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Erschienen in: Neuroradiology 5/2019

21.01.2019 | Diagnostic Neuroradiology

Amide proton transfer-weighted MRI in distinguishing high- and low-grade gliomas: a systematic review and meta-analysis

verfasst von: Chong Hyun Suh, Ji Eun Park, Seung Chai Jung, Choong Gon Choi, Sang Joon Kim, Ho Sung Kim

Erschienen in: Neuroradiology | Ausgabe 5/2019

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Abstract

Purpose

Grading of brain gliomas is of clinical importance, and noninvasive molecular imaging may help differentiate low- and high-grade gliomas. We aimed to evaluate the diagnostic performance of amide proton transfer-weighted (APTw) MRI for differentiating low- and high-grade gliomas on 3-T scanners.

Methods

A systematic literature search of Ovid-MEDLINE and EMBASE was performed up to March 28, 2018. Original articles evaluating the diagnostic performance of APTw MRI for differentiating low- and high-grade gliomas were selected. The pooled sensitivity and specificity were calculated using a bivariate random-effects model. A coupled forest plot and a hierarchical summary receiver operating characteristic curve were obtained. Heterogeneity was investigated using Higgins inconsistency index (I2) test. Meta-regression was performed.

Results

Ten original articles with a total of 353 patients were included. High-grade gliomas showed significantly higher APT signal intensity than low-grade gliomas. The pooled sensitivity and specificity for the diagnostic performance of APTw MRI for differentiating low-grade and high-grade gliomas were 88% (95% CI, 77–94%) and 91% (95% CI, 82–96%), respectively. Higgins I2 statistic demonstrated heterogeneity in the sensitivity (I2 = 68.17%), whereas no heterogeneity was noted in the specificity (I2 = 44.84%). In meta-regression, RF saturation power was associated with study heterogeneity. Correlation coefficients between APT signal intensity and Ki-67 cellular proliferation index ranged from 0.430 to 0.597, indicating moderate correlation. All studies showed excellent interobserver agreement.

Conclusions

Although heterogeneous protocols were used, APTw MRI demonstrated excellent diagnostic performance for differentiating low- and high-grade gliomas. APTw MRI could be a reliable technique for glioma grading in clinical practice.
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Literatur
8.
Zurück zum Zitat Togao O, Yoshiura T, Keupp J, Hiwatashi A, Yamashita K, Kikuchi K, Suzuki Y, Suzuki SO, Iwaki T, Hata N, Mizoguchi M, Yoshimoto K, Sagiyama K, Takahashi M, Honda H (2014) Amide proton transfer imaging of adult diffuse gliomas: correlation with histopathological grades. Neuro-Oncology 16:441–448. https://doi.org/10.1093/neuonc/not158 CrossRefPubMed Togao O, Yoshiura T, Keupp J, Hiwatashi A, Yamashita K, Kikuchi K, Suzuki Y, Suzuki SO, Iwaki T, Hata N, Mizoguchi M, Yoshimoto K, Sagiyama K, Takahashi M, Honda H (2014) Amide proton transfer imaging of adult diffuse gliomas: correlation with histopathological grades. Neuro-Oncology 16:441–448. https://​doi.​org/​10.​1093/​neuonc/​not158 CrossRefPubMed
13.
Zurück zum Zitat Sakata A, Fushimi Y, Okada T, Arakawa Y, Kunieda T, Minamiguchi S, Kido A, Sakashita N, Miyamoto S, Togashi K (2017) Diagnostic performance between contrast enhancement, proton MR spectroscopy, and amide proton transfer imaging in patients with brain tumors. J Magn Reson Imaging 46:732–739. https://doi.org/10.1002/jmri.25597 CrossRefPubMed Sakata A, Fushimi Y, Okada T, Arakawa Y, Kunieda T, Minamiguchi S, Kido A, Sakashita N, Miyamoto S, Togashi K (2017) Diagnostic performance between contrast enhancement, proton MR spectroscopy, and amide proton transfer imaging in patients with brain tumors. J Magn Reson Imaging 46:732–739. https://​doi.​org/​10.​1002/​jmri.​25597 CrossRefPubMed
14.
Zurück zum Zitat Zhou J, Zhu H, Lim M, Blair L, Quinones-Hinojosa A, Messina SA, Eberhart CG, Pomper MG, Laterra J, Barker PB, van Zijl PCM, Blakeley JO (2013) Three-dimensional amide proton transfer MR imaging of gliomas: initial experience and comparison with gadolinium enhancement. J Magn Reson Imaging 38:1119–1128. https://doi.org/10.1002/jmri.24067 CrossRefPubMed Zhou J, Zhu H, Lim M, Blair L, Quinones-Hinojosa A, Messina SA, Eberhart CG, Pomper MG, Laterra J, Barker PB, van Zijl PCM, Blakeley JO (2013) Three-dimensional amide proton transfer MR imaging of gliomas: initial experience and comparison with gadolinium enhancement. J Magn Reson Imaging 38:1119–1128. https://​doi.​org/​10.​1002/​jmri.​24067 CrossRefPubMed
15.
Zurück zum Zitat Zou T, Yu H, Jiang C, Wang X, Jiang S, Rui Q, Mei Y, Zhou J, Wen Z (2018) Differentiating the histologic grades of gliomas preoperatively using amide proton transfer-weighted (APTW) and intravoxel incoherent motion MRI. NMR Biomed 31:e3850. https://doi.org/10.1002/nbm.3850 CrossRef Zou T, Yu H, Jiang C, Wang X, Jiang S, Rui Q, Mei Y, Zhou J, Wen Z (2018) Differentiating the histologic grades of gliomas preoperatively using amide proton transfer-weighted (APTW) and intravoxel incoherent motion MRI. NMR Biomed 31:e3850. https://​doi.​org/​10.​1002/​nbm.​3850 CrossRef
21.
Zurück zum Zitat Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Ann Intern Med 151:W65–W94CrossRefPubMed Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Ann Intern Med 151:W65–W94CrossRefPubMed
27.
Zurück zum Zitat Rutter CM, Gatsonis CA (2001) A hierarchical regression approach to meta-analysis of diagnostic test accuracy evaluations. Stat Med 20:2865–2884CrossRefPubMed Rutter CM, Gatsonis CA (2001) A hierarchical regression approach to meta-analysis of diagnostic test accuracy evaluations. Stat Med 20:2865–2884CrossRefPubMed
29.
36.
Zurück zum Zitat Jiang S, Yu H, Wang X, Lu S, Li Y, Feng L, Zhang Y, Heo HY, Lee DH, Zhou J, Wen Z (2016) Molecular MRI differentiation between primary central nervous system lymphomas and high-grade gliomas using endogenous protein-based amide proton transfer MR imaging at 3 tesla. Eur Radiol 26:64–71. https://doi.org/10.1007/s00330-015-3805-1 CrossRefPubMed Jiang S, Yu H, Wang X, Lu S, Li Y, Feng L, Zhang Y, Heo HY, Lee DH, Zhou J, Wen Z (2016) Molecular MRI differentiation between primary central nervous system lymphomas and high-grade gliomas using endogenous protein-based amide proton transfer MR imaging at 3 tesla. Eur Radiol 26:64–71. https://​doi.​org/​10.​1007/​s00330-015-3805-1 CrossRefPubMed
37.
Zurück zum Zitat Keupp J, Baltes C, Harvey P, Van den Brink J (2011) Parallel RF transmission based MRI technique for highly sensitive detection of amide proton transfer in the human brain at 3T. In: Proc Int Soc Magn Reson Med, p 710 Keupp J, Baltes C, Harvey P, Van den Brink J (2011) Parallel RF transmission based MRI technique for highly sensitive detection of amide proton transfer in the human brain at 3T. In: Proc Int Soc Magn Reson Med, p 710
Metadaten
Titel
Amide proton transfer-weighted MRI in distinguishing high- and low-grade gliomas: a systematic review and meta-analysis
verfasst von
Chong Hyun Suh
Ji Eun Park
Seung Chai Jung
Choong Gon Choi
Sang Joon Kim
Ho Sung Kim
Publikationsdatum
21.01.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
Neuroradiology / Ausgabe 5/2019
Print ISSN: 0028-3940
Elektronische ISSN: 1432-1920
DOI
https://doi.org/10.1007/s00234-018-02152-2

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