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Erschienen in: Neuroradiology 1/2020

26.11.2019 | Functional Neuroradiology

Altered Granger causality connectivity within motor-related regions of patients with Parkinson’s disease: a resting-state fMRI study

verfasst von: Li Hao, Zhao Sheng, Wang Ruijun, He Zhi Kun, Zhang Peng, Hong Yu

Erschienen in: Neuroradiology | Ausgabe 1/2020

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Abstract

Purpose

Although numerous clinical neuroimaging studies have demonstrated that there are functional abnormalities of motor-related regions in patients with Parkinson’s disease (PD) by resting-state functional magnetic resonance imaging (fMRI), little studies have explored the causal interactions within these motor-related regions. The present study aimed to examine Granger causality connectivity patterns within motor-related regions in PD patients.

Methods

Resting-state fMRI was conducted to investigate the causal connectivity differences within motor-related regions between 17 PD patients and 17 matched healthy controls. Subsequently, the relationship between the Unified Parkinson’s Disease Rating Scale scores and causal connectivity values within motor-related regions was examined in PD patients.

Results

An increased causal connectivity from the left premotor cortex (PMC) to right primary motor cortex (M1) was found in PD patients compared with that of healthy controls. Also, increased causal flow from the PMC to M1 was negatively correlated with motor scores.

Conclusion

PD patients have abnormal causal connectivity in specific motor-related regions, which may reflect a compensatory role of motor deficits in PD patients.
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Metadaten
Titel
Altered Granger causality connectivity within motor-related regions of patients with Parkinson’s disease: a resting-state fMRI study
verfasst von
Li Hao
Zhao Sheng
Wang Ruijun
He Zhi Kun
Zhang Peng
Hong Yu
Publikationsdatum
26.11.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
Neuroradiology / Ausgabe 1/2020
Print ISSN: 0028-3940
Elektronische ISSN: 1432-1920
DOI
https://doi.org/10.1007/s00234-019-02311-z

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