Ausgabe 1/2021
Inhalt (203 Artikel)
Portals to frailty? Data-driven analyses detect early frailty profiles
Linzy Bohn, Yao Zheng, G. Peggy McFall, Roger A. Dixon
Four subgroups based on tau levels in Alzheimer’s disease observed in two independent cohorts
Flora H. Duits, Kirsten E. J. Wesenhagen, Laura Ekblad, Emma Wolters, Eline A. J. Willemse, Philip Scheltens, Wiesje M. van der Flier, Charlotte E. Teunissen, Pieter Jelle Visser, Betty M. Tijms
Differences between memory encoding and retrieval failure in mild cognitive impairment: results from quantitative electroencephalography and magnetic resonance volumetry
Su-Hyun Han, Jung-Min Pyun, Soeun Yeo, Dong Won Kang, Ho Tae Jeong, Seung Wan Kang, SangYun Kim, Young Chul Youn
Region-specific amyloid-β accumulation in the olfactory system influences olfactory sensory neuronal dysfunction in 5xFAD mice
Gowoon Son, Seung-Jun Yoo, Shinwoo Kang, Ameer Rasheed, Da Hae Jung, Hyunjun Park, Bongki Cho, Harry W. M. Steinbusch, Keun-A Chang, Yoo-Hun Suh, Cheil Moon
The association of APOE ε4 with cognitive function over the adult life course and incidence of dementia: 20 years follow-up of the Whitehall II study
Amin Gharbi-Meliani, Aline Dugravot, Séverine Sabia, Melina Regy, Aurore Fayosse, Alexis Schnitzler, Mika Kivimäki, Archana Singh-Manoux, Julien Dumurgier
The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice
Jing Di, Ibrar Siddique, Zizheng Li, Ghattas Malki, Simon Hornung, Suman Dutta, Ian Hurst, Ella Ishaaya, Austin Wang, Sally Tu, Ani Boghos, Ida Ericsson, Frank-Gerrit Klärner, Thomas Schrader, Gal Bitan
Trichostatin A ameliorates Alzheimer’s disease-related pathology and cognitive deficits by increasing albumin expression and Aβ clearance in APP/PS1 mice
Qiang Su, Tian Li, Pei-Feng He, Xue-Chun Lu, Qi Yu, Qi-Chao Gao, Zhao-Jun Wang, Mei-Na Wu, Dan Yang, Jin-Shun Qi
Conditional genetic deletion of CSF1 receptor in microglia ameliorates the physiopathology of Alzheimer’s disease
Vincent Pons, Pascal Lévesque, Marie-Michèle Plante, Serge Rivest
The insulin resistance by triglyceride glucose index and risk for dementia: population-based study
Sangmo Hong, Kyungdo Han, Cheol-Young Park
Change in cognitive function according to cholinesterase inhibitor use and amyloid PET positivity in patients with mild cognitive impairment
Jung-Min Pyun, Nayoung Ryoo, Young Ho Park, SangYun Kim
Association of Aβ deposition and regional synaptic density in early Alzheimer’s disease: a PET imaging study with [11C]UCB-J
Ryan S. O’Dell, Adam P. Mecca, Ming-Kai Chen, Mika Naganawa, Takuya Toyonaga, Yihuan Lu, Tyler A. Godek, Joanna E. Harris, Hugh H. Bartlett, Emmie R. Banks, Victoria L. Kominek, Wenzhen Zhao, Nabeel B. Nabulsi, Jim Ropchan, Yunpeng Ye, Brent C. Vander Wyk, Yiyun Huang, Amy F. T. Arnsten, Richard E. Carson, Christopher H. van Dyck
Performance of the QPLEX™ Alz plus assay, a novel multiplex kit for screening cerebral amyloid deposition
Jong-Chan Park, Keum Sim Jung, Jiyeong Kim, Ji Sung Jang, Sunghoon Kwon, Min Soo Byun, Dahyun Yi, Gihwan Byeon, Gijung Jung, Yu Kyeong Kim, Dong Young Lee, Sun-Ho Han, Inhee Mook-Jung
Distinct network topology in Alzheimer’s disease and behavioral variant frontotemporal dementia
Adeline Su Lyn Ng, Juan Wang, Kwun Kei Ng, Joanna Su Xian Chong, Xing Qian, Joseph Kai Wei Lim, Yi Jayne Tan, Alisa Cui Wen Yong, Russell Jude Chander, Shahul Hameed, Simon Kang Seng Ting, Nagaendran Kandiah, Juan Helen Zhou
Biomarker testing in MCI patients—deciding who to test
Ingrid S. van Maurik, Hanneke F. M. Rhodius-Meester, Charlotte E. Teunissen, Philip Scheltens, Frederik Barkhof, Sebastian Palmqvist, Oskar Hansson, Wiesje M. van der Flier, Johannes Berkhof
Associations of Alzheimer’s disease risk variants with gene expression, amyloidosis, tauopathy, and neurodegeneration
Meng-Shan Tan, Yu-Xiang Yang, Wei Xu, Hui-Fu Wang, Lin Tan, Chuan-Tao Zuo, Qiang Dong, Lan Tan, John Suckling, Jin-Tai Yu
Recruitment and retention of participant and study partner dyads in two multinational Alzheimer’s disease registration trials
Olivia M. Bernstein, Joshua D. Grill, Daniel L. Gillen
Association between polygenic risk score of Alzheimer’s disease and plasma phosphorylated tau in individuals from the Alzheimer’s Disease Neuroimaging Initiative
Anna Zettergren, Jodie Lord, Nicholas J. Ashton, Andrea L. Benedet, Thomas K. Karikari, Juan Lantero Rodriguez, Anniina Snellman, Marc Suárez-Calvet, Petroula Proitsi, Henrik Zetterberg, Kaj Blennow
ADAM10 plasma levels predict worsening in cognition of older adults: a 3-year follow-up study
Maria Patrícia A. Oliveira Monteiro, Danielle S. M. Salheb Oliveira, Patrícia R. Manzine, Carla M. Crispim Nascimento, Ariene A. dos Santos Orlandi, Grace A. de Oliveira Gomes, Fabiana dos Santos Orlandi, Marisa S. Zazzetta, Henrique Pott-Junior, Marcia R. Cominetti
Characteristics and progression of patients with frontotemporal dementia in a regional memory clinic network
Mélanie Leroy, Maxime Bertoux, Emilie Skrobala, Elisa Mode, Catherine Adnet-Bonte, Isabelle Le Ber, Stéphanie Bombois, Pascaline Cassagnaud, Yaohua Chen, Vincent Deramecourt, Florence Lebert, Marie Anne Mackowiak, Adeline Rollin Sillaire, Marielle Wathelet, Florence Pasquier, Thibaud Lebouvier, Rachid Abied, Cathrine Adnet, Arnaud Barois, Stéphanie Baude, Véronique Berriot, Stéphanie Bombois, Gloria Boyer, Didier Brique, Gauthier Calais, Pascaline Cassagnaud, Hacène Drchekroud, Yaohua Chen, Joel Cliche, Charlotte Crinquette, Valérie Dachy, Valerie Debock, Anne Deprez, Vincent Deramecourt, Olivier Dereeper, Philippe Devos, Abdelghani Elazouzi, Adeline Enderle, Nicolas Fanjaud, Pierre Forzy, Karim Gallouj, Karine Garcon, Marie Honore, Dominique Huvent, Houria Idiri, Annabelle Ladeiro, Isabelle Lavenu, Florence Lebert, Thibaud Lebouvier, Patrick Le Coz, Eugénie Leclercq, Denis Lefebvre, Pierre Maciejasz, Marie-Anne Mackowiak, Rémi Messin, Florence Pasquier, Valérie Petit, Christine Plichon, Sandrine Ponthieu, Cécile Quievre, Jean Roche, Adeline Rollin Sillaire, Thierry Rosolacci, Olivier Senechal, Nathalie Taillez, Stéphanie Thibault Tanchou, Frédéric Tison, Sarah Tollot, Marie Trocmet, Charlotte Verpoort
Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer’s disease
Luke Whiley, Katie E. Chappell, Ellie D’Hondt, Matthew R. Lewis, Beatriz Jiménez, Stuart G. Snowden, Hilkka Soininen, Iwona Kłoszewska, Patrizia Mecocci, Magda Tsolaki, Bruno Vellas, Jonathan R. Swann, Abdul Hye, Simon Lovestone, Cristina Legido-Quigley, Elaine Holmes, Hilkka Soininen, Iwona Kłoszewska, Patrizia Mecocci, Magda Tsolaki, Bruno Vellas, Simon Lovestone
Kidney function and dementia risk in community-dwelling older adults: the Shanghai Aging Study
Mengjing Wang, Ding Ding, Qianhua Zhao, Wanqing Wu, Zhenxu Xiao, Xiaoniu Liang, Jianfeng Luo, Jing Chen
Alzheimer’s cerebrospinal biomarkers from Lumipulse fully automated immunoassay: concordance with amyloid-beta PET and manual immunoassay in Koreans
Sohee Moon, Sujin Kim, Sakulrat Mankhong, Seong Hye Choi, Manu Vandijck, Vesna Kostanjevecki, Jee Hyang Jeong, Soo Jin Yoon, Kyung Won Park, Eun-Joo Kim, Bora Yoon, Hee Jin Kim, Jae-Won Jang, Jin Yong Hong, Dong-Ho Park, Leslie M. Shaw, Ju-Hee Kang
An MRI-based strategy for differentiation of frontotemporal dementia and Alzheimer’s disease
Qun Yu, Yingren Mai, Yuting Ruan, Yishan Luo, Lei Zhao, Wenli Fang, Zhiyu Cao, Yi Li, Wang Liao, Songhua Xiao, Vincent C. T. Mok, Lin Shi, Jun Liu, Howard Rosen, Bradford C. Dickerson, Kimoko Domoto-Reilly, David Knopman, Bradley F. Boeve, Adam L. Boxer, John Kornak, Bruce L. Miller, William W. Seeley, Maria-Luisa Gorno-Tempini, Scott McGinnis, Maria Luisa Mandelli
AlzGPS: a genome-wide positioning systems platform to catalyze multi-omics for Alzheimer’s drug discovery
Yadi Zhou, Jiansong Fang, Lynn M. Bekris, Young Heon Kim, Andrew A. Pieper, James B. Leverenz, Jeffrey Cummings, Feixiong Cheng
Correction to: Amyloid-β misfolding as a plasma biomarker indicates risk for future clinical Alzheimer’s disease in individuals with subjective cognitive decline
Julia Stockmann, Inge M. W. Verberk, Nina Timmesfeld, Robin Denz, Brian Budde, Julia Lange-Leifhelm, Philip Scheltens, Wiesje M. van der Flier, Andreas Nabers, Charlotte E. Teunissen, Klaus Gerwert
Assessing individual-level change in dementia research: a review of methodologies
Aja Louise Murray, Marlena Vollmer, Ian J. Deary, Graciela Muniz-Terrera, Tom Booth
Longitudinal amyloid and tau accumulation in autosomal dominant Alzheimer’s disease: findings from the Colombia-Boston (COLBOS) biomarker study
Justin S. Sanchez, Bernard J. Hanseeuw, Francisco Lopera, Reisa A. Sperling, Ana Baena, Yamile Bocanegra, David Aguillon, Edmarie Guzmán-Vélez, Enmanuelle Pardilla-Delgado, Liliana Ramirez-Gomez, Clara Vila-Castelar, Jairo E. Martinez, Joshua T. Fox-Fuller, Claudia Ramos, Martin Ochoa-Escudero, Sergio Alvarez, Heidi I. L. Jacobs, Aaron P. Schultz, Jennifer R. Gatchel, J. Alex Becker, Samantha R. Katz, Danielle V. Mayblyum, Julie C. Price, Eric M. Reiman, Keith A. Johnson, Yakeel T. Quiroz
Recurrent and concurrent patterns of regional BOLD dynamics and functional connectivity dynamics in cognitive decline
Lingyan Liang, Yueming Yuan, Yichen Wei, Bihan Yu, Wei Mai, Gaoxiong Duan, Xiucheng Nong, Chong Li, Jiahui Su, Lihua Zhao, Zhiguo Zhang, Demao Deng
Topographic patterns of white matter hyperintensities are associated with multimodal neuroimaging biomarkers of Alzheimer’s disease
Malo Gaubert, Catharina Lange, Antoine Garnier-Crussard, Theresa Köbe, Salma Bougacha, Julie Gonneaud, Robin de Flores, Clémence Tomadesso, Florence Mézenge, Brigitte Landeau, Vincent de la Sayette, Gaël Chételat, Miranka Wirth
Differential effects of chronic immunosuppression on behavioral, epigenetic, and Alzheimer’s disease-associated markers in 3xTg-AD mice
Minesh Kapadia, M. Firoz Mian, Donglai Ma, Craig P. Hutton, Amber Azam, Klotilda Narkaj, Chuanhai Cao, Breanna Brown, Bernadeta Michalski, David Morgan, Paul Forsythe, Iva B. Zovkic, Margaret Fahnestock, Boris Sakic
Impact of APOE ε4 genotype on initial cognitive symptoms differs for Alzheimer’s and Lewy body neuropathology
Jagan A. Pillai, James Bena, Aaron Bonner-Jackson, James B. Leverenz
Erythropoietin-derived peptide treatment reduced neurological deficit and neuropathological changes in a mouse model of tauopathy
Yun-Beom Choi, Ambrose A. Dunn-Meynell, Michelle Marchese, Benjamin M. Blumberg, Deeya Gaindh, Peter C. Dowling, Wei Lu
High-intensity exercise and cognitive function in cognitively normal older adults: a pilot randomised clinical trial
Belinda M. Brown, Natalie Frost, Stephanie R. Rainey-Smith, James Doecke, Shaun Markovic, Nicole Gordon, Michael Weinborn, Hamid R. Sohrabi, Simon M. Laws, Ralph N. Martins, Kirk I. Erickson, Jeremiah J. Peiffer
Multi-trait association studies discover pleiotropic loci between Alzheimer’s disease and cardiometabolic traits
William P. Bone, Katherine M. Siewert, Anupama Jha, Derek Klarin, Scott M. Damrauer, Zuhair K. Ballas, Sujata Bhushan, Edward J. Boyko, David M. Cohen, John Concato, Joseph I. Constans, Louis J. Dellitalia, Joseph M. Fayad, Ronald S. Fernando, Hermes J. Florez, Melinda A. Gaddy, Saib S. Gappy, Gretchen Gibson, Michael Godschalk, Jennifer A. Greco, Samir Gupta, Salvador Gutierrez, Kimberly D. Hammer, Mark B. Hamner, John B. Harley, Adriana M. Hung, Mostaqul Huq, Robin A. Hurley, Pran R. Iruvanti, Douglas J. Ivins, Frank J. Jacono, Darshana N. Jhala, Laurence S. Kaminsky, Scott Kinlay, Jon B. Klein, Suthat Liangpunsakul, Jack H. Lichy, Stephen M. Mastorides, Roy O. Mathew, Kristin M. Mattocks, Rachel McArdle, Paul N. Meyer, Laurence J. Meyer, Jonathan P. Moorman, Timothy R. Morgan, Maureen Murdoch, Xuan-Mai T. Nguyen, Olaoluwa O. Okusaga, Kris-Ann K. Oursler, Nora R. Ratcliffe, Michael I. Rauchman, R. Brooks Robey, George W. Ross, Richard J. Servatius, Satish C. Sharma, Scott E. Sherman, Elif Sonel, Peruvemba Sriram, Todd Stapley, Robert T. Striker, Neeraj Tandon, Gerardo Villareal, Agnes S. Wallbom, John M. Wells, Jeffrey C. Whittle, Mary A. Whooley, Junzhe Xu, Shing-Shing Yeh, Michaela Aslan, Jessica V. Brewer, Mary T. Brophy, Todd Connor, Dean P. Argyres, Nhan V. Do, Elizabeth R. Hauser, Donald E. Humphries, Luis E. Selva, Shahpoor Shayan, Brady Stephens, Stacey B. Whitbourne, Hongyu Zhao, Jennifer Moser, Jean C. Beckham, Jim L. Breeling, J. P. Casas Romero, Grant D. Huang, Rachel B. Ramoni, Sumitra Muralidhar, Samuel M. Aguayo, Sunil K. Ahuja, Saiju Pyarajan, Yan V. Sun, Kelly Cho, J. Michael Gaziano, Peter W. Wilson, Christopher J. O’Donnell, Kyong-Mi Chang, Philip S. Tsao, Themistocles L. Assimes, Marylyn D. Ritchie, Benjamin F. Voight
In vivo tau pathology is associated with synaptic loss and altered synaptic function
Emma M. Coomans, Deborah N. Schoonhoven, Hayel Tuncel, Sander C. J. Verfaillie, Emma E. Wolters, Ronald Boellaard, Rik Ossenkoppele, Anouk den Braber, Wiep Scheper, Patrick Schober, Steven P. Sweeney, J. Michael Ryan, Robert C. Schuit, Albert D. Windhorst, Frederik Barkhof, Philip Scheltens, Sandeep S. V. Golla, Arjan Hillebrand, Alida A. Gouw, Bart N. M. van Berckel
Detecting Alzheimer’s disease biomarkers with a brief tablet-based cognitive battery: sensitivity to Aβ and tau PET
Elena Tsoy, Amelia Strom, Leonardo Iaccarino, Sabrina J. Erlhoff, Collette A. Goode, Anne-Marie Rodriguez, Gil D. Rabinovici, Bruce L. Miller, Joel H. Kramer, Katherine P. Rankin, Renaud La Joie, Katherine L. Possin
RETRACTED ARTICLE: Preservation of dendritic spine morphology and postsynaptic signaling markers after treatment with solid lipid curcumin particles in the 5xFAD mouse model of Alzheimer’s amyloidosis
Panchanan Maiti, Zackary Bowers, Ali Bourcier-Schultz, Jarod Morse, Gary L. Dunbar
Cerebrospinal fluid N-224 tau helps discriminate Alzheimer’s disease from subjective cognitive decline and other dementias
Claudia Cicognola, Oskar Hansson, Philip Scheltens, Hlin Kvartsberg, Henrik Zetterberg, Charlotte E. Teunissen, Kaj Blennow
Novel instructionless eye tracking tasks identify emotion recognition deficits in frontotemporal dementia
Lucy L. Russell, Caroline V. Greaves, Rhian S. Convery, Jennifer Nicholas, Jason D. Warren, Diego Kaski, Jonathan D. Rohrer
Metformin attenuates plaque-associated tau pathology and reduces amyloid-β burden in APP/PS1 mice
Yanxing Chen, Shuai Zhao, Ziqi Fan, Zheyu Li, Yueli Zhu, Ting Shen, Kaicheng Li, Yaping Yan, Jun Tian, Zhirong Liu, Baorong Zhang
Genetically determined blood pressure, antihypertensive medications, and risk of Alzheimer’s disease: a Mendelian randomization study
Ya-Nan Ou, Yu-Xiang Yang, Xue-Ning Shen, Ya-Hui Ma, Shi-Dong Chen, Qiang Dong, Lan Tan, Jin-Tai Yu
Early anterior cingulate involvement is seen in presymptomatic MAPT P301L mutation carriers
Mica T. M. Clarke, Frédéric St-Onge, Jean-Mathieu Beauregard, Martina Bocchetta, Emily Todd, David M. Cash, Jonathan D. Rohrer, Robert Laforce Jr
The use of angiotensin-converting enzyme inhibitors vs. angiotensin receptor blockers and cognitive decline in Alzheimer’s disease: the importance of blood-brain barrier penetration and APOE ε4 carrier status
Michael Ouk, Che-Yuan Wu, Jennifer S. Rabin, Aaron Jackson, Jodi D. Edwards, Joel Ramirez, Mario Masellis, Richard H. Swartz, Nathan Herrmann, Krista L. Lanctôt, Sandra E. Black, Walter Swardfager
Huanglian Jiedu decoction remodels the periphery microenvironment to inhibit Alzheimer’s disease progression based on the “brain-gut” axis through multiple integrated omics
Xinru Gu, Junyi Zhou, Yanyan Zhou, Hongjie Wang, Nan Si, Wei Ren, Wei Zhao, Xiaorui Fan, Wenya Gao, Xiaolu Wei, Jian Yang, Baolin Bian, Haiyu Zhao
CERTL reduces C16 ceramide, amyloid-β levels, and inflammation in a model of Alzheimer’s disease
Simone M. Crivelli, Qian Luo, Jo A.A. Stevens, Caterina Giovagnoni, Daan van Kruining, Gerard Bode, Sandra den Hoedt, Barbara Hobo, Anna-Lena Scheithauer, Jochen Walter, Monique T. Mulder, Christopher Exley, Matthew Mold, Michelle M. Mielke, Helga E. De Vries, Kristiaan Wouters, Daniel L. A. van den Hove, Dusan Berkes, María Dolores Ledesma, Joost Verhaagen, Mario Losen, Erhard Bieberich, Pilar Martinez-Martinez
Association of weight change with cerebrospinal fluid biomarkers and amyloid positron emission tomography in preclinical Alzheimer’s disease
Oriol Grau-Rivera, Irene Navalpotro-Gomez, Gonzalo Sánchez-Benavides, Marc Suárez-Calvet, Marta Milà-Alomà, Eider M. Arenaza-Urquijo, Gemma Salvadó, Aleix Sala-Vila, Mahnaz Shekari, José Maria González-de-Echávarri, Carolina Minguillón, Aida Niñerola-Baizán, Andrés Perissinotti, Maryline Simon, Gwendlyn Kollmorgen, Henrik Zetterberg, Kaj Blennow, Juan Domingo Gispert, José Luis Molinuevo, Annabella Beteta, Raffaele Cacciaglia, Alba Cañas, Carme Deulofeu, Irene Cumplido, Ruth Dominguez, Maria Emilio, Carles Falcon, Sherezade Fuentes, Laura Hernandez, Gema Huesa, Jordi Huguet, Karine Fauria, Paula Marne, Tania Menchón, Grégory Operto, Albina Polo, Sandra Pradas, Anna Soteras, Marc Vilanova, Natàlia Vilor-Tejedor
Does insulin resistance influence neurodegeneration in non-diabetic Alzheimer’s subjects?
Grazia Daniela Femminella, Nicholas R. Livingston, Sanara Raza, Thalia van der Doef, Eleni Frangou, Sharon Love, Gail Busza, Valeria Calsolaro, Stefan Carver, Clive Holmes, Craig W. Ritchie, Robert M. Lawrence, Brady McFarlane, George Tadros, Basil H. Ridha, Carol Bannister, Zuzana Walker, Hilary Archer, Elizabeth Coulthard, Ben Underwood, Aparna Prasanna, Paul Koranteng, Salman Karim, Kehinde Junaid, Bernadette McGuinness, Anthony Peter Passmore, Ramin Nilforooshan, Ajayverma Macharouthu, Andrew Donaldson, Simon Thacker, Gregor Russell, Naghma Malik, Vandana Mate, Lucy Knight, Sajeev Kshemendran, Tricia Tan, Christian Holscher, John Harrison, David J. Brooks, Clive Ballard, Paul Edison
Cognitive trajectories of patients with focal ß-amyloid deposition
Si Eun Kim, Byungju Lee, Hyemin Jang, Juhee Chin, Ching Soong Khoo, Yeong Sim Choe, Ji Sun Kim, Sung Hoon Kang, Hang-Rai Kim, Song Hwangbo, Jee Hyang Jeong, Soo Jin Yoon, Kyung Won Park, Eun-Joo Kim, Bora Yoon, Jae-Won Jang, Jin Yong Hong, Duk L. Na, Sang Won Seo, Seong Hye Choi, Hee Jin Kim
Data-driven FDG-PET subtypes of Alzheimer’s disease-related neurodegeneration
Fedor Levin, Daniel Ferreira, Catharina Lange, Martin Dyrba, Eric Westman, Ralph Buchert, Stefan J. Teipel, Michel J. Grothe
Introduction of an assessment toolkit associated with increased rate of DLB diagnosis
A. Surendranathan, J. Kane, A. Bentley, S. Barker, R. McNally, C. Bamford, J.-P. Taylor, A. Thomas, I. McKeith, D. Burn, J. T. O’Brien
Randomized crossover trial of a modified ketogenic diet in Alzheimer’s disease
Matthew C. L. Phillips, Laura M. Deprez, Grace M. N. Mortimer, Deborah K. J. Murtagh, Stacey McCoy, Ruth Mylchreest, Linda J. Gilbertson, Karen M. Clark, Patricia V. Simpson, Eileen J. McManus, Jee-Eun Oh, Satish Yadavaraj, Vanessa M. King, Avinesh Pillai, Beatriz Romero-Ferrando, Martijn Brinkhuis, Bronwyn M. Copeland, Shah Samad, Shenyang Liao, Jan A. C. Schepel
Melatonin levels in the Alzheimer’s disease continuum: a systematic review
Amber Nous, Sebastiaan Engelborghs, Ilse Smolders
Characterization of symptoms and determinants of disease burden in dementia with Lewy bodies: DEvELOP design and baseline results
M. van de Beek, I. van Steenoven, J. J. van der Zande, I. Porcelijn, F. Barkhof, C. J. Stam, P. G. H. M. Raijmakers, P. Scheltens, C. E. Teunissen, W. M. van der Flier, A. W. Lemstra
Association of CSF proteins with tau and amyloid β levels in asymptomatic 70-year-olds
Julia Remnestål, Sofia Bergström, Jennie Olofsson, Evelina Sjöstedt, Mathias Uhlén, Kaj Blennow, Henrik Zetterberg, Anna Zettergren, Silke Kern, Ingmar Skoog, Peter Nilsson, Anna Månberg
Genome-wide epistasis analysis for Alzheimer’s disease and implications for genetic risk prediction
Hui Wang, David A. Bennett, Philip L. De Jager, Qing-Ye Zhang, Hong-Yu Zhang
27-Hydroxycholesterol, cognition, and brain imaging markers in the FINGER randomized controlled trial
Anna Sandebring-Matton, Julen Goikolea, Ingemar Björkhem, Laura Paternain, Nina Kemppainen, Tiina Laatikainen, Tiia Ngandu, Juha Rinne, Hilkka Soininen, Angel Cedazo-Minguez, Alina Solomon, Miia Kivipelto
Human neural stem cell-derived extracellular vesicles mitigate hallmarks of Alzheimer’s disease
Lauren A. Apodaca, Al Anoud D. Baddour, Camilo Garcia Jr, Leila Alikhani, Erich Giedzinski, Ning Ru, Anshu Agrawal, Munjal M. Acharya, Janet E. Baulch
Development of a novel, sensitive translational immunoassay to detect plasma glial fibrillary acidic protein (GFAP) after murine traumatic brain injury
Emily B. Button, Wai Hang Cheng, Carlos Barron, Honor Cheung, Asma Bashir, Jennifer Cooper, Jasmine Gill, Sophie Stukas, David C. Baron, Jerome Robert, Elyn M. Rowe, Peter A. Cripton, Cheryl L. Wellington
Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport
Xu-Qiao Chen, Utpal Das, Gooho Park, William C. Mobley
Enhancing magnetic resonance imaging-driven Alzheimer’s disease classification performance using generative adversarial learning
Xiao Zhou, Shangran Qiu, Prajakta S. Joshi, Chonghua Xue, Ronald J. Killiany, Asim Z. Mian, Sang P. Chin, Rhoda Au, Vijaya B. Kolachalama
Additive interaction of mid- to late-life depression and cerebrovascular disease on the risk of dementia: a nationwide population-based cohort study
Yoo Jin Jang, Cinoo Kang, Woojae Myung, Shinn-Won Lim, Young Kyung Moon, Ho Kim, Doh Kwan Kim
A 36-week multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical trial of sodium oligomannate for mild-to-moderate Alzheimer’s dementia
Shifu Xiao, Piu Chan, Tao Wang, Zhen Hong, Shuzhen Wang, Weihong Kuang, Jincai He, Xiaoping Pan, Yuying Zhou, Yong Ji, Luning Wang, Yan Cheng, Ying Peng, Qinyong Ye, Xiaoping Wang, Yuncheng Wu, Qiumin Qu, Shengdi Chen, Shuhua Li, Wei Chen, Jun Xu, Dantao Peng, Zhongxin Zhao, Yansheng Li, Junjian Zhang, Yifeng Du, Weixian Chen, Dongsheng Fan, Yong Yan, Xiaowei Liu, Wei Zhang, Benyan Luo, Wenyuan Wu, Lu Shen, Chunfeng Liu, Peixian Mao, Qiumei Wang, Qianhua Zhao, Qihao Guo, Yongtao Zhou, Yi Li, Lijun Jiang, Wenwei Ren, Yingjun Ouyang, Yan Wang, Shuai Liu, Jianjun Jia, Nan Zhang, Zhonglin Liu, Raoli He, Tingyi Feng, Wenhui Lu, Huidong Tang, Ping Gao, Yingchun Zhang, Lanlan Chen, Lei Wang, You Yin, Qun Xu, Jinsong Xiao, Lin Cong, Xi Cheng, Hui Zhang, Dan Gao, Minghua Xia, Tenghong Lian, Guoping Peng, Xu Zhang, Bin Jiao, Hua Hu, Xueyan Chen, Yihui Guan, Ruixue Cui, Qiu Huang, Xianliang Xin, Hongjian Chen, Yu Ding, Jing Zhang, Teng Feng, Marc Cantillon, Kewei Chen, Jeffrey L. Cummings, Jian Ding, Meiyu Geng, Zhenxin Zhang
A competing risk joint model for dealing with different types of missing data in an intervention trial in prodromal Alzheimer’s disease
Floor M. van Oudenhoven, Sophie H. N. Swinkels, Hilkka Soininen, Miia Kivipelto, Tobias Hartmann, Dimitris Rizopoulos, Tobias Hartmann, Hilkka Soininen, Miia Kivipelto, Alina Solomon, Pieter Jelle Visser
Research diagnostic criteria for Alzheimer’s disease: findings from the LipiDiDiet randomized controlled trial
Anna Rosenberg, Alina Solomon, Hilkka Soininen, Pieter Jelle Visser, Kaj Blennow, Tobias Hartmann, Miia Kivipelto, Hilkka Soininen, Ilona Hallikainen, Merja Hallikainen, Seppo Helisalmi, Tarja Lappalainen, Yawu Liu, Teemu Paajanen, Miia Kivipelto, Alina Solomon, Lars-Olof Wahlund, Yvonne Freund-Levi, Göran Hagman, Kaj Blennow, Tobias Hartmann, Klaus Fassbender, Matthias Riemenschneider, Marcus O. W. Grimm, Aline Klees-Rollmann, Maxine Luley, Epameinondas Lyros, Robert Schomburg, Daniela Ramelli, Jennifer Kennel, Lutz Frölich, Lucrezia Hausner, Christoph Laske, Thomas Leyhe, Christian Mychajliw, Niklas Koehler, Stephan Schiekofer, Hans Klünemann, Johannes Schröder, Dieter Lütjohann, Pieter Jelle Visser, Philip Scheltens, Ineke van Rossum, Nienke Scheltens, Daniela Bertens, Mara ten Kate, Frederik Barkhof, Silvia Ingala, Johanna M. L. Henselmans, Gerwin Roks, Anneke M. J. van Hees, Floor M. van Oudenhoven, Suzanne B. Hendrix, Noel Ellison
Plasma neurofilament light and phosphorylated tau 181 as biomarkers of Alzheimer’s disease pathology and clinical disease progression
Christopher Clark, Piotr Lewczuk, Johannes Kornhuber, Jonas Richiardi, Bénédicte Maréchal, Thomas K. Karikari, Kaj Blennow, Henrik Zetterberg, Julius Popp
Efficacy and safety of GV1001 in patients with moderate-to-severe Alzheimer’s disease already receiving donepezil: a phase 2 randomized, double-blind, placebo-controlled, multicenter clinical trial
Seong-Ho Koh, Hyuk Sung Kwon, Seong Hye Choi, Jee Hyang Jeong, Hae Ri Na, Chan Nyoung Lee, YoungSoon Yang, Ae Young Lee, Jae-Hong Lee, Kyung Won Park, Hyun Jeong Han, Byeong C. Kim, Jin Se Park, Jee-Young Lee, Sangjae Kim, Kyu-Yong Lee
Early detection of amyloid load using 18F-florbetaben PET
Santiago Bullich, Núria Roé-Vellvé, Marta Marquié, Susan M. Landau, Henryk Barthel, Victor L. Villemagne, Ángela Sanabria, Juan Pablo Tartari, Oscar Sotolongo-Grau, Vincent Doré, Norman Koglin, Andre Müller, Audrey Perrotin, Aleksandar Jovalekic, Susan De Santi, Lluís Tárraga, Andrew W. Stephens, Christopher C. Rowe, Osama Sabri, John P. Seibyl, Mercè Boada
Plasma glial fibrillary acidic protein detects Alzheimer pathology and predicts future conversion to Alzheimer dementia in patients with mild cognitive impairment
Claudia Cicognola, Shorena Janelidze, Joakim Hertze, Henrik Zetterberg, Kaj Blennow, Niklas Mattsson-Carlgren, Oskar Hansson
Plasma pTau181 predicts cortical brain atrophy in aging and Alzheimer’s disease
Cécile Tissot, Andréa L. Benedet, Joseph Therriault, Tharick A. Pascoal, Firoza Z. Lussier, Paramita Saha-Chaudhuri, Mira Chamoun, Melissa Savard, Sulantha S. Mathotaarachchi, Gleb Bezgin, Yi-Ting Wang, Jaime Fernandez Arias, Juan Lantero Rodriguez, Anniina Snellman, Nicholas J. Ashton, Thomas K. Karikari, Kaj Blennow, Henrik Zetterberg, Etienne De Villers-Sidani, Philippe Huot, Serge Gauthier, Pedro Rosa-Neto
The efficacy of exergaming in people with major neurocognitive disorder residing in long-term care facilities: a pilot randomized controlled trial
Nathalie Swinnen, Mathieu Vandenbulcke, Eling D. de Bruin, Riekje Akkerman, Brendon Stubbs, Joseph Firth, Davy Vancampfort
An integrative multi-omics approach reveals new central nervous system pathway alterations in Alzheimer’s disease
Christopher Clark, Loïc Dayon, Mojgan Masoodi, Gene L. Bowman, Julius Popp
A novel age-informed approach for genetic association analysis in Alzheimer’s disease
Yann Le Guen, Michael E. Belloy, Valerio Napolioni, Sarah J. Eger, Gabriel Kennedy, Ran Tao, Zihuai He, Michael D. Greicius
Comorbidity between Alzheimer’s disease and major depression: a behavioural and transcriptomic characterization study in mice
Ana Martín-Sánchez, Janet Piñero, Lara Nonell, Magdalena Arnal, Elena M. Ribe, Alejo Nevado-Holgado, Simon Lovestone, Ferran Sanz, Laura I. Furlong, Olga Valverde
Glucose metabolism in the right middle temporal gyrus could be a potential biomarker for subjective cognitive decline: a study of a Han population
Qiu-Yue Dong, Tao-Ran Li, Xue-Yan Jiang, Xiao-Ni Wang, Ying Han, Jie-Hui Jiang
Baseline cognition is the best predictor of 4-year cognitive change in cognitively intact older adults
Jolien M. Schaeverbeke, Silvy Gabel, Karen Meersmans, Emma S. Luckett, Steffi De Meyer, Katarzyna Adamczuk, Natalie Nelissen, Valerie Goovaerts, Ahmed Radwan, Stefan Sunaert, Patrick Dupont, Koen Van Laere, Rik Vandenberghe
A comparative study of the effects of Aducanumab and scanning ultrasound on amyloid plaques and behavior in the APP23 mouse model of Alzheimer disease
Gerhard Leinenga, Wee Kiat Koh, Jürgen Götz
COVID-19 in adults with dementia: clinical features and risk factors of mortality—a clinical cohort study on 125 patients
Agathe Vrillon, Elsa Mhanna, Clément Aveneau, Manon Lebozec, Lina Grosset, Diane Nankam, Fernanda Albuquerque, Raphaelle Razou Feroldi, Barbara Maakaroun, Iana Pissareva, Dalenda Cherni Gherissi, Julien Azuar, Véronique François, Claire Hourrègue, Julien Dumurgier, Lisette Volpe-Gillot, Claire Paquet
Quality of opioid prescribing in older adults with or without Alzheimer disease and related dementia
Yu-Jung Jenny Wei, Siegfried Schmidt, Cheng Chen, Roger B. Fillingim, M. Carrington Reid, Steven DeKosky, Laurence Solberg, Marco Pahor, Babette Brumback, Almut G. Winterstein
Core Alzheimer’s disease cerebrospinal fluid biomarker assays are not affected by aspiration or gravity drip extraction methods
James D. Doecke, Cindy Francois, Christopher J. Fowler, Erik Stoops, Pierrick Bourgeat, Stephanie R. Rainey-Smith, Qiao-Xin Li, Colin L. Masters, Ralph N. Martins, Victor L. Villemagne, Steven J. Collins, Hugo Marcel Vanderstichele
A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer’s disease with lecanemab, an anti-Aβ protofibril antibody
Chad J. Swanson, Yong Zhang, Shobha Dhadda, Jinping Wang, June Kaplow, Robert Y. K. Lai, Lars Lannfelt, Heather Bradley, Martin Rabe, Akihiko Koyama, Larisa Reyderman, Donald A. Berry, Scott Berry, Robert Gordon, Lynn D. Kramer, Jeffrey L. Cummings
Associations of healthy lifestyles with cerebrospinal fluid biomarkers of Alzheimer’s disease pathology in cognitively intact older adults: the CABLE study
Xiao-He Hou, Wei Xu, Yan-Lin Bi, Xue-Ning Shen, Ya-Hui Ma, Qiang Dong, Lan Tan, Jin-Tai Yu
Strategies to reduce sample sizes in Alzheimer’s disease primary and secondary prevention trials using longitudinal amyloid PET imaging
Isadora Lopes Alves, Fiona Heeman, Lyduine E. Collij, Gemma Salvadó, Nelleke Tolboom, Natàlia Vilor-Tejedor, Pawel Markiewicz, Maqsood Yaqub, David Cash, Elizabeth C. Mormino, Philip S. Insel, Ronald Boellaard, Bart N. M. van Berckel, Adriaan A. Lammertsma, Frederik Barkhof, Juan Domingo Gispert
Correction to: Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation
Woo Shik Shin, Jing Di, Qin Cao, Binsen Li, Paul M. Seidler, Kevin A. Murray, Gal Bitan, Lin Jiang
Prognostic value of amyloid/tau/neurodegeneration (ATN) classification based on diagnostic cerebrospinal fluid samples for Alzheimer’s disease
Koen Delmotte, Jolien Schaeverbeke, Koen Poesen, Rik Vandenberghe
Use of the Clock Drawing Test and the Rey–Osterrieth Complex Figure Test-copy with convolutional neural networks to predict cognitive impairment
Young Chul Youn, Jung-Min Pyun, Nayoung Ryu, Min Jae Baek, Jae-Won Jang, Young Ho Park, Suk-Won Ahn, Hae-Won Shin, Kwang-Yeol Park, Sang Yun Kim
Diagnostic and prognostic value of plasma neurofilament light and total-tau in sporadic Creutzfeldt-Jakob disease
Inga Zerr, Anna Villar-Piqué, Peter Hermann, Matthias Schmitz, Daniela Varges, Isidre Ferrer, Joachim Riggert, Henrik Zetterberg, Kaj Blennow, Franc Llorens
Safety, pharmacokinetics and exploratory pro-cognitive effects of HTL0018318, a selective M1 receptor agonist, in healthy younger adult and elderly subjects: a multiple ascending dose study
Charlotte Bakker, Tim Tasker, Jan Liptrot, Ellen P. Hart, Erica S. Klaassen, Robert Jan Doll, Giles A. Brown, Alastair Brown, Miles Congreve, Malcolm Weir, Fiona H. Marshall, David M. Cross, Geert Jan Groeneveld, Pradeep J. Nathan
Correction to: The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice
Jing Di, Ibrar Siddique, Zizheng Li, Ghattas Malki, Simon Hornung, Suman Dutta, Ian Hurst, Ella Ishaaya, Austin Wang, Sally Tu, Ani Boghos, Ida Ericsson, Frank-Gerrit Klärner, Thomas Schrader, Gal Bitan
Remote monitoring technologies in Alzheimer’s disease: design of the RADAR-AD study
Marijn Muurling, Casper de Boer, Rouba Kozak, Dorota Religa, Ivan Koychev, Herman Verheij, Vera J. M. Nies, Alexander Duyndam, Meemansa Sood, Holger Fröhlich, Kristin Hannesdottir, Gul Erdemli, Federica Lucivero, Claire Lancaster, Chris Hinds, Thanos G. Stravopoulos, Spiros Nikolopoulos, Ioannis Kompatsiaris, Nikolay V. Manyakov, Andrew P. Owens, Vaibhav A. Narayan, Dag Aarsland, Pieter Jelle Visser, Maximilian Buegler, Richard Fischer, Robbert Harms, Irene B. Meier, Ioannis Tarnanas, Ana Diaz, Jean Georges, Dianne Gove, Casper de Boer, Marijn Muurling, Pieter Jelle Visser, Ioannis Kompatsiaris, Ioulietta Lazarou, Lampros Mpaltadoros, Spiros Nikolopoulos, Asterios Papastergiou, Thanos Stavropoulos, Dimitris Strantsalis, Holger Froehlich, Martin Hoffman-Apitius, Meemansa Sood, Nikolay Manyakov, Vaibhav A. Narayan, Jerry G. Novak, Dorota Religa, Emilia Schwertner, Juraj Secnik, Bengt Winblad, Dag Aarsland, Pauline Conde, Amos Folarin, Grace Lavelle, Andrew P. Owens, Andrew McCarthy, Aidan Nickerson, Janneke Boere, Bruna Consiglio, Yoanna Daskalova, Alexander Duyndam, Irene Kanter-Schlifke, Vera J. M. Nies, Pieter Stolk, Herman Verheij, Neva Coello, Jelena Curcic, Gul Erdemli, Tilo Hache, Kristin Hannesdottir, Alex Sverdlov, Vanessa Vallejo, Eric Yang, Ariel Dowling, Rouba Kozak, Melissa Naylor, Rodrigo Palma dos Reis, Gene Shin, Joris Borgdorff, Elisa Cirillo, Keyvan Hedayati, Nivethika Mahasivam, Aidan Doherty, Chris Hinds, Ivan Koychev, Claire Lancaster, Sebastien Libert, Federica Lucivero, Yuhao Wu, Andre Durudas
Characterization of the initial complaint and care pathways prior to diagnosis in very young sporadic Alzheimer’s disease
Pauline Olivieri, Lorraine Hamelin, Julien Lagarde, Valérie Hahn, Elodie Guichart-Gomez, Carole Roué-Jagot, Marie Sarazin
Investigating the relationship between BMI across adulthood and late life brain pathologies
Christopher A. Lane, Josephine Barnes, Jennifer M. Nicholas, John W. Baker, Carole H. Sudre, David M. Cash, Thomas D. Parker, Ian B. Malone, Kirsty Lu, Sarah-Naomi James, Ashvini Keshavan, Sarah Buchanan, Sarah Keuss, Heidi Murray-Smith, Andrew Wong, Elizabeth Gordon, William Coath, Marc Modat, David Thomas, Rebecca Hardy, Marcus Richards, Nick C. Fox, Jonathan M. Schott
Artificial intelligence-based computational framework for drug-target prioritization and inference of novel repositionable drugs for Alzheimer’s disease
Shingo Tsuji, Takeshi Hase, Ayako Yachie-Kinoshita, Taiko Nishino, Samik Ghosh, Masataka Kikuchi, Kazuro Shimokawa, Hiroyuki Aburatani, Hiroaki Kitano, Hiroshi Tanaka
Characterization of Alzheimer’s tau biomarker discordance using plasma, CSF, and PET
Yu Guo, Yu-Yuan Huang, Xue-Ning Shen, Shi-Dong Chen, Hao Hu, Zuo-Teng Wang, Lan Tan, Jin-Tai Yu
Evaluation of cerebrospinal fluid glycoprotein NMB (GPNMB) as a potential biomarker for Alzheimer’s disease
Freyja Aichholzer, Hans-Wolfgang Klafki, Isabella Ogorek, Jonathan Vogelgsang, Jens Wiltfang, Norbert Scherbaum, Sascha Weggen, Oliver Wirths
The role of sex and gender in the selection of Alzheimer patients for clinical trial pre-screening
Maitee Rosende-Roca, Carla Abdelnour, Ester Esteban, Juan Pablo Tartari, Emilio Alarcon, Juliana Martínez-Atienza, Antonio González-Pérez, María E. Sáez, Asunción Lafuente, Mar Buendía, Ana Pancho, Nuria Aguilera, Marta Ibarria, Susana Diego, Sara Jofresa, Isabel Hernández, Rogelio López, Miren Jone Gurruchaga, Lluís Tárraga, Sergi Valero, Agustín Ruiz, Marta Marquié, Mercè Boada
Anticancer drugs repurposed for Alzheimer’s disease: a systematic review
Antonio Ancidoni, Ilaria Bacigalupo, Giulia Remoli, Eleonora Lacorte, Paola Piscopo, Giulia Sarti, Massimo Corbo, Nicola Vanacore, Marco Canevelli
Using historical data to facilitate clinical prevention trials in Alzheimer disease? An analysis of longitudinal MCI (mild cognitive impairment) data sets
Manfred Berres, Andreas U. Monsch, René Spiegel
Aducanumab produced a clinically meaningful benefit in association with amyloid lowering
Jeffrey Cummings, Paul Aisen, Cynthia Lemere, Alireza Atri, Marwan Sabbagh, Stephen Salloway
Validation of amyloid PET positivity thresholds in centiloids: a multisite PET study approach
Sarah K. Royse, Davneet S. Minhas, Brian J. Lopresti, Alice Murphy, Tyler Ward, Robert A. Koeppe, Santiago Bullich, Susan DeSanti, William J. Jagust, Susan M. Landau
Pathological drivers of neurodegeneration in suspected non-Alzheimer’s disease pathophysiology
L. E. M. Wisse, R. de Flores, L. Xie, S. R. Das, C. T. McMillan, J. Q. Trojanowski, M. Grossman, E. B. Lee, D. Irwin, P. A. Yushkevich, D. A. Wolk
A neurologist’s perspective on serum neurofilament light in the memory clinic: a prospective implementation study
E. A. J. Willemse, P. Scheltens, C. E. Teunissen, E. G. B. Vijverberg
Correction to: Exploring the potential of the platelet membrane proteome as a source of peripheral biomarkers for Alzheimer’s disease
Laura E. Donovan, Eric B. Dammer, Duc M. Duong, John J. Hanfelt, Allan I. Levey, Nicholas T. Seyfried, James J. Lah
Repurposing beta-3 adrenergic receptor agonists for Alzheimer’s disease: beneficial effects in a mouse model
Marine Tournissac, Tra-My Vu, Nika Vrabic, Clara Hozer, Cyntia Tremblay, Koralie Mélançon, Emmanuel Planel, Fabien Pifferi, Frédéric Calon
Predict Alzheimer’s disease using hippocampus MRI data: a lightweight 3D deep convolutional network model with visual and global shape representations
Sreevani Katabathula, Qinyong Wang, Rong Xu
Brain connectivity and metacognition in persons with subjective cognitive decline (COSCODE): rationale and study design
Federica Ribaldi, Christian Chicherio, Daniele Altomare, Marta Martins, Szymon Tomczyk, Ileana Jelescu, Enrique Maturana, Max Scheffler, Sven Haller, Karl-Olof Lövblad, Michela Pievani, Valentina Garibotto, Matthias Kliegel, Giovanni B. Frisoni
A phase 2 double-blind placebo-controlled 24-week treatment clinical study of the p38 alpha kinase inhibitor neflamapimod in mild Alzheimer’s disease
Niels D. Prins, John E. Harrison, Hui-May Chu, Kelly Blackburn, John J. Alam, Philip Scheltens, Arnold, Coskinas, Gonzales, Joseph, Khan, McConnehey, Paricio, Taylor, Zarate Rowell, Groom, Summers, White, Thein, Bolouri, Schwartz, Vasquez, Asher, Ball, Munthali, Kabir, Langford, Komuravelli, Lynch, MacSweeney, Pearson, Faulkner, Miller, Underwood, Prins, Dautzenberg, Van Norden, Pazdera, Bar, Dvacka, Valis, Votypkova, Areovimata, Justesen, Schmidt
Association of accelerated long-term forgetting and senescence-related blood-borne factors in asymptomatic individuals from families with autosomal dominant Alzheimer’s disease
Jianwei Yang, Chaojun Kong, Longfei Jia, Tingting Li, Meina Quan, Yan Li, Diyang Lyu, Fangyu Li, Hongmei Jin, Ying Li, Qigeng Wang, Jianping Jia
Longitudinal change in hippocampal and dorsal anterior insulae functional connectivity in subjective cognitive decline
Raymond P. Viviano, Jessica S. Damoiseaux
Correlating natural language processing and automated speech analysis with clinician assessment to quantify speech-language changes in mild cognitive impairment and Alzheimer’s dementia
Anthony Yeung, Andrea Iaboni, Elizabeth Rochon, Monica Lavoie, Calvin Santiago, Maria Yancheva, Jekaterina Novikova, Mengdan Xu, Jessica Robin, Liam D. Kaufman, Fariya Mostafa
Network medicine links SARS-CoV-2/COVID-19 infection to brain microvascular injury and neuroinflammation in dementia-like cognitive impairment
Yadi Zhou, Jielin Xu, Yuan Hou, James B. Leverenz, Asha Kallianpur, Reena Mehra, Yunlong Liu, Haiyuan Yu, Andrew A. Pieper, Lara Jehi, Feixiong Cheng
Severe COVID-19 in Alzheimer’s disease: APOE4’s fault again?
Nian Xiong, Martin R. Schiller, Jingwen Li, Xiaowu Chen, Zhicheng Lin
Role of liraglutide in Alzheimer’s disease pathology
Maria Vargas-Soria, Maria Jose Carranza-Naval, Angel del Marco, Monica Garcia-Alloza
Differential effects of risk factors on the cognitive trajectory of early- and late-onset Alzheimer’s disease
Jaeho Kim, Sook-Young Woo, Seonwoo Kim, Hyemin Jang, Junpyo Kim, Jisun Kim, Sung Hoon Kang, Duk L. Na, Juhee Chin, Liana G. Apostolova, Sang Won Seo, Hee Jin Kim
Reversible GABAergic dysfunction involved in hippocampal hyperactivity predicts early-stage Alzheimer disease in a mouse model
Yang Li, Ke Zhu, Ning Li, Xiaotong Wang, Xuansheng Xiao, Linying Li, Lijuan Li, Ying He, Jinglan Zhang, Jiaoyang Wo, Yanqiu Cui, Haixia Huang, Jianliang Zhang, Wei Wang, Xiaomin Wang, Yan Zheng
GPS driving: a digital biomarker for preclinical Alzheimer disease
Sayeh Bayat, Ganesh M. Babulal, Suzanne E. Schindler, Anne M. Fagan, John C. Morris, Alex Mihailidis, Catherine M. Roe
Enriched gardens improve cognition and independence of nursing home residents with dementia: a pilot controlled trial
Etienne Bourdon, Joël Belmin
Identifying novel genetic variants for brain amyloid deposition: a genome-wide association study in the Korean population
Hang-Rai Kim, Sang-Hyuk Jung, Jaeho Kim, Hyemin Jang, Sung Hoon Kang, Song Hwangbo, Jun Pyo Kim, So Yeon Kim, Beomsu Kim, Soyeon Kim, Jee Hyang Jeong, Soo Jin Yoon, Kyung Won Park, Eun-Joo Kim, Bora Yoon, Jae-Won Jang, Jin Yong Hong, Seong Hye Choi, Young Noh, Ko Woon Kim, Si Eun Kim, Jin San Lee, Na-Yeon Jung, Juyoun Lee, Byeong C. Kim, Sang Joon Son, Chang Hyung Hong, Duk L. Na, Sang Won Seo, Hong-Hee Won, Hee Jin Kim
Pathological correlates of impaired self-awareness of memory function in Alzheimer’s disease
Geoffroy Gagliardi, Madeline Kuppe, Cristina Lois, Bernard Hanseeuw, Patrizia Vannini
VAMP-2 is a surrogate cerebrospinal fluid marker of Alzheimer-related cognitive impairment in adults with Down syndrome
Alberto Lleó, Maria Carmona-Iragui, Laura Videla, Susana Fernández, Bessy Benejam, Jordi Pegueroles, Isabel Barroeta, Miren Altuna, Silvia Valldeneu, Mei-Fang Xiao, Desheng Xu, Raúl Núñez-Llaves, Marta Querol-Vilaseca, Sònia Sirisi, Alexandre Bejanin, M. Florencia Iulita, Jordi Clarimón, Rafael Blesa, Paul Worley, Daniel Alcolea, Juan Fortea, Olivia Belbin
Race, APOE genotypes, and cognitive decline among middle-aged urban adults
May A. Beydoun, Jordan Weiss, Hind A. Beydoun, Sharmin Hossain, Ana I. Maldonado, Botong Shen, Michele K. Evans, Alan B. Zonderman
Arterial stiffening acts synergistically with APOE genotype and AD biomarker status to influence memory in older adults without dementia
Katherine J. Bangen, Denis S. Smirnov, Lisa Delano-Wood, Christina E. Wierenga, Mark W. Bondi, David P. Salmon, Douglas Galasko
Admixture mapping reveals the association between Native American ancestry at 3q13.11 and reduced risk of Alzheimer’s disease in Caribbean Hispanics
Andréa R. V. R. Horimoto, Diane Xue, Timothy A. Thornton, Elizabeth E. Blue
Plasma biomarker profiles and the correlation with cognitive function across the clinical spectrum of Alzheimer’s disease
Zhenxu Xiao, Xue Wu, Wanqing Wu, Jingwei Yi, Xiaoniu Liang, Saineng Ding, Li Zheng, Jianfeng Luo, Hongchen Gu, Qianhua Zhao, Hong Xu, Ding Ding
Lewy Body Dementia Association’s Industry Advisory Council: proceedings of the second annual meeting
Jennifer G. Goldman, Bradley F. Boeve, Melissa J. Armstrong, Doug R. Galasko, James E. Galvin, David J. Irwin, James B. Leverenz, Karen Marder, Victor Abler, Kevin Biglan, Michael C. Irizarry, Bill Keller, Robert Lai, Leanne Munsie, Michael Belleville, Ondrea Chaney, Ian Richard, Angela Taylor, Todd Graham
Aη-α and Aη-β peptides impair LTP ex vivo within the low nanomolar range and impact neuronal activity in vivo
Maria Mensch, Jade Dunot, Sandy M. Yishan, Samuel S. Harris, Aline Blistein, Alban Avdiu, Paula A. Pousinha, Camilla Giudici, Marc Aurel Busche, Peter Jedlicka, Michael Willem, Hélène Marie
Prediction of differentially expressed microRNAs in blood as potential biomarkers for Alzheimer’s disease by meta-analysis and adaptive boosting ensemble learning
Sze Chung Yuen, Xiaonan Liang, Hongmei Zhu, Yongliang Jia, Siu-wai Leung
The Revised Self-Monitoring Scale detects early impairment of social cognition in genetic frontotemporal dementia within the GENFI cohort
Hannah D. Franklin, Lucy L. Russell, Georgia Peakman, Caroline V. Greaves, Martina Bocchetta, Jennifer Nicholas, Jackie Poos, Rhian S. Convery, David M. Cash, John van Swieten, Lize Jiskoot, Fermin Moreno, Raquel Sanchez-Valle, Barbara Borroni, Robert Laforce Jr, Mario Masellis, Maria Carmela Tartaglia, Caroline Graff, Daniela Galimberti, James B. Rowe, Elizabeth Finger, Matthis Synofzik, Rik Vandenberghe, Alexandre de Mendonça, Fabrizio Tagliavini, Isabel Santana, Simon Ducharme, Chris Butler, Alex Gerhard, Johannes Levin, Adrian Danek, Markus Otto, Sandro Sorbi, Isabelle Le Ber, Florence Pasquier, Jonathan D. Rohrer, Sónia Afonso, Maria Rosario Almeida, Sarah Anderl-Straub, Christin Andersson, Anna Antonell, Silvana Archetti, Andrea Arighi, Mircea Balasa, Myriam Barandiaran, Nuria Bargalló, Robart Bartha, Benjamin Bender, Alberto Benussi, Maxime Bertoux, Anne Bertrand, Valentina Bessi, Sandra Black, Sergi Borrego-Ecija, Jose Bras, Alexis Brice, Rose Bruffaerts, Agnès Camuzat, Marta Cañada, Valentina Cantoni, Paola Caroppo, Miguel Castelo-Branco, Olivier Colliot, Thomas Cope, Vincent Deramecourt, María de Arriba, Giuseppe Di Fede, Alina Díez, Diana Duro, Chiara Fenoglio, Camilla Ferrari, Catarina B. Ferreira, Nick Fox, Morris Freedman, Giorgio Fumagalli, Aurélie Funkiewiez, Alazne Gabilondo, Roberto Gasparotti, Serge Gauthier, Stefano Gazzina, Giorgio Giaccone, Ana Gorostidi, Caroline Greaves, Rita Guerreiro, Carolin Heller, Tobias Hoegen, Begoña Indakoetxea, Vesna Jelic, Hans-Otto Karnath, Ron Keren, Gregory Kuchcinski, Tobias Langheinrich, Thibaud Lebouvier, Maria João Leitão, Albert Lladó, Gemma Lombardi, Sandra Loosli, Carolina Maruta, Simon Mead, Lieke Meeter, Gabriel Miltenberger, Rick van Minkelen, Sara Mitchell, Katrina Moore, Benedetta Nacmias, Annabel Nelson, Linn Öijerstedt, Jaume Olives, Sebastien Ourselin, Alessandro Padovani, Jessica Panman, Janne M. Papma, Yolande Pijnenburg, Cristina Polito, Enrico Premi, Sara Prioni, Catharina Prix, Rosa Rademakers, Veronica Redaelli, Daisy Rinaldi, Tim Rittman, Ekaterina Rogaeva, Adeline Rollin, Pedro Rosa-Neto, Giacomina Rossi, Martin Rossor, Beatriz Santiago, Dario Saracino, Sabrina Sayah, Elio Scarpini, Sonja Schönecker, Harro Seelaar, Elisa Semler, Rachelle Shafei, Christen Shoesmith, Imogen Swift, Miguel Tábuas-Pereira, Mikel Tainta, Ricardo Taipa, David Tang-Wai, David L. Thomas, Paul Thompson, Hakan Thonberg, Carolyn Timberlake, Pietro Tiraboschi, Emily Todd, Philip Van Damme, Mathieu Vandenbulcke, Michele Veldsman, Ana Verdelho, Jorge Villanua, Jason Warren, Carlo Wilke, Ione Woollacott, Elisabeth Wlasich, Henrik Zetterberg, Miren Zulaica
Verbal intelligence is a more robust cross-sectional measure of cognitive reserve than level of education in healthy older adults
R. Boyle, S. P. Knight, C. De Looze, D. Carey, S. Scarlett, Y. Stern, I. H. Robertson, R. A. Kenny, R. Whelan
White matter hyperintensities in autopsy-confirmed frontotemporal lobar degeneration and Alzheimer’s disease
Philippe Desmarais, Andrew F. Gao, Krista Lanctôt, Ekaterina Rogaeva, Joel Ramirez, Nathan Herrmann, Donald T. Stuss, Sandra E. Black, Julia Keith, Mario Masellis
Short leukocyte telomeres predict 25-year Alzheimer's disease incidence in non-APOE ε4-carriers
Fernanda Schäfer Hackenhaar, Maria Josefsson, Annelie Nordin Adolfsson, Mattias Landfors, Karolina Kauppi, Magnus Hultdin, Rolf Adolfsson, Sofie Degerman, Sara Pudas
Efficacy and safety of pharmacotherapy for Alzheimer’s disease and for behavioural and psychological symptoms of dementia in older patients with moderate and severe functional impairments: a systematic review of controlled trials
M. Seibert, V. Mühlbauer, J. Holbrook, S. Voigt-Radloff, S. Brefka, D. Dallmeier, M. Denkinger, C. Schönfeldt-Lecuona, S. Klöppel, C. A. F. von Arnim
A cross-sectional study in healthy elderly subjects aimed at development of an algorithm to increase identification of Alzheimer pathology for the purpose of clinical trial participation
Samantha Prins, Ahnjili Zhuparris, Ellen P. Hart, Robert-Jan Doll, Geert Jan Groeneveld
Plasma amyloid-β oligomerization assay as a pre-screening test for amyloid status
Rosha Babapour Mofrad, Philip Scheltens, SangYun Kim, Sungmin Kang, Young Chul Youn, Seong Soo A. An, Jori Tomassen, Bart N. M. van Berckel, Pieter Jelle Visser, Wiesje M. van der Flier, Charlotte E. Teunissen
Cognitively unimpaired individuals with a low burden of Aβ pathology have a distinct CSF biomarker profile
Marta Milà-Alomà, Mahnaz Shekari, Gemma Salvadó, Juan Domingo Gispert, Eider M. Arenaza-Urquijo, Grégory Operto, Carles Falcon, Natalia Vilor-Tejedor, Oriol Grau-Rivera, Aleix Sala-Vila, Gonzalo Sánchez-Benavides, José Maria González-de-Echávarri, Carolina Minguillon, Karine Fauria, Aida Niñerola-Baizán, Andrés Perissinotti, Maryline Simon, Gwendlyn Kollmorgen, Henrik Zetterberg, Kaj Blennow, Marc Suárez-Calvet, José Luis Molinuevo
Perivascular spaces are associated with tau pathophysiology and synaptic dysfunction in early Alzheimer’s continuum
Natalia Vilor-Tejedor, Iacopo Ciampa, Grégory Operto, Carles Falcón, Marc Suárez-Calvet, Marta Crous-Bou, Mahnaz Shekari, Eider M. Arenaza-Urquijo, Marta Milà-Alomà, Oriol Grau-Rivera, Carolina Minguillon, Gwendlyn Kollmorgen, Henrik Zetterberg, Kaj Blennow, Roderic Guigo, José Luis Molinuevo, Juan Domingo Gispert, Annabella Beteta, Anna Brugulat, Raffaele Cacciaglia, Alba Cañas, Carme Deulofeu, Irene Cumplido, Ruth Dominguez, Maria Emilio, Karine Fauria, Sherezade Fuentes, Laura Hernandez, Gema Huesa, Jordi Huguet, Paula Marne, Tania Menchón, Albina Polo, Sandra Pradas, Blanca Rodriguez-Fernandez, Aleix Sala-Vila, Gonzalo Sánchez-Benavides, Gemma Salvadó, Anna Soteras, Marc Vilanova
Developing methods to detect and diagnose chronic traumatic encephalopathy during life: rationale, design, and methodology for the DIAGNOSE CTE Research Project
Michael L. Alosco, Megan L. Mariani, Charles H. Adler, Laura J. Balcer, Charles Bernick, Rhoda Au, Sarah J. Banks, William B. Barr, Sylvain Bouix, Robert C. Cantu, Michael J. Coleman, David W. Dodick, Lindsay A. Farrer, Yonas E. Geda, Douglas I. Katz, Inga K. Koerte, Neil W. Kowall, Alexander P. Lin, Daniel S. Marcus, Kenneth L. Marek, Michael D. McClean, Ann C. McKee, Jesse Mez, Joseph N. Palmisano, Elaine R. Peskind, Yorghos Tripodis, Robert W. Turner II, Jennifer V. Wethe, Jeffrey L. Cummings, Eric M. Reiman, Martha E. Shenton, Robert A. Stern, Charles H. Adler, Michael L. Alosco, Rhoda Au, Laura Balcer, Sarah Banks, William Barr, Charles Bernick, Sylvain Bouix, Robert C. Cantu, Kewei Chen, Michael J. Coleman, Jeffrey L. Cummings, David W. Dodick, Lindsay Farrer, Jennifer Fitzsimmons, Yonas Geda, Judith Goldberg, Robert Helm, Keith A. Johnson, Douglas I. Katz, Ivan Kirov, Inga K. Koerte, Neil Kowall, Alexander P. Lin, Yvonne Lui, Daniel S. Marcus, Kenneth L. Marek, Megan Mariani, Charles Marmar, Michael McClean, Ann C. McKee, Jesse Mez, Jason Miller, Joseph N. Palmisano, Ofer Pasternak, Elaine R. Peskind, Hillary Protas, Eric Reiman, Aaron Ritter, Martha E. Shenton, Robert A. Stern, Yi Su, Yorghos Tripodis, Robert W. Turner, Jason Weller, Jennifer V. Wethe
Tau-PET and in vivo Braak-staging as prognostic markers of future cognitive decline in cognitively normal to demented individuals
Davina Biel, Matthias Brendel, Anna Rubinski, Katharina Buerger, Daniel Janowitz, Martin Dichgans, Nicolai Franzmeier
Tau-related grey matter network breakdown across the Alzheimer’s disease continuum
Wiesje Pelkmans, Rik Ossenkoppele, Ellen Dicks, Olof Strandberg, Frederik Barkhof, Betty M. Tijms, Joana B. Pereira, Oskar Hansson
Visuospatial alpha and gamma oscillations scale with the severity of cognitive dysfunction in patients on the Alzheimer’s disease spectrum
Alex I. Wiesman, Daniel L. Murman, Pamela E. May, Mikki Schantell, Sara L. Wolfson, Craig M. Johnson, Tony W. Wilson
Probability of Alzheimer’s disease based on common and rare genetic variants
Valentina Escott-Price, Karl Michael Schmidt
Combination of white matter hyperintensities and Aβ burden is related to cognitive composites domain scores in subjective cognitive decline: the FACEHBI cohort
G. Ortega, A. Espinosa, M. Alegret, GC. Monté-Rubio, O. Sotolongo-Grau, A. Sanabria, JP. Tartari, O. Rodríguez-Gómez, M. Marquié, A. Vivas, M. Gómez-Chiari, E. Alarcón-Martín, A. Pérez-Cordón, N. Roberto, I. Hernández, M. Rosende-Roca, L. Vargas, A. Mauleón, C. Abdelnour, E. Esteban De Antonio, R. López-Cuevas, S. Alonso-Lana, S. Moreno-Grau, I. de Rojas, A. Orellana, L. Montrreal, L. Tárraga, A. Ruiz, M. Boada, S. Valero, N. Aguilera, S. Alonso-Lana, M. Berthier, M. Buendia, S. Bullich, F. Campos, P. Cañabate, L. Cañada, C. Cuevas, S. Diego, A. Gailhajenet, P. García, J. Giménez, R. Gismondi, M. Guitart, M. Ibarria, A. Lafuente, F. Lomeña, E. Masip, E. Martín, J. Martínez, M. Moreno, A. Niñerola, A. B. Nogales, L. Núñez, A. Páez, A. Pancho, E. Pelejà, V. Pérez-Grijalba, A. Perissinotti, P. Pesini, S. Preckler, N. Roé-Vellvé, J. Romero, M. I. Ramis, M. Sarasa, M. A. Tejero, M. Torres
Rationale and study design of a randomized, placebo-controlled, double-blind phase 2b trial to evaluate efficacy, safety, and tolerability of an oral glutaminyl cyclase inhibitor varoglutamstat (PQ912) in study participants with MCI and mild AD—VIVIAD
E. G. B. Vijverberg, T. M. Axelsen, A. R. Bihlet, K. Henriksen, F. Weber, K. Fuchs, J. E. Harrison, K. Kühn-Wache, P. Alexandersen, N. D. Prins, Philip Scheltens
Neuroprotection in early stages of Alzheimer’s disease is promoted by transthyretin angiogenic properties
Tiago Gião, Joana Saavedra, José Ricardo Vieira, Marta Teixeira Pinto, Gemma Arsequell, Isabel Cardoso
High-fat diet-induced atherosclerosis promotes neurodegeneration in the triple transgenic (3 × Tg) mouse model of Alzheimer’s disease associated with chronic platelet activation
Min Wang, Junyan Lv, Xiaoshan Huang, Thomas Wisniewski, Wei Zhang
Aβ misfolding in blood plasma is inversely associated with body mass index even in middle adulthood
Tobias Möllers, Hannah Stocker, Laura Perna, Andreas Nabers, Dan Rujescu, Annette M. Hartmann, Bernd Holleczek, Ben Schöttker, Klaus Gerwert, Hermann Brenner
Detection of dementia on voice recordings using deep learning: a Framingham Heart Study
Chonghua Xue, Cody Karjadi, Ioannis Ch. Paschalidis, Rhoda Au, Vijaya B. Kolachalama
Leukotriene receptor antagonist use and cognitive decline in normal cognition, mild cognitive impairment, and Alzheimer’s dementia
Lisa Y. Xiong, Michael Ouk, Che-Yuan Wu, Jennifer S. Rabin, Krista L. Lanctôt, Nathan Herrmann, Sandra E. Black, Jodi D. Edwards, Walter Swardfager
Dynamic reciprocal relationships between cognitive and functional declines along the Alzheimer’s disease continuum in the prospective COGICARE study
Sophie Carles, Bachirou O. Taddé, Claudine Berr, Catherine Helmer, Hélène Jacqmin-Gadda, Isabelle Carrière, Cécile Proust-Lima
Association of plasma and CSF cytochrome P450, soluble epoxide hydrolase, and ethanolamide metabolism with Alzheimer’s disease
Kamil Borkowski, Theresa L. Pedersen, Nicholas T. Seyfried, James J. Lah, Allan I. Levey, Chadwick M. Hales, Eric B. Dammer, Colette Blach, Gregory Louie, Rima Kaddurah-Daouk, John W. Newman
Salivary lactoferrin is associated with cortical amyloid-beta load, cortical integrity, and memory in aging
Lucia Reseco, Mercedes Atienza, Marina Fernandez-Alvarez, Eva Carro, Jose L. Cantero
Predicting progression and cognitive decline in amyloid-positive patients with Alzheimer’s disease
Hákon Valur Dansson, Lena Stempfle, Hildur Egilsdóttir, Alexander Schliep, Erik Portelius, Kaj Blennow, Henrik Zetterberg, Fredrik D. Johansson
Impact of an educational programme on Alzheimer’s disease patients’ quality of life: results of the randomized controlled trial THERAD
Hélène Villars, Christelle Cantet, Eva de Peretti, Amelie Perrin, Maria Soto-martin, Virginie Gardette
Is comprehensiveness critical? Comparing short and long format cognitive assessments in preclinical Alzheimer disease
Jason Hassenstab, Jessica Nicosia, Megan LaRose, Andrew J. Aschenbrenner, Brian A. Gordon, Tammie L. S. Benzinger, Chengjie Xiong, John C. Morris
Intracerebroventricular injection of human umbilical cord blood mesenchymal stem cells in patients with Alzheimer’s disease dementia: a phase I clinical trial
Hee Jin Kim, Kyung Rae Cho, Hyemin Jang, Na Kyung Lee, Young Hee Jung, Jun Pyo Kim, Jung Il Lee, Jong Wook Chang, Seongbeom Park, Sung Tae Kim, Seung Whan Moon, Sang Won Seo, Soo Jin Choi, Duk L. Na
Data analysis with Shapley values for automatic subject selection in Alzheimer’s disease data sets using interpretable machine learning
Louise Bloch, Christoph M. Friedrich
Correction to: Probability of Alzheimer’s disease based on common and rare genetic variants
Valentina Escott-Price, Karl Michael Schmidt
Disparities in the participation and adherence of older adults in lifestyle-based multidomain dementia prevention and the motivational role of perceived disease risk and intervention benefits: an observational ancillary study to a randomised controlled trial
Nicola Coley, Delphine Coniasse-Brioude, Valérie Igier, Tristan Fournier, Jean-Pierre Poulain, Sandrine Andrieu, Sandrine Andrieu, Nicola Coley, Virginie Gardette, Alain Grand, Valérie Igier, Delphine Coniasse Brioude, Maria Teresa Munoz Sastre, Jean Pierre Poulain, Tristan Fournier, Christelle Arandjelovic, Bruno Vellas, Stephane Oustric, Julie Subra
Herpesvirus infections and Alzheimer’s disease: a Mendelian randomization study
Shu-Yi Huang, Yu-Xiang Yang, Kevin Kuo, Hong-Qi Li, Xue-Ning Shen, Shi-Dong Chen, Mei Cui, Lan Tan, Qiang Dong, Jin-Tai Yu
Associations between locus coeruleus integrity and nocturnal awakenings in the context of Alzheimer’s disease plasma biomarkers: a 7T MRI study
Maxime Van Egroo, Roy W. E. van Hooren, Heidi I. L. Jacobs
Cerebrospinal fluid levels of the neurotrophic factor neuroleukin are increased in early Alzheimer’s disease, but not in cerebral amyloid angiopathy
Anna M. De Kort, H. Bea Kuiperij, Daniel Alcolea, Iris Kersten, Alexandra A. M. Versleijen, Steven M. Greenberg, Erik Stoops, Floris H. B. M. Schreuder, Catharina J. M. Klijn, Alberto Lleó, Jurgen A. H. R. Claassen, Marcel M. Verbeek
The circadian rest-activity pattern predicts cognitive decline among mild-moderate Alzheimer’s disease patients
Adriano D. S. Targa, Iván D. Benítez, Faridé Dakterzada, John Fontenele-Araujo, Olga Minguez, Henrik Zetterberg, Kaj Blennow, Ferran Barbé, Gerard Piñol-Ripoll
Machine learning methods for predicting progression from mild cognitive impairment to Alzheimer’s disease dementia: a systematic review
Sergio Grueso, Raquel Viejo-Sobera
Meta-analysis of cerebrospinal fluid neuron-specific enolase levels in Alzheimer’s disease, Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy
Takayuki Katayama, Jun Sawada, Kae Takahashi, Osamu Yahara, Naoyuki Hasebe
BMI1 is associated with CSF amyloid-β and rates of cognitive decline in Alzheimer’s disease
Jun Pyo Kim, Bo-Hyun Kim, Paula J. Bice, Sang Won Seo, David A. Bennett, Andrew J. Saykin, Kwangsik Nho
Activation of PLCβ1 enhances endocannabinoid mobilization to restore hippocampal spike-timing-dependent potentiation and contextual fear memory impaired by Alzheimer’s amyloidosis
Jaedong Lee, Jeehyun Kwag
Characteristics of behavioral symptoms in right-sided predominant semantic dementia and their impact on caregiver burden: a cross-sectional study
Shunsuke Sato, Mamoru Hashimoto, Kenji Yoshiyama, Hideki Kanemoto, Maki Hotta, Shingo Azuma, Takashi Suehiro, Kyosuke Kakeda, Yoshitaka Nakatani, Sumiyo Umeda, Ryuji Fukuhara, Minoru Takebayashi, Manabu Ikeda
Visuospatial memory impairment as a potential neurocognitive marker to predict tau pathology in Alzheimer’s continuum
Eun Hyun Seo, Ho Jae Lim, Hyung-Jun Yoon, Kyu Yeong Choi, Jang Jae Lee, Jun Young Park, Seong Hye Choi, Hoowon Kim, Byeong C. Kim, Kun Ho Lee
Brain Health Services: organization, structure, and challenges for implementation. A user manual for Brain Health Services—part 1 of 6
Daniele Altomare, José Luis Molinuevo, Craig Ritchie, Federica Ribaldi, Emmanuel Carrera, Bruno Dubois, Frank Jessen, Laura McWhirter, Philip Scheltens, Wiesje M. van der Flier, Bruno Vellas, Jean-François Démonet, Giovanni B. Frisoni, Marc Abramowicz, Daniele Altomare, Frederik Barkhof, Marcelo Berthier, Melanie Bieler, Kaj Blennow, Carol Brayne, Andrea Brioschi, Emmanuel Carrera, Gael Chételat, Chantal Csajka, Jean-François Demonet, Alessandra Dodich, Bruno Dubois, Giovanni B. Frisoni, Valentina Garibotto, Jean Georges, Samia Hurst, Frank Jessen, Miia Kivipelto, David Llewellyn, Laura McWhirter, Richard Milne, Carolina Minguillón, Carlo Miniussi, José Luis Molinuevo, Peter M. Nilsson, Janice Ranson, Federica Ribaldi, Craig Ritchie, Philip Scheltens, Alina Solomon, Wiesje van Der Flier, Cornelia van Duijn, Bruno Vellas, Leonie Visser
Modifiable risk factors for dementia and dementia risk profiling. A user manual for Brain Health Services—part 2 of 6
Janice M. Ranson, Timothy Rittman, Shabina Hayat, Carol Brayne, Frank Jessen, Kaj Blennow, Cornelia van Duijn, Frederik Barkhof, Eugene Tang, Catherine J. Mummery, Blossom C. M. Stephan, Daniele Altomare, Giovanni B. Frisoni, Federica Ribaldi, José Luis Molinuevo, Philip Scheltens, David J. Llewellyn, Marc Abramowicz, Daniele Altomare, Frederik Barkhof, Marcelo Berthier, Melanie Bieler, Kaj Blennow, Carol Brayne, Andrea Brioschi, Emmanuel Carrera, Gael Chételat, Chantal Csajka, Jean-François Demonet, Alessandra Dodich, Bruno Dubois, Giovanni B. Frisoni, Valentina Garibotto, Jean Georges, Samia Hurst, Frank Jessen, Miia Kivipelto, David J. Llewellyn, Laura McWhirter, Richard Milne, Carolina Minguillón, Carlo Miniussi, José Luis Molinuevo, Peter M. Nilsson, Janice M. Ranson, Federica Ribaldi, Craig Ritchie, Philip Scheltens, Alina Solomon, Wiesje van der Flier, Cornelia van Duijn, Bruno Vellas, Leonie Visser
Dementia risk communication. A user manual for Brain Health Services—part 3 of 6
Leonie N. C. Visser, Carolina Minguillon, Gonzalo Sánchez-Benavides, Marc Abramowicz, Daniele Altomare, Karine Fauria, Giovanni B. Frisoni, Jean Georges, Federica Ribaldi, Philip Scheltens, Jetske van der Schaar, Marissa Zwan, Wiesje M. van der Flier, José Luis Molinuevo
Multidomain interventions: state-of-the-art and future directions for protocols to implement precision dementia risk reduction. A user manual for Brain Health Services—part 4 of 6
Alina Solomon, Ruth Stephen, Daniele Altomare, Emmanuel Carrera, Giovanni B. Frisoni, Jenni Kulmala, José Luis Molinuevo, Peter Nilsson, Tiia Ngandu, Federica Ribaldi, Bruno Vellas, Philip Scheltens, Miia Kivipelto, Marc Abramowicz, Daniele Altomare, Frederik Barkhof, Marcelo Berthier, Melanie Bieler, Kaj Blennow, Carol Brayne, Andrea Brioschi, Emmanuel Carrera, Gael Chételat, Chantal Csajka, Jean-François Demonet, Alessandra Dodich, Bruno Dubois, Giovanni B. Frisoni, Valentina Garibotto, Jean Georges, Samia Hurst, Frank Jessen, Miia Kivipelto, David Llewellyn, Laura Mcwhirter, Richard Milne, Carolina Minguillón, Carlo Miniussi, José Luis Molinuevo, Peter M. Nilsson, Janice Ranson, Federica Ribaldi, Craig Ritchie, Philip Scheltens, Alina Solomon, Cornelia van Duijn, Wiesje van der Flier, Bruno Vellas, Leonie Visser
Protocols for cognitive enhancement. A user manual for Brain Health Services—part 5 of 6
Andrea Brioschi Guevara, Melanie Bieler, Daniele Altomare, Marcelo Berthier, Chantal Csajka, Sophie Dautricourt, Jean-François Démonet, Alessandra Dodich, Giovanni B. Frisoni, Carlo Miniussi, José Luis Molinuevo, Federica Ribaldi, Philip Scheltens, Gael Chételat
Societal and equity challenges for Brain Health Services. A user manual for Brain Health Services—part 6 of 6
Richard Milne, Daniele Altomare, Federica Ribaldi, José Luis Molinuevo, Giovanni B. Frisoni, Carol Brayne
Age, vascular disease, and Alzheimer’s disease pathologies in amyloid negative elderly adults
Tengfei Guo, Susan M. Landau, William J. Jagust
Characterization of an APP/tau rat model of Alzheimer’s disease by positron emission tomography and immunofluorescent labeling
Thomas Filip, Severin Mairinger, Joerg Neddens, Michael Sauberer, Stefanie Flunkert, Johann Stanek, Thomas Wanek, Nobuyuki Okamura, Oliver Langer, Birgit Hutter-Paier, Claudia Kuntner
Homozygous R136S mutation in PRNP gene causes inherited early onset prion disease
Teresa Ximelis, Alba Marín-Moreno, Juan Carlos Espinosa, Hasier Eraña, Jorge M. Charco, Isabel Hernández, Carmen Riveira, Daniel Alcolea, Eva González-Roca, Iban Aldecoa, Laura Molina-Porcel, Piero Parchi, Marcello Rossi, Joaquín Castilla, Raquel Ruiz-García, Ellen Gelpi, Juan María Torres, Raquel Sánchez-Valle
Gut–microbiota–microglia–brain interactions in Alzheimer’s disease: knowledge-based, multi-dimensional characterization
QuanQiu Wang, Pamela B. Davis, Xin Qi, Shu G. Chen, Mark E. Gurney, George Perry, P. Murali Doraiswamy, Rong Xu
In vivo staging of regional amyloid progression in healthy middle-aged to older people at risk of Alzheimer’s disease
Fedor Levin, Irina Jelistratova, Tobey J. Betthauser, Ozioma Okonkwo, Sterling C. Johnson, Stefan J. Teipel, Michel J. Grothe
Performance of the plasma Aβ42/Aβ40 ratio, measured with a novel HPLC-MS/MS method, as a biomarker of amyloid PET status in a DPUK-KOREAN cohort
Hyemin Jang, Ji Sun Kim, Hye Joo Lee, Chi-Hun Kim, Duk L. Na, Hee Jin Kim, José Antonio Allué, Leticia Sarasa, Sergio Castillo, Pedro Pesini, John Gallacher, Sang Won Seo
Intracortical diffusion tensor imaging signature of microstructural changes in frontotemporal lobar degeneration
Mario Torso, Gerard R. Ridgway, Mark Jenkinson, Steven Chance
The apolipoprotein receptor LRP3 compromises APP levels
Inmaculada Cuchillo-Ibañez, Matthew P. Lennol, Sergio Escamilla, Trinidad Mata-Balaguer, Lucía Valverde-Vozmediano, Inmaculada Lopez-Font, Isidro Ferrer, Javier Sáez-Valero
High-intensity physical activity is not associated with better cognition in the elder: evidence from the China Health and Retirement Longitudinal Study
Zhiyuan Wu, Haiping Zhang, Xinlei Miao, Haibin Li, Huiying Pan, Di Zhou, Yue Liu, Zhiwei Li, Jinqi Wang, Xiangtong Liu, Deqiang Zheng, Xia Li, Wei Wang, Xiuhua Guo, Lixin Tao
Dysregulated expression levels of APH1B in peripheral blood are associated with brain atrophy and amyloid-β deposition in Alzheimer’s disease
Young Ho Park, Jung-Min Pyun, Angela Hodges, Jae-Won Jang, Paula J. Bice, SangYun Kim, Andrew J. Saykin, Kwangsik Nho
N-Methyl-D-aspartate (NMDA) and cannabinoid CB2 receptors form functional complexes in cells of the central nervous system: insights into the therapeutic potential of neuronal and microglial NMDA receptors
Rafael Rivas-Santisteban, Alejandro Lillo, Jaume Lillo, Joan-Biel Rebassa, Joan S. Contestí, Carlos A. Saura, Rafael Franco, Gemma Navarro
Boosting the diagnostic power of amyloid-β PET using a data-driven spatially informed classifier for decision support
Ashwin V. Venkataraman, Wenjia Bai, Alex Whittington, James F. Myers, Eugenii A. Rabiner, Anne Lingford-Hughes, Paul M. Matthews
The Alzheimer’s disease drug development landscape
Pieter van Bokhoven, Arno de Wilde, Lisa Vermunt, Prisca S. Leferink, Sasja Heetveld, Jeffrey Cummings, Philip Scheltens, Everard G. B. Vijverberg
In vivo human molecular neuroimaging of dopaminergic vulnerability along the Alzheimer’s disease phases
Arianna Sala, Silvia Paola Caminiti, Luca Presotto, Andrea Pilotto, Claudio Liguori, Agostino Chiaravalloti, Valentina Garibotto, Giovanni Battista Frisoni, Marcello D’Amelio, Barbara Paghera, Orazio Schillaci, Nicola Mercuri, Alessandro Padovani, Daniela Perani
Prodromal frontotemporal dementia: clinical features and predictors of progression
Alberto Benussi, Nicholas J. Ashton, Thomas K. Karikari, Antonella Alberici, Claudia Saraceno, Roberta Ghidoni, Luisa Benussi, Henrik Zetterberg, Kaj Blennow, Barbara Borroni
Correction to: Cerebrospinal fluid levels of the neurotrophic factor neuroleukin are increased in early Alzheimer’s disease, but not in cerebral amyloid angiopathy
Anna M. De Kort, H. Bea Kuiperij, Daniel Alcolea, Iris Kersten, Alexandra A. M. Versleijen, Steven M. Greenberg, Erik Stoops, Floris H. B. M. Schreuder, Catharina J. M. Klijn, Alberto Lleó, Jurgen A. H. R. Claassen, Marcel M. Verbeek
Serum zinc levels and in vivo beta-amyloid deposition in the human brain
Jee Wook Kim, Min Soo Byun, Dahyun Yi, Jun Ho Lee, Min Jung Kim, Gijung Jung, Jun-Young Lee, Koung Mi Kang, Chul-Ho Sohn, Yun-Sang Lee, Yu Kyeong Kim, Dong Young Lee
Improving 3D convolutional neural network comprehensibility via interactive visualization of relevance maps: evaluation in Alzheimer’s disease
Martin Dyrba, Moritz Hanzig, Slawek Altenstein, Sebastian Bader, Tommaso Ballarini, Frederic Brosseron, Katharina Buerger, Daniel Cantré, Peter Dechent, Laura Dobisch, Emrah Düzel, Michael Ewers, Klaus Fliessbach, Wenzel Glanz, John-Dylan Haynes, Michael T. Heneka, Daniel Janowitz, Deniz B. Keles, Ingo Kilimann, Christoph Laske, Franziska Maier, Coraline D. Metzger, Matthias H. Munk, Robert Perneczky, Oliver Peters, Lukas Preis, Josef Priller, Boris Rauchmann, Nina Roy, Klaus Scheffler, Anja Schneider, Björn H. Schott, Annika Spottke, Eike J. Spruth, Marc-André Weber, Birgit Ertl-Wagner, Michael Wagner, Jens Wiltfang, Frank Jessen, Stefan J. Teipel
Self-Administered Gerocognitive Examination: longitudinal cohort testing for the early detection of dementia conversion
Douglas W. Scharre, Shu ing Chang, Haikady N. Nagaraja, Natalie C. Wheeler, Maria Kataki
Structural MRI profiles and tau correlates of atrophy in autopsy-confirmed CTE
Michael L. Alosco, Asim Z. Mian, Karen Buch, Chad W. Farris, Madeline Uretsky, Yorghos Tripodis, Zachary Baucom, Brett Martin, Joseph Palmisano, Christian Puzo, Ting Fang Alvin Ang, Prajakta Joshi, Lee E. Goldstein, Rhoda Au, Douglas I. Katz, Brigid Dwyer, Daniel H. Daneshvar, Christopher Nowinski, Robert C. Cantu, Neil W. Kowall, Bertrand Russell Huber, Victor E. Alvarez, Robert A. Stern, Thor D. Stein, Ronald J. Killiany, Ann C. McKee, Jesse Mez
Intermittent hypoxia treatment alleviates memory impairment in the 6-month-old APPswe/PS1dE9 mice and reduces amyloid beta accumulation and inflammation in the brain
Xiangpei Yue, Yanzhao Zhou, Meng Qiao, Xingnan Zhao, Xin Huang, Tong Zhao, Xiang Cheng, Ming Fan, Yongqi Zhao, Ruoli Chen, Lingling Zhu
Dementia in Southeast Asia: influence of onset-type, education, and cerebrovascular disease
Ashwati Vipin, Vaynii Satish, Seyed Ehsan Saffari, Wilbur Koh, Levinia Lim, Eveline Silva, Mei Mei Nyu, Tanya-Marie Choong, Esther Chua, Linda Lim, Adeline Su Lyn Ng, Hui Jin Chiew, Kok Pin Ng, Nagaendran Kandiah
Baseline [18F]GTP1 tau PET imaging is associated with subsequent cognitive decline in Alzheimer’s disease
Edmond Teng, Paul T. Manser, Sandra Sanabria Bohorquez, Kristin R. Wildsmith, Karen Pickthorn, Suzanne L. Baker, Michael Ward, Geoffrey A. Kerchner, Robby M. Weimer
The association of antidiabetic medications and Mini-Mental State Examination scores in patients with diabetes and dementia
Juraj Secnik, Hong Xu, Emilia Schwertner, Niklas Hammar, Michael Alvarsson, Bengt Winblad, Maria Eriksdotter, Sara Garcia-Ptacek, Dorota Religa
Clinical and analytical comparison of six Simoa assays for plasma P-tau isoforms P-tau181, P-tau217, and P-tau231
Sherif Bayoumy, Inge M. W. Verberk, Ben den Dulk, Zulaiga Hussainali, Marissa Zwan, Wiesje M. van der Flier, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Jeroen Vanbrabant, Erik Stoops, Eugeen Vanmechelen, Jeffrey L. Dage, Charlotte E. Teunissen
Comparison of plasma neurofilament light and total tau as neurodegeneration markers: associations with cognitive and neuroimaging outcomes
Jordan D. Marks, Jeremy A. Syrjanen, Jonathan Graff-Radford, Ronald C. Petersen, Mary M. Machulda, Michelle R. Campbell, Alicia Algeciras-Schimnich, Val Lowe, David S. Knopman, Clifford R. Jack Jr, Prashanthi Vemuri, Michelle M. Mielke
P-tau and neurodegeneration mediate the effect of β-amyloid on cognition in non-demented elders
Ling-Zhi Ma, Hao Hu, Zuo-Teng Wang, Ya-Nan Ou, Qiang Dong, Lan Tan, Jin-Tai Yu
Impact of potential modifications to Alzheimer’s disease clinical trials in response to disruption by COVID-19: a simulation study
Lon S. Schneider, Yuqi Qiu, Ronald G. Thomas, Carol Evans, Diane M. Jacobs, Shelia Jin, Jeffrey A. Kaye, Andrea Z. LaCroix, Karen Messer, David P. Salmon, Mary Sano, Kimberly Schafer, Howard H. Feldman
Is kallikrein-8 a blood biomarker for detecting amnestic mild cognitive impairment? Results of the population-based Heinz Nixdorf Recall study
Sara Schramm, Martha Jokisch, Karl-Heinz Jöckel, Arne Herring, Kathy Keyvani
Impact of multisession 40Hz tACS on hippocampal perfusion in patients with Alzheimer’s disease
Giulia Sprugnoli, Fanny Munsch, Davide Cappon, Rachel Paciorek, Joanna Macone, Ann Connor, Georges El Fakhri, Ricardo Salvador, Giulio Ruffini, Kevin Donohoe, Mouhsin M. Shafi, Daniel Press, David C. Alsop, Alvaro Pascual Leone, Emiliano Santarnecchi