Skip to main content
Erschienen in: Brain Structure and Function 9/2023

21.09.2023 | Original Article

Alterations in rat brain modular organization during unconsciousness are dependent on communication efficiency and metabolic cost

verfasst von: Siyang Li, Yali Chen, Peng Ren, Zhipeng Li, Jun Zhang, Xia Liang

Erschienen in: Brain Structure and Function | Ausgabe 9/2023

Einloggen, um Zugang zu erhalten

Abstract

Spontaneous brain activity exhibits a highly structured modular organization that varies across individuals and reconfigures over time. Although it has been proposed that brain organization is shaped by an economic trade-off between minimizing costs and facilitating efficient information transfer, it remains untested whether modular variability and its changes during unconscious conditions might be constrained by the economy of brain organization. We acquired functional MRI and FDG-PET in rats under three different levels of consciousness induced by propofol administration. We examined alterations in brain modular variability during loss of consciousness from mild sedation to deep anesthesia. We also investigated the relationships between modular variability with glucose metabolism and functional connectivity strength as well as their alterations during unconsciousness. We observed that modular variability increased during loss of consciousness. Critically, across-individual modular variability is oppositely associated with functional connectivity strength and cerebral metabolism, and with deepening dosage of anesthesia, becoming increasingly dependent on basal metabolism over functional connectivity. These results suggested that, propofol-induced unconsciousness may lead to brain modular reorganization, which are putatively shaped by re-negotiations between energetic resources and communication efficiency.
Literatur
Zurück zum Zitat Luppi, A. I., Mediano, P. A. M., Rosas, F. E., Allanson, J., Pickard, J. D., Carhart-Harris, R. L., Williams, G. B., Craig, M. M., Finoia, P., Owen, A. M., Naci, L., Menon, D. K., Bor, D., & Stamatakis, E. A. (2020). A synergistic workspace for human consciousness revealed by integrated information decomposition, doi: https://doi.org/10.1101/2020.11.25.398081 Luppi, A. I., Mediano, P. A. M., Rosas, F. E., Allanson, J., Pickard, J. D., Carhart-Harris, R. L., Williams, G. B., Craig, M. M., Finoia, P., Owen, A. M., Naci, L., Menon, D. K., Bor, D., & Stamatakis, E. A. (2020). A synergistic workspace for human consciousness revealed by integrated information decomposition, doi: https://​doi.​org/​10.​1101/​2020.​11.​25.​398081
Zurück zum Zitat Tavor I, Parker Jones O, Mars RB, Smith SM, Behrens TE, Jbabdi S (2016) Task-free MRI predicts individual differences in brain activity during task performance. Science 352(6282):216–220CrossRefPubMedPubMedCentral Tavor I, Parker Jones O, Mars RB, Smith SM, Behrens TE, Jbabdi S (2016) Task-free MRI predicts individual differences in brain activity during task performance. Science 352(6282):216–220CrossRefPubMedPubMedCentral
Zurück zum Zitat Tononi G, Boly M, Massimini M, Koch C (2016) Integrated information theory: from consciousness to its physical substrate. Nat Rev Neurosci 17(7):450–461CrossRefPubMed Tononi G, Boly M, Massimini M, Koch C (2016) Integrated information theory: from consciousness to its physical substrate. Nat Rev Neurosci 17(7):450–461CrossRefPubMed
Zurück zum Zitat Valdes-Hernandez PA, Sumiyoshi A, Nonaka H, Haga R, Aubert-Vasquez E, Ogawa T, Iturria-Medina Y, Riera JJ, Kawashima R (2011) An in vivo MRI template set for morphometry, tissue segmentation, and fMRI localization in rats. Front Neuroinform 5:26PubMedPubMedCentral Valdes-Hernandez PA, Sumiyoshi A, Nonaka H, Haga R, Aubert-Vasquez E, Ogawa T, Iturria-Medina Y, Riera JJ, Kawashima R (2011) An in vivo MRI template set for morphometry, tissue segmentation, and fMRI localization in rats. Front Neuroinform 5:26PubMedPubMedCentral
Zurück zum Zitat Wang C, Ong JL, Patanaik A, Zhou J, Chee MW (2016) Spontaneous eyelid closures link vigilance fluctuation with fMRI dynamic connectivity states. Proc Natl Acad Sci USA 113(34):9653–9658CrossRefPubMedPubMedCentral Wang C, Ong JL, Patanaik A, Zhou J, Chee MW (2016) Spontaneous eyelid closures link vigilance fluctuation with fMRI dynamic connectivity states. Proc Natl Acad Sci USA 113(34):9653–9658CrossRefPubMedPubMedCentral
Metadaten
Titel
Alterations in rat brain modular organization during unconsciousness are dependent on communication efficiency and metabolic cost
verfasst von
Siyang Li
Yali Chen
Peng Ren
Zhipeng Li
Jun Zhang
Xia Liang
Publikationsdatum
21.09.2023
Verlag
Springer Berlin Heidelberg
Erschienen in
Brain Structure and Function / Ausgabe 9/2023
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI
https://doi.org/10.1007/s00429-023-02708-w

Weitere Artikel der Ausgabe 9/2023

Brain Structure and Function 9/2023 Zur Ausgabe

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.