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01.12.2014 | Case report | Ausgabe 1/2014 Open Access

Journal of Medical Case Reports 1/2014

Aminaphtone therapy in patients with type 1 diabetes and albuminuria: a case report

Journal of Medical Case Reports > Ausgabe 1/2014
Concetta Romano, Consuelo Tamburella, Martino Costa, Marco Messina, Anna Lisa Fassari, Marco Bertini
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1752-1947-8-443) contains supplementary material, which is available to authorized users.

Competing interests

C Romano, C Tamburella, M Costa, M Messina and AL Fassari declare that they have no competing interests.
Marco Bertini has competing interests because he is the Medical Department Director of Laboratori Baldacci, the company that produces aminaphtone.

Authors’ contributions

CR, CT, MC and MM clinically followed the patient during his hospitalisation time; CR performed videocapillaroscopy examination; ALF followed the time course of the retinal complications of the patient; MB conceived of the study, collected the data and helped to draft the manuscript. All authors read and approved the final manuscript.



Microalbuminuria in type 1 diabetes is the earliest manifestation of diabetic microangiopathy (nephropathy). To date, the pharmacological approach to microangiopathy has not been shown to be useful. By using aminaphtone to control nephrologic complications of insulin-dependent diabetes mellitus we first obtained a significant improvement in microalbuminuria confirming this new pharmacological approach for insulin-dependent diabetes mellitus organospecific complications control.

Case presentation

After being treated with standard therapy for insulin-dependent diabetes mellitus (insulin) for more than 20 years, a 49-year-old white man affected by insulin-dependent diabetes mellitus adopted the standard therapy aminaphtone for a period of 2 months.
This therapy allowed a significant reduction of proteinuria from baseline evaluation that immediately increased after he stopped aminaphtone therapy.


Aminaphtone therapy, used globally in the treatment and prevention of endothelial dysfunctions, could be an interesting option for patients with insulin-dependent diabetes mellitus with the express purpose of preventing diabetic nephropathy.

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