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Brain Topography

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18.09.2017 | Original Paper

Altered Structure and Intrinsic Functional Connectivity in Post-stroke Aphasia

verfasst von: Mi Yang, Pu Yang, Yun-Shuang Fan, Jiao Li, Dezhong Yao, Wei Liao, Huafu Chen

Erschienen in: Brain Topography | Ausgabe 2/2018

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Abstract

Previous studies have demonstrated that alterations of gray matter exist in post-stroke aphasia (PSA) patients. However, so far, few studies combined structural alterations of gray matter volume (GMV) and intrinsic functional connectivity (iFC) imbalances of resting-state functional MRI to investigate the mechanism underlying PSA. The present study investigated specific regions with GMV abnormality in patients with PSA (n = 17) and age- and sex- matched healthy controls (HCs, n = 20) using voxel-based morphometry. In addition, we examined whether there is a link between abnormal gray matter and altered iFC. Furthermore, we explored the correlations between abnormal iFC and clinical scores in aphasic patients. We found significantly increased GMV in the right superior temporal gyrus, right inferior parietal lobule (IPL)/supramarginal gyrus (SMG), and left middle occipital gyrus. Decreased GMV was found in the right caudate gyrus, bilateral thalami in PSA patients. Patients showed increased remote interregional FC between the right IPL/SMG and right precuneus, right angular gyrus, right superior occipital gyrus; while reduced FC in the right caudate gyrus and supplementary motor area, dorsolateral superior frontal gyrus. Moreover, iFC strength between the left middle occipital gyrus and the left orbital middle frontal gyrus was positively correlated with the performance quotient. We suggest that GMV abnormality contributes to interregional FC in PSA. These results may provide useful information to understand the pathogenesis of post-stroke aphasia.

Abdullaev YG, Bechtereva NP, Melnichuk KV (1998) Neuronal activity of human caudate nucleus and prefrontal cortex in cognitive tasks. Behav Brain Res 97:159–177CrossRefPubMed

Agosta F, Galantucci S, Valsasina P, Canu E, Meani A, Marcone A et al (2014) Disrupted brain connectome in semantic variant of primary progressive aphasia. Neurobiol Aging 35:2646–2655CrossRefPubMed

Ashburner J, Friston KJ (2000) Voxel-based morphometry—the methods. Neuroimage 11:805–821CrossRefPubMed

Ashizuka A, Mima T, Sawamoto N, Aso T, Oishi N, Sugihara G et al (2015) Functional relevance of the precuneus in verbal politeness. Neurosci Res 91:48–56CrossRefPubMed

Berthier ML (2005) Poststroke aphasia: epidemiology, pathophysiology and treatment. Drugs Aging 22:163–182CrossRefPubMed

Binder JR, Desai RH, Graves WW, Conant LL (2009) Where is the semantic system? A critical review and meta-analysis of 120 functional neuroimaging studies. Cereb Cortex 19:2767–2796CrossRefPubMedPubMedCentral

Braun AR, Guillemin A, Hosey L, Varga M (2001) The neural organization of discourse—an (H₂O)-O-15-PET study of narrative production in English and American sign language. Brain 124:2028–2044CrossRefPubMed

Brett M, Leff AP, Rorden C, Ashburner J (2001) Spatial normalization of brain images with focal lesions using cost function masking. Neuroimage 14:486–500CrossRefPubMed

Broyd SJ, Demanuele C, Debener S, Helps SK, James CJ, Sonuga-Barke EJS (2009) Default-mode brain dysfunction in mental disorders: a systematic review. Neurosci Biobehav Rev 33:279–296CrossRefPubMed

Cavanna AE, Trimble MR (2006) The precuneus: a review of its functional anatomy and behavioural correlates. Brain 129:564–583CrossRefPubMed

Chao-Gan Y, Yu-Feng Z (2010) DPARSF: a MATLAB toolbox for “pipeline” data analysis of resting-state fmRI. Front Syst Neurosci 4:13–13PubMedPubMedCentral

Charney JZ (1981) Aphasia and associated disorders: taxonomy, localization, and recovery. JAMA 245:78CrossRef

Chou T-L, Booth JR, Bitan T, Burman DD, Bigio JD, Cone NE et al (2006a) Developmental and skill effects on the neural correlates of semantic processing to visually presented words. Hum Brain Mapp 27:915–924CrossRefPubMedPubMedCentral

Chou TL, Booth JR, Burman DD, Bitan T, Bigio JD, Lu D et al (2006b) Developmental changes in the neural correlates of semantic processing. Neuroimage 29:1141–1149CrossRefPubMed

Crosson B, Benefield H, Cato MA, Sadek JR, Moore AB, Wierenga CE et al (2003) Left and right basal ganglia and frontal activity during language generation: contributions to lexical, semantic, and phonological processes. J Int Neuropsychol Soc 9:1061–1077PubMed

Cuadra MB, Cammoun L, Butz T, Cuisenaire O, Thiran JP (2005) Comparison and validation of tissue modelization and statistical classification methods in T1-weighted MR brain images. IEEE Trans Med Imaging 24:1548–1565CrossRefPubMed

Dong JW, Brennan NMP, Izzo G, Peck KK, Holodny AI (2016) fMRI activation in the middle frontal gyrus as an indicator of hemispheric dominance for language in brain tumor patients: a comparison with Broca’s area. Neuroradiology 58:513–520CrossRefPubMedPubMedCentral

Dronkers NF (1996) A new brain region for coordinating speech articulation. Nature 384:159–161CrossRefPubMed

Dronkers NF, Wilkins DP, Van Valin RD Jr, Redfern BB, Jaeger JJ (2004) Lesion analysis of the brain areas involved in language comprehension. Cognition 92:145–177CrossRefPubMed

Ellis C, Simpson AN, Bonilha H, Mauldin PD, Simpson KN (2012) The one-year attributable cost of poststroke aphasia. Stroke 43:1429–1431CrossRefPubMedPubMedCentral

Fox MD, Snyder AZ, Vincent JL, Corbetta M, Van Essen DC, Raichle ME (2005) The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proc Natl Acad Sci USA 102:9673–9678CrossRefPubMedPubMedCentral

Fridriksson J, Richardson JD, Fillmore P, Cai B (2012) Left hemisphere plasticity and aphasia recovery. Neuroimage 60:854–863CrossRefPubMed

Gao SR, Chu YF, Shi S, Peng Q, Dai SD, Wang YMH (1992) A standardization research of the aphasia battery of Chinese. Chin Mental Health J 6:125–128

Geva S, Baron JC, Jones PS, Price CJ, Warburton EA (2012) A comparison of VLSM and VBM in a cohort of patients with post-stroke aphasia. Neuroimage Clin 1:37–47CrossRefPubMedPubMedCentral

Ghosh S, Basu A, Kumaran SS, Khushu S (2010) Functional mapping of language networks in the normal brain using a word-association task. Indian J Radiol Imaging 20:182–187CrossRefPubMedPubMedCentral

Girbau-Massana D, Garcia-Marti G, Marti-Bonmati L, Schwartz RG (2014) Gray-white matter and cerebrospinal fluid volume differences in children with specific language impairment and/or reading disability. Neuropsychologia 56:90–100CrossRefPubMed

Good CD, Johnsrude IS, Ashburner J, Henson RNA, Friston KJ, Frackowiak RSJ (2001) A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage 14:21–36CrossRefPubMed

Greicius MD, Supekar K, Menon V, Dougherty RF (2009) Resting-state functional connectivity reflects structural connectivity in the default mode network. Cereb Cortex 19:72–78CrossRefPubMed

Hagmann P, Sporns O, Madan N, Cammoun L, Pienaar R, Wedeen VJ et al (2010) White matter maturation reshapes structural connectivity in the late developing human brain. Proc Natl Acad Sci USA 107:19067–19072CrossRefPubMedPubMedCentral

Hartwigsen G, Baumgaertner A, Price CJ, Koehnke M, Ulmer S, Siebner HR (2010) Phonological decisions require both the left and right supramarginal gyri. Proc Natl Acad Sci USA 107:16494–16499CrossRefPubMedPubMedCentral

Honey CJ, Sporns O, Cammoun L, Gigandet X, Thiran JP, Meuli R et al (2009) Predicting human resting-state functional connectivity from structural connectivity. Proc Natl Acad Sci USA 106:2035–2040CrossRefPubMedPubMedCentral

Ji GJ, Zhang Z, Xu Q, Zang YF, Liao W, Lu G (2014) Generalized tonic-clonic seizures: aberrant interhemispheric functional and anatomical connectivity. Radiology 271:839–847CrossRefPubMed

Johnson MD, Ojemann GA (2000) The role of the human thalamus in language and memory: evidence from electrophysiological studies. Brain Cogn 42:218–230CrossRefPubMed

Jonas S (1982) The thalamus and aphasia, including transcortical aphasia: a review. J Commun Disord 15:31–41CrossRefPubMed

Just MA, Cherkassky VL, Keller TA, Minshew NJ (2004) Cortical activation and synchronization during sentence comprehension in high-functioning autism: evidence of underconnectivity. Brain 127:1811–1821CrossRefPubMed

Kana RK, Keller TA, Cherkassky VL, Minshew NJ, Just MA (2006) Sentence comprehension in autism: thinking in pictures with decreased functional connectivity. Brain 129:2484–2493CrossRefPubMedPubMedCentral

Kochunov P, Thompson PM, Lancaster JL, Bartzokis G, Smith S, Coyle T et al (2007) Relationship between white matter fractional anisotropy and other indices of cerebral health in normal aging: tract-based spatial statistics study of aging. Neuroimage 35:478–487CrossRefPubMed

Liao W, Xu Q, Mantini D, Ding J, Machado-de-Sousa JP, Hallak JE et al (2011a) Altered gray matter morphometry and resting-state functional and structural connectivity in social anxiety disorder. Brain Res 1388:167–177CrossRefPubMed

Liao W, Zhang Z, Pan Z, Mantini D, Ding J, Duan X et al (2011b) Default mode network abnormalities in mesial temporal lobe epilepsy: a study combining fMRI and DTI. Hum Brain Mapp 32:883–895CrossRefPubMed

Liao W, Yu Y, Miao HH, Feng YX, Ji GJ, Feng JH (2017) Inter-hemispheric intrinsic connectivity as a neuromarker for the diagnosis of boys with Tourette syndrome. Mol Neurobiol 54:2781–2789CrossRefPubMed

Liu L, Luo X-G, Dy C-L, Ren Y, Feng Y, Yu H-M et al (2015) Characteristics of language impairment in Parkinson’s disease and its influencing factors. Transl Neurodegener 4:2–2CrossRefPubMedPubMedCentral

Long Z, Xu Q, Miao HH, Yu Y, Ding MP, Chen H et al (2017) Thalamocortical dysconnectivity in paroxysmal kinesigenic dyskinesia: Combining functional magnetic resonance imaging and diffusion tensor imaging. Mov Disord 32:592–600CrossRefPubMed

Lu J, Wu J, Yao C, Zhuang D, Qiu T, Hu X et al (2013) Awake language mapping and 3-Tesla intraoperative MRI-guided volumetric resection for gliomas in language areas. J Clin Neurosci 20:1280–1287CrossRefPubMed

Martensson F, Roll M, Lindgren M, Apt P, Horne M (2014) Sensory-specific anomic aphasia following left occipital lesions: data from free oral descriptions of concrete word meanings. Neurocase 20:192–207CrossRefPubMed

Menke R, Meinzer M, Kugel H, Deppe M, Baumgaertner A, Schiffbauer H et al (2009) Imaging short- and long-term training success in chronic aphasia. BMC Neurosci 10:118CrossRefPubMedPubMedCentral

Musso M, Weiller C, Kiebel S, Muller SP, Bulau P, Rijntjes M (1999) Training-induced brain plasticity in aphasia. Brain 122:1781–1790CrossRefPubMed

Nair VA, Young BM, La C, Reiter P, Nadkarni TN, Song J et al (2015) Functional connectivity changes in the language network during stroke recovery. Ann Clin Transl Neurol 2:185–195CrossRefPubMedPubMedCentral

Ogar JM, Baldo JV, Wilson SM, Brambati SM, Miller BL, Dronkers NF et al (2011) Semantic dementia and persisting Wernicke’s aphasia: Linguistic and anatomical profiles. Brain Lang 117:28–33CrossRefPubMedPubMedCentral

Oliver RT, Geiger EJ, Lewandowski BC, Thompson-Schill SL (2009) Remembrance of things touched: How sensorimotor experience affects the neural instantiation of object form. Neuropsychologia 47:239–247CrossRefPubMed

Power JD, Barnes KA, Snyder AZ, Schlaggar BL, Petersen SE (2012) Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion. Neuroimage 59:2142–2154CrossRefPubMed

Price CJ (2010) The anatomy of language: a review of 100 fMRI studies published in 2009. Ann NY Acad Sci 1191:62–88CrossRefPubMed

Price CJ, Devlin JT (2003) The myth of the visual word form area. Neuroimage 19:473–481CrossRefPubMed

Radulescu E, Minati L, Ganeshan B, Harrison NA, Gray MA, Beacher FDCC et al (2013) Abnormalities in fronto-striatal connectivity within language networks relate to differences in grey-matter heterogeneity in Asperger syndrome. Neuroimage Clin 2:716–726CrossRefPubMedPubMedCentral

Raposo A, Moss HE, Stamatakis EA, Tyler LK (2006) Repetition suppression and semantic enhancement: An investigation of the neural correlates of priming. Neuropsychologia 44:2284–2295CrossRefPubMed

Sakai KL, Nauchi A, Tatsuno Y, Hirano K, Muraishi Y, Kimura M et al (2009) Distinct roles of left inferior frontal regions that explain individual differences in second language acquisition. Hum Brain Mapp 30:2440–2452CrossRefPubMed

Sims JA, Kapse K, Glynn P, Sandberg C, Tripodis Y, Kiran S (2016) The relationships between the amount of spared tissue, percent signal change, and accuracy in semantic processing in aphasia. Neuropsychologia 84:113–126CrossRefPubMedPubMedCentral

Sollmann N, Tanigawa N, Ringel F, Zimmer C, Meyer B, Krieg SM (2014) Language and its right-hemispheric distribution in healthy brains: an investigation by repetitive transcranial magnetic stimulation. Neuroimage 102:776–788CrossRefPubMed

Stebbins GT, Nyenhuis DL, Wang C, Cox JL, Freels S, Bangen K et al (2008) Gray matter atrophy in patients with ischemic stroke with cognitive impairment. Stroke 39:785–793CrossRefPubMed

Turken AU, Dronkers NF (2011) The neural architecture of the language comprehension network: converging evidence from lesion and connectivity analyses. Front Syst Neurosci 5:1–1CrossRefPubMedPubMedCentral

van Hees S, McMahon K, Angwin A, de Zubicaray G, Read S, Copland DA (2014a) Changes in white matter connectivity following therapy for anomia post stroke. Neurorehabil Neural Repair 28:325–334CrossRefPubMed

van Hees S, McMahon K, Angwin A, de Zubicaray G, Read S, Copland DA (2014b) A functional MRI study of the relationship between naming treatment outcomes and resting state functional connectivity in post-stroke aphasia. Hum Brain Mapp 35:3919–3931CrossRefPubMed

Wang X, Wang M, Wang W, Liu H, Tao J, Yang C et al (2014) Resting state brain default network in patients with motor aphasia resulting from cerebral infarction. Chin Sci Bull 59:4069–4076CrossRef

Wise RJS, Greene J, Buchel C, Scott SK (1999) Brain regions involved in articulation. The Lancet 353:1057–1061CrossRef

Xu Y, Lin Q, Han Z, He Y, Bi Y (2016) Intrinsic functional network architecture of human semantic processing: modules and hubs. Neuroimage 132:542–555CrossRefPubMed

Yang M, Li J, Li Y, Li R, Pang Y, Yao D et al (2016a) Altered intrinsic regional activity and interregional functional connectivity in post-stroke aphasia. Sci Rep 6:24803CrossRefPubMedPubMedCentral

Yang M, Li J, Yao D, Chen H (2016b) Disrupted intrinsic local synchronization in poststroke aphasia. Medicine 95:e3101CrossRefPubMedPubMedCentral

Yang M, Li Y, Li J, Yao D, Liao W, Chen H (2017) Beyond the arcuate fasciculus: damage to ventral and dorsal language pathways in aphasia. Brain Topogr 30:249–256CrossRefPubMed

Zeng LL, Wang D, Fox MD, Sabuncu M, Hu D, Ge M et al (2014) Neurobiological basis of head motion in brain imaging. Proc Natl Acad Sci USA 111:6058–6062CrossRefPubMedPubMedCentral

Zhang Z, Liao W, Chen H, Mantini D, Ding JR, Xu Q et al (2011) Altered functional-structural coupling of large-scale brain networks in idiopathic generalized epilepsy. Brain 134:2912–2928CrossRefPubMed

Zhu D, Chang J, Freeman S, Tan Z, Xiao J, Gao Y et al (2014) Changes of functional connectivity in the left frontoparietal network following aphasic stroke. Front Behav Neurosci 8:167CrossRefPubMedPubMedCentral

Titel: Altered Structure and Intrinsic Functional Connectivity in Post-stroke Aphasia
verfasst von: Mi Yang
Pu Yang
Yun-Shuang Fan
Jiao Li
Dezhong Yao
Wei Liao
Huafu Chen
Publikationsdatum: 18.09.2017
Verlag: Springer US
Erschienen in: Brain Topography / Ausgabe 2/2018
Print ISSN: 0896-0267
Elektronische ISSN: 1573-6792
DOI: https://doi.org/10.1007/s10548-017-0594-7

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