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23.11.2016 | Neuro | Ausgabe 7/2017

European Radiology 7/2017

Altered intrinsic brain activity after chemotherapy in patients with gastric cancer: A preliminary study

Zeitschrift:
European Radiology > Ausgabe 7/2017
Autoren:
Hyun Gi Kim, Na-Young Shin, Yunjin Bak, Kyung Ran Kim, Young-Chul Jung, Kyunghwa Han, Seung-Koo Lee, Soo Mee Lim
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1007/​s00330-016-4578-x) contains supplementary material, which is available to authorized users.
The original version of this article was revised: The sentence, “Linear regression was estimated with six motion parameters, CSF signal, WM signal, and global mean as covariates to remove the head motion effect and other possible artefacts.” was deleted from the section on rsfMRI imaging preprocessing. Reason: We originally analyzed the data using the basic edition of DPARSF toolbox version 2.2 in which nuisance regression was not applied before calculating ALFF, fALFF and ReHo, but regression could be performed at a later date for preprocessing with the updated version of DPARSF. Since there was confusion about which edition of DPARSF was applied, we incorrectly added a sentence about the regression process during our revision.
Na-Young Shin had performed the study in Yonsei University College of Medicine and her current affiliation is Ewha Womans University School of Medicine.
An erratum to this article is available at http://​dx.​doi.​org/​10.​1007/​s00330-017-4748-5.

Abstract

Objectives

To characterize the pattern of altered intrinsic brain activity in gastric cancer patients after chemotherapy (CTx).

Methods

Patients before and after CTx (n = 14) and control subjects (n = 11) underwent resting-state functional MRI (rsfMRI) at baseline and 3 months after CTx. Regional homogeneity (ReHo), amplitude of low-frequency fluctuation (ALFF), and fractional ALFF (fALFF) were calculated and compared between the groups using the two-sample t test. Correlation analysis was also performed between rsfMRI values (i.e., ReHo, ALFF, and fALFF) and neuropsychological test results.

Results

Patients showed poor performance in verbal memory and executive function and decreased rsfMRI values in the frontal areas even before CTx and showed decreased attention/working memory and executive function after CTx compared to the control subjects. In direct comparison of values before and after CTx, there were no significant differences in neuropsychological test scores, but decreased rsfMRI values were observed at the frontal lobes and right cerebellar region. Among rsfMRI values, lower ALFF in the left inferior frontal gyrus was significantly associated with poor performance of the executive function test.

Conclusions

We observed decreased attention/working memory and executive function that corresponded to the decline of frontal region activation in gastric cancer patients who underwent CTx.

Key Points

Intrinsic brain activity of gastric cancer patients after chemotherapy was described.
Brain activity and neuropsychological test results were correlated.
Working memory and executive function decreased after chemotherapy.
Decreased cognitive function corresponded to decreased activation of the frontal region.

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Zusatzmaterial
Supplementary Table 1 (DOCX 52.7 kb)
330_2016_4578_MOESM1_ESM.docx
Literatur
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