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01.12.2018 | Research | Ausgabe 1/2018 Open Access

Molecular Autism 1/2018

Alterations in the inferior longitudinal fasciculus in autism and associations with visual processing: a diffusion-weighted MRI study

Zeitschrift:
Molecular Autism > Ausgabe 1/2018
Autoren:
Bart Boets, Lien Van Eylen, Kevin Sitek, Pieter Moors, Ilse Noens, Jean Steyaert, Stefan Sunaert, Johan Wagemans
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1186/​s13229-018-0188-6) contains supplementary material, which is available to authorized users.
Bart Boets and Lien Van Eylen contributed equally to this work.
Bart Boets and Lien Van Eylen are joint first author.

Abstract

Background

One of the most reported neural features of autism spectrum disorder (ASD) is the alteration of multiple long-range white matter fiber tracts, as assessed by diffusion-weighted imaging and indexed by reduced fractional anisotropy (FA). Recent methodological advances, however, have shown that this same pattern of reduced FA may be an artifact resulting from excessive head motion and poorer data quality and that aberrant structural connectivity in children with ASD is confined to the right inferior longitudinal fasciculus (ILF). This study aimed at replicating the observation of reduced FA along the right ILF in ASD, while controlling for group differences in head motion and data quality. In addition, we explored associations between reduced FA in the right ILF and quantitative ASD characteristics, and the involvement of the right ILF in visual processing, which is known to be altered in ASD.

Method

Global probabilistic tractography was performed on diffusion-weighted imaging data of 17 adolescent boys with ASD and 17 typically developing boys, matched for age, performance IQ, handedness, and data quality. Four tasks were administered to measure various aspects of visual information processing, together with questionnaires assessing ASD characteristics. Group differences were examined and the neural data were integrated with previously published findings using Bayesian statistics to quantify evidence for replication and to pool data and thus increase statistical power. (Partial) correlations were calculated to investigate associations between measures.

Results

The ASD group showed consistently reduced FA only in the right ILF and slower performance on the visual search task. Bayesian statistics pooling data across studies confirmed that group differences in FA were confined to the right ILF only, with the evidence for altered FA in the left ILF being indecisive. Lower FA in the right ILF tended to covary with slower visual search and a more fragmented part-oriented processing style. Individual differences in FA of the right ILF were not reliably associated with the severity of ASD traits after controlling for clinical status.

Conclusion

Our findings support the growing evidence for reduced FA along a specific fiber tract in ASD, the right ILF.
Zusatzmaterial
Additional file 2: Figure S1. Scatter plots displaying the association between individual differences in FA in right ILF (depicted on the X axis) and individual differences in quantitative ASD characteristics and visual processing measures (depicted on the Y axis). First row: Associations with (square root transformed) scores on the SRS questionnaire, the SRS Social and Communication subscale, the SRS RRBI subscale, and the RBS-R questionnaire. Second row: Associations with reaction time on the Fragmented Object Outlines task, (log-transformed) percentage coherence threshold on the Coherent Motion Task, (log-transformed) reaction time on the visual search task, and (square root transformed) fragmentation score on the Rey-Osterrieth Complex Figure task. ASD subjects are depicted by empty squares, TD subjects by filled diamonds. (PPTX 130 kb)
13229_2018_188_MOESM2_ESM.pptx
Additional file 3: Table S1. Pearson (partial) correlations between ASD characteristics, visual processing measures and fractional anisotropy (FA) in the white matter tracts. (DOCX 19 kb)
13229_2018_188_MOESM3_ESM.docx
Literatur
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