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Clinical Rheumatology

Erschienen in:

16.08.2019 | Original Article

Altered expression of circular RNA in primary Sjögren’s syndrome

verfasst von: Lin-Chong Su, Wang-Dong Xu, Xiao-Yan Liu, Lu Fu, An-Fang Huang

Erschienen in: Clinical Rheumatology | Ausgabe 12/2019

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Abstract

Objectives

This study evaluated expression of circRNA in primary Sjögren’s syndrome (pSS) patients so as to find novel biomarkers for pSS screening and discussed possible role of circRNA in pSS. We also evaluated expression profile of circRNA in systemic lupus erythematosus (SLE) patients.

Methods

Microarray analysis detected circRNA expression in PBMCs from five paired pSS, SLE patients, and controls. Then, differentially expressed circRNAs were validated in 30 pSS patients as compared to 30 SLE patients, healthy controls. CircRNAs interacting with miRNAs were discussed by Arraystar’s homemade miRNA target prediction software. ROC analysis assessed the diagnostic value.

Results

We identified 234 differentially expressed circRNAs in pSS patients and verified five selected circRNAs (including hsa_circRNA_001264, hsa_circRNA_104121, hsa_circRNA_045355, hsa_circRNA_103461, hsa_circRNA_105034). Expression of hsa_circRNA_001264, hsa_circRNA_104121, and hsa_circRNA_045355 was strongly related to some clinical, laboratory parameters, and disease activity index in pSS patients. ROC analysis indicated potential diagnostic ability for the three circRNAs in pSS patients. One hundred and forty-eight circRNAs were differently expressed between lupus patients and controls.

Conclusion

This study provides evidence that hsa_circRNA_001264, hsa_circRNA_104121, and hsa_circRNA_045355 might be biomarkers for pSS, correlate with pSS etiology.

Key Points
• Many circRNAs were dysregulated in pSS patients.
• Differentially expressed circRNAs correlated with pSS clinical, laboratory features.
• CircRNAs may be biomarkers for pSS.

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Titel: Altered expression of circular RNA in primary Sjögren’s syndrome
verfasst von: Lin-Chong Su
Wang-Dong Xu
Xiao-Yan Liu
Lu Fu
An-Fang Huang
Publikationsdatum: 16.08.2019
Verlag: Springer London
Erschienen in: Clinical Rheumatology / Ausgabe 12/2019
Print ISSN: 0770-3198
Elektronische ISSN: 1434-9949
DOI: https://doi.org/10.1007/s10067-019-04728-6

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Altered expression of circular RNA in primary Sjögren’s syndrome

Abstract

Objectives

Methods

Results

Conclusion

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Conclusion

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