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Clinical & Experimental Metastasis

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29.05.2018 | Research Paper

Alternative splicing and cancer metastasis: prognostic and therapeutic applications

verfasst von: Diego M. Marzese, Ayla O. Manughian-Peter, Javier I. J. Orozco, Dave S. B. Hoon

Erschienen in: Clinical & Experimental Metastasis | Ausgabe 5-6/2018

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Abstract

Metastatic cells exhibit an extraordinary phenotypic plasticity, not only in adapting to unfamiliar microenvironments but also in surviving aggressive treatments and immune responses. A major source of phenotypic variability is alternative splicing (AS) of the pre-messenger RNA. This process is catalyzed by one of the most complex pieces of cellular molecular regulatory events, the spliceosome, which is composed of ribonucleoproteins and polypeptides termed spliceosome factors. With strong evidence indicating that AS affects nearly all genes encoded by the human genome, aberrant AS programs have a significant impact on cancer cell development and progression. In this review, we present insights about the genomic and epigenomic factors affecting AS, summarize the most recent findings linking aberrant AS to metastatic progression, and highlight potential prognostic and therapeutic applications.

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Titel: Alternative splicing and cancer metastasis: prognostic and therapeutic applications
verfasst von: Diego M. Marzese
Ayla O. Manughian-Peter
Javier I. J. Orozco
Dave S. B. Hoon
Publikationsdatum: 29.05.2018
Verlag: Springer Netherlands
Erschienen in: Clinical & Experimental Metastasis / Ausgabe 5-6/2018
Print ISSN: 0262-0898
Elektronische ISSN: 1573-7276
DOI: https://doi.org/10.1007/s10585-018-9905-y

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Alternative splicing and cancer metastasis: prognostic and therapeutic applications

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