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Current Neurology and Neuroscience Reports
Erschienen in: Current Neurology and Neuroscience Reports 6/2016

01.06.2016 | Genetics (V Bonifati, Section Editor)

ALS: Recent Developments from Genetics Studies

Erschienen in: Current Neurology and Neuroscience Reports | Ausgabe 6/2016

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Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal disorder that is characterized by a progressive degeneration of the upper and lower motor neurons. Most cases appear to be sporadic, but 5–10 % of cases have a family history of the disease. High-throughput DNA sequencing and related genomic capture tools are methodological advances which have rapidly contributed to an acceleration in the discovery of genetic risk factors for both familial and sporadic ALS. It is interesting to note that as the number of ALS genes grows, many of the proteins they encode are in shared intracellular processes. This review will summarize some of the recent advances and gene discovery made in ALS.
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Metadaten
Titel
ALS: Recent Developments from Genetics Studies
Publikationsdatum
01.06.2016
Erschienen in
Current Neurology and Neuroscience Reports / Ausgabe 6/2016
Print ISSN: 1528-4042
Elektronische ISSN: 1534-6293
DOI
https://doi.org/10.1007/s11910-016-0658-1

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The Risk of Sleep Disorder Among Persons with Mild Traumatic Brain Injury

Neurology of Systemic Diseases (J Biller, Section Editor)

Neurologic Complications in the Intensive Care Unit

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Kleine-Levin Syndrome

Neuro-Ophthalmology (A Kawasaki, Section Editor)

Progressive External Ophthalmoplegia

Critical Care (SA Mayer, Section Editor)

Brain Multimodality Monitoring: Updated Perspectives

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