Skip to main content
Erschienen in: Comparative Clinical Pathology 2/2020

30.10.2019 | Original Article

Altered blood oxidative stress biomarkers in association with canine parvovirus enteritis

verfasst von: Noha M. Elsayed, A. A. Kubesy, Noha Y. Salem

Erschienen in: Comparative Clinical Pathology | Ausgabe 2/2020

Einloggen, um Zugang zu erhalten

Abstract

Canine parvovirus (CPV-2), a member of Parvoviridae, mainly affects puppies and it is a major cause of vomiting and diarrhea in canine; sometimes, it has fatal outcomes. This study aims to scrutinize the alterations in hematology as well as oxidative stress biomarkers in association with CPV-2 infection in puppies. The present study was applied on 22 dogs with different breeds, both sexes, and different age, divided into 8 healthy dogs enrolled as a control group and 14 dogs with clinical signs consistent with CPV-2 infection. Blood samples were withdrawn from each animal from cephalic vein for complete blood count using automated hematology analyzer and to estimate level of oxidant biomarkers (MDA and H2O2) and antioxidant biomarkers (SOD, GPX, catalase, Zn, Cu, and iron), with cortisol level. The elevation of MDA, H2O2, SOD, and GPX and decrease of catalase, Zn, Cu, and iron were recorded in diseased dogs compared with those in control dogs. In conclusion, dogs with CPV-2 infection, MDA, and H2O2 elevation contributed to oxidative stress state and alteration in antioxidant biomarkers as SOD, GPX, catalase, and trace minerals as Zn, Cu, and iron to counteract the expected damage of cells were recorded. Based on these findings, antioxidant supplementation might bolster body defense mechanism and decreases stress condition.
Literatur
Zurück zum Zitat Abdel-Saeed H, Salem NY (2019) Evaluation of total antioxidant capacity, malondialdehyde, catalase, proteins, zinc, copper and IgE response in ovine verminous pneumonia. Int J Vet Sci 8(4):255–258 Abdel-Saeed H, Salem NY (2019) Evaluation of total antioxidant capacity, malondialdehyde, catalase, proteins, zinc, copper and IgE response in ovine verminous pneumonia. Int J Vet Sci 8(4):255–258
Zurück zum Zitat Basha PS, Rani AU (2003) Cadmium induced antioxidant defense mechanism in freshwater teleost Oreochromis mossambicus (Tilapia). Ecotoxicol Environ Saf 56:218–221CrossRef Basha PS, Rani AU (2003) Cadmium induced antioxidant defense mechanism in freshwater teleost Oreochromis mossambicus (Tilapia). Ecotoxicol Environ Saf 56:218–221CrossRef
Zurück zum Zitat Bellwood B, Andrasik-Catton M (2014) Parasitology: veterinary technician’s handbook of laboratory procedures, 1st edn. Wiley, pp 77–83 Bellwood B, Andrasik-Catton M (2014) Parasitology: veterinary technician’s handbook of laboratory procedures, 1st edn. Wiley, pp 77–83
Zurück zum Zitat Boosinger TR, Rebar AH, DeNicola DB, Boon GD (1982) Bone marrow alterations associated with canine parvoviral enteritis. Vet Pathol 19:558–561CrossRef Boosinger TR, Rebar AH, DeNicola DB, Boon GD (1982) Bone marrow alterations associated with canine parvoviral enteritis. Vet Pathol 19:558–561CrossRef
Zurück zum Zitat Camkerten I, Sahin T, Borazan G, Gokcen A, Das A (2009) Evaluation of blood oxidant/antioxidant balance in dogs with sarcoptic mange. Vet Parasitol 161:106–109CrossRef Camkerten I, Sahin T, Borazan G, Gokcen A, Das A (2009) Evaluation of blood oxidant/antioxidant balance in dogs with sarcoptic mange. Vet Parasitol 161:106–109CrossRef
Zurück zum Zitat Carmichael LE (2005) An annotated historical account of canine parvovirus. J Vet Med B 52:303–311CrossRef Carmichael LE (2005) An annotated historical account of canine parvovirus. J Vet Med B 52:303–311CrossRef
Zurück zum Zitat Chow CK (1998) Inter-relationship of cellular antioxidant defense systems. In: Chow CK (ed) Cellular antioxidant defense systems. CRC, Boca Raton, pp 217–237 Chow CK (1998) Inter-relationship of cellular antioxidant defense systems. In: Chow CK (ed) Cellular antioxidant defense systems. CRC, Boca Raton, pp 217–237
Zurück zum Zitat DiMascio P, Murphy ME, Sies H (1991) Antioxidant defense systems: the role of carotenoids, tocopherols, and thiols. Am J Clin Nutr 53:194S–200SCrossRef DiMascio P, Murphy ME, Sies H (1991) Antioxidant defense systems: the role of carotenoids, tocopherols, and thiols. Am J Clin Nutr 53:194S–200SCrossRef
Zurück zum Zitat Esra B, Umit MS, Cansin S, Serpil E, Omer K (2012) Oxidative stress and antioxidant defense. World Allergy Organ J 5(1):9–19CrossRef Esra B, Umit MS, Cansin S, Serpil E, Omer K (2012) Oxidative stress and antioxidant defense. World Allergy Organ J 5(1):9–19CrossRef
Zurück zum Zitat Evans P, Halliwell B (2001) Micronutrients: oxidant/antioxidant status. Br J Nutr 85:67–74CrossRef Evans P, Halliwell B (2001) Micronutrients: oxidant/antioxidant status. Br J Nutr 85:67–74CrossRef
Zurück zum Zitat Frei B (1994) Reactive oxygen species and antioxidant vitamins: mechanism of action. Am J Med 97(suppl 3A):58 Frei B (1994) Reactive oxygen species and antioxidant vitamins: mechanism of action. Am J Med 97(suppl 3A):58
Zurück zum Zitat Goddard A, Leisewitz A (2010) Canine Parvovirus. Vet Clin Small Anim 40:1041–1053CrossRef Goddard A, Leisewitz A (2010) Canine Parvovirus. Vet Clin Small Anim 40:1041–1053CrossRef
Zurück zum Zitat Goddard A, Leisewitz AL, Christopher MM, Duncan NM, Becker PJ (2008) Prognostic usefulness of blood leukocyte changes in canine parvoviral enteritis. J Vet Intern Med 22:309–316CrossRef Goddard A, Leisewitz AL, Christopher MM, Duncan NM, Becker PJ (2008) Prognostic usefulness of blood leukocyte changes in canine parvoviral enteritis. J Vet Intern Med 22:309–316CrossRef
Zurück zum Zitat Halliwell B, Gutteridge JC (1995) The definition and measurement of antioxidants in biological systems. Free Radic Biol Med 18:125–126CrossRef Halliwell B, Gutteridge JC (1995) The definition and measurement of antioxidants in biological systems. Free Radic Biol Med 18:125–126CrossRef
Zurück zum Zitat Halliwell B, Gutteridge JMC (2007) Free radicals in biology and medicine, 4th edn. Oxford University Press Inc, New York, pp 79–120 Halliwell B, Gutteridge JMC (2007) Free radicals in biology and medicine, 4th edn. Oxford University Press Inc, New York, pp 79–120
Zurück zum Zitat Hancock JT, Desikan R, Neill SJ (2001) Role of reactive oxygen species in cell signaling pathways. Biochem Biomed Asp Oxid Modif 29(2):345–350 Hancock JT, Desikan R, Neill SJ (2001) Role of reactive oxygen species in cell signaling pathways. Biochem Biomed Asp Oxid Modif 29(2):345–350
Zurück zum Zitat Held P (2015) An introduction to reactive oxygen species measurement of ROS in cells. White paper. BioTek Instruments, USA Held P (2015) An introduction to reactive oxygen species measurement of ROS in cells. White paper. BioTek Instruments, USA
Zurück zum Zitat Irshad M, Chaudhuri PS (2002) Oxidant antioxidant system: role and significance in human body. Indian J Exp Biol 40:1233–1239PubMed Irshad M, Chaudhuri PS (2002) Oxidant antioxidant system: role and significance in human body. Indian J Exp Biol 40:1233–1239PubMed
Zurück zum Zitat Jacobs RM, Weiser MG, Hall RL, Kowalski JJ (1980) Clinicopathologic features of canine parvoviral enteritis. J Am Anim Hosp Assoc 16:809–814 Jacobs RM, Weiser MG, Hall RL, Kowalski JJ (1980) Clinicopathologic features of canine parvoviral enteritis. J Am Anim Hosp Assoc 16:809–814
Zurück zum Zitat Kalli I, Leontides LS, Mylonakis ME, Adamama-Moraitou K, Rallis T, Koutinas AF (2010) Factors affecting the occurrence, duration of hospitalization and final outcome in canine parvovirus infection. Res Vet Sci 89(2):174–178CrossRef Kalli I, Leontides LS, Mylonakis ME, Adamama-Moraitou K, Rallis T, Koutinas AF (2010) Factors affecting the occurrence, duration of hospitalization and final outcome in canine parvovirus infection. Res Vet Sci 89(2):174–178CrossRef
Zurück zum Zitat Kubesy AA, Salem NY, Jaheen AH (2017) Altered blood oxidative stress biomarkers in association with canine pyoderma and allergic contact dermatitis. Comp Clin Pathol 26(3):643–646CrossRef Kubesy AA, Salem NY, Jaheen AH (2017) Altered blood oxidative stress biomarkers in association with canine pyoderma and allergic contact dermatitis. Comp Clin Pathol 26(3):643–646CrossRef
Zurück zum Zitat Kumar A, VARSHNEY JP, Patra RC (2006) A comparative study on oxidative stress in dog infected with Ehrlichia canis with or without concurrent infection with babesia gibsoni. Vet Res Commun 30:917–920CrossRef Kumar A, VARSHNEY JP, Patra RC (2006) A comparative study on oxidative stress in dog infected with Ehrlichia canis with or without concurrent infection with babesia gibsoni. Vet Res Commun 30:917–920CrossRef
Zurück zum Zitat Macintire DK, Smith-Carr S (1997) Canine parvovirus. Part II. Clinical signs, diagnosis, and treatment. Compend Contin Educ Pract Vet 19(3):291–302 Macintire DK, Smith-Carr S (1997) Canine parvovirus. Part II. Clinical signs, diagnosis, and treatment. Compend Contin Educ Pract Vet 19(3):291–302
Zurück zum Zitat Marulappa SY, Kapil S (2009) Simple tests for rapid detection of canine parvovirus antigen and antibodies. Clin Vacc Immunol J 16:127–131CrossRef Marulappa SY, Kapil S (2009) Simple tests for rapid detection of canine parvovirus antigen and antibodies. Clin Vacc Immunol J 16:127–131CrossRef
Zurück zum Zitat Mathios EM, Iris K, Timoleon SR (2016) Canine parvoviral enteritis: an update on the clinical diagnosis, treatment, and prevention. Dove Press 7:91–100 Mathios EM, Iris K, Timoleon SR (2016) Canine parvoviral enteritis: an update on the clinical diagnosis, treatment, and prevention. Dove Press 7:91–100
Zurück zum Zitat McCaw DL, And Hoskins JD (2006) Canine parvovirus. In: Greene CE (ed) Infectious diseases of the dogs and cats, 3rd edn. Elsevier, pp 63–73 McCaw DL, And Hoskins JD (2006) Canine parvovirus. In: Greene CE (ed) Infectious diseases of the dogs and cats, 3rd edn. Elsevier, pp 63–73
Zurück zum Zitat Mylonakis ME, Kalli I, Rallis TS (2016) Canine parvoviral enteritis: an update on the clinical diagnosis, treatment, and prevention. Vet Med 7:91–100 Mylonakis ME, Kalli I, Rallis TS (2016) Canine parvoviral enteritis: an update on the clinical diagnosis, treatment, and prevention. Vet Med 7:91–100
Zurück zum Zitat Nandi S, Chidri S, Kumar M, Chauhan RS (2010) Occurrence of canine parvovirus type 2c in the dogs with haemorrhagic enteritis in India. Res Vet Sci 88:169–171CrossRef Nandi S, Chidri S, Kumar M, Chauhan RS (2010) Occurrence of canine parvovirus type 2c in the dogs with haemorrhagic enteritis in India. Res Vet Sci 88:169–171CrossRef
Zurück zum Zitat Nielsen F, Mikkelsen BB, Nielsen JB (2011) Plasma malondialdehyde as biomarker for oxidative stress: reference interval and effects of life-style factors. Clin Chem 43:1209–1214CrossRef Nielsen F, Mikkelsen BB, Nielsen JB (2011) Plasma malondialdehyde as biomarker for oxidative stress: reference interval and effects of life-style factors. Clin Chem 43:1209–1214CrossRef
Zurück zum Zitat Panda D, Patra RC, Nandi S, Swarup D (2009) Oxidative stress indices in gastroenteritis in dogs with canine parvoviral infection. Res Vet Sci 86:36–42CrossRef Panda D, Patra RC, Nandi S, Swarup D (2009) Oxidative stress indices in gastroenteritis in dogs with canine parvoviral infection. Res Vet Sci 86:36–42CrossRef
Zurück zum Zitat Pollock RV, Carmichael LE (1983) Canine viral enteritis. Vet Clin North Am Small Anim Pract 13:551–566CrossRef Pollock RV, Carmichael LE (1983) Canine viral enteritis. Vet Clin North Am Small Anim Pract 13:551–566CrossRef
Zurück zum Zitat Pollock RVH, Coyne MJ (1993) Canine parvovirus. Vet Clin North Am Small Anim Pract 23:555–568CrossRef Pollock RVH, Coyne MJ (1993) Canine parvovirus. Vet Clin North Am Small Anim Pract 23:555–568CrossRef
Zurück zum Zitat Popova MP, Popov CS (2002) Damage to subcellular structures evoked by lipid peroxidation. Zeitschrift Fur Naturforsch 57:361365 Popova MP, Popov CS (2002) Damage to subcellular structures evoked by lipid peroxidation. Zeitschrift Fur Naturforsch 57:361365
Zurück zum Zitat Prittie J (2004) Clinical practice review canine parvoviral enteritis: a review of diagnosis, management, and prevention. J Vet Emerg Crit Care 14(3):167–176CrossRef Prittie J (2004) Clinical practice review canine parvoviral enteritis: a review of diagnosis, management, and prevention. J Vet Emerg Crit Care 14(3):167–176CrossRef
Zurück zum Zitat Rajabian F, Mohri M, Heidarpour M (2017) Relationships between oxidative stress, haematology and iron profile in anaemic and non-anaemic calves: group.bmj.com: 1-4 Rajabian F, Mohri M, Heidarpour M (2017) Relationships between oxidative stress, haematology and iron profile in anaemic and non-anaemic calves: group.​bmj.​com: 1-4
Zurück zum Zitat Rakhshandehroo E, Razavi SM, Nazi SM (2014) Experimental Caprine Coccidiosis: the pattern of changes in antioxidant micronutrients and vitamins. Vet Sci Develop 4:1–6CrossRef Rakhshandehroo E, Razavi SM, Nazi SM (2014) Experimental Caprine Coccidiosis: the pattern of changes in antioxidant micronutrients and vitamins. Vet Sci Develop 4:1–6CrossRef
Zurück zum Zitat Raskins RE, Latimer KS, Tvedton H (2004) Leucocyte disorder. In: Willard MD, Tvedten H (eds) Small animal clinical diagnosis by laboratory methods, 4th edn. Saunders Raskins RE, Latimer KS, Tvedton H (2004) Leucocyte disorder. In: Willard MD, Tvedten H (eds) Small animal clinical diagnosis by laboratory methods, 4th edn. Saunders
Zurück zum Zitat Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG (1973) Selenium: biochemical role as a component of glutathione peroxidase. Science. 179:588–590CrossRef Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG (1973) Selenium: biochemical role as a component of glutathione peroxidase. Science. 179:588–590CrossRef
Zurück zum Zitat Salem NY (2014) Canine viral diarrhea: clinical, hematologic and biochemical alterations with particular reference to in-clinic rapid diagnosis. Glob Vet 13(3):302–307 Salem NY (2014) Canine viral diarrhea: clinical, hematologic and biochemical alterations with particular reference to in-clinic rapid diagnosis. Glob Vet 13(3):302–307
Zurück zum Zitat Salem NY, Yehia SG, Farag HS, Soliman SM (2018) Evaluation of hepcidin level and clinico-pathological modifications in canine parvovirus enteritis. Int J Vet Sci 7(2):93–96 Salem NY, Yehia SG, Farag HS, Soliman SM (2018) Evaluation of hepcidin level and clinico-pathological modifications in canine parvovirus enteritis. Int J Vet Sci 7(2):93–96
Zurück zum Zitat Schoeman JP, Goddard A, Herrtage ME (2007) Serum cortisol and thyroxine concentrations as predictors of death in critically ill puppies with parvoviral diarrhea. J Am Vet Med Assoc 231:1534–1539CrossRef Schoeman JP, Goddard A, Herrtage ME (2007) Serum cortisol and thyroxine concentrations as predictors of death in critically ill puppies with parvoviral diarrhea. J Am Vet Med Assoc 231:1534–1539CrossRef
Zurück zum Zitat Wazir VS, Gupta SK, Bhardwaj RK, Taku AK, Soodan JS, Kotwal SK, Singh R, Singh VP (2011) Clinic-hematological alterations in CPV gastroenteritis in canines. In Proceedings of 29th ISVM Convention and National Symposium on “recent developments in diagnostics and therapeutics including applications of nano-technology in veterinary medicine”. 17th -19th February 2011 Wazir VS, Gupta SK, Bhardwaj RK, Taku AK, Soodan JS, Kotwal SK, Singh R, Singh VP (2011) Clinic-hematological alterations in CPV gastroenteritis in canines. In Proceedings of 29th ISVM Convention and National Symposium on “recent developments in diagnostics and therapeutics including applications of nano-technology in veterinary medicine”. 17th -19th February 2011
Zurück zum Zitat Yoshikawa T, Naito Y (2002) What is oxidative stress? JMAJ. 45(7):271–276 Yoshikawa T, Naito Y (2002) What is oxidative stress? JMAJ. 45(7):271–276
Zurück zum Zitat Zafar MS, Khan SA, Rabbani A (1999) Hematological studies and estimation of electrolytes in dogs. Pak Vet J 19(1):40–42 Zafar MS, Khan SA, Rabbani A (1999) Hematological studies and estimation of electrolytes in dogs. Pak Vet J 19(1):40–42
Metadaten
Titel
Altered blood oxidative stress biomarkers in association with canine parvovirus enteritis
verfasst von
Noha M. Elsayed
A. A. Kubesy
Noha Y. Salem
Publikationsdatum
30.10.2019
Verlag
Springer London
Erschienen in
Comparative Clinical Pathology / Ausgabe 2/2020
Print ISSN: 1618-5641
Elektronische ISSN: 1618-565X
DOI
https://doi.org/10.1007/s00580-019-03067-x

Weitere Artikel der Ausgabe 2/2020

Comparative Clinical Pathology 2/2020 Zur Ausgabe

Neu im Fachgebiet Pathologie