Harries M et al. Towards a consensus on how to diagnose and quantify female pattern hair loss — The ‚Female Pattern Hair Loss Severity Index (FPHL-SI)‘. J Eur Acad Dermatol Venereol 2016; 30: 667–76 CrossRef
4.
Zurück zum Zitat Hamilton JB. Patterned loss of hair in man; types and incidence. Ann N Y Acad Sci 1951; 53: 708–28 CrossRef Hamilton JB. Patterned loss of hair in man; types and incidence. Ann N Y Acad Sci 1951; 53: 708–28 CrossRef
5.
Zurück zum Zitat Norwood OT. Male pattern baldness: classification and incidence. South Med J 1975; 68: 1359–65 CrossRef Norwood OT. Male pattern baldness: classification and incidence. South Med J 1975; 68: 1359–65 CrossRef
6.
Zurück zum Zitat Thigpen AE et al. Tissue distribution and ontogeny of steroid 5 alpha-reductase isozyme expression. J Clin Invest 1993; 92: 903–10 CrossRef Thigpen AE et al. Tissue distribution and ontogeny of steroid 5 alpha-reductase isozyme expression. J Clin Invest 1993; 92: 903–10 CrossRef
7.
Zurück zum Zitat Whigley et al. Natural mutagenesis study of the human steroid 5-alpha-reductase 2 isozyme. Biochemistry 1994; 33: 1265–70 CrossRef Whigley et al. Natural mutagenesis study of the human steroid 5-alpha-reductase 2 isozyme. Biochemistry 1994; 33: 1265–70 CrossRef
8.
Zurück zum Zitat Lutz G. Alopecia androgenetica des Mannes — Status Quo. Der Deutsche Dermatologe 2002; 5: 324–33 Lutz G. Alopecia androgenetica des Mannes — Status Quo. Der Deutsche Dermatologe 2002; 5: 324–33
9.
Zurück zum Zitat Sawaya ME, Price VH. Different levels of 5-alpha-reductase type I and II, aromatase, and androgen receptor in hair follicles of women and men with androgenetic alopecia. J Invest Dermatol 1997; 109: 296–300 CrossRef Sawaya ME, Price VH. Different levels of 5-alpha-reductase type I and II, aromatase, and androgen receptor in hair follicles of women and men with androgenetic alopecia. J Invest Dermatol 1997; 109: 296–300 CrossRef
10.
Zurück zum Zitat Redler S et al. Selected variants of the steroid-5-alpha-reductase isoforms SRD5A1 and SRD5A2 and the sex steroid hormone receptors ESR1, ESR2 and PGR: no association with female pattern hair loss identified. Exp Dermatol 2012; 21: 390–3 CrossRef Redler S et al. Selected variants of the steroid-5-alpha-reductase isoforms SRD5A1 and SRD5A2 and the sex steroid hormone receptors ESR1, ESR2 and PGR: no association with female pattern hair loss identified. Exp Dermatol 2012; 21: 390–3 CrossRef
11.
Zurück zum Zitat Messenger AG, Sinclair R. Follicular miniaturization in female pattern hair loss: clinicopathological correlations. Br J Dermatol 2006; 155: 926–30 CrossRef Messenger AG, Sinclair R. Follicular miniaturization in female pattern hair loss: clinicopathological correlations. Br J Dermatol 2006; 155: 926–30 CrossRef
12.
Zurück zum Zitat Price VH. Androgenetic alopecia in women. J Investig Dermatol Symp Proc 2003; 8: 24–7 CrossRef Price VH. Androgenetic alopecia in women. J Investig Dermatol Symp Proc 2003; 8: 24–7 CrossRef
13.
Zurück zum Zitat Adachi K, Kano M. Adenyl cyclase in human hair follicles. Its inhibition by dihydrotestosterone. Biochem Biophys Res Commun 1970; 41: 884–90 CrossRef Adachi K, Kano M. Adenyl cyclase in human hair follicles. Its inhibition by dihydrotestosterone. Biochem Biophys Res Commun 1970; 41: 884–90 CrossRef
14.
Zurück zum Zitat Riedel-Baima B, Riedel A. Female pattern hair loss may be triggered by low oestrogen to androgen ratio. Endocr Regul 2008; 42: 13–6 PubMed Riedel-Baima B, Riedel A. Female pattern hair loss may be triggered by low oestrogen to androgen ratio. Endocr Regul 2008; 42: 13–6 PubMed
15.
Zurück zum Zitat Skalnaya MG, Tkachev VP. Trace elements content and hormonal profiles in women with androgenetic alopecia. J Trace Elem Med Biol 2011; 25 Suppl 1: 50–3 CrossRef Skalnaya MG, Tkachev VP. Trace elements content and hormonal profiles in women with androgenetic alopecia. J Trace Elem Med Biol 2011; 25 Suppl 1: 50–3 CrossRef
16.
Zurück zum Zitat Urysiak-Czubatka I et al. Assessment of the usefulness of dihydrotestosterone in the diagnostics of patients with androgenetic alopecia. Postepy Dermatol Alergol 2014; 31: 207–15 CrossRef Urysiak-Czubatka I et al. Assessment of the usefulness of dihydrotestosterone in the diagnostics of patients with androgenetic alopecia. Postepy Dermatol Alergol 2014; 31: 207–15 CrossRef
17.
Zurück zum Zitat Lutz G. Hair loss and hyperprolactinemia in women. Dermatoendocrinol 2012; 4: 65–71 CrossRef Lutz G. Hair loss and hyperprolactinemia in women. Dermatoendocrinol 2012; 4: 65–71 CrossRef
18.
Zurück zum Zitat Lutz G. Drug- induced hair loss. In: Dyall-Smith D, Marks R (eds.), Dermatology at the Millenium. The Proceedings of the 19th World Congress of Dermatology, Sydney, Australia, June 15–20, The Parthenon Publishing Group Ltd, New York, Carnforth 1999; 706–10 Lutz G. Drug- induced hair loss. In: Dyall-Smith D, Marks R (eds.), Dermatology at the Millenium. The Proceedings of the 19th World Congress of Dermatology, Sydney, Australia, June 15–20, The Parthenon Publishing Group Ltd, New York, Carnforth 1999; 706–10
19.
20.
Zurück zum Zitat Hillmer AM et al. Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopecia. Am J Hum Genet 2005; 77: 140–8 CrossRef Hillmer AM et al. Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopecia. Am J Hum Genet 2005; 77: 140–8 CrossRef
21.
Zurück zum Zitat Brent JR et al. Male-pattern baldness susceptibility locus at 20p11. Nat Genet 2008; 40: 1282–4 CrossRef Brent JR et al. Male-pattern baldness susceptibility locus at 20p11. Nat Genet 2008; 40: 1282–4 CrossRef
22.
Zurück zum Zitat Brockschmidt FF et al. Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases. Fine mapping of the human AR/EDA2R locus in androgenetic alopecia. PLoS Genet 2012; May; 8(5): e1002746 CrossRef Brockschmidt FF et al. Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases. Fine mapping of the human AR/EDA2R locus in androgenetic alopecia. PLoS Genet 2012; May; 8(5): e1002746 CrossRef
23.
Zurück zum Zitat Redler S et al. Investigation of variants of the aromatase gene (CYP19A1) in female pattern hair loss. Br J Dermatol 2011; 165: 703–5 CrossRef Redler S et al. Investigation of variants of the aromatase gene (CYP19A1) in female pattern hair loss. Br J Dermatol 2011; 165: 703–5 CrossRef
24.
Zurück zum Zitat Redler S et al. Investigation of the male pattern baldness major genetic susceptibility loci AR/EDA2R and 20p11 in women with female pattern hair loss. Br J Dermatol 2012; 166: 1314–8 CrossRef Redler S et al. Investigation of the male pattern baldness major genetic susceptibility loci AR/EDA2R and 20p11 in women with female pattern hair loss. Br J Dermatol 2012; 166: 1314–8 CrossRef
25.
Zurück zum Zitat Redler S et al. Investigation of six novel susceptibility loci for male androgenetic alopecia in women with female pattern hair loss. J Dermatol Sci 2013; 72: 186–8 CrossRef Redler S et al. Investigation of six novel susceptibility loci for male androgenetic alopecia in women with female pattern hair loss. J Dermatol Sci 2013; 72: 186–8 CrossRef
26.
Zurück zum Zitat Yip L et al. Gene-wide association study between the aromatase gene (CYP19A1) and female pattern hair loss. Br J Dermatol 2009; 161: 289–94 CrossRef Yip L et al. Gene-wide association study between the aromatase gene (CYP19A1) and female pattern hair loss. Br J Dermatol 2009; 161: 289–94 CrossRef
27.
Zurück zum Zitat Mahmoudi H et al. Selected variants of the melanocortin 4 receptor gene (MC4R) do not confer susceptibility to female pattern hair Loss. Arch Dermatol Res 2013; 305: 249–53 CrossRef Mahmoudi H et al. Selected variants of the melanocortin 4 receptor gene (MC4R) do not confer susceptibility to female pattern hair Loss. Arch Dermatol Res 2013; 305: 249–53 CrossRef
28.
Zurück zum Zitat Yip L et al. (2012) Association analysis of estrogen receptor beta gene (ESR2) polymorphism with female pattern hair loss. Br J Dermatol 2012; 166: 1131–4 CrossRef Yip L et al. (2012) Association analysis of estrogen receptor beta gene (ESR2) polymorphism with female pattern hair loss. Br J Dermatol 2012; 166: 1131–4 CrossRef
29.
Zurück zum Zitat Lutz G. Das Trichogramm — Indikation, Durchführung und Interpretation. Der Deutsche Dermatologe 2001; 4: 254–61 Lutz G. Das Trichogramm — Indikation, Durchführung und Interpretation. Der Deutsche Dermatologe 2001; 4: 254–61
30.
Zurück zum Zitat Hoffmann R. TrichoScan: Combining epiluminescence microscopy with digital image analysis for the measurement of hair growth in vivo. Eur J Dermatol 2001; 11: 362–8 PubMed Hoffmann R. TrichoScan: Combining epiluminescence microscopy with digital image analysis for the measurement of hair growth in vivo. Eur J Dermatol 2001; 11: 362–8 PubMed
31.
Zurück zum Zitat van Neste DJ. Hair growth evaluation in clinical dermatology. Dermatology 1993; 187: 233–4 CrossRef van Neste DJ. Hair growth evaluation in clinical dermatology. Dermatology 1993; 187: 233–4 CrossRef
32.
Zurück zum Zitat Canfield D. Photographic documentation of hair growth in androgenetic alopecia. Dermatol Clin 1996; 14: 713–21 CrossRef Canfield D. Photographic documentation of hair growth in androgenetic alopecia. Dermatol Clin 1996; 14: 713–21 CrossRef
33.
Zurück zum Zitat Blumeyer A et al. Evidence-based (S3) guideline for the treatment of androgenetic alopecia in women and in men. J Dtsch Dermatol Ges 2011; 9 Suppl 6: 1–57 CrossRef Blumeyer A et al. Evidence-based (S3) guideline for the treatment of androgenetic alopecia in women and in men. J Dtsch Dermatol Ges 2011; 9 Suppl 6: 1–57 CrossRef
34.
Zurück zum Zitat Adil A, Godwin M. The effectiveness of treatments for androgenetic alopecia: A systematic review and meta-analysis. J Am Acad Dermatol 2017; 77: 136–41 CrossRef Adil A, Godwin M. The effectiveness of treatments for androgenetic alopecia: A systematic review and meta-analysis. J Am Acad Dermatol 2017; 77: 136–41 CrossRef
35.
Zurück zum Zitat Lachgar S et al. Minoxidil upregulates the expression of vascular endothelial growth factor in human hair dermal papilla cells. Br J Dermaltol 1998; 138: 407–11 CrossRef Lachgar S et al. Minoxidil upregulates the expression of vascular endothelial growth factor in human hair dermal papilla cells. Br J Dermaltol 1998; 138: 407–11 CrossRef
36.
Zurück zum Zitat Blume-Peytavi U et al. Efficacy and Safety of Once-Daily Minoxidil Foam 5% Versus Twice-Daily Minoxidil Solution 2% in Female Pattern Hair Loss: A Phase III, Randomized, Investigator-Blinded Study. J Drugs Dermatol 2016; 15: 883–9 PubMed Blume-Peytavi U et al. Efficacy and Safety of Once-Daily Minoxidil Foam 5% Versus Twice-Daily Minoxidil Solution 2% in Female Pattern Hair Loss: A Phase III, Randomized, Investigator-Blinded Study. J Drugs Dermatol 2016; 15: 883–9 PubMed
37.
Zurück zum Zitat Bergfeld W et al. A Phase III, Multicenter, Parallel-Design Clinical Trial to Compare the Efficacy and Safety of 5% Minoxidil Foam Versus Vehicle in Women With Female Pattern Hair Loss. J Drugs Dermatol 2016; 15: 874–81 PubMed Bergfeld W et al. A Phase III, Multicenter, Parallel-Design Clinical Trial to Compare the Efficacy and Safety of 5% Minoxidil Foam Versus Vehicle in Women With Female Pattern Hair Loss. J Drugs Dermatol 2016; 15: 874–81 PubMed
38.
Zurück zum Zitat Price VH et al. Changes in hair weight and hair count in men with androgenetic alopecia, after application of 5% and 2% topical minoxidil, placebo, or no treatment. J Am Acad Dermatol 1999; 41: 717–21 CrossRef Price VH et al. Changes in hair weight and hair count in men with androgenetic alopecia, after application of 5% and 2% topical minoxidil, placebo, or no treatment. J Am Acad Dermatol 1999; 41: 717–21 CrossRef
39.
Zurück zum Zitat Mc Coy et al. Minoxidil dose response study in female pattern hair loss patients determined to be non-responders to 5% topical minoxidil. J Biol Regul Homeost Agents 2016; 30: 1153–5 Mc Coy et al. Minoxidil dose response study in female pattern hair loss patients determined to be non-responders to 5% topical minoxidil. J Biol Regul Homeost Agents 2016; 30: 1153–5
40.
Zurück zum Zitat Orfanos CE, Vogels L. Lokaltherapie der Alopecia androgenetica mit 17 α-Estradiol-Östradiol. Dermatologica 1980; 161: 124–32 CrossRef Orfanos CE, Vogels L. Lokaltherapie der Alopecia androgenetica mit 17 α-Estradiol-Östradiol. Dermatologica 1980; 161: 124–32 CrossRef
41.
Zurück zum Zitat Wozel G et al. Alfatradiol (0,025%) — Eine wirksame und sichere Therapieoption zur Behandlung der androgenetischen Alopezie bei Frauen und Männern. Akt Dermatol 2005; 31: 549–52 CrossRef Wozel G et al. Alfatradiol (0,025%) — Eine wirksame und sichere Therapieoption zur Behandlung der androgenetischen Alopezie bei Frauen und Männern. Akt Dermatol 2005; 31: 549–52 CrossRef
42.
Zurück zum Zitat Kim HJ et al. The Efficacy and Savety of 17 α-Estradiol (Ell-Cranell®)alpha 0,025%) Solution on Female Pattern Hair Loss: Single Center, Open-Label, Non-Comporative, Phase IV Study. Ann Dermatol 2012; 24: 295–305 CrossRef Kim HJ et al. The Efficacy and Savety of 17 α-Estradiol (Ell-Cranell®)alpha 0,025%) Solution on Female Pattern Hair Loss: Single Center, Open-Label, Non-Comporative, Phase IV Study. Ann Dermatol 2012; 24: 295–305 CrossRef
43.
Zurück zum Zitat Schriefers H et al. Hemmung des Testosteronstoffwechsel durch 17 α-Estradiol in Rattenleberschnitten. Arzneimittelforschung/Drug Res 1991; 41: 1186–9 Schriefers H et al. Hemmung des Testosteronstoffwechsel durch 17 α-Estradiol in Rattenleberschnitten. Arzneimittelforschung/Drug Res 1991; 41: 1186–9
44.
Zurück zum Zitat Hoffmann R et al. 17alpha-estradiol induces aromatase activity in intact human anagen hair follicles ex vivo. Exp Dermatol 2002; 11: 376–80 CrossRef Hoffmann R et al. 17alpha-estradiol induces aromatase activity in intact human anagen hair follicles ex vivo. Exp Dermatol 2002; 11: 376–80 CrossRef
45.
Zurück zum Zitat Georgala S et al. Topical Estrogen Therapy for Androgenetic Alopecia in Menopausal Females. Dermatology 2004; 208: 178–9 CrossRef Georgala S et al. Topical Estrogen Therapy for Androgenetic Alopecia in Menopausal Females. Dermatology 2004; 208: 178–9 CrossRef
46.
Zurück zum Zitat Abadjieva TI. Treatment of androgenetic alopecia in females in reproductive age with topical estradiolbenzoate, prednisolon and salicylic acid. Folia Med (Plovdiv) 2000; 42: 26–9 Abadjieva TI. Treatment of androgenetic alopecia in females in reproductive age with topical estradiolbenzoate, prednisolon and salicylic acid. Folia Med (Plovdiv) 2000; 42: 26–9
47.
Zurück zum Zitat Emons G et al. Postmenopausal bleeding following the application of an estrogen-containing hair lotion — concomitant endocrine changes. Geburtshilfe Frauenheilkd 1984; 460–2 Emons G et al. Postmenopausal bleeding following the application of an estrogen-containing hair lotion — concomitant endocrine changes. Geburtshilfe Frauenheilkd 1984; 460–2
48.
Zurück zum Zitat Choe SJ et al. Therapeutic Efficacy of a Combination Therapy of Topical 17α-Estradiol and Topical Minoxidil on Female Pattern Hair Loss: A Noncomparative, Retrospective Evaluation. Ann Dermatol 2017; 29: 276–82 CrossRef Choe SJ et al. Therapeutic Efficacy of a Combination Therapy of Topical 17α-Estradiol and Topical Minoxidil on Female Pattern Hair Loss: A Noncomparative, Retrospective Evaluation. Ann Dermatol 2017; 29: 276–82 CrossRef
49.
Zurück zum Zitat Gassmueller J et al. Topical fulvestrant solution has no effect on male and postmenopausal female androgenetic alopecia: results from two randomized, proof-of-concept studies. Br J Dermatol 2008; 158:109–15 PubMed Gassmueller J et al. Topical fulvestrant solution has no effect on male and postmenopausal female androgenetic alopecia: results from two randomized, proof-of-concept studies. Br J Dermatol 2008; 158:109–15 PubMed
50.
Zurück zum Zitat Emer J et al. Novel treatment of female-pattern androgenetic alopecia with injected bimatoprost 0.03% solution. Drugs Dermatol 2011; 10: 795–8 Emer J et al. Novel treatment of female-pattern androgenetic alopecia with injected bimatoprost 0.03% solution. Drugs Dermatol 2011; 10: 795–8
52.
Zurück zum Zitat Cohen JL. Enhancing the growth of natural eyelashes: the mechanism of bimatoprost-induced eyelash growth. Dermatol Surg 2010; 36: 1361–71 CrossRef Cohen JL. Enhancing the growth of natural eyelashes: the mechanism of bimatoprost-induced eyelash growth. Dermatol Surg 2010; 36: 1361–71 CrossRef
53.
Zurück zum Zitat Wester ST et al. Eyelash growth from application of bimatoprost in gel suspension to the base of the yelashes. Ophthalmology 2010; 117: 1024–31 CrossRef Wester ST et al. Eyelash growth from application of bimatoprost in gel suspension to the base of the yelashes. Ophthalmology 2010; 117: 1024–31 CrossRef
54.
Zurück zum Zitat Legro RS et al. Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline. In: The Journal of clinical endocrinology and metabolism. 2013, Bd 98, 12: 4565–92 CrossRef Legro RS et al. Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline. In: The Journal of clinical endocrinology and metabolism. 2013, Bd 98, 12: 4565–92 CrossRef
55.
Zurück zum Zitat Dadachanji R et al. Genetic Variants Associated with Hyperandrogenemia in PCOS Pathophysiology. Genet Res Int 2018; 2018: 7624932 PubMedPubMedCentral Dadachanji R et al. Genetic Variants Associated with Hyperandrogenemia in PCOS Pathophysiology. Genet Res Int 2018; 2018: 7624932 PubMedPubMedCentral
56.
Zurück zum Zitat Orfanos CE et al. „The SAHA syndrome“. Horm Res 2000; 54: 251–8 PubMed Orfanos CE et al. „The SAHA syndrome“. Horm Res 2000; 54: 251–8 PubMed
57.
Zurück zum Zitat Simard J et al. Characteristics of interaction of the antiandrogen flutamide with the androgen receptor in various target tissues. Mol Cell Endocrinol 1986; 44: 261–70 CrossRef Simard J et al. Characteristics of interaction of the antiandrogen flutamide with the androgen receptor in various target tissues. Mol Cell Endocrinol 1986; 44: 261–70 CrossRef
58.
Zurück zum Zitat Carmina E, Lobo RA. Treatment of hyperandrogenic alopecia in women. Fertil Steril 2003; 79: 91–5 CrossRef Carmina E, Lobo RA. Treatment of hyperandrogenic alopecia in women. Fertil Steril 2003; 79: 91–5 CrossRef
59.
Zurück zum Zitat Yazdabadi A, Sinclair R. Treatment of female pattern hair loss with the androgen receptor antagonist flutamide. Australas J Dermatol 2011; 52: 132–34 CrossRef Yazdabadi A, Sinclair R. Treatment of female pattern hair loss with the androgen receptor antagonist flutamide. Australas J Dermatol 2011; 52: 132–34 CrossRef
60.
Zurück zum Zitat Paradisi R et al. Prospective cohort study on the effects and tolerability of flutamide in patients with female pattern hair loss. Ann Pharmacother 2011; 45: 469–75 CrossRef Paradisi R et al. Prospective cohort study on the effects and tolerability of flutamide in patients with female pattern hair loss. Ann Pharmacother 2011; 45: 469–75 CrossRef
61.
Zurück zum Zitat Spinucci G, Pasquali R. Finasteride: a new drug for the treatment of male hirsutism and androgenetic alopecia? Clin Ter 1996; 147: 305–15 PubMed Spinucci G, Pasquali R. Finasteride: a new drug for the treatment of male hirsutism and androgenetic alopecia? Clin Ter 1996; 147: 305–15 PubMed
62.
Zurück zum Zitat Trueb RM. Finasteride treatment of patterned hair loss in normoandrogenic postmenopausal women. Dermatology 2004; 209: 202–7 CrossRef Trueb RM. Finasteride treatment of patterned hair loss in normoandrogenic postmenopausal women. Dermatology 2004; 209: 202–7 CrossRef
63.
Zurück zum Zitat Iorizzo M et al. Finasteride treatment of female pattern hair loss. Arch Dermatol 2006; 142: 298–302 CrossRef Iorizzo M et al. Finasteride treatment of female pattern hair loss. Arch Dermatol 2006; 142: 298–302 CrossRef
64.
Zurück zum Zitat Camacho-Martinez FM. Hair loss in women. Semin Cutan Med Surg 2009; 28: 19–32 CrossRef Camacho-Martinez FM. Hair loss in women. Semin Cutan Med Surg 2009; 28: 19–32 CrossRef
65.
Zurück zum Zitat Price VH et al. Lack of efficacy of finasteride in postmenopausal women with androgenetic alopecia. J Am Acad Dermatol 2000; 43: 768–76. CrossRef Price VH et al. Lack of efficacy of finasteride in postmenopausal women with androgenetic alopecia. J Am Acad Dermatol 2000; 43: 768–76. CrossRef
66.
Zurück zum Zitat Lee SW et al. A Systematic Review of Topical Finasteride in the Treatment of Androgenetic Alopecia in Men and Women. J Drugs Dermatol 2018; 17: 457–63 PubMed Lee SW et al. A Systematic Review of Topical Finasteride in the Treatment of Androgenetic Alopecia in Men and Women. J Drugs Dermatol 2018; 17: 457–63 PubMed
67.
Zurück zum Zitat Olszewska M, Rudnicka L. Effective treatment of female androgenic alopecia with dutasteride. J Drugs Dermatol 2005; 4: 637–40. PubMed Olszewska M, Rudnicka L. Effective treatment of female androgenic alopecia with dutasteride. J Drugs Dermatol 2005; 4: 637–40. PubMed
68.
Zurück zum Zitat Moftah N et al. Mesotherapy using dutasteride-containing preparation in treatment of female pattern hair loss: photographic, morphometric and ultrustructural evaluation. J Eur Acad Dermatol Venereol 2013; 27: 686–93 CrossRef Moftah N et al. Mesotherapy using dutasteride-containing preparation in treatment of female pattern hair loss: photographic, morphometric and ultrustructural evaluation. J Eur Acad Dermatol Venereol 2013; 27: 686–93 CrossRef
69.
Zurück zum Zitat Wolff H et al. Diagnostik und Therapie von Haar- und Kopfhauterkrankungen. Dtsch Arztebl 2016; 113: 377–86. Wolff H et al. Diagnostik und Therapie von Haar- und Kopfhauterkrankungen. Dtsch Arztebl 2016; 113: 377–86.
70.
Zurück zum Zitat Seale LR et al. Side Effects Related to 5α-Reductase Inhibitor Treatment of Hair Loss in Women: A Review. J Drugs Dermatol 2016; 15: 414–9 PubMed Seale LR et al. Side Effects Related to 5α-Reductase Inhibitor Treatment of Hair Loss in Women: A Review. J Drugs Dermatol 2016; 15: 414–9 PubMed
71.
Zurück zum Zitat Roque LV et al. Design of Finasteride-Loaded Nanoparticles for Potential Treatment of Alopecia. Skin Pharmacol Physiol 2017; 30: 197–204 CrossRef Roque LV et al. Design of Finasteride-Loaded Nanoparticles for Potential Treatment of Alopecia. Skin Pharmacol Physiol 2017; 30: 197–204 CrossRef
72.
Zurück zum Zitat Vexiau P et al. Effects of minoxidil 2 % vs. cyproterone acetate treatment on female androgenetic alopecia: a controlled, 12 month randomized trial. Br J Dermatol 2002; 146: 992–9 CrossRef Vexiau P et al. Effects of minoxidil 2 % vs. cyproterone acetate treatment on female androgenetic alopecia: a controlled, 12 month randomized trial. Br J Dermatol 2002; 146: 992–9 CrossRef
73.
Zurück zum Zitat Santos Z et al. Drug discovery for alopecia: gone today, hair tomorrow. Expert Opin Drug Discov 2015; 10: 269–92 CrossRef Santos Z et al. Drug discovery for alopecia: gone today, hair tomorrow. Expert Opin Drug Discov 2015; 10: 269–92 CrossRef
74.
Zurück zum Zitat Conrad F et al. Substantial sex-dependent differences in the response of human scalp hair follicles to estrogen stimulation in vitro advocate gender-tailored management of female versus male pattern balding. J Investig Dermatol Symp Proc 2005; 10: 243–6. CrossRef Conrad F et al. Substantial sex-dependent differences in the response of human scalp hair follicles to estrogen stimulation in vitro advocate gender-tailored management of female versus male pattern balding. J Investig Dermatol Symp Proc 2005; 10: 243–6. CrossRef
75.
Zurück zum Zitat Conrad F, Paus R. Estrogens and the hair follicle. J Dtsch Dermatol Ges 2004; 2: 412–23. CrossRef Conrad F, Paus R. Estrogens and the hair follicle. J Dtsch Dermatol Ges 2004; 2: 412–23. CrossRef
76.
Zurück zum Zitat Mirmirani P. Hormonal changes in menopause: do they contribute to a ‚midlife hair crisis‘ in women? Br J Dermatol 2011; 165 Suppl 3: 7–11 CrossRef Mirmirani P. Hormonal changes in menopause: do they contribute to a ‚midlife hair crisis‘ in women? Br J Dermatol 2011; 165 Suppl 3: 7–11 CrossRef
77.
Zurück zum Zitat Adenuga P et al. Hair regrowth in a male patient with extensive androgenetic alopecia on estrogen therapy. Am Acad Dermatol 2012; 67: 121–3 CrossRef Adenuga P et al. Hair regrowth in a male patient with extensive androgenetic alopecia on estrogen therapy. Am Acad Dermatol 2012; 67: 121–3 CrossRef
78.
Zurück zum Zitat Gabrilove JL, Luria M. Persistent gynecomastia resulting from scalp inuction of estradiol: a model for persisting gynecomastia. Arch Dermatol 1978; 114: 1672–3 CrossRef Gabrilove JL, Luria M. Persistent gynecomastia resulting from scalp inuction of estradiol: a model for persisting gynecomastia. Arch Dermatol 1978; 114: 1672–3 CrossRef
79.
Zurück zum Zitat Orfanos CE, Wüstner H. Penetration and side effects of local estrogen application in alopecia androgenetica. Hautarzt 1975; 26:367–9 PubMed Orfanos CE, Wüstner H. Penetration and side effects of local estrogen application in alopecia androgenetica. Hautarzt 1975; 26:367–9 PubMed
80.
Zurück zum Zitat Robbins C et al. What women want — quantifying the perception of hair amount: an analysis of hair diameter and density changes with age in caucasian women. Br J Dermatol 2012; 167: 324–32 CrossRef Robbins C et al. What women want — quantifying the perception of hair amount: an analysis of hair diameter and density changes with age in caucasian women. Br J Dermatol 2012; 167: 324–32 CrossRef
81.
Zurück zum Zitat Check JH, Cohen R. An update on the treatment of female alopecia and the introduction of a potential novel therapy. Clin Exp Obstet Gynecol 2015; 42: 411–5 PubMed Check JH, Cohen R. An update on the treatment of female alopecia and the introduction of a potential novel therapy. Clin Exp Obstet Gynecol 2015; 42: 411–5 PubMed
82.
Zurück zum Zitat Harfmann KL, Bechtel MA. Hair loss in women. Clin Obstet Gynecol 2015; 58:185–99 CrossRef Harfmann KL, Bechtel MA. Hair loss in women. Clin Obstet Gynecol 2015; 58:185–99 CrossRef
83.
Zurück zum Zitat Guida M et al. Review of the safety, efficacy and patient acceptability of the combined dienogest/estradiol valerate contraceptive pill. J Womens Health Int 2010; 2: 279–90 Guida M et al. Review of the safety, efficacy and patient acceptability of the combined dienogest/estradiol valerate contraceptive pill. J Womens Health Int 2010; 2: 279–90
84.
Zurück zum Zitat Kossard S. Postmenopausal frontal fibrosing alopecia. Scarring alopecia in a patter distribution. Arch Dermatol 1994; 130: 770–4 CrossRef Kossard S. Postmenopausal frontal fibrosing alopecia. Scarring alopecia in a patter distribution. Arch Dermatol 1994; 130: 770–4 CrossRef
85.
Zurück zum Zitat Kossard S et al. Postmenopausal frontal fibrosing alopecia: a frontal variant of lichen planopilaris. J Am Acad Dermatol 1997; 36: 59–66 CrossRef Kossard S et al. Postmenopausal frontal fibrosing alopecia: a frontal variant of lichen planopilaris. J Am Acad Dermatol 1997; 36: 59–66 CrossRef
86.
Zurück zum Zitat Lutz G, Löser C. Primäre vernarbende Alopezien. Der Deutsche Dermatologe 2015; 4: 294–300 CrossRef Lutz G, Löser C. Primäre vernarbende Alopezien. Der Deutsche Dermatologe 2015; 4: 294–300 CrossRef
87.
Zurück zum Zitat Kanti V et al. Vernarbende Alopezien. J Dtsch Dermatol Ges 2018; 4: 435–61 Kanti V et al. Vernarbende Alopezien. J Dtsch Dermatol Ges 2018; 4: 435–61
88.
Zurück zum Zitat Olsen EA et al. Iron deficiency in female pattern hair loss, chronic telogen effluvium, and control groups. J Am Acad Dermatol 2010; 63: 991–9 CrossRef Olsen EA et al. Iron deficiency in female pattern hair loss, chronic telogen effluvium, and control groups. J Am Acad Dermatol 2010; 63: 991–9 CrossRef
89.
Zurück zum Zitat Lutz G. Nutritive Haarwachstumsförderung mit Spurenelementen, Vitaminen und sekundären Pflanzenbegleitstoffen bei Frauen. Akt Dermatol 2012; 38: 199–205 CrossRef Lutz G. Nutritive Haarwachstumsförderung mit Spurenelementen, Vitaminen und sekundären Pflanzenbegleitstoffen bei Frauen. Akt Dermatol 2012; 38: 199–205 CrossRef
90.
Zurück zum Zitat Gerkowicz A et al. The Role of Vitamin D in Non-Scarring Alopecia. Int J Mol Sci 2017; Dec 7; 18(12). pii: E2653 CrossRef Gerkowicz A et al. The Role of Vitamin D in Non-Scarring Alopecia. Int J Mol Sci 2017; Dec 7; 18(12). pii: E2653 CrossRef
91.
Zurück zum Zitat Conic RRZ et al. Vitamin D Status in Scarring and Non-Scarring Alopecia. J Am Acad Dermatol 2018 Apr 21. pii: S0190–9622(18)30631–5 Conic RRZ et al. Vitamin D Status in Scarring and Non-Scarring Alopecia. J Am Acad Dermatol 2018 Apr 21. pii: S0190–9622(18)30631–5
92.
Zurück zum Zitat Halsner U. Eigenhaartransplantion — Punch Technik. Kosmet Med 2000; 21: 16–8 Halsner U. Eigenhaartransplantion — Punch Technik. Kosmet Med 2000; 21: 16–8
93.
Zurück zum Zitat Neidel G, Leonhardt K. Haartransplantation bei Frauen — eine normale Prozedur? derm 2004; 10: 1–6 Neidel G, Leonhardt K. Haartransplantation bei Frauen — eine normale Prozedur? derm 2004; 10: 1–6
94.
Zurück zum Zitat Unger RH. Female hair restoration. Facial Plast Surg Clin North Am 2013; 21: 407–17 CrossRef Unger RH. Female hair restoration. Facial Plast Surg Clin North Am 2013; 21: 407–17 CrossRef
95.
Zurück zum Zitat Sinclair R et al. Hair loss in women: medical and cosmetic approaches to increase scalp hair fullness. Br J Dermatol 2011; 165 Suppl 3: 12–8 CrossRef Sinclair R et al. Hair loss in women: medical and cosmetic approaches to increase scalp hair fullness. Br J Dermatol 2011; 165 Suppl 3: 12–8 CrossRef
Metadaten
Titel
Ein Haarausfall mit vielen Facetten
Alopecia androgenetica der Frau
verfasst von
PD Dr. med. Gerhard Lutz
Publikationsdatum
12.10.2018
Verlag
Springer Medizin
Erschienen in
ästhetische dermatologie & kosmetologie / Ausgabe 5/2018
Print ISSN: 1867-481X
Elektronische ISSN: 2198-6517
DOI
https://doi.org/10.1007/s12634-018-5562-z

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