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01.01.2018 | Neuro

Amide proton transfer imaging for differentiation of benign and atypical meningiomas

verfasst von: Bio Joo, Kyunghwa Han, Yoon Seong Choi, Seung-Koo Lee, Sung Soo Ahn, Jong Hee Chang, Seok-Gu Kang, Se Hoon Kim, Jinyuan Zhou

Erschienen in: European Radiology | Ausgabe 1/2018

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Abstract

Purpose

To investigate the difference in amide proton transfer (APT)-weighted signals between benign and atypical meningiomas and determine the value of APT imaging for differentiating the two.

Methods

Fifty-seven patients with pathologically diagnosed meningiomas (benign, 44; atypical, 13), who underwent preoperative MRI with APT imaging between December 2014 and August 2016 were included. We compared normalised magnetisation transfer ratio asymmetry (nMTR _asym) values between benign and atypical meningiomas on APT-weighted images. Conventional MRI features were qualitatively assessed. Both imaging features were evaluated by multivariable logistic regression analysis. The discriminative value of MRI with and without nMTR _asym was evaluated.

Results

The nMTR _asym of atypical meningiomas was significantly greater than that of benign meningiomas (2.46% vs. 1.67%; P < 0.001). In conventional MR images, benign and atypical meningiomas exhibited significant differences in maximum tumour diameter, non-skull base location, and heterogeneous enhancement. On multivariable logistic regression analysis, high nMTR _asym was an independent predictor of atypical meningiomas (adjusted OR, 11.227; P = 0.014). The diagnostic performance of MRI improved with nMTR _asym for predicting atypical meningiomas.

Conclusion

Atypical meningiomas exhibited significantly higher APT-weighted signal intensities than benign meningiomas. The discriminative value of conventional MRI improved significantly when combined with APT imaging for diagnosis of atypical meningioma.

Key Points

• APT imaging is useful for differentiating between atypical and benign meningiomas.

• Atypical meningiomas exhibited high APT-weighted signal intensity than benign meningiomas.

• The diagnostic performance of MRI improved with nMTR _asym for predicting atypical meningiomas.

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Titel: Amide proton transfer imaging for differentiation of benign and atypical meningiomas
verfasst von: Bio Joo
Kyunghwa Han
Yoon Seong Choi
Seung-Koo Lee
Sung Soo Ahn
Jong Hee Chang
Seok-Gu Kang
Se Hoon Kim
Jinyuan Zhou
Publikationsdatum: 01.01.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 1/2018
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-017-4962-1

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Amide proton transfer imaging for differentiation of benign and atypical meningiomas

Abstract

Purpose

Methods

Results

Conclusion

Key Points

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Purpose

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Conclusion

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