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Erschienen in: European Radiology 11/2016

05.03.2016 | Magnetic Resonance

Alterations of diffusion tensor MRI parameters in the brains of patients with Parkinson’s disease compared with normal brains: possible diagnostic use

verfasst von: Chin-Song Lu, Shu-Hang Ng, Yi-Hsin Weng, Jur-Shan Cheng, Wey-Yil Lin, Yau-Yau Wai, Yao-Liang Chen, Jiun-Jie Wang

Erschienen in: European Radiology | Ausgabe 11/2016

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Abstract

Objectives

To investigate the diagnostic performance of diffusion tensor imaging in patients with Parkinson’s disease (PD).

Methods

We examined a total of 126 PD patients (68 males/58 females, mean age: 62.0 ±7.6 years) and 91 healthy controls (43 males/48 females, mean age: 59.8 ±7.2 years). Images were acquired on a 3 Tesla magnetic resonance scanner. The Camino software was used to normalize and parcellate diffusion-weighted images into 90 cerebral regions based on the automatic anatomical labelling template. The minimum, median, and maximum values of the mean/radial/axial diffusivity/fractional anisotropy were determined. The diagnostic performance was assessed by receiver operating characteristic analysis. The associations of imaging parameters with disease severity were tested using Pearson’s correlation coefficients after adjustment for disease duration.

Results

Compared with healthy controls, PD patients showed increased diffusivity in multiple cortical regions that extended beyond the basal ganglia. An area under curve of 85 % was identified for the maximum values of mean diffusivity in the ipsilateral middle temporal gyrus. The most significant intergroup difference was 26.8 % for the ipsilateral inferior parietal gyrus.

Conclusion

The measurement of water diffusion from the parcellated cortex may be clinically useful for the assessment of PD patients.

Key Points

Increased diffusivity was identified in multiple cortical regions of Parkinson’s disease patients.
The area under the receiver operating curve was 85 % in the middle temporal gyrus.
The ipsilateral inferior parietal gyrus showed the most significant change.
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Literatur
1.
Zurück zum Zitat Lang AE, Lozano AM (1998) Parkinson's disease. First of two parts. N Engl J Med 339:1044–1053CrossRefPubMed Lang AE, Lozano AM (1998) Parkinson's disease. First of two parts. N Engl J Med 339:1044–1053CrossRefPubMed
2.
Zurück zum Zitat Lang AE, Lozano AM (1998) Parkinson's disease. Second of two parts. N Engl J Med 339:1130–1143CrossRefPubMed Lang AE, Lozano AM (1998) Parkinson's disease. Second of two parts. N Engl J Med 339:1130–1143CrossRefPubMed
3.
Zurück zum Zitat Adler CH, Beach TG, Hentz JG et al (2014) Low clinical diagnostic accuracy of early vs advanced Parkinson disease: clinicopathologic study. Neurology 83:406–412CrossRefPubMedPubMedCentral Adler CH, Beach TG, Hentz JG et al (2014) Low clinical diagnostic accuracy of early vs advanced Parkinson disease: clinicopathologic study. Neurology 83:406–412CrossRefPubMedPubMedCentral
4.
Zurück zum Zitat Tessitore A, Amboni M, Cirillo G et al (2012) Regional gray matter atrophy in patients with Parkinson disease and freezing of gait. AJNR Am J Neuroradiol 33:1804–1809CrossRefPubMed Tessitore A, Amboni M, Cirillo G et al (2012) Regional gray matter atrophy in patients with Parkinson disease and freezing of gait. AJNR Am J Neuroradiol 33:1804–1809CrossRefPubMed
5.
Zurück zum Zitat Choi SH, Jung TM, Lee JE, Lee SK, Sohn YH, Lee PH (2012) Volumetric analysis of the substantia innominata in patients with Parkinson's disease according to cognitive status. Neurobiol Aging 33:1265–1272CrossRefPubMed Choi SH, Jung TM, Lee JE, Lee SK, Sohn YH, Lee PH (2012) Volumetric analysis of the substantia innominata in patients with Parkinson's disease according to cognitive status. Neurobiol Aging 33:1265–1272CrossRefPubMed
6.
Zurück zum Zitat Carlesimo GA, Piras F, Assogna F, Pontieri FE, Caltagirone C, Spalletta G (2012) Hippocampal abnormalities and memory deficits in Parkinson disease: a multimodal imaging study. Neurology 78:1939–1945CrossRefPubMed Carlesimo GA, Piras F, Assogna F, Pontieri FE, Caltagirone C, Spalletta G (2012) Hippocampal abnormalities and memory deficits in Parkinson disease: a multimodal imaging study. Neurology 78:1939–1945CrossRefPubMed
7.
Zurück zum Zitat Chang CC, Chang WN, Lui CC et al (2011) Clinical significance of the pallidoreticular pathway in patients with carbon monoxide intoxication. Brain 134:3632–3646CrossRefPubMed Chang CC, Chang WN, Lui CC et al (2011) Clinical significance of the pallidoreticular pathway in patients with carbon monoxide intoxication. Brain 134:3632–3646CrossRefPubMed
8.
Zurück zum Zitat Wang J, Wai Y, Lin WY et al (2010) Microstructural changes in patients with progressive supranuclear palsy: a diffusion tensor imaging study. J Magn Reson Imaging 32:69–75CrossRefPubMed Wang J, Wai Y, Lin WY et al (2010) Microstructural changes in patients with progressive supranuclear palsy: a diffusion tensor imaging study. J Magn Reson Imaging 32:69–75CrossRefPubMed
9.
Zurück zum Zitat Menke RA, Scholz J, Miller KL et al (2009) MRI characteristics of the substantia nigra in Parkinson's disease: a combined quantitative T1 and DTI study. NeuroImage 47:435–441CrossRefPubMed Menke RA, Scholz J, Miller KL et al (2009) MRI characteristics of the substantia nigra in Parkinson's disease: a combined quantitative T1 and DTI study. NeuroImage 47:435–441CrossRefPubMed
10.
Zurück zum Zitat Karagulle Kendi AT, Lehericy S, Luciana M, Ugurbil K, Tuite P (2008) Altered diffusion in the frontal lobe in Parkinson disease. AJNR Am J Neuroradiol 29:501–505CrossRefPubMed Karagulle Kendi AT, Lehericy S, Luciana M, Ugurbil K, Tuite P (2008) Altered diffusion in the frontal lobe in Parkinson disease. AJNR Am J Neuroradiol 29:501–505CrossRefPubMed
11.
Zurück zum Zitat Zhang Y, Schuff N, Jahng GH et al (2007) Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease. Neurology 68:13–19CrossRefPubMedPubMedCentral Zhang Y, Schuff N, Jahng GH et al (2007) Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease. Neurology 68:13–19CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat Acosta-Cabronero J, Alley S, Williams GB, Pengas G, Nestor PJ (2012) Diffusion tensor metrics as biomarkers in Alzheimer's disease. PLoS One 7, e49072CrossRefPubMedPubMedCentral Acosta-Cabronero J, Alley S, Williams GB, Pengas G, Nestor PJ (2012) Diffusion tensor metrics as biomarkers in Alzheimer's disease. PLoS One 7, e49072CrossRefPubMedPubMedCentral
13.
Zurück zum Zitat Gattellaro G, Minati L, Grisoli M et al (2009) White matter involvement in idiopathic Parkinson disease: a diffusion tensor imaging study. AJNR Am J Neuroradiol 30:1222–1226CrossRefPubMed Gattellaro G, Minati L, Grisoli M et al (2009) White matter involvement in idiopathic Parkinson disease: a diffusion tensor imaging study. AJNR Am J Neuroradiol 30:1222–1226CrossRefPubMed
14.
Zurück zum Zitat Vaillancourt DE, Spraker MB, Prodoehl J et al (2009) High-resolution diffusion tensor imaging in the substantia nigra of de novo Parkinson disease. Neurology 72:1378–1384CrossRefPubMedPubMedCentral Vaillancourt DE, Spraker MB, Prodoehl J et al (2009) High-resolution diffusion tensor imaging in the substantia nigra of de novo Parkinson disease. Neurology 72:1378–1384CrossRefPubMedPubMedCentral
15.
16.
Zurück zum Zitat Kikuchi A, Baba T, Hasegawa T et al (2013) Hypometabolism in the supplementary and anterior cingulate cortices is related to dysphagia in Parkinson's disease: a cross-sectional and 3-year longitudinal cohort study. BMJ open 3 Kikuchi A, Baba T, Hasegawa T et al (2013) Hypometabolism in the supplementary and anterior cingulate cortices is related to dysphagia in Parkinson's disease: a cross-sectional and 3-year longitudinal cohort study. BMJ open 3
17.
Zurück zum Zitat Chan LL, Rumpel H, Yap K et al (2007) Case control study of diffusion tensor imaging in Parkinson's disease. J Neurol Neurosurg Psychiatry 78:1383–1386CrossRefPubMedPubMedCentral Chan LL, Rumpel H, Yap K et al (2007) Case control study of diffusion tensor imaging in Parkinson's disease. J Neurol Neurosurg Psychiatry 78:1383–1386CrossRefPubMedPubMedCentral
18.
Zurück zum Zitat Chen Z, Ma L, Lou X, Zhou Z (2010) Diagnostic value of minimum apparent diffusion coefficient values in prediction of neuroepithelial tumor grading. J Magn Reson Imaging 31:1331–1338CrossRefPubMed Chen Z, Ma L, Lou X, Zhou Z (2010) Diagnostic value of minimum apparent diffusion coefficient values in prediction of neuroepithelial tumor grading. J Magn Reson Imaging 31:1331–1338CrossRefPubMed
19.
Zurück zum Zitat Murakami R, Hirai T, Sugahara T et al (2009) Grading astrocytic tumors by using apparent diffusion coefficient parameters: superiority of a one- versus two-parameter pilot method. Radiology 251:838–845CrossRefPubMed Murakami R, Hirai T, Sugahara T et al (2009) Grading astrocytic tumors by using apparent diffusion coefficient parameters: superiority of a one- versus two-parameter pilot method. Radiology 251:838–845CrossRefPubMed
20.
Zurück zum Zitat Lo CY, Wang PN, Chou KH, Wang J, He Y, Lin CP (2010) Diffusion tensor tractography reveals abnormal topological organization in structural cortical networks in Alzheimer's disease. J Neurosci Off J Soc Neurosci 30:16876–16885CrossRef Lo CY, Wang PN, Chou KH, Wang J, He Y, Lin CP (2010) Diffusion tensor tractography reveals abnormal topological organization in structural cortical networks in Alzheimer's disease. J Neurosci Off J Soc Neurosci 30:16876–16885CrossRef
21.
Zurück zum Zitat Ng SH, Hsu WC, Wai YY et al (2013) Sex dimorphism of cortical water diffusion in normal aging measured by magnetic resonance imaging. Front Aging Neurosci 5:71CrossRefPubMedPubMedCentral Ng SH, Hsu WC, Wai YY et al (2013) Sex dimorphism of cortical water diffusion in normal aging measured by magnetic resonance imaging. Front Aging Neurosci 5:71CrossRefPubMedPubMedCentral
22.
Zurück zum Zitat Alexander DC, Pierpaoli C, Basser PJ, Gee JC (2001) Spatial transformations of diffusion tensor magnetic resonance images. IEEE Trans Med Imaging 20:1131–1139CrossRefPubMed Alexander DC, Pierpaoli C, Basser PJ, Gee JC (2001) Spatial transformations of diffusion tensor magnetic resonance images. IEEE Trans Med Imaging 20:1131–1139CrossRefPubMed
23.
Zurück zum Zitat Modrego PJ, Fayed N, Artal J, Olmos S (2011) Correlation of findings in advanced MRI techniques with global severity scales in patients with Parkinson disease. Acad Radiol 18:235–241CrossRefPubMed Modrego PJ, Fayed N, Artal J, Olmos S (2011) Correlation of findings in advanced MRI techniques with global severity scales in patients with Parkinson disease. Acad Radiol 18:235–241CrossRefPubMed
24.
Zurück zum Zitat Litvan I, Bhatia KP, Burn DJ et al (2003) SIC task force appraisal of clinical diagnostic criteria for parkinsonian disorders. Mov Disord 18:467–486CrossRefPubMed Litvan I, Bhatia KP, Burn DJ et al (2003) SIC task force appraisal of clinical diagnostic criteria for parkinsonian disorders. Mov Disord 18:467–486CrossRefPubMed
25.
26.
Zurück zum Zitat Cook PA, Bai Y, Nedjati-Gilani S, Seunarine KK, Hall MG, Parker GJ, Alexander DC (2006) Camino: open-source diffusion-mri reconstruction and processing 14th scientific meeting of the International Society for Magnetic Resonance in Medicine, Seattle, WA, USA, p 2759 Cook PA, Bai Y, Nedjati-Gilani S, Seunarine KK, Hall MG, Parker GJ, Alexander DC (2006) Camino: open-source diffusion-mri reconstruction and processing 14th scientific meeting of the International Society for Magnetic Resonance in Medicine, Seattle, WA, USA, p 2759
27.
Zurück zum Zitat Schulz JB, Skalej M, Wedekind D et al (1999) Magnetic resonance imaging-based volumetry differentiates idiopathic Parkinson's syndrome from multiple system atrophy and progressive supranuclear palsy. Ann Neurol 45:65–74CrossRefPubMed Schulz JB, Skalej M, Wedekind D et al (1999) Magnetic resonance imaging-based volumetry differentiates idiopathic Parkinson's syndrome from multiple system atrophy and progressive supranuclear palsy. Ann Neurol 45:65–74CrossRefPubMed
28.
Zurück zum Zitat Geng DY, Li YX, Zee CS (2006) Magnetic resonance imaging-based volumetric analysis of basal ganglia nuclei and substantia nigra in patients with Parkinson's disease. Neurosurgery 58:256–262, discussion 256–262 CrossRefPubMed Geng DY, Li YX, Zee CS (2006) Magnetic resonance imaging-based volumetric analysis of basal ganglia nuclei and substantia nigra in patients with Parkinson's disease. Neurosurgery 58:256–262, discussion 256–262 CrossRefPubMed
29.
Zurück zum Zitat Burton EJ, McKeith IG, Burn DJ, Williams ED, O'Brien JT (2004) Cerebral atrophy in Parkinson's disease with and without dementia: a comparison with Alzheimer's disease, dementia with Lewy bodies and controls. Brain 127:791–800CrossRefPubMed Burton EJ, McKeith IG, Burn DJ, Williams ED, O'Brien JT (2004) Cerebral atrophy in Parkinson's disease with and without dementia: a comparison with Alzheimer's disease, dementia with Lewy bodies and controls. Brain 127:791–800CrossRefPubMed
30.
Zurück zum Zitat Gonzalez-Redondo R, Garcia-Garcia D, Clavero P et al (2014) Grey matter hypometabolism and atrophy in Parkinson's disease with cognitive impairment: a two-step process. Brain 137:2356–2367CrossRefPubMedPubMedCentral Gonzalez-Redondo R, Garcia-Garcia D, Clavero P et al (2014) Grey matter hypometabolism and atrophy in Parkinson's disease with cognitive impairment: a two-step process. Brain 137:2356–2367CrossRefPubMedPubMedCentral
31.
Zurück zum Zitat Cunnington R, Egan GF, O'Sullivan JD, Hughes AJ, Bradshaw JL, Colebatch JG (2001) Motor imagery in Parkinson's disease: a PET study. Mov Disord 16:849–857CrossRefPubMed Cunnington R, Egan GF, O'Sullivan JD, Hughes AJ, Bradshaw JL, Colebatch JG (2001) Motor imagery in Parkinson's disease: a PET study. Mov Disord 16:849–857CrossRefPubMed
32.
Zurück zum Zitat Matsui H, Udaka F, Miyoshi T et al (2006) Frontal assessment battery and brain perfusion image in Parkinson's disease. J Geriatr Psychiatry Neurol 19:41–45CrossRefPubMed Matsui H, Udaka F, Miyoshi T et al (2006) Frontal assessment battery and brain perfusion image in Parkinson's disease. J Geriatr Psychiatry Neurol 19:41–45CrossRefPubMed
33.
Zurück zum Zitat Braak H, Del Tredici K (2008) Invited Article: Nervous system pathology in sporadic Parkinson disease. Neurology 70:1916–1925CrossRefPubMed Braak H, Del Tredici K (2008) Invited Article: Nervous system pathology in sporadic Parkinson disease. Neurology 70:1916–1925CrossRefPubMed
34.
Zurück zum Zitat Zhang H, Schneider T, Wheeler-Kingshott CA, Alexander DC (2012) NODDI: practical in vivo neurite orientation dispersion and density imaging of the human brain. NeuroImage 61:1000–1016CrossRefPubMed Zhang H, Schneider T, Wheeler-Kingshott CA, Alexander DC (2012) NODDI: practical in vivo neurite orientation dispersion and density imaging of the human brain. NeuroImage 61:1000–1016CrossRefPubMed
36.
Zurück zum Zitat Basser PJ, Pierpaoli C (1996) Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. J Magn Reson B 111:209–219CrossRefPubMed Basser PJ, Pierpaoli C (1996) Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. J Magn Reson B 111:209–219CrossRefPubMed
37.
Zurück zum Zitat Choe BY, Park JW, Lee KS et al (1998) Neuronal laterality in Parkinson's disease with unilateral symptom by in vivo 1H magnetic resonance spectroscopy. Investig Radiol 33:450–455CrossRef Choe BY, Park JW, Lee KS et al (1998) Neuronal laterality in Parkinson's disease with unilateral symptom by in vivo 1H magnetic resonance spectroscopy. Investig Radiol 33:450–455CrossRef
38.
Zurück zum Zitat Lyoo CH, Ryu YH, Lee MS (2010) Topographical distribution of cerebral cortical thinning in patients with mild Parkinson's disease without dementia. Mov Disord 25:496–499CrossRefPubMed Lyoo CH, Ryu YH, Lee MS (2010) Topographical distribution of cerebral cortical thinning in patients with mild Parkinson's disease without dementia. Mov Disord 25:496–499CrossRefPubMed
39.
Zurück zum Zitat Summerfield C, Junque C, Tolosa E et al (2005) Structural brain changes in Parkinson disease with dementia: a voxel-based morphometry study. Arch Neurol 62:281–285CrossRefPubMed Summerfield C, Junque C, Tolosa E et al (2005) Structural brain changes in Parkinson disease with dementia: a voxel-based morphometry study. Arch Neurol 62:281–285CrossRefPubMed
40.
Zurück zum Zitat Aarsland D, Andersen K, Larsen JP, Lolk A, Nielsen H, Kragh-Sorensen P (2001) Risk of dementia in Parkinson's disease: a community-based, prospective study. Neurology 56:730–736CrossRefPubMed Aarsland D, Andersen K, Larsen JP, Lolk A, Nielsen H, Kragh-Sorensen P (2001) Risk of dementia in Parkinson's disease: a community-based, prospective study. Neurology 56:730–736CrossRefPubMed
Metadaten
Titel
Alterations of diffusion tensor MRI parameters in the brains of patients with Parkinson’s disease compared with normal brains: possible diagnostic use
verfasst von
Chin-Song Lu
Shu-Hang Ng
Yi-Hsin Weng
Jur-Shan Cheng
Wey-Yil Lin
Yau-Yau Wai
Yao-Liang Chen
Jiun-Jie Wang
Publikationsdatum
05.03.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
European Radiology / Ausgabe 11/2016
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-016-4232-7

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