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13.08.2018 | Oncology

Amid proton transfer (APT) and magnetization transfer (MT) MRI contrasts provide complimentary assessment of brain tumors similarly to proton magnetic resonance spectroscopy imaging (MRSI)

verfasst von: Changliang Su, Lingyun Zhao, Shihui Li, Jingjing Jiang, Kejia Cai, Jingjing Shi, Yihao Yao, Qilin Ao, Guiling Zhang, Nanxi Shen, Shan Hu, Jiaxuan Zhang, Yuanyuan Qin, Wenzhen Zhu

Erschienen in: European Radiology | Ausgabe 3/2019

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Abstract

Objectives

Using MRSI as comparison, we aimed to explore the difference between amide proton transfer (APT) MRI and conventional semi-solid magnetization transfer ratio (MTR) MRI, and to investigate if molecular APT and structural MTR can provide complimentary information in assessing brain tumors.

Methods

Seventeen brain tumor patients and 17 age- and gender-matched volunteers were included and scanned with anatomical MRI, APT and MT-weighted MRI, and MRSI. Multi-voxel choline (Cho) and N-acetylaspartic acid (NAA) signals were quantified from MRSI and compared with MTR and MTR_asym(3.5ppm) contrasts averaged from corresponding voxels. Correlations between contrasts were explored voxel-by-voxel by pooling values from all voxels into Pearson’s correlation analysis. Differences in correlation coefficients were tested with the Z-test (set at p<0.05).

Results

APT and MT provide good contrast and quantitative parameters in tumor imaging, as do the metabolite (Cho and NAA) maps. MTR_asym(3.5ppm) significantly correlated with MTR (R=-0.61, p<0.0001), Cho (R=0.568, p<0.0001) and NAA (R=-0.619, p<0.0001) in tumors, and MTR also significantly correlated with Cho (R=-0.346, p<0.0001) and NAA (R=0.624, p<0.0001). In healthy volunteers, MTR_asym(3.5ppm) was non-significantly correlated with MTR (R=-0.049, p=0.239), Cho (R=0.030, p=0.478) and NAA (R=-0.083, p=0.046). Significant correlations were found among MTR with Cho (R=0.199, p<0.0001) and NAA (R=0.263, p<0.0001) in the group of healthy volunteers with lower correlation R values than those in tumor patients.

Conclusions

APT and MT could provide independent and supplementary information for the comprehensive assessment of molecular and structural changes due to brain tumor cancerogenesis.

Key Points

• MTR _asym(3.5ppm) positively correlated with Cho while negatively with NAA in tumors.

• MTR positively correlated with NAA while negatively with Cho in tumors.

• Combining APT/MT provides molecular and structural information similarly to MRSI.

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Titel: Amid proton transfer (APT) and magnetization transfer (MT) MRI contrasts provide complimentary assessment of brain tumors similarly to proton magnetic resonance spectroscopy imaging (MRSI)
verfasst von: Changliang Su
Lingyun Zhao
Shihui Li
Jingjing Jiang
Kejia Cai
Jingjing Shi
Yihao Yao
Qilin Ao
Guiling Zhang
Nanxi Shen
Shan Hu
Jiaxuan Zhang
Yuanyuan Qin
Wenzhen Zhu
Publikationsdatum: 13.08.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 3/2019
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-018-5615-8

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Amid proton transfer (APT) and magnetization transfer (MT) MRI contrasts provide complimentary assessment of brain tumors similarly to proton magnetic resonance spectroscopy imaging (MRSI)

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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Abstract

Objectives

Methods

Results

Conclusions

Key Points

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