The online version of this article (https://doi.org/10.1186/s13229-018-0195-7) contains supplementary material, which is available to authorized users.
Neurobiological research in autism spectrum disorders (ASD) has paid little attention on brain mechanisms that cause and maintain restricted and repetitive behaviors and interests (RRBIs). Evidence indicates an imbalance in the brain’s reward system responsiveness to social and non-social stimuli may contribute to both social deficits and RRBIs. Thus, this study’s central aim was to compare brain responsiveness to individual RRBI (i.e., circumscribed interests), with social rewards (i.e., social approval), in youth with ASD relative to typically developing controls (TDCs).
We conducted a 3T functional magnetic resonance imaging (fMRI) study to investigate the blood-oxygenation-level-dependent effect of personalized circumscribed interest rewards versus social rewards in 39 youth with ASD relative to 22 TDC. To probe the reward system, we employed short video clips as reinforcement in an instrumental incentive delay task. This optimization increased the task’s ecological validity compared to still pictures that are often used in this line of research.
Compared to TDCs, youth with ASD had stronger reward system responses for CIs mostly within the non-social realm (e.g., video games) than social rewards (e.g., approval). Additionally, this imbalance within the caudate nucleus’ responsiveness was related to greater social impairment.
The current data support the idea of reward system dysfunction that may contribute to enhanced motivation for RRBIs in ASD, accompanied by diminished motivation for social engagement. If a dysregulated reward system indeed supports the emergence and maintenance of social and non-social symptoms of ASD, then strategically targeting the reward system in future treatment endeavors may allow for more efficacious treatment practices that help improve outcomes for individuals with ASD and their families.
Additional file 1: Additional methods and tables. (DOCX 48 kb)13229_2018_195_MOESM1_ESM.docx
Yerys BE. An update on the neurobiology of repetitive behaviors in autism. In: International review of research in developmental disabilities. 2015. 91–150.
Mercier C, Mottron L, Belleville S. A psychosocial study on restricted interests in high functioning persons with pervasive developmental disorders. Autism. 2000;4:406–25. CrossRef
Elliott CD. Differential Ability Scales-II (DAS-II). San Antonio: Pearson Assessments; 2007.
American Psychiatric Association. Diagnostic and statistical manual of mental disorders, fifth edition (DSM-5). Washington: American Psychiatric Association; 2013. CrossRef
Gadow KD, Sprafkin J. Child symptom inventories manual. Stony Brook: Checkmate Plus; 1994.
Constantino J, Gruber C. The Social Responsiveness Scale—second edition (SRS-2) manual. Torrance: Western Psychological Services; 2012.
Smith SM, Jenkinson M, Woolrich MW, Beckmann CF, Behrens TEJ, Johansen-Berg H, et al. Advances in functional and structural MR image analysis and implementation as FSL. NeuroImage. 2004;23 S(1):208–19. CrossRef
Bandura A. Self-reinforcement: theoretical and methodological considerations. Behaviorism. 1976;4:135–55.
Pankert A, Pankert K, Herpertz-Dahlmann B, Konrad K, Kohls G. Responsivity to familiar versus unfamiliar social reward in children with autism. J Neural Transm. 2014;
- Altered reward system reactivity for personalized circumscribed interests in autism
Maya G. Mosner
Robert T. Schultz
Benjamin E. Yerys
- BioMed Central
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