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Zeitschrift

Alzheimer's Research & Therapy

Alzheimer's Research & Therapy 1/2017

Ausgabe 1/2017

Inhaltsverzeichnis ( 101 Artikel )

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Tau passive immunization inhibits not only tau but also Aβ pathology

Chun-ling Dai, Yunn Chyn Tung, Fei Liu, Cheng-Xin Gong, Khalid Iqbal

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Diagnostic impact of [18F]flutemetamol PET in early-onset dementia

Marissa D. Zwan, Femke H. Bouwman, Elles Konijnenberg, Wiesje M. van der Flier, Adriaan A. Lammertsma, Frans R. J. Verhey, Pauline Aalten, Bart N. M. van Berckel, Philip Scheltens

01.12.2017 | Research | Ausgabe 1/2017 Open Access

A cognitive electrophysiological signature differentiates amnestic mild cognitive impairment from normal aging

Juan Li, Lucas S. Broster, Gregory A. Jicha, Nancy B. Munro, Frederick A. Schmitt, Erin Abner, Richard Kryscio, Charles D. Smith, Yang Jiang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Sorting nexin-4 regulates β-amyloid production by modulating β-site-activating cleavage enzyme-1

Na-Young Kim, Mi-Hyang Cho, Se-Hoon Won, Hoe-Jin Kang, Seung-Yong Yoon, Dong-Hou Kim

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Peripheral apoE isoform levels in cognitively normal APOE ε3/ε4 individuals are associated with regional gray matter volume and cerebral glucose metabolism

Henrietta M. Nielsen, Kewei Chen, Wendy Lee, Yinghua Chen, Robert J. Bauer III, Eric Reiman, Richard Caselli, Guojun Bu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Interaction between personality traits and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology modulates cognitive performance

Domilė Tautvydaitė, Deepti Kukreja, Jean-Philippe Antonietti, Hugues Henry, Armin von Gunten, Julius Popp

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Increased dementia risk predominantly in diabetes mellitus rather than in hypertension or hyperlipidemia: a population-based cohort study

Yen-Chun Fan, Jung-Lung Hsu, Hong-Yi Tung, Chia-Chi Chou, Chyi-Huey Bai

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Unbiased estimates of cerebrospinal fluid β-amyloid 1–42 cutoffs in a large memory clinic population

Daniela Bertens, Betty M. Tijms, Philip Scheltens, Charlotte E. Teunissen, Pieter Jelle Visser

01.12.2017 | Research | Ausgabe 1/2017 Open Access

The effects of different familial Alzheimer’s disease mutations on APP processing in vivo

Steinunn Thordardottir, Anne Kinhult Ståhlbom, Ove Almkvist, Håkan Thonberg, Maria Eriksdotter, Henrik Zetterberg, Kaj Blennow, Caroline Graff

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Evidence for benefit of statins to modify cognitive decline and risk in Alzheimer’s disease

Nophar Geifman, Roberta Diaz Brinton, Richard E. Kennedy, Lon S. Schneider, Atul J. Butte

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Proportion of dementia in Australia explained by common modifiable risk factors

Kimberly Ashby-Mitchell, Richard Burns, Jonathan Shaw, Kaarin J. Anstey

01.12.2017 | Erratum | Ausgabe 1/2017 Open Access

Erratum to: The societal costs of dementia in Sweden 2012 – relevance and methodological challenges in valuing informal care

Anders Wimo, Linus Jönsson, Laura Fratiglioni, Per Olof Sandman, Anders Gustavsson, Anders Sköldunger, John Lennarth Johansson

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Retinal vascular and structural changes are associated with amyloid burden in the elderly: ophthalmic biomarkers of preclinical Alzheimer’s disease

S.Mojtaba Golzan, Kathryn Goozee, Dana Georgevsky, Alberto Avolio, Pratishtha Chatterjee, Kaikai Shen, Vivek Gupta, Roger Chung, Greg Savage, Carolyn F. Orr, Ralph N. Martins, Stuart L. Graham

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Role of neuroinflammation in neurodegeneration: new insights

Róisín M. McManus, Michael T. Heneka

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Evaluation of a research diagnostic algorithm for DSM-5 neurocognitive disorders in a population-based cohort of older adults

Ranmalee Eramudugolla, Moyra E. Mortby, Perminder Sachdev, Chantal Meslin, Rajeev Kumar, Kaarin J. Anstey

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Validating the role of the Australian National University Alzheimer’s Disease Risk Index (ANU-ADRI) and a genetic risk score in progression to cognitive impairment in a population-based cohort of older adults followed for 12 years

Shea J. Andrews, Ranmalee Eramudugolla, Jorge I. Velez, Nicolas Cherbuin, Simon Easteal, Kaarin J. Anstey

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Reduced cGMP levels in CSF of AD patients correlate with severity of dementia and current depression

Raphael Hesse, Ludwig Lausser, Pauline Gummert, Florian Schmid, Anke Wahler, Cathrin Schnack, Katja S. Kroker, Markus Otto, Hayrettin Tumani, Hans A. Kestler, Holger Rosenbrock, Christine A. F. von Arnim

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Cost-effectiveness of cerebrospinal biomarkers for the diagnosis of Alzheimer’s disease

Spencer A. W. Lee, Luciano A. Sposato, Vladimir Hachinski, Lauren E. Cipriano

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Cognitive profile in prodromal dementia with Lewy bodies

Jennifer Kemp, Nathalie Philippi, Clélie Phillipps, Catherine Demuynck, Timothée Albasser, Catherine Martin-Hunyadi, Catherine Schmidt-Mutter, Benjamin Cretin, Frédéric Blanc

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Chemically treated plasma Aβ is a potential blood-based biomarker for screening cerebral amyloid deposition

Jong-Chan Park, Sun-Ho Han, Hyun Jin Cho, Min Soo Byun, Dahyun Yi, Young Min Choe, Seokjo Kang, Eun Sun Jung, Su Jin Won, Eun Hye Kim, Yu Kyeong Kim, Dong Young Lee, Inhee Mook-Jung

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Predicting dementia using socio-demographic characteristics and the Free and Cued Selective Reminding Test in the general population

Thibault Mura, Marieta Baramova, Audrey Gabelle, Sylvaine Artero, Jean-François Dartigues, Hélène Amieva, Claudine Berr

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Structured relearning of activities of daily living in dementia: the randomized controlled REDALI-DEM trial on errorless learning

Sebastian Voigt-Radloff, Maartje M. E. de Werd, Rainer Leonhart, Danielle H. E. Boelen, Marcel G. M. Olde Rikkert, Klaus Fliessbach, Stefan Klöppel, Bernhard Heimbach, Andreas Fellgiebel, Richard Dodel, Gerhard W. Eschweiler, Lucrezia Hausner, Roy P. C. Kessels, Michael Hüll

01.12.2017 | Research | Ausgabe 1/2017 Open Access

DHA brain uptake and APOE4 status: a PET study with [1-11C]-DHA

Hussein N. Yassine, Etienne Croteau, Varun Rawat, Joseph R. Hibbeln, Stanley I. Rapoport, Stephen C. Cunnane, John C. Umhau

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Memory performance-related dynamic brain connectivity indicates pathological burden and genetic risk for Alzheimer’s disease

Frances C. Quevenco, Maria G. Preti, Jiri M. G. van Bergen, Jun Hua, Michael Wyss, Xu Li, Simon J. Schreiner, Stefanie C. Steininger, Rafael Meyer, Irene B. Meier, Adam M. Brickman, Sandra E. Leh, Anton F. Gietl, Alfred Buck, Roger M. Nitsch, Klaas P. Pruessmann, Peter C. M. van Zijl, Christoph Hock, Dimitri Van De Ville, Paul G. Unschuld

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain

Kok Pin Ng, Tharick A. Pascoal, Sulantha Mathotaarachchi, Joseph Therriault, Min Su Kang, Monica Shin, Marie-Christine Guiot, Qi Guo, Ryuichi Harada, Robert A. Comley, Gassan Massarweh, Jean-Paul Soucy, Nobuyuki Okamura, Serge Gauthier, Pedro Rosa-Neto

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Perseverance time of informal caregivers for people with dementia: construct validity, responsiveness and predictive validity

Anke Richters, René J. F. Melis, N. Job van Exel, Marcel G. M. Olde Rikkert, Marjolein A. van der Marck

01.12.2017 | Review | Ausgabe 1/2017 Open Access

The need for harmonisation and innovation of neuropsychological assessment in neurodegenerative dementias in Europe: consensus document of the Joint Program for Neurodegenerative Diseases Working Group

Alberto Costa, Thomas Bak, Paolo Caffarra, Carlo Caltagirone, Mathieu Ceccaldi, Fabienne Collette, Sebastian Crutch, Sergio Della Sala, Jean François Démonet, Bruno Dubois, Emrah Duzel, Peter Nestor, Sokratis G. Papageorgiou, Eric Salmon, Sietske Sikkes, Pietro Tiraboschi, Wiesje M. van der Flier, Pieter Jelle Visser, Stefano F. Cappa

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Multireceptor fingerprints in progressive supranuclear palsy

Wang Zheng Chiu, Laura Donker Kaat, Agnita J. W. Boon, Wouter Kamphorst, Axel Schleicher, Karl Zilles, John C. van Swieten, Nicola Palomero-Gallagher

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Analyzing the genes related to Alzheimer’s disease via a network and pathway-based approach

Yan-Shi Hu, Juncai Xin, Ying Hu, Lei Zhang, Ju Wang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Evaluation of a DNA Aβ42 vaccine in adult rhesus monkeys (Macaca mulatta): antibody kinetics and immune profile after intradermal immunization with full-length DNA Aβ42 trimer

Doris Lambracht-Washington, Min Fu, Pat Frost, Roger N. Rosenberg

01.12.2017 | Review | Ausgabe 1/2017 Open Access

The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer’s pathology

Sarah Westwood, Benjamine Liu, Alison L. Baird, Sneha Anand, Alejo J. Nevado-Holgado, Danielle Newby, Maria Pikkarainen, Merja Hallikainen, Johanna Kuusisto, Johannes R. Streffer, Gerald Novak, Kaj Blennow, Ulf Andreasson, Henrik Zetterberg, Ulf Smith, Markku Laakso, Hilkka Soininen, Simon Lovestone

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Comparison of CSF markers and semi-quantitative amyloid PET in Alzheimer’s disease diagnosis and in cognitive impairment prognosis using the ADNI-2 database

Fayçal Ben Bouallègue, Denis Mariano-Goulart, Pierre Payoux, the Alzheimer’s Disease Neuroimaging Initiative (ADNI)

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Memory is preserved in older adults taking AT1 receptor blockers

Jean K. Ho, Daniel A. Nation, for the Alzheimer’s Disease Neuroimaging Initiative

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Antipsychotic prescribing for Alzheimer’s disease and related disorders in specialized settings from 2010 to 2014 in France: a repeated cross-sectional study

Karim Tifratene, Valeria Manera, Roxane Fabre, Auriane Gros, Susanne Thummler, Christian Pradier, Philippe Robert, Renaud David

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Communicating mild cognitive impairment diagnoses with and without amyloid imaging

Joshua D. Grill, Liana G. Apostolova, Szofia Bullain, Jeffrey M. Burns, Chelsea G. Cox, Malcolm Dick, Dean Hartley, Claudia Kawas, Sarah Kremen, Jennifer Lingler, Oscar L. Lopez, Mark Mapstone, Aimee Pierce, Gil Rabinovici, J. Scott Roberts, Seyed Ahmad Sajjadi, Edmond Teng, Jason Karlawish

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Optimizing medication appropriateness in older adults: a randomized clinical interventional trial to decrease anticholinergic burden

Daniela C. Moga, Erin L. Abner, Dorinda N. Rigsby, Lynne Eckmann, Mark Huffmyer, Richard R. Murphy, Beth B. Coy, Gregory A. Jicha

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Association between blood pressure and Alzheimer disease measured up to 27 years prior to diagnosis: the HUNT Study

Jessica Mira Gabin, Kristian Tambs, Ingvild Saltvedt, Erik Sund, Jostein Holmen

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Glutaminyl cyclase activity correlates with levels of Aβ peptides and mediators of angiogenesis in cerebrospinal fluid of Alzheimer’s disease patients

Claire Bridel, Torsten Hoffmann, Antje Meyer, Sisi Durieux, Marleen A. Koel-Simmelink, Matthias Orth, Philip Scheltens, Inge Lues, Charlotte E. Teunissen

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Efficacy of the Ubiquitous Spaced Retrieval-based Memory Advancement and Rehabilitation Training (USMART) program among patients with mild cognitive impairment: a randomized controlled crossover trial

Ji Won Han, Kyung Lak Son, Hye Jin Byun, Ji Won Ko, Kayoung Kim, Jong Woo Hong, Tae Hyun Kim, Ki Woong Kim

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Recommendations for cerebrospinal fluid collection for the analysis by ELISA of neurogranin trunc P75, α-synuclein, and total tau in combination with Aβ(1–42)/Aβ(1–40)

Hugo Vanderstichele, Leentje Demeyer, Shorena Janelidze, Els Coart, Erik Stoops, Kimberley Mauroo, Victor Herbst, Cindy François, Oskar Hansson

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

A vaccine with Aβ oligomer-specific mimotope attenuates cognitive deficits and brain pathologies in transgenic mice with Alzheimer’s disease

Shao-wei Wang, Dong-qun Liu, Ling-xiao Zhang, Mei Ji, Yang-xin Zhang, Quan-xiu Dong, Shu-ying Liu, Xi-xiu Xie, Rui-tian Liu

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Stem cell models of Alzheimer’s disease: progress and challenges

Charles Arber, Christopher Lovejoy, Selina Wray

01.12.2017 | Research | Ausgabe 1/2017 Open Access

One-carbon metabolism, cognitive impairment and CSF measures of Alzheimer pathology: homocysteine and beyond

Loïc Dayon, Seu Ping Guiraud, John Corthésy, Laeticia Da Silva, Eugenia Migliavacca, Domilė Tautvydaitė, Aikaterini Oikonomidi, Barbara Moullet, Hugues Henry, Sylviane Métairon, Julien Marquis, Patrick Descombes, Sebastiano Collino, François-Pierre J. Martin, Ivan Montoliu, Martin Kussmann, Jérôme Wojcik, Gene L. Bowman, Julius Popp

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Digitally translated Self-Administered Gerocognitive Examination (eSAGE): relationship with its validated paper version, neuropsychological evaluations, and clinical assessments

Douglas W. Scharre, Shu ing Chang, Haikady N. Nagaraja, Nicole E. Vrettos, Robert A. Bornstein

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Prevention of dendritic and synaptic deficits and cognitive impairment with a neurotrophic compound

Narjes Baazaoui, Khalid Iqbal

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Oligomeric tau-targeted immunotherapy in Tg4510 mice

Sulana Schroeder, Aurelie Joly-Amado, Ahlam Soliman, Urmi Sengupta, Rakiz Kayed, Marcia N. Gordon, David Morgan

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Long-term cognitive outcome of Alzheimer’s disease and dementia with Lewy bodies: dual disease is worse

Frédéric Blanc, Rachid Mahmoudi, Thérèse Jonveaux, Jean Galmiche, Gilles Chopard, Benjamin Cretin, Catherine Demuynck, Catherine Martin-Hunyadi, Nathalie Philippi, François Sellal, Jean-Marc Michel, Gregory Tio, Melanie Stackfleth, Pierre Vandel, Eloi Magnin, Jean-Luc Novella, Georges Kaltenbach, Athanase Benetos, Erik A. Sauleau

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Cerebrospinal fluid biomarkers for Alzheimer's and vascular disease vary by age, gender, and APOE genotype in cognitively normal adults

Ge Li, Jane B. Shofer, Eric C. Petrie, Chang-En Yu, Charles W. Wilkinson, Dianne P. Figlewicz, Andrew Shutes-David, Jing Zhang, Thomas J. Montine, Murray A. Raskind, Joseph F. Quinn, Douglas R. Galasko, Elaine R. Peskind

01.12.2017 | Research | Ausgabe 1/2017 Open Access

No added diagnostic value of non-phosphorylated tau fraction (p-taurel) in CSF as a biomarker for differential dementia diagnosis

Joery Goossens, Maria Bjerke, Hanne Struyfs, Ellis Niemantsverdriet, Charisse Somers, Tobi Van den Bossche, Sara Van Mossevelde, Bart De Vil, Anne Sieben, Jean-Jacques Martin, Patrick Cras, Johan Goeman, Peter Paul De Deyn, Christine Van Broeckhoven, Julie van der Zee, Sebastiaan Engelborghs

01.12.2017 | Research | Ausgabe 1/2017 Open Access

A novel Alzheimer’s disease drug candidate targeting inflammation and fatty acid metabolism

Daniel Daugherty, Joshua Goldberg, Wolfgang Fischer, Richard Dargusch, Pamela Maher, David Schubert

01.12.2017 | Research | Ausgabe 1/2017 Open Access

The medical food Souvenaid affects brain phospholipid metabolism in mild Alzheimer’s disease: results from a randomized controlled trial

Anne Rijpma, Marinette van der Graaf, Marieke M. Lansbergen, Olga Meulenbroek, Aysun Cetinyurek-Yavuz, John W. Sijben, Arend Heerschap, Marcel G. M. Olde Rikkert

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Differential role of CSF fatty acid binding protein 3, α-synuclein, and Alzheimer’s disease core biomarkers in Lewy body disorders and Alzheimer’s dementia

Davide Chiasserini, Leonardo Biscetti, Paolo Eusebi, Nicola Salvadori, Giulia Frattini, Simone Simoni, Naomi De Roeck, Nicola Tambasco, Erik Stoops, Hugo Vanderstichele, Sebastiaan Engelborghs, Brit Mollenhauer, Paolo Calabresi, Lucilla Parnetti

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Behavioural and neuroanatomical correlates of auditory speech analysis in primary progressive aphasias

Chris J. D. Hardy, Jennifer L. Agustus, Charles R. Marshall, Camilla N. Clark, Lucy L. Russell, Rebecca L. Bond, Emilie V. Brotherhood, David L. Thomas, Sebastian J. Crutch, Jonathan D. Rohrer, Jason D. Warren

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Increased Aβ42-α7-like nicotinic acetylcholine receptor complex level in lymphocytes is associated with apolipoprotein E4-driven Alzheimer’s disease pathogenesis

Hoau-Yan Wang, Caryn Trocmé-Thibierge, Andres Stucky, Sanket M. Shah, Jessica Kvasic, Amber Khan, Philippe Morain, Isabelle Guignot, Eva Bouguen, Karine Deschet, Maria Pueyo, Elisabeth Mocaer, Pierre-Jean Ousset, Bruno Vellas, Vera Kiyasova

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Sensitivity of restriction spectrum imaging to memory and neuropathology in Alzheimer’s disease

Emilie T. Reas, Donald J. Hagler Jr, Nathan S. White, Joshua M. Kuperman, Hauke Bartsch, Karalani Cross, Richard Q. Loi, Akshara R. Balachandra, M. J. Meloy, Christina E. Wierenga, Douglas Galasko, James B. Brewer, Anders M. Dale, Linda K. McEvoy

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Association between chronic periodontitis and the risk of Alzheimer’s disease: a retrospective, population-based, matched-cohort study

Chang-Kai Chen, Yung-Tsan Wu, Yu-Chao Chang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with γ-secretase and regulates neuronal amyloid β-peptide levels

Sophia Schedin-Weiss, Mitsuhiro Inoue, Lenka Hromadkova, Yasuhiro Teranishi, Natsuko Goto Yamamoto, Birgitta Wiehager, Nenad Bogdanovic, Bengt Winblad, Anna Sandebring-Matton, Susanne Frykman, Lars O. Tjernberg

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Anticholinergic drugs and functional, cognitive impairment and behavioral disturbances in patients from a memory clinic with subjective cognitive decline or neurocognitive disorders

Virginie Dauphinot, Christelle Mouchoux, Sébastien Veillard, Floriane Delphin-Combe, Pierre Krolak-Salmon

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Risk of head and traumatic brain injuries associated with antidepressant use among community-dwelling persons with Alzheimer’s disease: a nationwide matched cohort study

Heidi Taipale, Marjaana Koponen, Antti Tanskanen, Piia Lavikainen, Reijo Sund, Jari Tiihonen, Sirpa Hartikainen, Anna-Maija Tolppanen

01.12.2017 | Review | Ausgabe 1/2017 Open Access

On the path to 2025: understanding the Alzheimer’s disease continuum

Paul S. Aisen, Jeffrey Cummings, Clifford R. Jack Jr, John C. Morris, Reisa Sperling, Lutz Frölich, Roy W. Jones, Sherie A. Dowsett, Brandy R. Matthews, Joel Raskin, Philip Scheltens, Bruno Dubois

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Can cognitive assessment really discriminate early stages of Alzheimer’s and behavioural variant frontotemporal dementia at initial clinical presentation?

Sophia Reul, Hubertus Lohmann, Heinz Wiendl, Thomas Duning, Andreas Johnen

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Non-canonical soluble amyloid-beta aggregates and plaque buffering: controversies and future directions for target discovery in Alzheimer’s disease

David L. Brody, Hao Jiang, Norelle Wildburger, Thomas J. Esparza

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Distinct white matter microstructural abnormalities and extracellular water increases relate to cognitive impairment in Alzheimer’s disease with and without cerebrovascular disease

Fang Ji, Ofer Pasternak, Siwei Liu, Yng Miin Loke, Boon Linn Choo, Saima Hilal, Xin Xu, Mohammad Kamran Ikram, Narayanaswamy Venketasubramanian, Christopher Li-Hsian Chen, Juan Zhou

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Associations of thyroid hormone serum levels with in-vivo Alzheimer’s disease pathologies

Hyo Jung Choi, Min Soo Byun, Dahyun Yi, Bo Kyung Sohn, Jun Ho Lee, Jun-Young Lee, Yu Kyung Kim, Dong Young Lee, for the KBASE Research Group

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Cost of diagnosing dementia in a German memory clinic

Bernhard Michalowsky, Steffen Flessa, Johannes Hertel, Olav Goetz, Wolfgang Hoffmann, Stefan Teipel, Ingo Kilimann

01.12.2017 | Research | Ausgabe 1/2017 Open Access

A coiled conformation of amyloid-β recognized by antibody C706

Alexey Teplyakov, Galina Obmolova, Gary L. Gilliland

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Cognitive and imaging markers in non-demented subjects attending a memory clinic: study design and baseline findings of the MEMENTO cohort

Carole Dufouil, Bruno Dubois, Bruno Vellas, Florence Pasquier, Frédéric Blanc, Jacques Hugon, Olivier Hanon, Jean-François Dartigues, Sandrine Harston, Audrey Gabelle, Mathieu Ceccaldi, Olivier Beauchet, Pierre Krolak-Salmon, Renaud David, Olivier Rouaud, Olivier Godefroy, Catherine Belin, Isabelle Rouch, Nicolas Auguste, David Wallon, Athanase Benetos, Jérémie Pariente, Marc Paccalin, Olivier Moreaud, Caroline Hommet, François Sellal, Claire Boutoleau-Bretonniére, Isabelle Jalenques, Armelle Gentric, Pierre Vandel, Chabha Azouani, Ludovic Fillon, Clara Fischer, Helen Savarieau, Gregory Operto, Hugo Bertin, Marie Chupin, Vincent Bouteloup, Marie-Odile Habert, Jean-François Mangin, Geneviève Chêne, on behalf of the MEMENTO cohort Study Group

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Structured physical exercise improves neuropsychiatric symptoms in acute dementia care: a hospital-based RCT

Tim Fleiner, Hannah Dauth, Marleen Gersie, Wiebren Zijlstra, Peter Haussermann

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Dietary arachidonic acid increases deleterious effects of amyloid-β oligomers on learning abilities and expression of AMPA receptors: putative role of the ACSL4-cPLA2 balance

Mélanie H. Thomas, Cédric Paris, Mylène Magnien, Julie Colin, Sandra Pelleïeux, Florence Coste, Marie-Christine Escanyé, Thierry Pillot, Jean-Luc Olivier

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Early- versus late-onset Alzheimer’s disease in clinical practice: cognitive and global outcomes over 3 years

Carina Wattmo, Åsa K. Wallin

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Alzheimer’s disease prevention: from risk factors to early intervention

Marta Crous-Bou, Carolina Minguillón, Nina Gramunt, José Luis Molinuevo

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Moderating effects of sex on the impact of diagnosis and amyloid positivity on verbal memory and hippocampal volume

Jessica Z. K. Caldwell, Jody-Lynn Berg, Jeffrey L. Cummings, Sarah J. Banks, for the Alzheimer’s Disease Neuroimaging Initiative

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Amyloid-independent atrophy patterns predict time to progression to dementia in mild cognitive impairment

Mara ten Kate, Frederik Barkhof, Pieter Jelle Visser, Charlotte E. Teunissen, Philip Scheltens, Wiesje M. van der Flier, Betty M. Tijms

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Serotonin augmentation therapy by escitalopram has minimal effects on amyloid-β levels in early-stage Alzheimer’s-like disease in mice

Christian Ulrich von Linstow, Jonas Waider, Manuela Grebing, Athanasios Metaxas, Klaus Peter Lesch, Bente Finsen

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Personalized predictive modeling for patients with Alzheimer’s disease using an extension of Sullivan’s life table model

Eric Stallard, Bruce Kinosian, Yaakov Stern

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Serotonin 5-HT6 receptors affect cognition in a mouse model of Alzheimer’s disease by regulating cilia function

Lili Hu, Bingjie Wang, Yan Zhang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Tracking progressive pathological and functional decline in the rTg4510 mouse model of tauopathy

Thomas Blackmore, Soraya Meftah, Tracey Karen Murray, Peter James Craig, Anthony Blockeel, Keith Phillips, Brian Eastwood, Michael J. O’Neill, Hugh Marston, Zeshan Ahmed, Gary Gilmour, Francois Gastambide

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Metabolic status of CSF distinguishes rats with tauopathy from controls

Radana Karlíková, Kateřina Mičová, Lukáš Najdekr, Alžběta Gardlo, Tomáš Adam, Petra Majerová, David Friedecký, Andrej Kováč

01.12.2017 | Research | Ausgabe 1/2017 Open Access

ERβ and ApoE isoforms interact to regulate BDNF–5-HT2A signaling and synaptic function in the female brain

Anindit Chhibber, Liqin Zhao

01.12.2017 | Research | Ausgabe 1/2017 Open Access

N-truncated Aβ4–x peptides in sporadic Alzheimer’s disease cases and transgenic Alzheimer mouse models

Oliver Wirths, Susanne Walter, Inga Kraus, Hans W. Klafki, Martina Stazi, Timo J. Oberstein, Jorge Ghiso, Jens Wiltfang, Thomas A. Bayer, Sascha Weggen

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Attitudes toward clinical trials across the Alzheimer’s disease spectrum

Michelle M. Nuño, Daniel L. Gillen, Kulwant K. Dosanjh, Jenny Brook, David Elashoff, John M. Ringman, Joshua D. Grill

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Gene suppression approaches to neurodegeneration

Rhia Ghosh, Sarah J. Tabrizi

01.12.2017 | Review | Ausgabe 1/2017 Open Access

PKR involvement in Alzheimer’s disease

Jacques Hugon, François Mouton-Liger, Julien Dumurgier, Claire Paquet

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Incremental value of biomarker combinations to predict progression of mild cognitive impairment to Alzheimer’s dementia

Lutz Frölich, Oliver Peters, Piotr Lewczuk, Oliver Gruber, Stefan J. Teipel, Hermann J. Gertz, Holger Jahn, Frank Jessen, Alexander Kurz, Christian Luckhaus, Michael Hüll, Johannes Pantel, Friedel M. Reischies, Johannes Schröder, Michael Wagner, Otto Rienhoff, Stefanie Wolf, Chris Bauer, Johannes Schuchhardt, Isabella Heuser, Eckart Rüther, Fritz Henn, Wolfgang Maier, Jens Wiltfang, Johannes Kornhuber

01.12.2017 | Commentary | Ausgabe 1/2017 Open Access

The Edinburgh Consensus: preparing for the advent of disease-modifying therapies for Alzheimer’s disease

Craig W. Ritchie, Tom C. Russ, Sube Banerjee, Bob Barber, Andrew Boaden, Nick C. Fox, Clive Holmes, Jeremy D. Isaacs, Ira Leroi, Simon Lovestone, Matt Norton, John O’Brien, Jim Pearson, Richard Perry, James Pickett, Adam D. Waldman, Wai Lup Wong, Martin N. Rossor, Alistair Burns

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Dynamic changes of oligomeric amyloid β levels in plasma induced by spiked synthetic Aβ42

Seong Soo A. An, Byoung-sub Lee, Ji Sun Yu, Kuntaek Lim, Gwang Je Kim, Ryan Lee, Shinwon Kim, Sungmin Kang, Young Ho Park, Min Jeong Wang, Young Soon Yang, Young Chul Youn, SangYun Kim

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Preclinical effects of APOE ε4 on cerebrospinal fluid Aβ42 concentrations

Ronald Lautner, Philip S. Insel, Tobias Skillbäck, Bob Olsson, Mikael Landén, Giovanni B. Frisoni, Sanna-Kaisa Herukka, Harald Hampel, Anders Wallin, Lennart Minthon, Oskar Hansson, Kaj Blennow, Niklas Mattsson, Henrik Zetterberg

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Race modifies the relationship between cognition and Alzheimer’s disease cerebrospinal fluid biomarkers

Jennifer C. Howell, Kelly D. Watts, Monica W. Parker, Junjie Wu, Alexander Kollhoff, Thomas S. Wingo, Cornelya D. Dorbin, Deqiang Qiu, William T. Hu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Circulating brain-enriched microRNAs as novel biomarkers for detection and differentiation of neurodegenerative diseases

Kira S. Sheinerman, Jon B. Toledo, Vladimir G. Tsivinsky, David Irwin, Murray Grossman, Daniel Weintraub, Howard I. Hurtig, Alice Chen-Plotkin, David A. Wolk, Leo F. McCluskey, Lauren B. Elman, John Q. Trojanowski, Samuil R. Umansky

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Neurons derived from sporadic Alzheimer’s disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation

Anna Ochalek, Balázs Mihalik, Hasan X. Avci, Abinaya Chandrasekaran, Annamária Téglási, István Bock, Maria Lo Giudice, Zsuzsanna Táncos, Kinga Molnár, Lajos László, Jørgen E. Nielsen, Bjørn Holst, Kristine Freude, Poul Hyttel, Julianna Kobolák, András Dinnyés

01.12.2017 | Research | Ausgabe 1/2017 Open Access

The clinical significance of plasma clusterin and Aβ in the longitudinal follow-up of patients with Alzheimer’s disease

Jung-Lung Hsu, Wei-Ju Lee, Yi-Chu Liao, Shuu-Jiun Wang, Jong-Ling Fuh

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Amnestic MCI patients’ experiences after disclosure of their amyloid PET result in a research context

Gwendolien Vanderschaeghe, Jolien Schaeverbeke, Rose Bruffaerts, Rik Vandenberghe, Kris Dierickx

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Study partners should be required in preclinical Alzheimer’s disease trials

Joshua D. Grill, Jason Karlawish

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Anemia is associated with incidence of dementia: a national health screening study in Korea involving 37,900 persons

Su-Min Jeong, Dong Wook Shin, Ji Eun Lee, Jung Hyeon Hyeon, Jinkook Lee, SangYun Kim

01.12.2017 | Research | Ausgabe 1/2017 Open Access

A phase III randomized trial of gantenerumab in prodromal Alzheimer’s disease

Susanne Ostrowitzki, Robert A. Lasser, Ernest Dorflinger, Philip Scheltens, Frederik Barkhof, Tania Nikolcheva, Elizabeth Ashford, Sylvie Retout, Carsten Hofmann, Paul Delmar, Gregory Klein, Mirjana Andjelkovic, Bruno Dubois, Mercè Boada, Kaj Blennow, Luca Santarelli, Paulo Fontoura, for the SCarlet RoAD Investigators

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Comparative binding properties of the tau PET tracers THK5117, THK5351, PBB3, and T807 in postmortem Alzheimer brains

Laetitia Lemoine, Per-Göran Gillberg, Marie Svedberg, Vladimir Stepanov, Zhisheng Jia, Jinghai Huang, Sangram Nag, He Tian, Bernardino Ghetti, Nobuyuki Okamura, Makoto Higuchi, Christer Halldin, Agneta Nordberg

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Rho GTPases as therapeutic targets in Alzheimer’s disease

Byron J. Aguilar, Yi Zhu, Qun Lu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Oligomeric forms of amyloid-β protein in plasma as a potential blood-based biomarker for Alzheimer’s disease

Min Jeong Wang, SangHak Yi, Jee-young Han, So Young Park, Jae-Won Jang, In Kook Chun, Sang Eun Kim, Byoung Sub Lee, Gwang Je Kim, Ji Sun Yu, Kuntaek Lim, Sung Min Kang, Young Ho Park, Young Chul Youn, Seong Soo A. An, SangYun Kim

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Posterior atrophy predicts time to dementia in patients with amyloid-positive mild cognitive impairment

Jung-Min Pyun, Young Ho Park, Hang-Rai Kim, Jeewon Suh, Min Ju Kang, Beom Joon Kim, Young Chul Youn, Jae-Won Jang, SangYun Kim, the Alzheimer’s Disease Neuroimaging Initiative

01.12.2017 | Research | Ausgabe 1/2017 Open Access

A selenium species in cerebrospinal fluid predicts conversion to Alzheimer’s dementia in persons with mild cognitive impairment

Marco Vinceti, Annalisa Chiari, Marcel Eichmüller, Kenneth J. Rothman, Tommaso Filippini, Carlotta Malagoli, Jennifer Weuve, Manuela Tondelli, Giovanna Zamboni, Paolo F. Nichelli, Bernhard Michalke

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline

Isabelle Bos, Frans R. Verhey, Inez H.G.B. Ramakers, Heidi I. L. Jacobs, Hilkka Soininen, Yvonne Freund-Levi, Harald Hampel, Magda Tsolaki, Åsa K. Wallin, Mark A. van Buchem, Ania Oleksik, Marcel M. Verbeek, Marcel Olde Rikkert, Wiesje M. van der Flier, Philip Scheltens, Pauline Aalten, Pieter Jelle Visser, Stephanie J. B. Vos

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